CN103565904A - Applications of red bean in preparation of blood glucose-lowering medicines or blood glucose-lowering food - Google Patents
Applications of red bean in preparation of blood glucose-lowering medicines or blood glucose-lowering food Download PDFInfo
- Publication number
- CN103565904A CN103565904A CN201210258811.2A CN201210258811A CN103565904A CN 103565904 A CN103565904 A CN 103565904A CN 201210258811 A CN201210258811 A CN 201210258811A CN 103565904 A CN103565904 A CN 103565904A
- Authority
- CN
- China
- Prior art keywords
- blood glucose
- preparation
- lowering
- red bean
- food
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
The invention discloses applications of red bean in preparation of blood glucose-lowering medicines or blood glucose-lowering food. The invention provides a method of preparing blood glucose-lowering red bean medicines or food. The method includes extruding and expanding red bean powder by utilization of a twin screw to obtain whole wheat flour of the red bean having a blood glucose-lowering function. Test results show that the red bean extruding and expanding compound has a good inhibiting function for a vitro alpha-glycosidase, and red bean extruding and expanding compound administration teams with different specifications can significantly lower the blood glucose level induced by streptozotocin.
Description
Technical field
The present invention relates to the new purposes of extruding puffing Semen Phaseoli, particularly relate to the application of extruding puffing Semen Phaseoli in preparing hypoglycemic drug or blood sugar reducing food.
Background technology
Diabetes (diabetes mellitus, DM) be one of the major disease of harm humans health, he has become the Chronic Non-Communicable Diseases of the malignant tumor that continues, cardiovascular and cerebrovascular vessel serious threat human health after being ill, diabetes have become a kind of worldwide disease of bringing heavy burden to the mankind now, diabetics approximately has 1.5 hundred million according to statistics, estimate 2010, this numeral will be increased to 2.2 hundred million.At present China DM patient has 3,000 ten thousand, and due to reasons such as living standard raising, overnutrition, motion are few, onset diabetes rate is still increasing year by year, and the treatment of diabetics brings heavy financial burden to society.Therefore, treatment treatment diabetes and to control its complication be very important, and the research and development of hypoglycemic medicine to control DM patient blood glucose, delay or to reduce complication significant.
Clinical conventional antidiabetic drug mostly is the medicine (as alpha-glucosidase inhibitor) of chemosynthesis at present.Small intestinal glycosidase is not only relevant with long-term blood sugar increasing by the poisoning effect due to inhibition hyperglycemia, and the relative level also raising with post-prandial glycemia is relevant.Polysaccharide in food enters small intestinal and is degraded to some oligosaccharide and disaccharide by amylase, then is decomposed into monosaccharide with absorbed into serum by the alpha-Glucosidase of intestinal brush border.So can reduce hyperglycemia level after the meal to the competitive inhibition of small intestinal glucosidase.But these medicine long-term takings can produce serious adverse reaction, as: feel sick, the phenomenon such as the symptom such as vomiting, abdominal discomfort and leukopenia, beta-oxybutyria and lactic acidosis, make its application be subject to certain limitation.Research and development are efficient, to reduce blood glucose be clinical problem demanding prompt solution to slow down diabetic complication for low toxicity, cheap natural antidiabetic medicine, thereby from plant, find the emphasis that efficient low antidiabetic medicine becomes domestic and international antidiabetic medicine research.
Summary of the invention
The object of the invention is to Semen Phaseoli medicine or food that preparation has hypoglycemic activity.
Preparation method provided by the present invention, is that Semen Phaseoli powder is utilized to twin screw extruding and extruding puffing, has the full powder of Semen Phaseoli of hypoglycemic activity described in obtaining.
Wherein, the condition of extruding puffing step is: the barrel zone temperature in described twin (double) screw extruder Yi Zhi five each districts, district is followed successively by: 150～180 ℃ of 50～70 ℃, 80～110 ℃, 100～140 ℃, 120～170 ℃ profits; Screw speed is 100～150rpm, and charging rate is 25～50g/min.
The dosage form of described hypoglycemic drug is ordinary preparation, can be also slow releasing preparation, control preparation, targeting preparation and various particulate delivery system.Route of administration can be oral, and form of administration can be liquid dosage form, solid dosage forms.If liquid type can be true solution class, colloidal type, particulate formulations, emulsion dosage form; Solid dosage forms can be tablet, capsule, granule, powder; Or other dosage forms are as drop pill, aerosol, pill, mixed suspension form etc.Described blood sugar reducing food is beverage, confection, rice food, rice flour produts, meat products or the fish product that contains Semen Phaseoli puff.
The specific embodiment
The preparation of embodiment 1 Semen Phaseoli extruding puffing thing
1. Semen Phaseoli is pulverized and sieved, the barrel zone temperature in twin (double) screw extruder Yi Zhi five each districts, district is followed successively by: 70 ℃-110 ℃-140 ℃-140 ℃-150 ℃, extruder is carried out to preheating, the temperature of Ji Ge to be extruded district machine barrel reaches after preset value, adjusting charging rate is 250g/min, setting screw speed is 100rpm, carries out extruding puffing processing, has discharging opening can obtain Semen Phaseoli extruding puffing thing.
