CN103584072A - Fatigue-alleviating composition, preparation method and application thereof - Google Patents
Fatigue-alleviating composition, preparation method and application thereof Download PDFInfo
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- CN103584072A CN103584072A CN201210290894.3A CN201210290894A CN103584072A CN 103584072 A CN103584072 A CN 103584072A CN 201210290894 A CN201210290894 A CN 201210290894A CN 103584072 A CN103584072 A CN 103584072A
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- A—HUMAN NECESSITIES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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Abstract
The invention discloses a fatigue-alleviating composition, a preparation method and application thereof. The fatigue-alleviating composition comprises yeast extract and zinc-rich yeast/zinc-rich yeast extract, wherein the mass ratio of the yeast extract to the zinc-rich yeast/the zinc-rich yeast extract is 2:3-19:1. The provided fatigue-alleviating composition containing yeast extract and zinc-rich yeast/zinc-rich yeast extract helps to fill the blank of yeast extracts in health product application field and develop a new direction for research and development of yeast extracts. The mixing usage of yeast extract and zinc-rich yeast/zinc-rich yeast extract helps the fatigue-alleviating composition to enhance the efficacy of resisting fatigue, resisting anoxia, delaying ageing, improving immunity and the like, and has substantial synergistic effect.
Description
Technical field
The present invention relates to field of health care products, in particular to a kind of fatigue-relieving composition, preparation method and application thereof.
Background technology
With the increase of social pressures, in some cities, except the patient that a part is made a definite diagnosis, the healthy person in ordinary person's eye has half left and right in " inferior health " state with the quickening pace of modern life.Inferior health is the category concept between health fatigue and disease fatigue, and the tired mechanism producing is fuzzyyer, and factor is complicated.During physical fatigue, in body, can there is the physiological change of series of complex; this variation is to prevent that body from a kind of aversion response that life-threatening excessive failure function produces occurring; physical fatigue major embodiment is that body is uncomfortable; the uncomfortable main manifestations of body is tired sleepy; also have some tired simultaneous phenomenons, as degradation under dizzy, forgetful, sleep quality.According to statistics, showing that ， China is domestic has people more than half at present in fatigue state, therefore, is tiredly not only medical problem with inferior health, and day by day becomes and need the social concern paid close attention to, seriously affects people's quality of life.
These health products raw material that use are at present more expensive, consumer groups have been limited, yeast is a kind of edible, nutritious unicellular microorganism product, contain the materials such as rich in protein, B family vitamin, fat, nucleic acid, sterol and multiple enzyme, yeast or the carrier of various trace elements, it is worth gradually by human development and utilization.Yeast extract is again yeast extract, and it is obtained by the activated yeast cells processing of tool, is the concentrate of material in yeast cells, and product itself has not possessed fermentation activity.In process of production, yeast is through synergy such as himself contained enzyme and additional commercial enzyme preparation and some cosolvents, intracellular protein is resolved into and take the material that amino acid, peptide class is main component, and stripping yeast cells is outer by separated, concentrated and drying and other steps is refining forms.But yeast extract is mainly used for flavouring aspect, so yeast extract etc. become current research tendency in the exploitation of other side.
Summary of the invention
The present invention aims to provide a kind of fatigue-relieving composition, preparation method and application thereof, to solve the technical problem that yeast extract application is narrower and its function is not in full use existing in prior art.
To achieve these goals, according to an aspect of the present invention, a kind of fatigue-relieving composition is provided, has comprised yeast extract and Zinc-rich saccharomyces cerevisiae or Zinc-rich saccharomyces cerevisiae extract, wherein the mass ratio of yeast extract and Zinc-rich saccharomyces cerevisiae or Zinc-rich saccharomyces cerevisiae extract is 2: 3～19: 1.
Further, the yeast extract that is 40%～95% by mass percent and mass percent are that 5%～60% Zinc-rich saccharomyces cerevisiae or Zinc-rich saccharomyces cerevisiae extract form.
Further, the yeast extract that is 60%～90% by mass percent and mass percent are that 10%～40% Zinc-rich saccharomyces cerevisiae or Zinc-rich saccharomyces cerevisiae extract form.
Further, the yeast extract that is 65% by mass percent and mass percent are that 35% Zinc-rich saccharomyces cerevisiae or Zinc-rich saccharomyces cerevisiae extract form.
Further, in Zinc-rich saccharomyces cerevisiae or Zinc-rich saccharomyces cerevisiae extract, the content of zinc is 2000～50000ppm; In yeast extract, the mass percent of protein is 40%～80%.
