CN108261511B - Composition with weight-losing effect and preparation method and application thereof - Google Patents

Composition with weight-losing effect and preparation method and application thereof Download PDF

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CN108261511B
CN108261511B CN201611258806.6A CN201611258806A CN108261511B CN 108261511 B CN108261511 B CN 108261511B CN 201611258806 A CN201611258806 A CN 201611258806A CN 108261511 B CN108261511 B CN 108261511B
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parts
seed
weight
composition
liquorice
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CN108261511A (en
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朱永红
王颖
俞金蓉
刘昉
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Lanzhou Qizheng Ecological Health Products Co ltd
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Lanzhou Qizheng Ecological Health Products Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A61K36/8994—Coix (Job's tears)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/733—Fructosans, e.g. inulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/62—Nymphaeaceae (Water-lily family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The invention particularly relates to a composition with a weight-losing effect, and a preparation method and application thereof. The raw materials of the composition comprise: 50-120 parts of inulin, 5-14 parts of codonopsis pilosula, 3-14 parts of bighead atractylodes rhizome, 5-17 parts of poria cocos, 11-26 parts of Chinese yam, 4-17 parts of lotus seed, 3-17 parts of gordon euryale seed, 3-17 parts of white hyacinth bean, 11-26 parts of coix seed, 3-6 parts of dried orange peel, 1-7 parts of liquorice and 1-8 parts of hawthorn. The invention fully considers the composition of the raw materials and the proportion of the raw materials to each other, so that the raw materials are mutually matched and act together under the specific proportion, thereby playing the role of losing weight; in addition, the composition has the advantages of small toxic and side effects, high safety, simple composition and low cost.

Description

Composition with weight-losing effect and preparation method and application thereof
Technical Field
The invention belongs to the field of medicines, health-care products or foods, and particularly relates to a composition with a weight-losing effect, and a preparation method and application thereof.
Background
With the development of economy, the living standard of people is continuously improved, and over nutrition and high-fat food intake cause obesity to some people. Obesity has become a serious global medical and social problem. According to WHO obesity standards, the obesity incidence rate of adults in China is increased from 14.6% to 30.1% from 1992 to 2012, and the obesity incidence rate of children in 5-17 years old teenagers is 9.6%; by 2015, obesity has affected the health of over 3 hundred million Chinese people, and the number of obese people in China is expected to increase rapidly in the coming decades. Obesity not only brings the trouble of self-posture to people, but also causes the overload of heart function, causes diseases such as coronary heart disease, cerebral apoplexy, cerebral thrombosis, hypertension, hyperlipidemia, hyperglycemia and the like, and endangers the health of people.
At present, weight-loss drugs mainly include the following two major classes: pancreatic lipase inhibitors and appetite suppressants; pancreatic lipase inhibitors which are used for weight loss by inhibiting pancreatic lipase activity and thus inhibiting the decomposition and absorption of fat in food, appetite suppressants are limited in use because they cause adverse reactions in the nervous system. To date, only the lipase inhibitor orlistat (orlistat), the 5-hydroxytryptamine 2C receptor agonist lorcaserin (lorcaserin) and the compound antiobesity drug Qsymia (a sustained release agent containing phentermine and topiramate) have been approved by the FDA for long-term use. However, the above-mentioned weight-loss drugs can cause adverse reactions such as fatty diarrhea, fat-soluble vitamin deficiency, etc., and there is a great uncertainty as to whether there are toxic and side effects on the brain center and cardiovascular system, etc.
In order to solve the problems of more adverse reactions and larger toxic and side effects of the existing weight-reducing drugs, Chinese patent document CN102860390A discloses: the mulberry leaf weight-reducing tea comprises the following raw material medicines in parts by weight: 10-20 parts of radix ophiopogonis, 10-20 parts of poria cocos, 10-20 parts of honeysuckle, 10-20 parts of codonopsis pilosula, 10-20 parts of eupatorium, 10-20 parts of gynostemma pentaphyllum, 10-20 parts of Chinese violet, 10-20 parts of polygonatum odoratum, 10-20 parts of perilla leaf, 10-20 parts of oldenlandia diffusa, 10-20 parts of Chinese yam, 10-20 parts of rhizoma anemarrhenae, 10-20 parts of ligusticum wallichii, 10-20 parts of salvia miltiorrhiza, 10-20 parts of coix seed, 10-20 parts of bighead atractylodes rhizome and 10-20 parts of prunus persica. However, the above composition has disadvantages of complicated composition, high cost, etc., thereby limiting its application.
Therefore, the research on the novel composition with the weight-losing effect, which has the advantages of good treatment effect, small toxic and side effect, simple composition and lower cost, has important significance.
Disclosure of Invention
Therefore, the invention provides the composition with the weight-losing effect, which has the advantages of good treatment effect, small toxic and side effect, simple composition and lower cost, and further provides the preparation method and the application thereof.