The alpha-glucosidase of embodiment 2 Semen Phaseoli extruding puffing things suppresses experiment
Semen Phaseoli extruding puffing thing is dissolved, and being mixed with concentration is the detection liquid of 50mg/ml, adds respectively alpha-glucosidase enzyme (NaH
2pO
4-Na
2hPO
4for solvent, pH7.0, contains 150mmol/L NaCl, 1%BSA) 100 μ L, 37 ℃ of water-bath 15min, then add 10mg/mL maltose solution 100 μ L, mix 37 ℃ of reaction 20min.Boiling water bath 2min cessation reaction, cooling rear with glucose external diagnosis reagent case mensuration glucose growing amount.Take mass concentration as abscissa, and 490nm place absorbance is that vertical coordinate mapping calculating Semen Phaseoli extruding puffing thing suppresses situation to alpha-glucosidase, the results are shown in Table 1. explanation Semen Phaseoli extruding puffing things alpha-glucosidase is had to good inhibitory action.
Table 1:
The hypoglycemic activity of embodiment 3 Semen Phaseoli extruding puffing things to the diabetes rat of streptozotocin induction
The diabetes rat of streptozotocin induction is divided into model control group and Semen Phaseoli extruding puffing thing administration group, animal overnight fasting, Semen Phaseoli extruding puffing thing administration group gavage gives Semen Phaseoli extruding puffing thing 300mg/kg; Model control group is given and isopyknic water, after administration 1 time, gavage sucrose (2.5g/kg), in administration 0,0.5,1,2h gets blood, by blood glucose meter, measures blood glucose.The results are shown in Table 3. experimental results and show that Semen Phaseoli extruding puffing thing is significantly improved the sugared dosis tolerata tool of the diabetes rat of streptozotocin induction.
The impact (* and model control group ratio, p < 0.05) of table 2 Semen Phaseoli extruding puffing thing on the carbohydrate tolerance of the diabetes rat of streptozotocin induction
Claims (4)
1. preparation has the Semen Phaseoli medicine of hypoglycemic activity or the method for food, is Semen Phaseoli powder is utilized to twin screw extruding and extruding puffing, has the full powder of Semen Phaseoli of hypoglycemic activity described in obtaining.
2. method according to claim 1, is characterized in that: the condition of described extruding puffing step is: the barrel zone temperature in described twin (double) screw extruder Yi Zhi five each districts, district is followed successively by: 50～70 ℃, 80～110 ℃, 100～140 ℃, 120～170 ℃ and 150～180 ℃; Screw speed is 100～150rpm, and charging rate is 25～50g/min.
3. method according to claim 1, is characterized in that: described hypoglycemic drug or blood sugar reducing food can be made ordinary preparation, can be also slow releasing preparation, control preparation, targeting preparation and various particulate delivery system.Route of administration can be oral, and form of administration can be that liquid agent is other, solid dosage forms.If liquid type can be true solution class, colloidal type, particulate formulations, emulsion dosage form; Solid dosage forms can be tablet, capsule, granule, powder; Or other dosage forms are as drop pill, aerosol, pill, mixed suspension form etc.
4. method according to claim 1, is characterized in that: described hypoglycemic drug or blood sugar reducing food can be made beverage, confection, rice food, rice flour produts, meat products or the fish product that contains Semen Phaseoli puff.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210258811.2A CN103565904A (en) | 2012-07-25 | 2012-07-25 | Applications of red bean in preparation of blood glucose-lowering medicines or blood glucose-lowering food |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210258811.2A CN103565904A (en) | 2012-07-25 | 2012-07-25 | Applications of red bean in preparation of blood glucose-lowering medicines or blood glucose-lowering food |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103565904A true CN103565904A (en) | 2014-02-12 |
Family
ID=50039185
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210258811.2A Pending CN103565904A (en) | 2012-07-25 | 2012-07-25 | Applications of red bean in preparation of blood glucose-lowering medicines or blood glucose-lowering food |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103565904A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108813331A (en) * | 2018-07-06 | 2018-11-16 | 中国农业科学院作物科学研究所 | A kind of production method of the steamed bun with function of blood sugar reduction |
| CN110734476A (en) * | 2019-11-28 | 2020-01-31 | 中国农业科学院作物科学研究所 | Soybean peptide composition with blood sugar reducing function and preparation method and application thereof |
| CN110790824A (en) * | 2019-11-28 | 2020-02-14 | 中国农业科学院作物科学研究所 | Small bean peptide composition with glycosidase inhibition and preparation method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101715832A (en) * | 2009-11-09 | 2010-06-02 | 国家粮食局科学研究院 | Preparation method of modified nutritional powder and nutritional drink of edible beans |
-
2012
