CN107711833A - A kind of antiviral composition containing octyl trichlamide - Google Patents
A kind of antiviral composition containing octyl trichlamide Download PDFInfo
- Publication number
- CN107711833A CN107711833A CN201710916752.6A CN201710916752A CN107711833A CN 107711833 A CN107711833 A CN 107711833A CN 201710916752 A CN201710916752 A CN 201710916752A CN 107711833 A CN107711833 A CN 107711833A
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- Prior art keywords
- octyl trichlamide
- compound
- antiviral composition
- trichlamide
- octyl
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/04—Nitrogen directly attached to aliphatic or cycloaliphatic carbon atoms
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to pesticide field, there is provided a kind of antiviral composition containing octyl trichlamide, said composition principle active component are the compound A of octyl trichlamide and the structure containing acylhydrazone, wherein the compound A of the structure containing acylhydrazone and the weight ratio of octyl trichlamide are 1:40‑10:1；Octyl trichlamide is 1.5~60% with weight fractions of the compound A in whole composition；Antiviral composition of the present invention can be prepared into the formulations such as suspending agent, wettable powder, water dispersible granules, aqueous emulsion, antiviral composition of the present invention is mainly used in preventing and treating various crop virus, such as tobacco mosaic virus disease, rice stripe disease, rice dead leaf disease, Tomato yellow mosaic virus, maize dwarf mosaic virus disease etc..
Description
Technical field
The invention belongs to technical field of pesticide, there is provided a kind of antiviral composition containing octyl trichlamide, it is particularly a kind of pungent
The antiviral composition of bacterium amine or its acetate and the compound A of the structure containing acylhydrazone.
Background technology
The compound A of the structure containing acylhydrazone is a kind of pesticide activity composition developed by Nankai University, such active ingredient
Thing A, the chemical name of the compound mainly included are (1S, 3S)-N '-(4- chlorobenzenes methylene) -1- methyl -2,3,4,9- tetra-
Pyridinium hydroxide simultaneously [3,4-b] indoles -3- formylhydrazines).The compound A of such structure containing acylhydrazone is to tobacco mosaic virus (TMV), tobacco mosaic
Virus, which waits, has an extraordinary bioactivity, at the same such compound be easily absorbed by plants, in the environment it is degradable, have it is good
Environmental compatibility.
Compound A mainly includes following compound：
Octyl trichlamide, it is a kind of environment-friendly type amino acids high molecular polymer bactericide, the organosilicon of composition containing synergy and mew
Class sterilization factors, it is high-tech of new generation, environment-friendly type, high-efficiency broad spectrum, less toxic bactericide, for crop disease to old brand bactericide
Caused resistance, it is special develop, formula it is unique, infiltration is strong, kills fungi, bacterium and virus within several seconds, can readily penetrate through virus,
Fungi, the cell membrane of bacterium, it is intracellular to be directly entered pathogen, hits its respiratory system, thoroughly roots out pathogen working condition,
And impaired position can be cured rapidly.Half-and-half know, load, ascus, four subphylum class fungies such as flagellum, the control rate of virus exist
More than 97%, there is fabulous prevention, treat, root out effect, long-term use does not produce resistance.
Virus disease is the important disease of the industrial crops such as tomato, rice, tobacco and capsicum, gives vegetable cultivation and cigarette every year
Grass production causes serious loss.In the chemical control of plant virus, years of researches have been carried out both at home and abroad, although one
A little viral agents come into practical stage, but still have the shortcomings of resistance, cost are high, drug effect is low, high poison, far from
Meet agricultural sustainable development requirement, so development of new, efficient agricultural chemicals turn into the key of preventing and treating virus.
Have some applications of the patent containing octyl trichlamide in terms of viral diseases at present.Such as octyl trichlamide and gold alloy hydride (specially
A kind of composition containing gold alloy hydride and octyl trichlamide of sharp name, number of patent application：201110115008.9), octyl trichlamide is Yu Hereby enols
(proprietary term：It is a kind of containing octyl trichlamide He the composition of Hereby enols, number of patent application：201510648713.3), but above-mentioned sterilization
The defects of single effect, validity difference be present in agent.
