CN103550761A - Cream for wound surface and preparation method thereof - Google Patents
Cream for wound surface and preparation method thereof Download PDFInfo
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- CN103550761A CN103550761A CN201310470350.XA CN201310470350A CN103550761A CN 103550761 A CN103550761 A CN 103550761A CN 201310470350 A CN201310470350 A CN 201310470350A CN 103550761 A CN103550761 A CN 103550761A
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- water
- cream
- wound surface
- emulsifiable paste
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Abstract
The invention discloses a cream for a wound surface and a preparation method thereof. The cream comprises coconut oil, a self-emulsifying compound emulsifier AC-402, alpha-chymotrypsin, lidocaine, glycerin, carbomer, triethanolamine, an ethanol solution of ethylparaben and distilled water. Compared with the prior art, the cream prepared in the invention has the following advantages: the cream comprises alpha-chymotrypsin and lidocaine, and the cream has appropriate viscosity and good coating and spreading performance, is fine and uniform and can clean wound surfaces, eliminate suppurative exudate and necrotic tissue, promote growth of newborn granulation, accelerate healing, mitigate pains and substantially improve compliance of patients, wherein the elimination rate of necrotic tissue reaches more than 90%.
Description
Technical field:
The invention belongs to emulsifiable paste and preparation method thereof, particularly a kind of emulsifiable paste for wound surface and preparation method thereof.
Background technology:
On the wound surface of human body burn, often there will be totally, have pus and slough.Though chemotherapy can be treated the diseases such as skin infection, gangrene, can not remove slough.
Summary of the invention
The 1st technical problem to be solved by this invention is to provide a kind of for emulsifiable paste wound surface, that can remove slough.
The 2nd technical problem to be solved by this invention is the preparation method of above-mentioned emulsifiable paste.
The technical problem that the present invention solves is: a kind of emulsifiable paste for wound surface, contains following material in 51g emulsifiable paste:
Described emulsifying agent is self emulsifying mixed emulsifier AC-402.
Every is equivalent to 0.04-0.08ml.
The preparation method of described a kind of emulsifiable paste for wound surface, comprises the following steps:
A) take carbomer 0.05-0.75g, be dispersed in 18-35ml distilled water, complete swelling becomes the liquid of clear, standby, is liquid A;
B) take Oleum Cocois 5-12g, emulsifying agent 0.5-5g, be placed in heating and melting in 60-90 ℃ of water-bath; Measure 8-15ml distilled water and be placed in 60-90 ℃ of water-bath and heat, wait the complete melting of oil phase, water and oil phase reach in the situation of uniform temp, water is to thread shape and adds in oil phase, and limit edged stirs, and form emulsion bases B;
C) lignocaine 0.1-5g, Chymetin 4000-40000 unit are dissolved in remaining distilled water, form solution C;
D) solution C, liquid A are added in emulsion bases B and be uniformly mixed, splash into triethanolamine 5-17 and drip, be uniformly mixed, add glycerol 1-6ml, 6% ethyl hydroxybenzoate alcoholic solution (75% ethanol) 0.1-2.0ml is uniformly mixed.
Described ethyl hydroxybenzoate alcoholic solution is that the ethyl hydroxybenzoate of 6 grams is dissolved in to volumetric concentration is in 75% 100ml ethanol.
The effect of the various compositions in the present invention is as follows:
Chymetin has the effect of endopeptidase, by cutting off the carboxylic end peptide chain effect of tyrosine, phenylalanine in protein peptide chain, single-minded hydrolysis carboxylic end aromatic amino acid (tyrosine, tryptophan, leucine) or side switch large volume hydrophobic residue methionine etc.It can decompose the fibrinous concretion of inflammation part, promotes the decomposition of dissolving of blood clot, purulent secretion and slough, thereby purifies wound surface, removes foreign body, makes granulation tissue newborn, promotes wound healing.
Lignocaine is local anesthetic.Local anesthesia effect, compared with strong and lasting, has good surperficial penetration power, and injectable also can be done topical anesthesia.Generally use after one to three minute and come into force, effect maintains one to three hour.Be used for the treatment of oral ulcer etc., and can strengthen the removal slough ability of Chymetin.