In order to solve the technical problems, the invention is realized by the following technical scheme:
the invention provides a composition with a weight-losing effect, which comprises the following raw materials:
50-120 parts of inulin, 5-14 parts of codonopsis pilosula, 3-14 parts of bighead atractylodes rhizome, 5-17 parts of poria cocos, 11-26 parts of Chinese yam, 4-17 parts of lotus seed, 3-17 parts of gordon euryale seed, 3-17 parts of white hyacinth bean, 11-26 parts of coix seed, 3-6 parts of dried orange peel, 1-7 parts of liquorice and 1-8 parts of hawthorn.
Preferably, the composition with weight-reducing effect of the present invention comprises the following raw materials:
60-100 parts of inulin, 7-12 parts of codonopsis pilosula, 5-12 parts of bighead atractylodes rhizome, 8-14 parts of poria cocos, 14-22 parts of Chinese yam, 8-14 parts of lotus seed, 5-14 parts of gordon euryale seed, 6-14 parts of white hyacinth bean, 14-22 parts of coix seed, 4-5 parts of dried orange peel, 2-6 parts of liquorice and 3-6 parts of hawthorn.
Further preferably, the composition with weight-reducing effect of the present invention comprises the following raw materials:
100 parts of inulin, 12 parts of codonopsis pilosula, 12 parts of bighead atractylodes rhizome, 8 parts of poria cocos, 22 parts of Chinese yam, 8 parts of lotus seed, 5 parts of gordon euryale seed, 6 parts of white hyacinth bean, 22 parts of coix seed, 5 parts of dried orange peel, 2 parts of liquorice and 5 parts of hawthorn; or
75 parts of inulin, 12 parts of codonopsis pilosula, 12 parts of bighead atractylodes rhizome, 8 parts of poria cocos, 22 parts of Chinese yam, 8 parts of lotus seed, 5 parts of gordon euryale seed, 6 parts of white hyacinth bean, 22 parts of coix seed, 5 parts of dried orange peel, 2 parts of liquorice and 5 parts of hawthorn; or
60 parts of inulin, 12 parts of codonopsis pilosula, 12 parts of bighead atractylodes rhizome, 8 parts of poria cocos, 22 parts of Chinese yam, 8 parts of lotus seed, 5 parts of gordon euryale seed, 6 parts of white hyacinth bean, 22 parts of coix seed, 5 parts of dried orange peel, 2 parts of liquorice and 5 parts of hawthorn; or
75 parts of inulin, 7 parts of codonopsis pilosula, 5 parts of bighead atractylodes rhizome, 14 parts of poria cocos, 14 parts of Chinese yam, 14 parts of lotus seed, 14 parts of gordon euryale seed, 14 parts of white hyacinth bean, 14 parts of coix seed, 4 parts of dried orange peel, 2 parts of liquorice and 5 parts of hawthorn; or
100 parts of inulin, 7 parts of codonopsis pilosula, 5 parts of bighead atractylodes rhizome, 14 parts of poria cocos, 14 parts of Chinese yam, 14 parts of lotus seed, 14 parts of gordon euryale seed, 14 parts of white hyacinth bean, 14 parts of coix seed, 4 parts of dried orange peel, 2 parts of liquorice and 5 parts of hawthorn; or
75 parts of inulin, 8 parts of codonopsis pilosula, 9 parts of bighead atractylodes rhizome, 11 parts of poria cocos, 18 parts of Chinese yam, 11 parts of lotus seed, 10 parts of gordon euryale seed, 10 parts of white hyacinth bean, 18 parts of coix seed, 4.5 parts of dried orange peel, 2 parts of liquorice and 5 parts of hawthorn; or
60 parts of inulin, 12 parts of codonopsis pilosula, 5 parts of bighead atractylodes rhizome, 14 parts of poria cocos, 14 parts of Chinese yam, 14 parts of lotus seed, 5 parts of gordon euryale seed, 14 parts of white hyacinth bean, 14 parts of coix seed, 5 parts of dried orange peel, 2 parts of liquorice and 6 parts of hawthorn; or
100 parts of inulin, 7 parts of codonopsis pilosula, 12 parts of bighead atractylodes rhizome, 8 parts of poria cocos, 22 parts of Chinese yam, 8 parts of lotus seed, 14 parts of gordon euryale seed, 6 parts of white hyacinth bean, 22 parts of coix seed, 4 parts of dried orange peel, 6 parts of liquorice and 3 parts of hawthorn.
