CN103570753A - Preparation method of arylboronic acid compound - Google Patents
Preparation method of arylboronic acid compound Download PDFInfo
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- CN103570753A CN103570753A CN201310561231.5A CN201310561231A CN103570753A CN 103570753 A CN103570753 A CN 103570753A CN 201310561231 A CN201310561231 A CN 201310561231A CN 103570753 A CN103570753 A CN 103570753A
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Abstract
The invention provides a preparation method of an arylboronic acid compound and belongs to the field of organic synthesis. According to the preparation method of the arylboronic acid compound, the arylboronic acid compound is prepared from aryl halohydrocarbon by Grignard reaction and esterification hydrolysis reaction; and the prepared arylboronic acid compound is applied to a hydrocarbon sensor, nucleoside and saccharides selective transporters, an enzyme inhibitor and the like in biology, medical science or materials science. According to the preparation method, a single solvent used in reaction is replaced with a mixed solvent so that the reaction and industrial safety can be improved, and the cost of the raw material can be decreased; in addition, a simple and efficient purification method is provided; and the method is simple in preparation process, mild in reaction conditions, simple and controllable in operation, and suitable for massive industrial production.
Description
Technical field
The present invention relates to a kind of preparation method's of aryl boric acid compound method, belong to organic synthesis field.
Background technology
Aryl boric acid compound is the boronic acid compounds with monocycle, the aryl boric acid of various replacements is important organic synthesis intermediate and medicine, pesticide intermediate, be widely used in Suzuki cross-coupling reaction, amino acid whose asymmetric synthesis, aminocompound catalyzer etc., for example, replace ortho-nitrophenyl boric acid and participate in the synthetic of various heterocycles; Phenylo boric acid is the precursor of the important activity compounds such as substituted diphenylamine derivative, and in biology, medical science or materialogy, the selectivity that aryl boric acid has been used to sensor, nucleosides and the carbohydrate of hydro carbons transports the inhibitor of carrier, enzyme.At present, the universal method of synthesizing aryl boronic acid compounds is Grignard reagent method, by aryl halide and magnesium chips effect, generates Grignard reagent, and then Grignard reagent reacts with boric acid ester and obtains aryl boric acid compound.In the method, select tetrahydrofuran (THF) to make solvent, yet tetrahydrofuran (THF) price is higher, reclaims difficulty.
the industrial production cost that reduces aryl boric acid compound is significant.
Summary of the invention
The object of the invention is to solve the higher problem of solvent cost in above-mentioned synthetic method, a kind of method that adopts mixed solvent low cost to prepare aryl boric acid compound is provided, and a kind of simple and effective purification way is provided.
The technical solution used in the present invention is: a kind of preparation method of aryl boric acid compound be take aryl halide as raw material, through grignard reaction, reacts two steps with esterification catalysis:
(1) under nitrogen protection, under room temperature, in four-hole round-bottomed flask, add 1.0-1.5eq magnesium rod, solvent, the mixed solvent that is 1:3～3:1 by 1.0eq aryl halide and mass ratio mixes, and under nitrogen protection, slowly in the four-hole bottle that contains magnesium rod, adds 1/5 of volume, temperature in flask rises to 30-60 ℃, keep temperature, drip 4/5 of residual volume, control rate of addition, maintain the temperature at 50-60 ℃, obtain Grignard reagent;
(2) in another four-hole round-bottomed flask, add boric acid ester and solvent, be cooled to 0-5 ℃, the above-mentioned Grignard reagent preparing is dripped so far in flask, Grignard reagent dropwises in backward flask and drips dilute hydrochloric acid cancellation reaction, and esterification catalysis has reacted; Separatory drips 1.0-5.0eq inorganic base aqueous solution salify in organic layer, and extraction separatory drips dilute hydrochloric acid in water layer, separates out solid, filters, and is dried to obtain aryl boric acid compound.
When the consumption of described aryl halide is 1.0eq, the consumption of magnesium rod is 1.0-1.5eq, and the consumption of mineral alkali is 1.0-5.0eq.
Described aryl halide is selected from tertiary butyl bromobenzene, para chlorobromobenzene, p-Fluoro bromo benzene.
Described solvent is selected from one or both in toluene, tetrahydrofuran (THF), dimethylbenzene, ether, anhydrous methyl THF.
Described mixed solvent is selected from toluene/tetrahydrofuran (THF), dimethylbenzene/methyltetrahydrofuran, dimethylbenzene/tetrahydrofuran (THF).
Described boric acid ester is selected from trimethyl borate, triisopropyl borate ester, tributyl borate, tri-n-butyl borate.
Described mineral alkali is selected from sodium carbonate, salt of wormwood, sodium hydroxide, potassium hydroxide, sodium bicarbonate, saleratus.
The invention has the beneficial effects as follows: the preparation method of this aryl boric acid compound be take aryl halide as raw material, through grignard reaction, react with esterification catalysis, the aryl boric acid compound of preparation is in biology, medical science or materialogy, and the selectivity that has been used to sensor, nucleosides and the carbohydrate of hydro carbons transports the inhibitor of carrier, enzyme etc.This preparation method changes the related single solvent of reaction into mixed solvent, improved reaction industry security, reduced material cost, and provide a kind of simple and effective method of purification, preparation process is simple, reaction conditions is gentle, simple to operate easy to control, is applicable to large-scale industrial production.
