CN103583528B - A kind of sterilized water suspending agent containing beta-schardinger dextrin-and preparation method thereof - Google Patents
A kind of sterilized water suspending agent containing beta-schardinger dextrin-and preparation method thereof Download PDFInfo
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- CN103583528B CN103583528B CN201310480189.4A CN201310480189A CN103583528B CN 103583528 B CN103583528 B CN 103583528B CN 201310480189 A CN201310480189 A CN 201310480189A CN 103583528 B CN103583528 B CN 103583528B
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- beta cyclodextrin
- pyraclostrobin
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- deionized water
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Abstract
The invention discloses a kind of sterilized water suspending agent containing beta cyclodextrin, each constituent mass mark is: antibacterial beta cyclodextrin clathrate 0.1 40%, wetting dispersing agent 3 10%, thickening agent 0.01 0.2%, defoamer 0.1 0.5%, antifreeze 1 5%, preservative 0.01 0.1%, deionized water complements to 100%.The invention also discloses its preparation method.It is contemplated that utilize the characteristic of beta cyclodextrin, antibacterial and beta cyclodextrin are prepared as a kind of solid clathrates, then add corresponding auxiliary agent and make the pesticide water suspension being available for spraying use.The suspending agent using this technology to prepare significantly improves antibacterial stability in the environment, greatly improves its utilization rate and efficiency time, and gives its sustained release performance.
Description
Technical field
The present invention relates to a kind of sterilized water suspending agent containing beta-schardinger dextrin-and preparation method thereof.
Background technology
Cyclodextrin found in 1891, had been widely used for now food, medicine, the aspect such as makeup and agricultural.
Due to the configuration that it is special, cyclodextrin is referred to as molecular capsule, to comprise various active component on its molecular level, and
Give new physicochemical property and famous.Its common type have α-, β-, γ-3 kinds, wherein beta-schardinger dextrin-application is at most, is medicine etc.
The good embedding of all conglomeraties.It is mainly used in improving the dissolubility of medicine, improves medicine stability, increase the biological profit of medicine
Expenditure, reduces the toxicity etc. of medicine, and its derivant also has good effect.The preparation technology religion of cyclodextrin is simple, by forming sediment
Powder obtains cyclodextrin invertase through the cultivation of Bacillus alcalophilus, remakes the product with rear formation, by 6-12 Fructus Vitis viniferae sugar
The cyclic oligomer compound that son connects into 1-4 glycosidic bond.
Beta-schardinger dextrin-is the cyclic compound become continuously by 7 glucose molecules, sees there is cavity, 2 ends in main body configuration picture
The tubbiness compound do not closed.In the structure in cavity, in cavity, defined hydrophobic region, upper end by the shielding action of c h bond
I.e. larger open end is made up of the secondary hydroxyl of C2 and C3, and lower end both smaller opening ends are made up of the primary hydroxyl of C6, have hydrophilic.
Beta-schardinger dextrin-is stable in the environment, is susceptible to cracking in strong acid media.There is preferable heat stability, be heated to about 200 and take the photograph
Start when family name spends to decompose.Owing to there is no reducing end, Gu without reproducibility, easily form various stable hydrates, no hygroscopicity, energy
Alcohol and aqueous solution well crystallize.Cyclodextrin can be interlinked on cyclodextrin molecular, carry out chemical property improvement.Profit
By these special character, beta-schardinger dextrin-and organic molecule inorganic with many can be combined into Host-guest inclusion complex, and energy
Change by the chemical and physical features of clathrate, there is protection and stablize guest molecule and the characteristic of selectivity oriented molecule.Just
Being these character, beta-schardinger dextrin-has had extensive use.
Antibacterial, particularly protective fungicide, it is necessary to form stable, lasting killing at plant surface by active component
Bacterium protecting film.But this sterilization protecting film of destruction that the conditions such as the light in the Nature, heat can continue, is allowed to lose efficacy, does not has
The effect that long-time protection harmful levels of pathogens infects.Therefore generally require repeatedly dispenser a season of growth, the most both made
Become environmental pollution, increase the weight of again peasant burden.The technology that this patent provides, it is intended to by the method for simple possible, by agricultural
Antibacterial is effectively protected by the method for clathrate, the most slowly discharges.Thus reach to improve disinfectant use in agriculture
Utilization rate, reduces natural loss, drops oligosaprobic effect.
Summary of the invention
It is contemplated that by the characteristic using beta-schardinger dextrin-, disinfectant use in agriculture is made a kind of antibacterial beta-schardinger dextrin-
Clathrate, be subsequently processed into aqueous suspension agent.After this process, disinfectant use in agriculture is effectively protected, reduces ultraviolet
The destruction to antibacterial such as light, heat, microorganism, is allowed to the most slowly discharge.Thus reach to improve disinfectant use in agriculture
Utilization rate, reduces natural loss, drops oligosaprobic effect.
Technical scheme: a kind of sterilized water suspending agent containing beta-schardinger dextrin-, each constituent mass mark is:
Wherein, agriculture chemicals fungicide and the beta-schardinger dextrin-mass fraction ratio in aqueous suspension agent is 10:1-1:1.