Further, also comprise that one or more in Radix Codonopsis, ginseng, rhodiola root, Chinese yam and extract thereof, matrimony vine and extract thereof, American Ginseng and extract thereof, Soybean Peptide, albumin peptide, spirulina are as batching, the addition of batching accounts for 0%～5% of composition weight.
According to a further aspect in the invention, provide the preparation method of above-mentioned any fatigue-relieving composition, the method comprises: get above-mentioned any yeast extract and Zinc-rich saccharomyces cerevisiae or Zinc-rich saccharomyces cerevisiae extract; And yeast extract and Zinc-rich saccharomyces cerevisiae or Zinc-rich saccharomyces cerevisiae extract are directly mixed, tired composition is eased.
According to another aspect of the invention, provide the application of above-mentioned fatigue-relieving composition in capsule, tablet and oral liquid.
The fatigue-relieving composition that contains yeast extract and Zinc-rich saccharomyces cerevisiae or Zinc-rich saccharomyces cerevisiae extract provided by the invention, filled up the blank of yeast extract in health products application, for the research and development application of yeast extract provides a kind of new direction, by yeast extract and Zinc-rich saccharomyces cerevisiae or Zinc-rich saccharomyces cerevisiae extract mixing use, make fatigue-relieving composition in antifatigue, resistance to anoxic, delay senility and the effect that improves the aspects such as immunity obviously strengthens, there is significant synergy.
Accompanying drawing explanation
Fig. 1 shows preparation technology's flow chart of the fatigue-relieving composition of exemplary embodiments of the present invention.
The specific embodiment
It should be noted that, in the situation that not conflicting, embodiment and the feature in embodiment in the application can combine mutually.Describe below with reference to the accompanying drawings and in conjunction with the embodiments the present invention in detail.
Yeast extract of the present invention, Zinc-rich saccharomyces cerevisiae and Zinc-rich saccharomyces cerevisiae extract are commercially available prod, by Angel Yeast Co.,Ltd, produce.Wherein yeast extract is common yeast extract, does not comprise Zinc-rich saccharomyces cerevisiae extract.
Yeast extract is a large series products of Angel Yeast Co.,Ltd, yeast contains rich in protein, amino acid, polypeptide, nucleic acid, nucleotides and B family vitamin, these compositions all have the effect of alleviating physical fatigue, but the yeast extract of using in currently available technology, just in cosmetics or field of seasoning, yet there are no relevant report in field of health care products.
Zinc has multiple important physiological function to human body, as strengthened immunity, enhancing development, improve appetite, adaptive capacity and strengthen fecundity.Zinc-rich saccharomyces cerevisiae is exactly in the process of culture yeasts, to add zinc element, by yeast in growth course to the absorption of zinc element and conversion, protein and the polysaccharide organic of zinc in yeast body is combined, thereby inorganic zinc and the organic zinc of having eliminated chemical property stimulate the toxic and side effect of human body and stomach, guarantee that zinc can be absorbed by human body efficiently and safely.
According to a kind of exemplary embodiment of the present invention, a kind of fatigue-relieving composition is provided, comprise yeast extract and Zinc-rich saccharomyces cerevisiae or Zinc-rich saccharomyces cerevisiae extract, wherein the mass ratio of yeast extract and Zinc-rich saccharomyces cerevisiae or Zinc-rich saccharomyces cerevisiae extract is 2: 3～19: 1.The fatigue-relieving composition that contains yeast extract and Zinc-rich saccharomyces cerevisiae or Zinc-rich saccharomyces cerevisiae extract provided by the invention, has filled up the blank of yeast extract in health products application, for new direction has been opened up in the research and development application of yeast extract.Yeast extract and Zinc-rich saccharomyces cerevisiae or Zinc-rich saccharomyces cerevisiae extract mix and used, strengthened fatigue-relieving composition in antifatigue, resistance to anoxic, the effect that delays senility and improve the aspects such as immunity, there is significant synergy.
Preferably, Zinc-rich saccharomyces cerevisiae or Zinc-rich saccharomyces cerevisiae extract that the yeast extract that fatigue-relieving composition is 40%～95% by mass percent and mass percent are 5%～60% form.The present invention preferably but be not limited to above-mentioned scope.The main component playing a role in yeast extract is free amino acid and polypeptide, if the composition of the free amino acid testing out and polypeptide is high, the loss that active ingredient in the preparation process of yeast extract is described is little, the quality of the yeast extract finally obtaining is better, and during use, the yeast extract of unit mass plays a role better.After considering the each side factors such as synergy, the prices of raw and semifnished materials and preparation cost, we adopt the yeast extract of aforementioned proportion and Zinc-rich saccharomyces cerevisiae or Zinc-rich saccharomyces cerevisiae extract to be mixed with fatigue-relieving composition.