The present invention compared with prior art, made emulsifiable paste carrys out prescription by Chymetin, lignocaine, and viscosity is suitable, evenly fine and smooth, stretchability is good, can clean wound surface, eliminate suppuration liquid and slough, the elimination factor of slough reaches more than 90%, promote the growth newly granulating, promote to cure, ease the pain, can greatly improve patient's compliance.
The specific embodiment
Below in conjunction with embodiment, the present invention will be further described.
Glycerol in the present invention, carbomer, lignocaine, self emulsifying mixed emulsifier AC-402 are commercially available.
Embodiment 1
A) take carbomer 0.2g, be dispersed in 20ml distilled water, complete swelling becomes the liquid of clear, standby, is liquid A;
B) take Oleum Cocois 7g, self emulsifying mixed emulsifier AC-4021g puts heating and melting in 85 ℃ of water-baths; Measure 8ml distilled water and put in 85 ℃ of water-baths and heat, wait the complete melting of oil phase, water and oil phase reach in the situation of uniform temp, water is to thread shape and adds in oil phase, and limit edged stirs, and form emulsion bases B;
C) lignocaine 0.2g, Chymetin 4000 units are dissolved in remaining distilled water, form solution C;
D) solution C, liquid A are added in emulsion bases B and be uniformly mixed, splash into 8 of triethanolamine, be uniformly mixed, add glycerol 1ml, 6% ethyl hydroxybenzoate alcoholic solution (75% ethanol) 0.3ml is uniformly mixed, obtains.
Embodiment 2
A) take carbomer 0.5g, be dispersed in 30ml distilled water, complete swelling becomes the liquid of clear, standby, is liquid A;
B) take Oleum Cocois 8g, self emulsifying mixed emulsifier AC-4023g puts heating and melting in 75 ℃ of water-baths; Measure 12ml distilled water and put in 75 ℃ of water-baths and heat, wait the complete melting of oil phase, water and oil phase reach in the situation of uniform temp, water is to thread shape and adds in oil phase, and limit edged stirs, and form emulsion bases B;
C) lignocaine 3g, Chymetin 30000 units are dissolved in remaining distilled water, form solution C;
D) solution C, liquid A are added in emulsion bases B and be uniformly mixed, splash into 12 of triethanolamine, be uniformly mixed, add glycerol 5ml, 6% ethyl hydroxybenzoate alcoholic solution (75% ethanol) 1.0ml is uniformly mixed.
Embodiment 3
Except Caledonia caine not, all the other are identical with embodiment 2.
Embodiment 4
The physical and chemical index of embodiment 1,2,3 is as follows:
1, character
This emulsifiable paste is creamy white, and denseness is suitable, and evenly fine and smooth, stretchability is good, odorlessness.
2, pH value inspection
Get this product, fixed with PH instrumentation, recording pH value is between 6.5-7.0.
3, caloric test
Emulsifiable paste is packaged in transparent dressing product bottle, in the refrigerator cold-storages of 4 ℃, within one month, observes without lamination.In the calorstat of 55 ℃, place 24h, condensation is without layering, the phenomenon such as spoiled.
4, centrifugal test
Emulsifiable paste is packaged in to the centrifugal 20min of 3000r/min in tool plug test tube, without lamination.
5, room temperature is placed experiment
Embodiment 1,2,3 made emulsifiable pastes are placed in to bottle for cosmetics, the standing investigation of room temperature 6 months, without lamination, use aftersensation is unchanged, abnormal smells from the patient is unchanged.
6, irritation test, anaphylaxis experiment
White mice back cuts off hair, smears respectively by the emulsifiable paste of embodiment 1,2,3 preparation in cutting plucked position, and is not coated with position and compares, and result does not have zest and anaphylaxis.
Get embodiment 1,2,3 each 1g and be applied in volunteer (20-70 year, 17 people) gesture and facial expression, observe after spending 30 minutes, all do not occur rubescent, dermexanthesis, foaming phenomenon.
7, clinical trial result
Respectively embodiment 1,2,3 is used for to the wound surface of 30 burn patients at Yi Ji mountain hospital burn department, all effective in cure, the elimination factor of its slough reaches and is respectively 91%, 92%, 80%.