Described wetting dispersing agent selects sodium lignin sulfonate, lignin calcium iodate, polycarboxylic acid salt, lauryl alcohol polyoxy second
Alkene ether sodium sulfate, alkyl naphthalene formaldehyde condensate sulfonates, sodium lauryl sulphate, alkyl polyoxyethylene ether sulfonate, alkyl
Phenol polyethenoxy base ether formaldehyde condensation products, polyoxyethylene polyoxypropylene base ether block copolymers or alkyl naphthalene formaldehyde condensation substance sulfonic acid
The mixing of one or more in salt.
Described thickening agent selects water-soluble resin, xanthan gum, carboxymethyl cellulose, carboxyethyl cellulose, Methyl cellulose
The mixing of one or more in element, hydrated SiO 2, bentonite, polyvinyl alcohol, polyvinyl alcohol.
The one in ethylene glycol, propylene glycol, glycerol, carbamide selected by described antifreeze.
Described defoamer selects silicone oil, organic silicone, C10-C20Saturated fat acid compounds, C8-C10Fatty alcohol
The mixing of one or more in compounds.
Described preservative one in sodium benzoate, sodium sorbate, Kazon KF88.
The manufacture method of a kind of sterilized water suspending agent containing beta-schardinger dextrin-of the present invention is: in the presence of water, will
A certain proportion of agriculture chemicals fungicide, deionized water and beta-schardinger dextrin-colloid mill grind and (need if desired to add a definite proportion for 2-5 hour
The organic environmental-protection solvent of example), after standing 1 hour, it is dried, obtains stable agriculture chemicals fungicide Benexate Hydrochloride, then
Agriculture chemicals fungicide Benexate Hydrochloride, wetting dispersing agent, defoamer, antifreeze, anti-maize ear rot and deionized water are put into and stirs
Mix and still carries out shear-mixed uniformly, then pass to sand mill and carry out sand milling, after sand milling to qualified particle diameter, be eventually adding thickening steady
Determine agent, again shear and just form product.
The suspending agent using the technology of the present invention to prepare significantly improves antibacterial stability in the environment, carries greatly
High its utilization rate and efficiency time, and give its sustained release performance.
Detailed description of the invention
In order to be better understood from the essence of the present invention, the technology contents of the present invention is described by embodiment below, but this
Bright content is not limited thereto.
Embodiment 1:10% hexaconazole beta cyclodextrin clathrate suspending agent.
1, hexaconazole beta cyclodextrin clathrate is produced,
Formula: hexaconazole 20%,
Beta cyclodextrin 30%,
Deionized water surplus,
Processing technology: weigh hexaconazole, deionized water, beta cyclodextrin, first by hexaconazole and deionized water mix homogeneously,
Add hexaconazole, grind 4 hours with colloid mill after mix homogeneously, sand grinding process is properly added moisture, with the evaporation that keeps the skin wet.
The mixture that will grind, settles 1 hour, dries, detection level.
2,10% hexaconazole beta cyclodextrin clathrate suspending agent is made.
Accurately weigh hexaconazole beta cyclodextrin clathrate, polyoxyethylene polyoxypropylene base ether block copolymers, lauryl alcohol gather
Oxyethylene group ether sodium sulfate, Kazon KF88, propylene glycol, deionized water, stirring mixing 30 minutes in agitator tank, through colloid mill
Rear sand milling less than 5 microns, is subsequently adding xanthan gum to D95, shears 30 minutes through high-shear emulsifying agent.Detect qualified after can wrap
Dress.
The 10% hexaconazole beta cyclodextrin clathrate suspending agent using the method to make, is used for preventing and treating rice sheath blight disease,
Occur serious field, 1 use can control whole trophophase, the infringement of sheath blight fungus.10% common hexaconazole is used to hang
Floating agent, according to the development of the state of an illness, generally requires repeatedly dispenser.Embodiment 2:20% pyraclostrobin beta cyclodextrin clathrate suspends
Agent.
1, pyraclostrobin beta cyclodextrin clathrate is produced.
Formula: pyraclostrobin 20%,
Beta cyclodextrin 30%,
Deionized water surplus,
Processing technology: weigh pyraclostrobin, deionized water, beta cyclodextrin, first beta cyclodextrin and deionized water are mixed all
Even, adding pyraclostrobin, grinding 5 hours with colloid mill after mix homogeneously, sand grinding process is properly added moisture, to supplement
Moisture evaporates.The mixture that will grind, settles 1 hour, dries, detection level.
2,20% pyraclostrobin beta cyclodextrin clathrate suspending agent is made.
Accurately weigh pyraclostrobin beta cyclodextrin clathrate, polyoxyethylene polyoxypropylene base ether block copolymers, Laurel
Alcohol polyoxyethylene groups ether sodium sulfate, alkylphenol-polyethenoxy base ether formaldehyde condensation products Kazon KF88, propylene glycol, deionized water,
Stirring mixing 30 minutes in agitator tank, after colloid mill, sand milling is to D95 less than 5 microns, is subsequently adding xanthan gum, through high shear
Emulsifying agent is sheared 30 minutes.Detect qualified after can pack.