The invention also provides a preparation method of the composition with the weight-losing effect, which comprises the following steps:
respectively taking selected parts by weight of codonopsis pilosula, bighead atractylodes rhizome, poria cocos, Chinese yam, lotus seed, gordon euryale seed, white hyacinth bean, coix seed, dried orange peel, liquorice and hawthorn, crushing, then adding selected parts by weight of inulin, and uniformly mixing to obtain the traditional Chinese medicine composition; or
Respectively taking selected parts by weight of radix codonopsitis, largehead atractylodes rhizome, tuckahoe, yam, lotus seed, gordon euryale seed, white hyacinth bean, coix seed, tangerine peel, liquorice and hawthorn, heating until the water content is below 10%, crushing, then adding selected parts by weight of inulin, and uniformly mixing to obtain the traditional Chinese medicine composition; or
Respectively taking selected parts by weight of codonopsis pilosula, bighead atractylodes rhizome, poria cocos, Chinese yam, lotus seed meat, gordon euryale seed, white hyacinth bean, coix seed, dried orange peel, liquorice and hawthorn, heating and refluxing for 2-4 times, taking the total weight of the codonopsis pilosula, the bighead atractylodes rhizome, the poria cocos, the Chinese yam, the lotus seed meat, the gordon euryale seed, the white hyacinth bean, the coix seed, the dried orange peel, the liquorice and the hawthorn as a reference, adding 2-4 times of water by weight for 1-3 hours each time, filtering, combining filtrates, concentrating to a relative density of 1.05-1.30 at 50 ℃, then adding selected parts by weight of inulin, and uniformly mixing to.
Preferably, the preparation method of the composition with weight-losing effect of the invention comprises the following steps:
respectively taking selected parts by weight of codonopsis pilosula, bighead atractylodes rhizome, poria cocos, Chinese yam, lotus seed, gordon euryale seed, white hyacinth bean, coix seed, dried orange peel, liquorice and hawthorn, heating at 60-120 ℃ until the water content is below 10%, crushing, then adding selected parts by weight of inulin, and uniformly mixing to obtain the traditional Chinese medicine composition; or
Respectively taking selected parts by weight of radix codonopsitis, white atractylodes rhizome, tuckahoe, yam, lotus seed, gordon euryale seed, white hyacinth bean, coix seed, dried orange peel, liquorice and hawthorn, heating and refluxing for 3 times, taking the total weight of the radix codonopsitis, the white atractylodes rhizome, the tuckahoe, the yam, the lotus seed, the gordon euryale seed, the white hyacinth bean, the coix seed, the dried orange peel, the liquorice and the hawthorn as a reference, adding 2-4 times of water by weight for 1-3 hours each time, filtering, combining filtrates, concentrating to the relative density of 1.10-1.25 at 50 ℃, then adding selected parts by weight of inulin, and uniformly mixing to obtain the traditional Chinese medicine.
Further preferably, the preparation method of the composition with weight-reducing effect of the invention comprises the following steps:
respectively taking selected parts by weight of radix codonopsitis, white atractylodes rhizome, tuckahoe, yam, lotus seed, gordon euryale seed, white hyacinth bean, coix seed, dried orange peel, liquorice and hawthorn, heating and refluxing for 3 times, taking the total weight of the radix codonopsitis, the white atractylodes rhizome, the tuckahoe, the yam, the lotus seed, the gordon euryale seed, the white hyacinth bean, the coix seed, the dried orange peel, the liquorice and the hawthorn as a reference, adding 3 times of water by weight for 2 hours each time, filtering, combining filtrates, concentrating until the relative density is 1.10-1.25 at 50 ℃, then adding selected parts by weight of inulin, and uniformly mixing to obtain the traditional Chinese medicine.
Further preferably, the preparation method of the composition with weight-reducing effect of the invention comprises the following steps:
respectively taking selected parts by weight of codonopsis pilosula, bighead atractylodes rhizome, poria cocos, Chinese yam, lotus seed, gordon euryale seed, white hyacinth bean, coix seed, dried orange peel, liquorice and hawthorn, heating to 80-100 ℃ until the water content is below 10%, crushing, then adding selected parts by weight of inulin, and uniformly mixing to obtain the traditional Chinese medicine composition; or
Respectively taking selected parts by weight of radix codonopsitis, white atractylodes rhizome, tuckahoe, yam, lotus seed, gordon euryale seed, white hyacinth bean, coix seed, dried orange peel, liquorice and hawthorn, heating and refluxing for 3 times, taking the total weight of the radix codonopsitis, the white atractylodes rhizome, the tuckahoe, the yam, the lotus seed, the gordon euryale seed, the white hyacinth bean, the coix seed, the dried orange peel, the liquorice and the hawthorn as a reference, adding 2 times of water by weight for 2 hours at the 1 st time, adding 3 times of water by weight for 2.5 hours at the 2 nd time, adding 4 times of water by weight for 3 hours at the 3 rd time, filtering, combining filtrates, concentrating to the relative density of 1.10-1.25 at 50 ℃, adding selected parts by weight of inulin, and uniformly mixing to obtain.
Further preferably, the method for preparing the composition with weight-losing effect of the present invention is to pulverize to a particle size of 150 μm.
The invention also provides a preparation containing the composition with the weight-losing effect or a preparation containing the composition prepared by the preparation method,
the composition is added with conventional auxiliary materials and prepared into clinically acceptable tablets, capsules, powder, mixtures, pills, granules, solutions, syrups, soft extracts, beverages, biscuits, candies or cakes according to a conventional process.