Claims (3)
1. for an emulsifiable paste for wound surface, it is characterized in that: in 51g emulsifiable paste, contain following material:
2. a kind of emulsifiable paste for wound surface according to claim 1, is characterized in that: described emulsifying agent is self emulsifying mixed emulsifier AC-402.
3. the preparation method of a kind of emulsifiable paste for wound surface claimed in claim 1, comprises the following steps:
A) take carbomer 0.05-0.75g, be dispersed in 18-35ml distilled water, complete swelling becomes the liquid of clear, standby, is liquid A;
B) take Oleum Cocois 5-12g, emulsifying agent 0.5-5g, be placed in heating and melting in 60-90 ℃ of water-bath; Measure 8-15ml distilled water and be placed in 60-90 ℃ of water-bath and heat, wait the complete melting of oil phase, water and oil phase reach in the situation of uniform temp, water is to thread shape and adds in oil phase, and limit edged stirs, and form emulsion bases B;
C) lignocaine 0.1-5g, Chymetin 4000-40000 unit are dissolved in remaining distilled water, form solution C;
D) solution C, liquid A are added in emulsion bases B and be uniformly mixed, splash into triethanolamine 5-17 and drip, be uniformly mixed, add glycerol 1-6ml, 6% ethyl hydroxybenzoate alcoholic solution (75% ethanol) 0.1-2.0ml is uniformly mixed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310470350.XA CN103550761B (en) | 2013-10-10 | 2013-10-10 | Cream for wound surface and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310470350.XA CN103550761B (en) | 2013-10-10 | 2013-10-10 | Cream for wound surface and preparation method thereof |
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| Publication Number | Publication Date |
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| CN103550761A true CN103550761A (en) | 2014-02-05 |
| CN103550761B CN103550761B (en) | 2015-06-10 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106806338A (en) * | 2015-12-01 | 2017-06-09 | 四川海思科制药有限公司 | A kind of compound lidocaine emulsifiable paste pharmaceutical composition and preparation method thereof |
| CN110585312A (en) * | 2019-10-18 | 2019-12-20 | 北京博达绿洲医药科技研究有限公司 | Liduodeoxyemulsion and preparation method and application thereof |
-
2013
- 2013-10-10 CN CN201310470350.XA patent/CN103550761B/en active Active
Non-Patent Citations (3)
| Title |
|---|
| 张宪英等: "α-糜蛋白酶、利多卡因、氟美松联合灌肠治疗以便血为主的溃疡性直肠炎疗效观察", 《山东医药》 * |
| 陈伟等: "松解疗法治疗肛裂1500例", 《中医杂志》 * |
| 陈阳则: "糜蛋白酶治疗蜈蚣咬伤10例", 《西南国防医药》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106806338A (en) * | 2015-12-01 | 2017-06-09 | 四川海思科制药有限公司 | A kind of compound lidocaine emulsifiable paste pharmaceutical composition and preparation method thereof |
| CN106806338B (en) * | 2015-12-01 | 2021-05-25 | 四川海思科制药有限公司 | Compound lidocaine cream pharmaceutical composition and preparation method thereof |
| CN110585312A (en) * | 2019-10-18 | 2019-12-20 | 北京博达绿洲医药科技研究有限公司 | Liduodeoxyemulsion and preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103550761B (en) | 2015-06-10 |
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Effective date of registration: 20190102 Address after: 2/F Shunpu Building, 99 Park Road, Qingpu District, Shanghai, 201700 Patentee after: Shanghai Daerwei Trading Co. Ltd. Address before: 241002 No. 22 Wenchang West Road, Yijiang Higher Education Park, Wuhu, Anhui Patentee before: Wannan Medical College |
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Effective date of registration: 20201021 Address after: Room 296, R District, 2nd Floor, Shunpu Building, 99 Park Road, Qingpu District, Shanghai, 201700 Patentee after: SHANGHAI DAERWEI BIOTECHNOLOGY RESEARCH AND DEVELOPMENT Co.,Ltd. Address before: 2/F Shunpu Building, 99 Park Road, Qingpu District, Shanghai, 201700 Patentee before: Shanghai Daerwei Trading Co.,Ltd. |