The content of the invention
The present invention is directed to deficiencies of the prior art, there is provided a kind of antiviral composition containing octyl trichlamide, should
Composition principle active component is the compound A of octyl trichlamide and the structure containing acylhydrazone, wherein the compound A of the structure containing acylhydrazone and pungent bacterium
The weight ratio of amine is 1:40-10:1；Octyl trichlamide is 1.5~60% with weight fractions of the compound A in whole composition；This hair
Bright antiviral composition can be prepared into the formulations such as suspending agent, wettable powder, water dispersible granules, aqueous emulsion, and the present invention is antiviral
Composition is mainly used in preventing and treating various crop virus, such as tobacco mosaic virus disease, rice stripe disease, rice dead leaf disease, tomato
Mosaic virus, maize dwarf mosaic virus disease etc..
Octyl trichlamide provided by the present invention or its acetate also find no report at present with compound A combinations thing
Application on plant virus resistance, compound A are a kind of new bio source compounds, and there is induction crop to produce premunition, suppression
The effect of virus infection processed, have the function that antiviral, increase yield with octyl trichlamide or its acetate compounding and improve quality.
The concrete technical scheme of the present invention is as follows：
A kind of antiviral composition containing octyl trichlamide, said composition principle active component are octyl trichlamide and the structure containing acylhydrazone
Compound A；
The compound A of the wherein described structure containing acylhydrazone is (1S, 3S)-N '-(4- chlorobenzenes methylene) -1- methyl -2,
3,4,9- tetrahydropyridines simultaneously [3,4-b] indoles -3- formylhydrazines；
The wherein compound A of the structure containing acylhydrazone and the weight ratio of octyl trichlamide are 1:40-10:1；
Wherein octyl trichlamide and weight fractions of the compound A in whole composition are 1.5~60%.
The further preferably compound A of the structure containing acylhydrazone and the weight ratio of octyl trichlamide are 1：10~1：1；Such a
Under ratio, compound A weight fraction is 0.5%~20% in preferable antiviral composition, and octyl trichlamide weight fraction is 1%
~40%.
After the content that above-mentioned main active component is determined, above-mentioned composition is further prepared into various doses by inventor
Type, predominantly missible oil, water and milk, micro emulsion, suspending agent, wettable powder, water dispersion granule, soluble liquid, bulky grain agent etc.
When one kind in the formulations of pesticide, wherein formulation are wettable powder, specific proportioning (percentage by weight) is as follows：
The specific procedure of processing of bactericidal composition wettable powder is：By above-mentioned formula by octyl trichlamide and compound A and
Dispersant, wetting agent and filler mixing, the uniform stirring in stirred tank, well mixed after airslide disintegrating mill, you can be made
The wettable powder of the present composition；
When described bactericidal composition is suspending agent, the percentage by weight of component is：
The specific production stage of the suspending agent is well mixed through high speed shear first to mix solid material, adds liquid and help
Agent, be eventually adding water, the abrading-ball 2-3 hours in ball crusher, make a diameter below 5 μm, be made it is of the present invention containing
The aqueous suspension formulations of octyl trichlamide and compound A bactericidal composition；
When described bactericidal composition is aqueous emulsion, the percentage by weight of component is：
The specific production stage of the aqueous emulsion is：First by active compound octyl trichlamide and compound A, solvent and emulsifying agent, hydrotropy
Agent is added together, and makes to be dissolved into uniform oil phase；Other insecticides adjuvants such as part water, antifreeze, preservative are blended in one
Rise into uniform aqueous phase；Oil phase is added into aqueous phase while high-speed stirred in a kettle, slowly plus water is up to reaching phase inversion point,
Open cutter and carry out high speed shear, and add remaining water, shear about half an hour, form the aqueous emulsion of oil-in-water type.It is made
The aqueous emulsion of bactericidal composition containing compound A and octyl trichlamide；
When described bactericidal composition is water dispersible granules, the percentage by weight of component is：
The specific procedure of processing of bactericidal composition water dispersible granules is：By octyl trichlamide compound A and disperse by above-mentioned formula
Agent, wetting agent, disintegrant and filler are well mixed, and are crushed with micro jet, through mediating, are then added fluid bed and are made
Be granulated, dried in grain drying machine, sieve after through sampling analysis, it is obtained of the present invention to contain compound A and octyl trichlamide
Bactericidal composition water dispersible granules.