Embodiment 3:25% Fluoxastrobin beta cyclodextrin clathrate suspending agent,
1, Fluoxastrobin beta cyclodextrin clathrate is produced.
Formula: Fluoxastrobin 20%,
Beta cyclodextrin 20%,
Deionized water surplus.
Processing technology: weigh Fluoxastrobin, deionized water, beta cyclodextrin, first by beta cyclodextrin and deionized water mix homogeneously,
Add Fluoxastrobin, grind 5 hours with colloid mill after mix homogeneously, sand grinding process is properly added moisture, with the evaporation that keeps the skin wet.
The mixture that will grind, settles 1 hour, dries, detection level.
2,25% Fluoxastrobin beta cyclodextrin clathrate suspending agent is made.
Accurately weigh Fluoxastrobin beta cyclodextrin clathrate, polyoxyethylene polyoxypropylene base ether block copolymers, lauryl alcohol gather
Oxyethylene group ether sodium sulfate, alkylphenol-polyethenoxy base ether formaldehyde condensation products Kazon KF88, propylene glycol, deionized water, stirring
Mixing stirring mixing 30 minutes in tank, after colloid mill, sand milling is to D95 less than 5 microns, is subsequently adding xanthan gum, through high-shear emulsifying
Agent is sheared 30 minutes.Detect qualified after can pack.
Claims (1)
1. the sterilized water suspending agent containing beta-schardinger dextrin-, it is characterised in that mass fraction:
Pyraclostrobin beta cyclodextrin clathrate 20%,
Polyoxyethylene polyoxypropylene base ether block copolymers 2%,
Lauryl alcohol polyethylene glycol oxide base ether sodium sulfate 1%,
Alkylphenol-polyethenoxy base ether formaldehyde condensation products 1%,
Xanthan gum 0.1%,
Propylene glycol 5%,
Kazon KF88 0.1%,
Deionized water surplus；
Weigh pyraclostrobin beta cyclodextrin clathrate, polyoxyethylene polyoxypropylene base ether block copolymers, lauryl alcohol polyoxy second
Alkene ether sodium sulfate, alkylphenol-polyethenoxy base ether formaldehyde condensation products, Kazon KF88, propylene glycol, deionized water, at agitator tank
Middle stirring mixing 30 minutes, after colloid mill, sand milling is to D95 less than 5 microns, is subsequently adding xanthan gum, cuts through high-shear emulsifying agent
Cut 30 minutes, detect qualified after can pack；
Wherein, pyraclostrobin beta cyclodextrin clathrate is prepared as: weighing pyraclostrobin 20%, beta cyclodextrin 30%, surplus is gone
Ionized water, first by beta cyclodextrin and deionized water mix homogeneously, is adding pyraclostrobin, is grinding 5 with colloid mill after mix homogeneously
Hour, sand grinding process is properly added moisture, with the evaporation that keeps the skin wet；The mixture that will grind, settles 1 hour, dries,
Pyraclostrobin beta cyclodextrin clathrate.
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| CN201310480189.4A CN103583528B (en) | 2013-10-14 | 2013-10-14 | A kind of sterilized water suspending agent containing beta-schardinger dextrin-and preparation method thereof |
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| CN106359423A (en) * | 2016-08-20 | 2017-02-01 | 广东中迅农科股份有限公司 | Novel methylaminoavermectin and hexaflumuron suspension and preparation method thereof |
| EP4241563A3 (en) * | 2018-06-01 | 2023-11-15 | Bayer CropScience LP | Stabilized fungicidal composition comprising cyclodextrin |
| CN111286204B (en) * | 2020-03-12 | 2021-08-20 | 复旦大学 | Polymer compound capable of being rapidly dissolved or dispersed in aqueous solvent and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1047607A (en) * | 1989-05-29 | 1990-12-12 | 火箭兄弟公司 | Plant protection composition, the purposes of its preparation method and control cryptogams disease thereof |
| CN101743959A (en) * | 2008-12-18 | 2010-06-23 | 张保银 | Inclusion complex with insecticidal activity |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT509876B1 (en) * | 2010-08-20 | 2011-12-15 | Ge Jenbacher Gmbh & Co Ohg | pre-chamber system |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1047607A (en) * | 1989-05-29 | 1990-12-12 | 火箭兄弟公司 | Plant protection composition, the purposes of its preparation method and control cryptogams disease thereof |
| CN101743959A (en) * | 2008-12-18 | 2010-06-23 | 张保银 | Inclusion complex with insecticidal activity |
Non-Patent Citations (1)
| Title |
|---|
| 烯草酮-β-环糊精包合物悬浮剂的制备及流变学行为;徐妍 等;《农药》;20110228;第50卷(第2期);第109-112页 * |
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Effective date of registration: 20161028 Address after: 330000 Jiangxi city of Nanchang province Anyi County Industrial Park metal materials industry base (Dongyang Road) Patentee after: JIANGXI ZHONGXUN AGROCHEMICAL CO., LTD. Address before: 516000 Guangdong province Huizhou Zhongkai hi tech Development Zone No. 24 District Patentee before: Guangdong Zhongxun Agricultural Technology Co., Ltd. |