Further preferably, Zinc-rich saccharomyces cerevisiae or Zinc-rich saccharomyces cerevisiae extract that the yeast extract that fatigue-relieving composition is 60%～90% by mass percent and mass percent are 10%～40% form.The fatigue-relieving composition obtaining within the scope of aforementioned proportion has good fatigue-relieving effect.Most preferably, Zinc-rich saccharomyces cerevisiae or Zinc-rich saccharomyces cerevisiae extract that the yeast extract that fatigue-relieving composition is 65% by mass percent and mass percent are 35% form.
According to a kind of exemplary embodiment of the present invention, the zinc content in Zinc-rich saccharomyces cerevisiae or Zinc-rich saccharomyces cerevisiae extract is 2000～50000ppm; In yeast extract, the mass percent of protein is 40%～80%.Zinc has the activity of plurality of enzymes in reinforcement and strengthens the function of fatigue-relieving, per day for adults need to be supplemented zinc 15mg, remove and in food, take in part, also need extra supplementing, according to nutrient prime replenisher requirements of customs declaration, to supplement zinc every day be recommended amounts 1/3～2/3, need to supplement 5～10mg every day, need so supplement composition 0.1～5g, the zinc content in Zinc-rich saccharomyces cerevisiae or Zinc-rich saccharomyces cerevisiae extract is controlled at and in above-mentioned scope, substantially can meets the daily demand of human body to zinc.Protein has the effect of fatigue-relieving, supplement the effect of certain albumen mass-energy enhancing fatigue-relieving, in yeast extract, protein content is higher, in composition, protein is higher, more contribute to strengthen the effect of fatigue-relieving, selecting protein quality percentage is that 40%～80% yeast extract can meet above-mentioned functions.
Preferably, yeast extract is one or more mixing in beer yeast extract, white wine yeast extract, wine yeast extract, yellow wine yeast extract and rice wine yeast extract.The present invention preferably but be not limited to above-mentioned yeast extract.Wherein in brewer's yeast, contain 8 kinds of necessary amino acid, eat the 20 grams of balances that just can supplement human body cell construction and destruction every day, meet daily required amino acid.In brewer's yeast, contained amino acid is 3 times of beef, 2.5 times of pork, 18 times of milk.
In fatigue-relieving composition except comprising yeast extract and Zinc-rich saccharomyces cerevisiae or Zinc-rich saccharomyces cerevisiae extract, also comprise that one or more in Radix Codonopsis, ginseng, rhodiola root, Chinese yam and extract thereof, matrimony vine and extract thereof, American Ginseng and extract thereof, Soybean Peptide, albumin peptide, spirulina are as batching, the addition of described batching accounts for 0%～5% of described composition weight.The present invention preferably but be not limited to above-mentioned batching, adds above-mentioned batching can play better fatigue-relieving and health-care effect.
A kind of preparation method of fatigue-relieving composition is provided according to a further aspect in the invention.As shown in Figure 1, the method comprises: get above-mentioned any yeast extract and Zinc-rich saccharomyces cerevisiae or Zinc-rich saccharomyces cerevisiae extract; And yeast extract and Zinc-rich saccharomyces cerevisiae or Zinc-rich saccharomyces cerevisiae extract are directly mixed, tired composition is eased.This production method technique is simple, cost is lower and be easily applicable to large-scale commercial Application.
In the process of above-mentioned mixing, can also adopt spray dry or roller drying mixture is dried, with the moisture that guarantees fatigue-relieving composition lower than 5%, wherein dry the and roller drying of spraying be not only suitable for industrialization but also can guarantee dry after uniformity and the dispersiveness of particle.
According to another aspect of the invention, provide above-mentioned any fatigue-relieving composition application in capsule, tablet or oral liquid.Fatigue-relieving composition of the present invention has been filled up the blank of yeast extract in health products application, for the research and development application of yeast extract provides a kind of new direction.
Introduce the preparation technology of capsule of the present invention below, yeast extract, Zinc-rich saccharomyces cerevisiae or Zinc-rich saccharomyces cerevisiae extract and soybean oil are mixed, add gelatin solution, through pelleting, shape, wash the soft capsule that ball, the technique such as dry are made.The gelatin solution adding in this technical scheme is the main material of preparing soft capsule, and the composition of general gelatin solution is with gelatin: glycerine: water=1: 0.3～0.4: 0.7～1.4 is advisable, otherwise that capsule wall is crossed is soft or really up to the mark.Soft capsule have sample-loading amount accurately, better tightness, good looking appearance and produce in product qualified rate advantages of higher, this soft capsule is as a kind of health products, alleviating physical fatigue efficiently, taking convenience, in addition, this preparation technology is simple, can be mass-produced.The preparation method of capsule is conventional method, and the present invention preferably but be not limited to the application in fields such as above-mentioned capsule, tablet and oral liquids, also can be made into particle etc.