The conventional auxiliary materials are as follows: fillers, disintegrants, lubricants, suspending agents, binders, sweeteners, flavoring agents, preservatives, bases, and the like. The filler comprises: starch, pregelatinized starch, lactose, mannitol, chitin, microcrystalline cellulose, sucrose, etc.; the disintegrating agent comprises: starch, pregelatinized starch, microcrystalline cellulose, sodium carboxymethyl starch, cross-linked polyvinylpyrrolidone, low-substituted hydroxypropylcellulose, cross-linked sodium carboxymethyl cellulose, etc.; the lubricant comprises: magnesium stearate, sodium lauryl sulfate, talc, silica, and the like; the suspending agent comprises: polyvinylpyrrolidone, microcrystalline cellulose, sucrose, agar, hydroxypropyl methylcellulose, and the like; the adhesive comprises starch slurry, polyvinylpyrrolidone, hydroxypropyl methylcellulose, etc.; the sweetener comprises: saccharin sodium, aspartame, sucrose, sodium cyclamate, glycyrrhetinic acid, and the like; the flavoring agent comprises: sweeteners and various essences; the preservative comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its salts, benzalkonium bromide, chloroacetidine acetate, eucalyptus oil, etc.; the matrix comprises: PEG6000, PEG4000, insect wax, etc.
The invention also provides application of the composition, the composition prepared by the preparation method, or a preparation of the composition in preparation of medicines, health-care products or foods with the weight-losing effect.
The technical scheme of the invention has the following advantages:
(1) the composition of the raw materials and the proportion of the raw materials are fully considered, so that the raw materials are mutually matched and act together in a specific proportion, and the weight-losing effect is achieved;
(2) the composition disclosed by the invention has a remarkable weight-losing effect, and is small in toxic and side effects and high in safety;
(3) the composition disclosed by the invention is simple in composition and low in cost.
Detailed Description
In the following examples and experimental examples, inulin, codonopsis pilosula, bighead atractylodes rhizome, poria cocos, Chinese yam, lotus seed, gordon euryale seed, white hyacinth bean, coix seed, dried tangerine peel, liquorice and hawthorn are all commercially available products.
Example 1
The composition with the weight-losing effect comprises the following raw materials: 100g of inulin, 12g of codonopsis pilosula, 12g of bighead atractylodes rhizome, 8g of poria cocos, 22g of Chinese yam, 8g of lotus seed, 5g of gordon euryale seed, 6g of white hyacinth bean, 22g of coix seed, 5g of dried orange peel, 2g of liquorice and 5g of hawthorn;
the preparation method of the composition comprises the following steps: respectively taking selected weight of radix Codonopsis, Atractylodis rhizoma, Poria, rhizoma Dioscoreae, semen Nelumbinis, semen euryales, semen lablab album, Coicis semen, pericarpium Citri Tangerinae, Glycyrrhrizae radix and fructus crataegi, heating at 60 deg.C until water content is below 10% to particle size of 150 μm, adding selected weight of inulin, and mixing well to obtain the final product.
The composition with the weight-losing effect is added with conventional auxiliary materials and prepared into tablets according to a conventional process.
Example 2
The composition with the weight-losing effect comprises the following raw materials: 75g of inulin, 12g of codonopsis pilosula, 12g of bighead atractylodes rhizome, 8g of poria cocos, 22g of Chinese yam, 8g of lotus seed, 5g of gordon euryale seed, 6g of white hyacinth bean, 22g of coix seed, 5g of dried orange peel, 2g of liquorice and 5g of hawthorn;
the preparation method of the composition comprises the following steps: respectively taking selected weight of radix Codonopsis, Atractylodis rhizoma, Poria, rhizoma Dioscoreae, semen Nelumbinis, semen euryales, semen lablab album, Coicis semen, pericarpium Citri Tangerinae, Glycyrrhrizae radix and fructus crataegi, heating at 80 deg.C until water content is below 10% to particle size of 150 μm, adding selected weight of inulin, and mixing well to obtain the final product.
The composition with the weight-losing effect is added with conventional auxiliary materials and prepared into capsules according to a conventional process.
Example 3
The composition with the weight-losing effect comprises the following raw materials: 60g of inulin, 12g of codonopsis pilosula, 12g of bighead atractylodes rhizome, 8g of poria cocos, 22g of Chinese yam, 8g of lotus seed, 5g of gordon euryale seed, 6g of white hyacinth bean, 22g of coix seed, 5g of dried orange peel, 2g of liquorice and 5g of hawthorn;
the preparation method of the composition comprises the following steps: respectively taking radix Codonopsis, Atractylodis rhizoma, Poria, rhizoma Dioscoreae, semen Nelumbinis, semen euryales, semen lablab album, Coicis semen, pericarpium Citri Tangerinae, Glycyrrhrizae radix and fructus crataegi of selected weight, heating at 120 deg.C until water content is below 10% and particle size is 150 μm, adding inulin of selected weight, and mixing well to obtain the final product.
The composition with the weight-losing effect is added with conventional auxiliary materials and prepared into granules according to a conventional process.