Auxiliary agent range of choice in above-mentioned various formulations is identical, specific as follows：
Described emulsifying agent is selected from calcium dodecyl benzene sulfonate and aliphatic acid polyethenoxy ether, APES sulphur
Base succinate, styrylphenol polyoxyethylene ether, NPE, castor oil polyoxyethylene ether, fatty acid polyglycol
Any of oxyethylene group ester, polyoxyethylene aliphatic alcohol ether or more than one mixtures formed with arbitrary proportion.
The solvent be dimethylbenzene or biodiesel, toluene, diesel oil, methanol, ethanol, n-butanol, isopropanol, turpentine oil,
Any of solvent naphtha, dimethylformamide, dimethyl sulfoxide (DMSO), water equal solvent or more than one formed with arbitrary proportion it is mixed
Bonding solvent.
Described dispersant is selected from polycarboxylate, lignosulfonates, APES formaldehyde condensation product sulfuric acid
Salt, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, APES, aliphatic amine polyoxyethylene ether, fat
One or more in sour polyoxyethylene ester, glycerine fatty acid ester APEO.
Described wetting agent is selected from：Lauryl sodium sulfate, calcium dodecyl benzene sulfonate, Nekal BX, wetting and penetrating agent
F, the one or more in alkylnaphthalene sulfonate, polyoxyethylene tri-styryl phosphenylic acid salt, spaonin powder, silkworm excrement, spaonin powder.
Described disintegrant is selected from：In bentonite, urea, ammonium sulfate, aluminium chloride, citric acid, succinic acid, sodium acid carbonate
It is one or more.
Described thickener is selected from：Xanthans, hydroxymethyl cellulose, hydroxyethyl cellulose, methylcellulose, alumina silicate
One or more in magnesium, polyvinyl alcohol.
Described stabilizer is selected from：One kind in sodium citrate, resorcinol.
Described antifreezing agent is selected from：One or more in ethylene glycol, propane diols, glycerine.
Described defoamer is selected from：The fat of the saturated fat acids compound of silicone oil, silicone compound, C10~20, C8~10
One or more in fat alcohol compound.
Described filler is selected from：In kaolin, diatomite, bentonite, attapulgite, white carbon, starch, precipitated calcium carbonate
One or more.
Described preservative is selected from：Kathon CG, sodium benzoate, benzoic acid etc.；
Two active components selected by the present invention are combined, and can reach higher antiviral effect, are embodied
：Compound A is tetrahydrochysene-carboline class compound of the structure containing acylhydrazone, has higher bioactivity, the compounded combination with octyl trichlamide
Thing is used for crop, and drug effect is fast, duration length, and forms layer protecting film on the surface, can prevent virus from encroaching on again,
In addition, octyl trichlamide also has the impaired position effect of certain rapid healing, the anti-virus ability of composition is so substantially increased
The effect treated and prevented is taken into account.
In summary, antiviral composition provided by the present invention can freely be prepared into a variety of formulations, adapt to different works
The demand of thing, such as vegetables or melon and fruit or tobacco or rice, antiviral composition of the present invention are mainly used in preventing and treating and treated a variety of
Crop virus, such as tobacco mosaic virus disease, rice stripe disease, rice dead leaf disease, Tomato yellow mosaic virus, maize dwarf mosaic
Viral disease etc.