Embodiment
The present invention will be further described by the following examples.
In following examples, the purity of synthesized compound is according to high effective liquid chromatography for measuring.
embodiment 1to tert.-butylbenzene boric acid
under nitrogen protection, under room temperature, in 250 mL four-hole round-bottomed flasks, add magnesium rod 3.23 g(0.13 moL, 1.03 eq), anhydrous tetrahydro furan 37.5 g, dimethylbenzene 12.5 g.Will be to tertiary butyl bromobenzene 26.7 g(0.126 moL, 1.0 eq), and dimethylbenzene/tetrahydrofuran (THF) of 85 g (1:3) mixing, under nitrogen protection, slowly in the four-hole bottle that contains magnesium rod, add 1/5 of about volume, when temperature rising is obviously greater than 15 ℃, illustrate and start to cause, now the temperature in flask approximately can rise to 55～60 ℃ of left and right, keeps temperature, drip remaining to tertiary butyl bromobenzene, control rate of addition, maintain the temperature at 50～60 ℃, grignard reaction is complete; In another 250 mL four-hole round-bottomed flask, add trimethyl borate 13.1 g(0.126 moL, 1.0 eq), with 75 g tetrahydrofuran (THF)s, be cooled to 0～5 ℃, the above-mentioned Grignard reagent preparing is dripped so far in flask, Grignard reagent dropwises in backward flask and drips dilute hydrochloric acid cancellation reaction, and esterification catalysis has reacted; Separatory drips wet chemical salify in organic layer, and extraction separatory drips dilute hydrochloric acid in water layer, separates out solid, filters, and is dried to obtain solid 16.9 g.Purity is 98.1%, and yield is 75.1%.
embodiment 2to chlorobenzene boric acid
Under nitrogen protection, under room temperature, in 250 mL four-hole round-bottomed flasks, add magnesium rod 2.52 g(0.105 moL, 1.05 eq), anhydrous methyltetrahydrofuran 36.5 g, dimethylbenzene 13.5 g.By para chlorobromobenzene 19.2 g(0.1 moL, 1.0 eq), mix with dimethylbenzene/anhydrous methyltetrahydrofuran (1:3) of 85 g, under nitrogen protection, slowly in the four-hole bottle that contains magnesium rod, add 1/5 of about volume, when temperature rising is obviously greater than 15 ℃, illustrates and start to cause, now the temperature in flask approximately can rise to 50～60 ℃ of left and right, keep temperature, drip remaining para chlorobromobenzene solution, grignard reaction is complete; In another 250 mL four-hole round-bottomed flask, add trimethyl borate 10.4 g(0.1 moL, 1.0 eq) and 75 g dimethylbenzene, be cooled to 0～5 ℃, the above-mentioned Grignard reagent preparing is dripped so far in flask, Grignard reagent dropwises rear dropping dilute hydrochloric acid cancellation reaction, and esterification catalysis has reacted; Separatory drips aqueous sodium hydroxide solution salify in organic layer, and extraction separatory drips dilute hydrochloric acid in water layer, separates out solid, filters, and is dried to obtain solid 12.8 g, and purity is 98.7%, and yield is 82.3%.
embodiment 3to fluorobenzoic boric acid
under nitrogen protection, under room temperature, in 250 mL four-hole round-bottomed flasks, add magnesium rod 2.52 g(0.105 moL, 1.05 eq), anhydrous tetrahydro furan 13.5 g, toluene 37.5 g.By p-Fluoro bromo benzene 17.3 g(0.1 moL, toluene/tetrahydrofuran (THF) of 1.0eq) He 85 g (3:1) mixes, under nitrogen protection, slowly in the four-hole bottle that contains magnesium rod, add 1/8 of about volume, when temperature rising is obviously greater than 15 ℃, illustrate and start to cause, now the temperature in flask approximately can rise to 50～60 ℃ of left and right, keeps temperature, drip remaining santochlor solution, grignard reaction is complete; In another 250 mL four-hole round-bottomed flask, add tributyl borate 23.0 g(0.1 moL, 1.0eq) He 75 g toluene, be cooled to 0～5 ℃, the above-mentioned Grignard reagent preparing is dripped so far in flask, Grignard reagent dropwises in backward flask and drips dilute hydrochloric acid cancellation reaction, and esterification catalysis has reacted; Separatory drips sodium bicarbonate aqueous solution salify in organic layer, and extraction separatory drips dilute hydrochloric acid in water layer, separates out solid, filters, and is dried to obtain solid 11.0 g, and purity is 98.9%, and yield is 79.1%.