Example 4
The composition with the weight-losing effect comprises the following raw materials: 75g of inulin, 7g of codonopsis pilosula, 5g of bighead atractylodes rhizome, 14g of poria cocos, 14g of Chinese yam, 14g of lotus seed, 14g of gordon euryale seed, 14g of white hyacinth bean, 14g of coix seed, 4g of dried orange peel, 2g of liquorice and 5g of hawthorn;
the preparation method of the composition comprises the following steps: respectively taking radix Codonopsis, Atractylodis rhizoma, Poria, rhizoma Dioscoreae, semen Nelumbinis, semen euryales, semen lablab album, Coicis semen, pericarpium Citri Tangerinae, Glycyrrhrizae radix and fructus crataegi of selected weight, heating at 100 deg.C until water content is below 10% to particle size of 150 μm, adding inulin of selected weight, and mixing well to obtain the final product.
The composition with the weight-losing effect is added with conventional auxiliary materials and prepared into powder according to a conventional process.
Example 5
The composition with the weight-losing effect comprises the following raw materials: 100g of inulin, 7g of codonopsis pilosula, 5g of bighead atractylodes rhizome, 14g of poria cocos, 14g of Chinese yam, 14g of lotus seed, 14g of gordon euryale seed, 14g of white hyacinth bean, 14g of coix seed, 4g of dried orange peel, 2g of liquorice and 5g of hawthorn;
the preparation method of the composition comprises the following steps: respectively taking radix codonopsitis, white atractylodes rhizome, tuckahoe, yam, lotus seed, gordon euryale seed, white hyacinth bean, coix seed, dried orange peel, liquorice and hawthorn with selected weight, heating and refluxing for 3 times, taking the total weight of the radix codonopsitis, the white atractylodes rhizome, the tuckahoe, the yam, the lotus seed, the gordon euryale seed, the white hyacinth bean, the coix seed, the dried orange peel, the liquorice and the hawthorn as a reference, adding 2 times of water by weight for 2 hours at the 1 st time, adding 3 times of water by weight for 2.5 hours at the 2 nd time, adding 4 times of water by weight for 3 hours at the 3 rd time, filtering, combining filtrates, concentrating to the relative density of 1.10-1.25 at 50 ℃, adding inulin with selected weight, and uniformly mixing to obtain the product.
The composition with the weight-losing effect is added with conventional auxiliary materials and prepared into tablets according to a conventional process.
Example 6
The composition with the weight-losing effect comprises the following raw materials: 75g of inulin, 8g of codonopsis pilosula, 9g of bighead atractylodes rhizome, 11g of poria cocos, 18g of Chinese yam, 11g of lotus seed, 10g of gordon euryale seed, 10g of white hyacinth bean, 18g of coix seed, 4.5g of dried orange peel, 2g of liquorice and 5g of hawthorn;
the preparation method of the composition comprises the following steps: respectively taking radix codonopsitis, white atractylodes rhizome, tuckahoe, yam, lotus seed, gordon euryale seed, white hyacinth bean, coix seed, dried orange peel, liquorice and hawthorn with selected weight, heating and refluxing for 3 times, taking the total weight of the radix codonopsitis, the white atractylodes rhizome, the tuckahoe, the yam, the lotus seed, the gordon euryale seed, the white hyacinth bean, the coix seed, the dried orange peel, the liquorice and the hawthorn as a reference, adding 3 times of water by weight for 2 hours each time, filtering, combining filtrates, concentrating until the relative density is 1.10-1.25 at 50 ℃, then adding inulin with selected weight, and uniformly mixing to obtain the traditional Chinese medicine.
The composition with the weight-losing effect is added with conventional auxiliary materials and prepared into capsules according to a conventional process.
Example 7
The composition with the weight-losing effect comprises the following raw materials: 60g of inulin, 12g of codonopsis pilosula, 5g of bighead atractylodes rhizome, 14g of poria cocos, 14g of Chinese yam, 14g of lotus seed, 5g of gordon euryale seed, 14g of white hyacinth bean, 14g of coix seed, 5g of dried orange peel, 2g of liquorice and 6g of hawthorn;
the preparation method of the composition comprises the following steps: respectively taking radix codonopsitis, white atractylodes rhizome, tuckahoe, yam, lotus seed, gordon euryale seed, white hyacinth bean, coix seed, dried orange peel, liquorice and hawthorn with selected weight, heating and refluxing for 3 times, taking the total weight of the radix codonopsitis, the white atractylodes rhizome, the tuckahoe, the yam, the lotus seed, the gordon euryale seed, the white hyacinth bean, the coix seed, the dried orange peel, the liquorice and the hawthorn as a reference, adding 2 times of water by weight for 3 hours each time, filtering, combining filtrates, concentrating until the relative density is 1.10-1.25 at 50 ℃, then adding inulin with selected weight, and uniformly mixing to obtain the traditional Chinese medicine.
The composition with the weight-losing effect is added with conventional auxiliary materials and prepared into granules according to a conventional process.