Embodiment
The embodiment of form by the following examples, the above of the present invention is done further specifically
It is bright, but the scope that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to following example.It is all to be based on the above of the present invention
The technology realized belongs to the scope of the present invention.
The preparation of the compound A octyl trichlamide suspending agents of embodiment 1 20%
Raw material is by weight ratio：Compound A 1%, octyl trichlamide 19%, calcium dodecyl benzene sulfonate 2%, phenethyl phenol first
Aldehyde resin APEO 3%, phenethyl phenol APEO 2%, naphthalenesulfonatedispersant dispersant 1%, xanthans 0.2%, silicon
Sour magnalium 1.5%, ethylene glycol 5%, water supplement 100%；Routinely the aqueous suspension agent mode of production is prepared.
The sample of embodiment 1, the octyl trichlamide suspending agent of comparison medicament 30% (laboratory self-control) and 2% compound A suspending agents are (real
Test room making) carry out comparative efficacy test for contrast.
Controlling object：Graw mold of tomato.
Temperature on average is at 21-25 DEG C during medication, and weather is based on fine, above-mentioned as shown by data：Complex preparation and single dose phase
Than anti-efficiency is significantly improved.
Embodiment 2：The preparation of 36% compound A octyl trichlamide water dispersion granules
Raw material is by weight ratio：Compound A 18%, octyl trichlamide 18%, 10% di-2-ethylhexylphosphine oxide bitter edible plant sodium sulfonate, 7% naphthalene sulfonic acids
Salt formaldehyde condensation products, 10% polycarboxylate, remaining is supplied with ammonium sulfate.Routinely the granule mode of production is prepared.
The sample of embodiment 2, the octyl trichlamide WP of comparison medicament 30% (laboratory self-control) and 8% compound A suspending agents (laboratory
Make) carry out comparative efficacy test for contrast.
Controlling object：X. c. pv. oryzicola, bacterial leaf-blight.
Temperature on average is at 21-25 DEG C during medication, and weather is based on fine, as shown by data：The present embodiment complex preparation and single dose
Compare, anti-efficiency is significantly improved.
The preparation of the compound A octyl trichlamide wettable powders of embodiment 3 60%
Raw material is by weight ratio：Compound A 20%, octyl trichlamide 40%, 8% di-2-ethylhexylphosphine oxide bitter edible plant sodium sulfonate, 8% naphthalene sulfonic acids
Salt formaldehyde condensation products, 5% polycarboxylate, remaining is supplied with diatomite.Routinely the wettable powder mode of production is prepared.
The sample of embodiment 3, the octyl trichlamide WP of comparison medicament 30% (laboratory self-control) and 8% compound A suspending agents (laboratory
Make) carry out comparative efficacy test for contrast.
Controlling object：Tobacco mosaic disease.
Temperature on average is at 21-25 DEG C during medication, and weather is based on fine, as shown by data：The present embodiment complex preparation and single dose
Compare, anti-efficiency is significantly improved.
The preparation of the compound A octyl trichlamide suspending agents of embodiment 4 22%
Raw material is by weight ratio：Compound A 20%, octyl trichlamide 2%, calcium dodecyl benzene sulfonate 3%, phenethyl phenol first
Aldehyde resin APEO 1%, special phenethyl phenol APEO 2%, naphthalenesulfonatedispersant dispersant 1.5%, xanthans
0.2%th, aluminium-magnesium silicate 1%, ethylene glycol 5%, water supplement 100%.Routinely the aqueous suspension agent mode of production is prepared.
The sample of embodiment 4, the octyl trichlamide WP of comparison medicament 30% (laboratory self-control) and 8% compound A suspending agents (laboratory
Make) carry out comparative efficacy test for contrast.