Below in conjunction with specific embodiment, further illustrate beneficial effect of the present invention.
Embodiment 1
Pulverous Zinc-rich saccharomyces cerevisiae (zinc content is 5000ppm) that is by mass percentage 40% beer yeast extract and mass percent are 60% is joined in three-dimensional mixer and mixed, obtain yeast mixt.This product obtaining can directly be packed the health products as fatigue-relieving, or as the raw material of producing other products.The product making is powdery, by detecting its moisture lower than 5.0%.
Embodiment 2
Identical with the preparation method of embodiment 1, difference is the proportioning of each component and adopts white wine yeast extract.
Embodiment 3-6
Identical with the preparation method of embodiment 1, difference is the proportioning of each component and adopts wine yeast extract.
Comparative example 1-2
In comparative example 1, adopt wine yeast extract, wherein protein content is 50wt%; In comparative example 2, adopt Zinc-rich saccharomyces cerevisiae, wherein zinc content is 50000ppm.
Table 1
| Composition | Yeast extract (%) | Zinc-rich saccharomyces cerevisiae or Zinc-rich saccharomyces cerevisiae extract (%) | Ginseng (%) |
| Embodiment 1 | 40 (containing protein 40%) | 60 (zinc content 2000ppm) | 0 |
| Embodiment 2 | 65 (containing protein 80%) | 35 (zinc content 50000ppm) | 0 |
| Embodiment 3 | 60 (containing protein 60%) | 40 (zinc content 20000ppm) | 0 |
| Embodiment 4 | 90 (containing protein 50%) | 10 (zinc content 5000ppm) | 0 |
| Embodiment 5 | 90 (containing protein 70%) | 5 (zinc content 8000ppm) | 5％ |
| Embodiment 6 | 95 (containing protein 70%) | 5 (zinc content 8000ppm) | 0 |
| Comparative example 1 | 100 | 0 | 0 |
| Comparative example 2 | 0 | 100 (zinc content 50000ppm) | 0 |
Effect experiment
For product of the present invention, carried out mice burden swimming experiment, study the effect of relieving physical fatigue of this product.Experimental result shows, this product has good effect of relieving physical fatigue, can improve body exercise tolerance, improve exercise load adaptability and reach the effect of alleviating physical fatigue, be the Ergonomy test of this product below.
Experiment purpose
By the zoopery of alleviating physical fatigue functional check, observe the fatigue-relieving effect of this product, evaluate its effect, for the exploitation of this health product provides Ergonomy foundation.
Tested material
The health product that adopts fatigue-relieving composition of the present invention to prepare.The suspension of before use medicinal powder being made to required variable concentrations with 0.5% carboxymethylcellulose sodium solution is standby.
Animal used as test
Healthy ICR mouse, body weight 20～24g, male.
Instrument and reagent
Swimming trunk 50 * 50 * 40cm, electric heating constant temperature tank; Sodium carboxymethylcellulose is Wenzhou City, Zhejiang Province Dong Sheng chemical reagent factory product, and water is self-control ultra-pure water.
Method of administration
Gastric infusion, consistent with the route of administration of intending recommending.
Experiment contrast
Negative control group be get the sodium carboxymethylcellulose of equal-volume 0.5% (0.5%CMC-Na) and the fatigue-relieving composition of single yeast extract, single Zinc-rich saccharomyces cerevisiae or Zinc-rich saccharomyces cerevisiae extract, yeast extract and Zinc-rich saccharomyces cerevisiae or Zinc-rich saccharomyces cerevisiae extract be all configured to the suspension of required variable concentrations with 0.5% carboxymethylcellulose sodium solution standby.
Experimental technique and result
1, method
Before experiment, first mouse is screened, the negative 1.2g weight of mouse tail root is placed in to swimming trunk went swimming, the depth of water is no less than 34cm, and 24 ℃ ± 1.0 ℃ of water temperatures can be swum the above person of 12min and be selected into swimming with a load attached to the body and test.Through screening qualified mouse, be divided at random 8 groups, i.e. product group: 8mg/kg, 35mg/kg, 70mg/kg, 4 dosage groups of 100mg/kg; Zinc-rich saccharomyces cerevisiae and Zinc-rich saccharomyces cerevisiae extract control group are respectively 8mg/kg, 2 dosage groups of 35mg/kg; Yeast extract control group is respectively sodium carboxymethylcellulose (0.5%CMC-Na) control group of 70mg/kg, 2 dosage groups of 100mg/kg and 0.5%.