Example 8
The composition with the weight-losing effect comprises the following raw materials: 100g of inulin, 7g of codonopsis pilosula, 12g of bighead atractylodes rhizome, 8g of poria cocos, 22g of Chinese yam, 8g of lotus seed, 14g of gordon euryale seed, 6g of white hyacinth bean, 22g of coix seed, 4g of dried orange peel, 6g of liquorice and 3g of hawthorn;
the preparation method of the composition comprises the following steps: respectively taking radix codonopsitis, white atractylodes rhizome, tuckahoe, yam, lotus seed, gordon euryale seed, white hyacinth bean, coix seed, dried orange peel, liquorice and hawthorn with selected weight, heating and refluxing for 3 times, taking the total weight of the radix codonopsitis, the white atractylodes rhizome, the tuckahoe, the yam, the lotus seed, the gordon euryale seed, the white hyacinth bean, the coix seed, the dried orange peel, the liquorice and the hawthorn as a reference, adding 4 times of water by weight for 1 hour each time, filtering, combining filtrates, concentrating until the relative density is 1.10-1.25 at 50 ℃, then adding inulin with selected weight, and uniformly mixing to obtain the traditional Chinese medicine.
The composition with the weight-losing effect is added with conventional auxiliary materials and prepared into powder according to a conventional process.
Comparative example 1
The composition of this comparative example having a weight-reducing effect differs from example 1 only in that: inulin 0g, the composition of the other raw materials and the proportion of each raw material are the same as those in example 1;
the preparation of this composition differs from example 1 only in that: inulin 0g, and the remaining experimental conditions and experimental procedures were the same as in example 1.
Comparative example 2
The composition of this comparative example having a weight-reducing effect differs from example 1 only in that: 0g of dried orange peel, and the composition and the mixture ratio of the other raw materials are the same as those in the embodiment 1;
the preparation of this composition differs from example 1 only in that: 0g of dried orange peel, and the rest experimental conditions and experimental operation steps are the same as those in example 1.
Comparative example 3
The composition of this comparative example having a weight-reducing effect differs from example 1 only in that: 0g of bighead atractylodes rhizome, and the composition and the proportion of the other raw materials are the same as those in the example 1;
the preparation of this composition differs from example 1 only in that: 0g of rhizoma atractylodis macrocephalae, and the rest experimental conditions and experimental operating procedures are the same as those of example 1.
Comparative example 4
The composition of this comparative example having a weight-reducing effect differs from example 1 only in that: 0g of poria cocos, and the composition and the proportion of the other raw materials are the same as those in example 1;
the preparation of this composition differs from example 1 only in that: poria cocos wolf 0g, and the rest of the experimental conditions and experimental procedures were the same as in example 1.
Experimental example 1Study of the weight-reducing Effect of the composition of the present invention
1. Purpose of experiment
The effect of the composition of the present invention on weight loss was studied.
2. Experimental methods
2.1 Experimental instruments and materials
The body fat is named as the body fat, and is purchased from a product M1301 of Zhuhai Yunmai science and technology Limited.
2.2 design of the experiment
650 simple obese people with BMI more than or equal to 24Kg/m are selected2The waistline of the male is more than or equal to 95cm, and the waistline of the female is more than or equal to 90 cm. The following patients were excluded: under 18 years of age or over 65 years of age, pregnant or non-compliant (meaning a person who cannot properly control their diet); patients with serious complications such as heart, liver and kidney, serious gastrointestinal diseases, or other serious primary diseases, and psychosis detected by B-ultrasonic examination, chest X-ray examination and electrocardiographic examination; diabetic ketosis, ketoacidosis and infections in the last 3 months; those taking glucocorticoids and often using other medications that affect blood glucose.
During the experiment, the subjects can keep diet and living habits as much as possible and can not take the medicines for reducing blood sugar or blood fat.
The 650 subjects were randomly divided into experimental groups 1-8, control groups 1-4 and blank control groups, each of which had 50 subjects.
The experimental groups 1 to 8 were administered 10g of the compositions prepared in examples 1 to 8 before a meal, the control groups 1 to 4 were administered 10g of the compositions prepared in comparative examples 1 to 4 before a meal, and the blank control group was administered 10g of a placebo before a meal; each group was taken 3 times daily for 14 consecutive days. The rest time of each group is not restricted to diet and does not change life style.
The effect of each group was evaluated by combining the patient self-control method with the inter-group control method in this experiment.
2.3 detection of indicators
Before and at the end of the experiment, the following physical indicators were measured for each group: body weight, height, body mass index, body fat percentage, visceral fat%, basal metabolic rate (Kcal/d), waist circumference, waist-hip ratio, blood pressure.
Wherein, the waist and hip circumference can be measured by a tape measure; the body fat percentage%, visceral fat%, and basal metabolic rate (Kcal/d) can be obtained by weighing commercially available body fat scales.
The change of any body index of the patient in self control before and after the experiment is more than 1 percent and marked as effective, more than 5 percent and less than 1 percent are marked as ineffective.
3. Results of the experiment
The results of the experiments for each group are shown in table 1.