Claims (7)
1. a preparation method for aryl boric acid compound, is characterized in that: described preparation method be take aryl halide as raw material, through grignard reaction, reacts two steps with esterification catalysis:
(1) under nitrogen protection, under room temperature, in four-hole round-bottomed flask, add magnesium rod, solvent, the mixed solvent that is 1:3～3:1 by aryl halide and mass ratio mixes, and under nitrogen protection, slowly in the four-hole bottle that contains magnesium rod, adds 1/5 of volume, temperature in flask rises to 30-60 ℃, keep temperature, drip 4/5 of residual volume, control rate of addition, maintain the temperature at 50-60 ℃, obtain Grignard reagent;
(2) in another four-hole round-bottomed flask, add boric acid ester and solvent, be cooled to 0-5 ℃, the above-mentioned Grignard reagent preparing is dripped so far in flask, Grignard reagent dropwises in backward flask and drips dilute hydrochloric acid cancellation reaction, and esterification catalysis has reacted; Separatory drips inorganic base aqueous solution salify in organic layer, and extraction separatory drips dilute hydrochloric acid in water layer, separates out solid, filters, and is dried to obtain aryl boric acid compound.
2. the preparation method of a kind of aryl boric acid compound according to claim 1, is characterized in that: when the consumption of described aryl halide is 1.0eq, the consumption of magnesium rod is 1.0-1.5eq, and the consumption of mineral alkali is 1.0-5.0eq.
3. the preparation method of a kind of aryl boric acid compound according to claim 1, is characterized in that: described aryl halide is selected from tertiary butyl bromobenzene, para chlorobromobenzene, p-Fluoro bromo benzene.
4. the preparation method of a kind of aryl boric acid compound according to claim 1, is characterized in that: described solvent is selected from one or both in toluene, tetrahydrofuran (THF), dimethylbenzene, ether, anhydrous methyl THF.
5. the preparation method of a kind of aryl boric acid compound according to claim 1, is characterized in that:
Described mixed solvent is selected from toluene/tetrahydrofuran (THF), dimethylbenzene/methyltetrahydrofuran, dimethylbenzene/tetrahydrofuran (THF).
6. the preparation method of a kind of aryl boric acid compound according to claim 1, is characterized in that: described boric acid ester is selected from trimethyl borate, triisopropyl borate ester, tributyl borate, tri-n-butyl borate.
7. the preparation method of a kind of aryl boric acid compound according to claim 1, is characterized in that: described mineral alkali is selected from sodium carbonate, salt of wormwood, sodium hydroxide, potassium hydroxide, sodium bicarbonate, saleratus.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104119367A (en) * | 2014-07-09 | 2014-10-29 | 中国科学技术大学苏州研究院 | Preparation method of aryl boric acid |
| CN106478707A (en) * | 2016-10-14 | 2017-03-08 | 大连九信精细化工有限公司 | A kind of method that utilization continuous flow reactor produces 3 difluoro-methoxy 5 fluorobenzoic boric acid |
| WO2017173668A1 (en) * | 2016-04-08 | 2017-10-12 | 苏州大学张家港工业技术研究院 | Method for preparing phenylboronic acid neopentyl glycol ester |
| CN108690063A (en) * | 2018-07-19 | 2018-10-23 | 济南爱思医药科技有限公司 | A kind of preparation method to chlorophenylboronic acid |
| CN109608341A (en) * | 2018-12-28 | 2019-04-12 | 西南交通大学 | A kind of aryl aniline compound and preparation method thereof |
| CN110054642A (en) * | 2019-04-24 | 2019-07-26 | 京博农化科技有限公司 | A kind of preparation method of pair of chlorophenylboronic acid |
| CN110669064A (en) * | 2018-07-03 | 2020-01-10 | 华东师范大学 | Preparation method of arylboronic acid |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104119367A (en) * | 2014-07-09 | 2014-10-29 | 中国科学技术大学苏州研究院 | Preparation method of aryl boric acid |
| WO2017173668A1 (en) * | 2016-04-08 | 2017-10-12 | 苏州大学张家港工业技术研究院 | Method for preparing phenylboronic acid neopentyl glycol ester |
| US10696696B1 (en) | 2016-04-08 | 2020-06-30 | Soochow University | Method for preparing phenylboronic acid neopentyl glycol ester |
| CN106478707A (en) * | 2016-10-14 | 2017-03-08 | 大连九信精细化工有限公司 | A kind of method that utilization continuous flow reactor produces 3 difluoro-methoxy 5 fluorobenzoic boric acid |
| CN106478707B (en) * | 2016-10-14 | 2018-08-24 | 大连九信精细化工有限公司 | A method of producing 3- difluoro-methoxy -5- fluorobenzoic boric acids using continuous flow reactor |
| CN110669064A (en) * | 2018-07-03 | 2020-01-10 | 华东师范大学 | Preparation method of arylboronic acid |
| CN108690063A (en) * | 2018-07-19 | 2018-10-23 | 济南爱思医药科技有限公司 | A kind of preparation method to chlorophenylboronic acid |
| CN109608341A (en) * | 2018-12-28 | 2019-04-12 | 西南交通大学 | A kind of aryl aniline compound and preparation method thereof |
| CN110054642A (en) * | 2019-04-24 | 2019-07-26 | 京博农化科技有限公司 | A kind of preparation method of pair of chlorophenylboronic acid |
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Application publication date: 20140212 |