- 2012-07-25 CN CN201210258811.2A patent/CN103565904A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101715832A (en) * | 2009-11-09 | 2010-06-02 | 国家粮食局科学研究院 | Preparation method of modified nutritional powder and nutritional drink of edible beans |
Non-Patent Citations (1)
| Title |
|---|
| 陆勤丰: "膳食纤维制品的开发研究", 《粮食加工》, no. 04, 30 August 2005 (2005-08-30), pages 44 - 47 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108813331A (en) * | 2018-07-06 | 2018-11-16 | 中国农业科学院作物科学研究所 | A kind of production method of the steamed bun with function of blood sugar reduction |
| CN110734476A (en) * | 2019-11-28 | 2020-01-31 | 中国农业科学院作物科学研究所 | Soybean peptide composition with blood sugar reducing function and preparation method and application thereof |
| CN110790824A (en) * | 2019-11-28 | 2020-02-14 | 中国农业科学院作物科学研究所 | Small bean peptide composition with glycosidase inhibition and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106360310A (en) | Composition for dropping after meal blood sugar and application thereof | |
| CN101590007A (en) | A kind of metformin hydrochloride/voigelibo sugar-lowering oral preparation compositions and preparation thereof | |
| CN108523126A (en) | It is a kind of that there is the composition and preparation method thereof for improving blood glucose level | |
| CN104758920A (en) | Gout health care product based on homology of medicine and food | |
| CN104107188A (en) | Application and preparation method of apple polysaccharides for regulating alteration of intestinal flora and relaxing bowel | |
| US6815433B2 (en) | Composition and method for the treatment of dysglucaemia | |
| CN103565904A (en) | Applications of red bean in preparation of blood glucose-lowering medicines or blood glucose-lowering food | |
| CN104012743A (en) | Production method of L-arabinose functional tribute cake | |
| CN103977409A (en) | Dietary supplement composition and blood sugar regulating method thereof | |
| JP4657396B2 (en) | Amylase inhibitory active substance and use thereof | |
| CN105055459A (en) | Hypoglycemic composition and application thereof | |
| CN105725187A (en) | Blood sugar reducing composition and application in preparation of foods and health-care foods | |
| JP6607667B2 (en) | Intestinal preparation containing indigestible glucan and method for producing the same | |
| CN102258570B (en) | Composition for inhibiting activity of alpha-glycuronide and preparation method of composition | |
| CN104543662A (en) | Production method of sugar-reducing polysaccharide granules with coprinus comatus | |
| CN104126806A (en) | Vitamin B12 sublingual tablet and preparation method thereof | |
| KR101660834B1 (en) | Anti-diabetic effects of Gypenoside 75 | |
| CN113519852A (en) | Selenium-rich chitosan oligosaccharide tablet and preparation method thereof | |
| CN107853712A (en) | A kind of composition for alleviating hyperglycaemia and preparation method thereof and purposes | |
| CN102048132B (en) | Health-care food for reducing blood sugar | |
| CN101433534B (en) | Use of resveratrol dimer for preparing medicament for reducing blood sugar | |
| CN108261511B (en) | Composition with weight-losing effect and preparation method and application thereof | |
| CN102210866B (en) | Oral preparation for slowing down absorption of alpha-glycosidase inhibitor and enhancing hypoglycemic drug effect | |
| CN105796632A (en) | Tamarind fruit shell extract, preparing method and application thereof in reducing glycosylated hemoglobin level | |
| CN104095868B (en) | A kind of pharmaceutical composition and pharmaceutical applications thereof improving sugar tolerance |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: JINLIN REAWIN BIOLOGICAL TECHNOLOGY CO., LTD. Free format text: FORMER OWNER: INSTITUTE OF CROP SCIENCE, CHINESE ACADEMY OF AGRICULTURAL SCIENCE Effective date: 20150428 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 100081 HAIDIAN, BEIJING TO: 130061 CHANGCHUN, JILIN PROVINCE |
|
| TA01 | Transfer of patent application right |
Effective date of registration: 20150428 Address after: Yatai street and prosperity Road, Nanguan District, Jilin province 130061 city Changchun prosperity Road intersection project (Maison des Artistes) 11 Building 1 Applicant after: Rui De bio tech ltd, Jilin Address before: 100081 Beijing, Zhongguancun, South Street, No. 12, No. Applicant before: Institute of Crop Science, Chinese Academy of Agricultural Science |
|
| DD01 | Delivery of document by public notice |
Addressee: Rui De bio tech ltd, Jilin Document name: Notification of Passing Examination on Formalities |
|
| DD01 | Delivery of document by public notice |
Addressee: Rui De bio tech ltd, Jilin Document name: the First Notification of an Office Action |
|
| DD01 | Delivery of document by public notice |
Addressee: Rui De bio tech ltd, Jilin Document name: Notification of an Office Action |
|
| DD01 | Delivery of document by public notice |
Addressee: Rui De bio tech ltd, Jilin Document name: Decision of Rejection |
|
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20140212 |