Table 1 specific results of the weight loss experiments for each group
Group of Number of examples Number of effective cases Effective number of cases Number of invalid cases Total effective rate (%)
Blank control group 50 8 3 39 22
Control group 1 50 11 6 33 34
Control group 2 group 50 12 4 34 32
Control group 3 50 9 5 36 28
Control group 4 50 8 6 36 28
Experimental group 1 group 50 24 19 7 86
Experimental group 2 groups 50 23 18 9 82
Experimental group 3 groups 50 25 17 8 84
Experimental group 4 groups 50 24 16 10 80
Experimental group 5 groups 50 25 15 10 80
Experimental group 6 50 26 15 9 82
Experimental group 7 groups 50 24 18 8 84
Experimental group 8 50 25 16 9 82
As can be seen from Table 1: compared with the blank control group and the control group 1-4, the weight-reducing effect of the experimental groups 1-8 is more obvious.
5. Conclusion of the experiment
The raw materials of the composition of the invention are matched and acted together in a specific proportion, and the composition has obvious weight-losing effect.
It should be understood that the above examples are only for clarity of illustration and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications therefrom are within the scope of the invention.

Claims (8)

1. The composition with the weight-losing effect is characterized by comprising the following raw material medicines:
50-120 parts of inulin, 5-14 parts of codonopsis pilosula, 3-14 parts of bighead atractylodes rhizome, 5-17 parts of poria cocos, 11-26 parts of Chinese yam, 4-17 parts of lotus seed, 3-17 parts of gordon euryale seed, 3-17 parts of white hyacinth bean, 11-26 parts of coix seed, 3-6 parts of dried orange peel, 1-7 parts of liquorice and 1-8 parts of hawthorn.
2. The composition with weight-losing effect according to claim 1, wherein the bulk drugs of the composition comprise:
60-100 parts of inulin, 7-12 parts of codonopsis pilosula, 5-12 parts of bighead atractylodes rhizome, 8-14 parts of poria cocos, 14-22 parts of Chinese yam, 8-14 parts of lotus seed, 5-14 parts of gordon euryale seed, 6-14 parts of white hyacinth bean, 14-22 parts of coix seed, 4-5 parts of dried orange peel, 2-6 parts of liquorice and 3-6 parts of hawthorn.
3. The composition with weight-losing effect according to claim 2, wherein the bulk drugs of the composition comprise:
100 parts of inulin, 12 parts of codonopsis pilosula, 12 parts of bighead atractylodes rhizome, 8 parts of poria cocos, 22 parts of Chinese yam, 8 parts of lotus seed, 5 parts of gordon euryale seed, 6 parts of white hyacinth bean, 22 parts of coix seed, 5 parts of dried orange peel, 2 parts of liquorice and 5 parts of hawthorn; or
75 parts of inulin, 12 parts of codonopsis pilosula, 12 parts of bighead atractylodes rhizome, 8 parts of poria cocos, 22 parts of Chinese yam, 8 parts of lotus seed, 5 parts of gordon euryale seed, 6 parts of white hyacinth bean, 22 parts of coix seed, 5 parts of dried orange peel, 2 parts of liquorice and 5 parts of hawthorn; or
60 parts of inulin, 12 parts of codonopsis pilosula, 12 parts of bighead atractylodes rhizome, 8 parts of poria cocos, 22 parts of Chinese yam, 8 parts of lotus seed, 5 parts of gordon euryale seed, 6 parts of white hyacinth bean, 22 parts of coix seed, 5 parts of dried orange peel, 2 parts of liquorice and 5 parts of hawthorn; or
75 parts of inulin, 7 parts of codonopsis pilosula, 5 parts of bighead atractylodes rhizome, 14 parts of poria cocos, 14 parts of Chinese yam, 14 parts of lotus seed, 14 parts of gordon euryale seed, 14 parts of white hyacinth bean, 14 parts of coix seed, 4 parts of dried orange peel, 2 parts of liquorice and 5 parts of hawthorn; or
100 parts of inulin, 7 parts of codonopsis pilosula, 5 parts of bighead atractylodes rhizome, 14 parts of poria cocos, 14 parts of Chinese yam, 14 parts of lotus seed, 14 parts of gordon euryale seed, 14 parts of white hyacinth bean, 14 parts of coix seed, 4 parts of dried orange peel, 2 parts of liquorice and 5 parts of hawthorn; or
75 parts of inulin, 8 parts of codonopsis pilosula, 9 parts of bighead atractylodes rhizome, 11 parts of poria cocos, 18 parts of Chinese yam, 11 parts of lotus seed, 10 parts of gordon euryale seed, 10 parts of white hyacinth bean, 18 parts of coix seed, 4.5 parts of dried orange peel, 2 parts of liquorice and 5 parts of hawthorn; or
60 parts of inulin, 12 parts of codonopsis pilosula, 5 parts of bighead atractylodes rhizome, 14 parts of poria cocos, 14 parts of Chinese yam, 14 parts of lotus seed, 5 parts of gordon euryale seed, 14 parts of white hyacinth bean, 14 parts of coix seed, 5 parts of dried orange peel, 2 parts of liquorice and 6 parts of hawthorn; or
100 parts of inulin, 7 parts of codonopsis pilosula, 12 parts of bighead atractylodes rhizome, 8 parts of poria cocos, 22 parts of Chinese yam, 8 parts of lotus seed, 14 parts of gordon euryale seed, 6 parts of white hyacinth bean, 22 parts of coix seed, 4 parts of dried orange peel, 6 parts of liquorice and 3 parts of hawthorn.