Controlling object：MRDV
| Treatment agent | Preparation dosage gram/acre | Prevention effect (%) | Key situation |
| 22% compound A octyl trichlamide suspending agents | 20 | 87.2 | Nothing |
| 8% compound A suspending agents | 40 | 65.7 | Nothing |
| 30% octyl trichlamide WP | 60 | 67.4 | Nothing |
Temperature on average is at 21-25 DEG C during medication, and weather is based on fine, as shown by data：Complex preparation is prevented compared with single dose
Efficiency is significantly improved.
As can be seen from the above embodiments, octyl trichlamide is below 80% with compound A single doses to the prevention effect of virus, leads to
Cross and compounded both, the prevention effect of composition is above 80%, and best can reach more than 90%, hence it is evident that is better than list
The prevention effect of agent, main cause is that have high bioactivity because of compound A, and drug effect is fast, and octyl trichlamide, which not only has, enough kills
Bacterium acts on, and the position effect being damaged with certain rapid healing, both combination anti-virals will be significantly better than single dose
Antivirus action, and occur without poisoning situation, it is significant for agricultural volume increase, it is worthy to be popularized.
Claims (5)
- A kind of 1. antiviral composition containing octyl trichlamide, it is characterised in that：Said composition principle active component is octyl trichlamide with containing The compound A of acylhydrazone structure；The compound A of the wherein described structure containing acylhydrazone is (1S, 3S)-N '-(4- chlorobenzenes methylene) -1- methyl -2,3,4, 9- tetrahydropyridines simultaneously [3,4-b] indoles -3- formylhydrazines；The wherein compound A of the structure containing acylhydrazone and the weight ratio of octyl trichlamide are 1:40-10:1；Wherein octyl trichlamide and weight fractions of the compound A in whole composition are 1.5~60%.
- 2. the antiviral composition according to claim 1 containing octyl trichlamide, it is characterised in that：The compound of the structure containing acylhydrazone The weight of A and octyl trichlamide ratio is 1：10~1：1.
- 3. the antiviral composition according to claim 2 containing octyl trichlamide, it is characterised in that：Chemical combination in antiviral composition Thing A weight fraction is 0.5%~20%, and octyl trichlamide weight fraction is 1%~40%.
- 4. the antiviral composition according to claim 1 containing octyl trichlamide, it is characterised in that：It is prepared by the antiviral composition Formulation is the agricultural chemicals such as missible oil, water and milk, micro emulsion, suspending agent, wettable powder, water dispersion granule, soluble liquid, bulky grain agent One kind in formulation.
- 5. the antiviral composition containing octyl trichlamide described in claim 1, applied to vegetables or melon and fruit or tobacco or the disease of rice Viral disease is prevented and treated and prevention.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710916752.6A CN107711833A (en) | 2017-09-30 | 2017-09-30 | A kind of antiviral composition containing octyl trichlamide |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710916752.6A CN107711833A (en) | 2017-09-30 | 2017-09-30 | A kind of antiviral composition containing octyl trichlamide |
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| CN107711833A true CN107711833A (en) | 2018-02-23 |
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| CN201710916752.6A Pending CN107711833A (en) | 2017-09-30 | 2017-09-30 | A kind of antiviral composition containing octyl trichlamide |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110973136A (en) * | 2019-12-13 | 2020-04-10 | 京博农化科技有限公司 | Pesticide composition containing flonicamid and sincalide and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104744460A (en) * | 2013-12-30 | 2015-07-01 | 南开大学 | B-carboline, dihydro-B-carboline and tetrahydro-B-carboline alkaloid derivative as well as preparation method and application in aspects of plant virus prevention and cure, sterilization and insecticide |
-
2017
- 2017-09-30 CN CN201710916752.6A patent/CN107711833A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104744460A (en) * | 2013-12-30 | 2015-07-01 | 南开大学 | B-carboline, dihydro-B-carboline and tetrahydro-B-carboline alkaloid derivative as well as preparation method and application in aspects of plant virus prevention and cure, sterilization and insecticide |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110973136A (en) * | 2019-12-13 | 2020-04-10 | 京博农化科技有限公司 | Pesticide composition containing flonicamid and sincalide and application thereof |
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