Gavage successively, all by 15ml/kg administration, once a day, and continuous 30～40 days, after last administration, after 30min, the mouse of the weight of negative 5% body weight of root of the tail portion is put into swimming trunk, record mouse freestyle swimming and start to the dead time, be i.e. the mice burden swimming time.
2, experimental result
The composition of this fatigue-relieving on the impact of mice burden swimming time in Table 1.
The impact of table 1. fatigue-relieving composition of the present invention on the mice burden swimming time
From the data of table 1, can find out, the swimming with a load attached to the body time of fatigue-relieving composition energy significant prolongation mouse of the present invention, the product of same dose is compared the fatigue-relieving better effects if of independent use yeast extract or Zinc-rich saccharomyces cerevisiae or Zinc-rich saccharomyces cerevisiae extract, illustrate that Zinc-rich saccharomyces cerevisiae in fatigue-relieving composition of the present invention and yeast extract or Zinc-rich saccharomyces cerevisiae extract have the synergy strengthening significantly aspect antifatigue, in like manner in resistance to anoxic, delay senility and improve the synergy that also there is enhancing the aspects such as immunity.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, for a person skilled in the art, the present invention can have various modifications and variations.Within the spirit and principles in the present invention all, any modification of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (8)
1. a fatigue-relieving composition, is characterized in that, comprises yeast extract and Zinc-rich saccharomyces cerevisiae or Zinc-rich saccharomyces cerevisiae extract, and the mass ratio of wherein said yeast extract and described Zinc-rich saccharomyces cerevisiae or described Zinc-rich saccharomyces cerevisiae extract is 2: 3～19: 1.
2. composition according to claim 1, is characterized in that, the described Zinc-rich saccharomyces cerevisiae that the described yeast extract that is 40%～95% by mass percent and mass percent are 5%～60% or described Zinc-rich saccharomyces cerevisiae extract form.
3. composition according to claim 2, is characterized in that, the described Zinc-rich saccharomyces cerevisiae that the described yeast extract that is 60%～90% by mass percent and mass percent are 10%～40% or described Zinc-rich saccharomyces cerevisiae extract form.
4. composition according to claim 3, is characterized in that, the described Zinc-rich saccharomyces cerevisiae that the described yeast extract that is 65% by mass percent and mass percent are 35% or described Zinc-rich saccharomyces cerevisiae extract form.
5. according to the composition described in any one in claim 1 to 4, it is characterized in that, in described Zinc-rich saccharomyces cerevisiae or described Zinc-rich saccharomyces cerevisiae extract, the content of zinc is 2000～50000ppm; In described yeast extract, the mass percent of protein is 40%～80%.
6. composition according to claim 1, it is characterized in that, also comprise that one or more in Radix Codonopsis, ginseng, rhodiola root, Chinese yam and extract thereof, matrimony vine and extract thereof, American Ginseng and extract thereof, Soybean Peptide, albumin peptide, spirulina are as batching, the addition of described batching accounts for 0%～5% of described composition weight.
7. a preparation method for fatigue-relieving composition, is characterized in that, the method comprises:
Get yeast extract and Zinc-rich saccharomyces cerevisiae or the Zinc-rich saccharomyces cerevisiae extract of any one in claim 1 to 6; And
Described yeast extract and described Zinc-rich saccharomyces cerevisiae or described Zinc-rich saccharomyces cerevisiae extract are directly mixed, and tired composition is eased.
8. the application in capsule, tablet or oral liquid according to the composition described in any one in claim 1 to 6.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105395818A (en) * | 2015-11-25 | 2016-03-16 | 兰州大学 | Preparation and application of lycium ruthenicum murr and rhodiola rosea medicine composition capable of enhancing immunity |
| CN109090614A (en) * | 2018-08-21 | 2018-12-28 | 大连美耶国际贸易有限公司 | Have effects that beauty, relieve fatigue, the health care product of strengthen immunity |
| CN110200884A (en) * | 2019-06-19 | 2019-09-06 | 广州环亚化妆品科技有限公司 | It is a kind of to have effects that oil-control and the composition repaired and preparation method thereof and the application in cosmetics |
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| CN105395818A (en) * | 2015-11-25 | 2016-03-16 | 兰州大学 | Preparation and application of lycium ruthenicum murr and rhodiola rosea medicine composition capable of enhancing immunity |
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