4. A method for preparing the composition with weight-losing effect according to any one of claims 1 to 3, comprising the steps of:
respectively taking selected parts by weight of codonopsis pilosula, bighead atractylodes rhizome, poria cocos, Chinese yam, lotus seed, gordon euryale seed, white hyacinth bean, coix seed, dried orange peel, liquorice and hawthorn, crushing, then adding selected parts by weight of inulin, and uniformly mixing to obtain the traditional Chinese medicine composition; or
Respectively taking selected parts by weight of radix codonopsitis, largehead atractylodes rhizome, tuckahoe, yam, lotus seed, gordon euryale seed, white hyacinth bean, coix seed, tangerine peel, liquorice and hawthorn, heating until the water content is below 10%, crushing, then adding selected parts by weight of inulin, and uniformly mixing to obtain the traditional Chinese medicine composition; or
Respectively taking selected parts by weight of codonopsis pilosula, bighead atractylodes rhizome, poria cocos, Chinese yam, lotus seed meat, gordon euryale seed, white hyacinth bean, coix seed, dried orange peel, liquorice and hawthorn, heating and refluxing for 2-4 times, taking the total weight of the codonopsis pilosula, the bighead atractylodes rhizome, the poria cocos, the Chinese yam, the lotus seed meat, the gordon euryale seed, the white hyacinth bean, the coix seed, the dried orange peel, the liquorice and the hawthorn as a reference, adding 2-4 times of water by weight for 1-3 hours each time, filtering, combining filtrates, concentrating to a relative density of 1.05-1.30 at 50 ℃, then adding selected parts by weight of inulin, and uniformly mixing to.
5. The method for preparing the composition with the effect of losing weight according to claim 4, which is characterized by comprising the following steps of:
respectively taking selected parts by weight of codonopsis pilosula, bighead atractylodes rhizome, poria cocos, Chinese yam, lotus seed, gordon euryale seed, white hyacinth bean, coix seed, dried orange peel, liquorice and hawthorn, heating at 60-120 ℃ until the water content is below 10%, crushing, then adding selected parts by weight of inulin, and uniformly mixing to obtain the traditional Chinese medicine composition; or
Respectively taking selected parts by weight of radix codonopsitis, white atractylodes rhizome, tuckahoe, yam, lotus seed, gordon euryale seed, white hyacinth bean, coix seed, dried orange peel, liquorice and hawthorn, heating and refluxing for 3 times, taking the total weight of the radix codonopsitis, the white atractylodes rhizome, the tuckahoe, the yam, the lotus seed, the gordon euryale seed, the white hyacinth bean, the coix seed, the dried orange peel, the liquorice and the hawthorn as a reference, adding 2-4 times of water by weight for 1-3 hours each time, filtering, combining filtrates, concentrating to the relative density of 1.10-1.25 at 50 ℃, then adding selected parts by weight of inulin, and uniformly mixing to obtain the traditional Chinese medicine.
6. The method for preparing the composition with the effect of losing weight according to claim 5, which is characterized by comprising the following steps:
respectively taking selected parts by weight of codonopsis pilosula, bighead atractylodes rhizome, poria cocos, Chinese yam, lotus seed, gordon euryale seed, white hyacinth bean, coix seed, dried orange peel, liquorice and hawthorn, heating to 80-100 ℃ until the water content is below 10%, crushing, then adding selected parts by weight of inulin, and uniformly mixing to obtain the traditional Chinese medicine composition; or
Respectively taking selected parts by weight of radix codonopsitis, white atractylodes rhizome, tuckahoe, yam, lotus seed, gordon euryale seed, white hyacinth bean, coix seed, dried orange peel, liquorice and hawthorn, heating and refluxing for 3 times, taking the total weight of the radix codonopsitis, the white atractylodes rhizome, the tuckahoe, the yam, the lotus seed, the gordon euryale seed, the white hyacinth bean, the coix seed, the dried orange peel, the liquorice and the hawthorn as a reference, adding 2 times of water by weight for 2 hours at the 1 st time, adding 3 times of water by weight for 2.5 hours at the 2 nd time, adding 4 times of water by weight for 3 hours at the 3 rd time, filtering, combining filtrates, concentrating to the relative density of 1.10-1.25 at 50 ℃, adding selected parts by weight of inulin, and uniformly mixing to obtain.
7. A preparation made of the composition with weight-losing effect according to any one of claims 1 to 3, or a preparation made of the composition prepared by the preparation method according to any one of claims 4 to 6,
the composition is added with conventional auxiliary materials and prepared into clinically acceptable tablets, capsules, powder, mixtures, pills, granules, solutions, syrups and soft extracts according to the conventional process.
8. Use of a composition according to any one of claims 1 to 3, a composition prepared by a method according to any one of claims 4 to 6, or a formulation of a composition according to claim 7 for the manufacture of a medicament for weight loss.
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