CN103549386A - Compound Chinese caterpillar fungus-lucid ganoderma composition and preparation method thereof - Google Patents
Compound Chinese caterpillar fungus-lucid ganoderma composition and preparation method thereof Download PDFInfo
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- A61K36/06—Fungi, e.g. yeasts
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Abstract
The invention discloses a compound Chinese caterpillar fungus-lucid ganoderma composition and a preparation method thereof. The composition comprises the following components in parts by weight: 100-300 parts of Chinese caterpillar fungus powder, 100-220 parts of ganoderma lucidum powder and 100-220 parts of coriolus versicolor powder. The compound Chinese caterpillar fungus-lucid ganoderma composition can remarkably promote vital energy, consolidate vital essential and increase immunity of the organism and has an anti-tumor assisting effect.
Description
Technical field
The present invention relates to a kind of compound Chinese caterpillar fungus glossy ganoderma composition and preparation method thereof, belong to biomedicine field.
Background technology
At present, on market, health products are of a great variety, mostly have the immunity of raising, anti-oxidant, the anti-ageing effect of waiting for a long time, but these health products mostly add chemicals in order to promote drug effect, people's short-term is taken can not there is any harm, but after long-term taking, just there will be various side effect.
Summary of the invention
The object of this invention is to provide a kind of formula simple, dose is low but can significantly improve body immunity, improves microcirculation, the compound Chinese caterpillar fungus glossy ganoderma composition delaying senility.
The object of the invention is to realize in the following manner:
A glossy ganoderma composition, is characterized in that the weight portion of each composition in said composition is:
Cordyceps 100-300 weight portion ganoderma lucidum powder (claiming again Ganoderma lucidum mycelium powder) 100-220 weight portion manyzoned polypore bacteria powder 100-220 weight portion.
Preferably in said composition, the weight portion of each composition is:
Cordyceps 100-250 weight portion ganoderma lucidum powder 150-220 weight portion manyzoned polypore bacteria powder 100-200 weight portion.
Preferably in said composition, the weight portion of each composition is:
Cordyceps 100-250 weight portion ganoderma lucidum powder 100-200 weight portion manyzoned polypore bacteria powder 150-220 weight portion.
Preferably in said composition, the weight portion of each composition is:
Cordyceps 100-300 weight portion ganoderma lucidum powder 100-200 weight portion manyzoned polypore bacteria powder 100-220 weight portion.
Cordyceps sinensis polysaccharide >=1.5% in above-mentioned cordyceps, GL-B >=1.5% in ganoderma lucidum powder, coriolan >=4.0% in manyzoned polypore bacteria powder.
The preparation method of above-mentioned compound Chinese caterpillar fungus glossy ganoderma composition comprises the following steps: cordyceps, ganoderma lucidum powder, manyzoned polypore bacteria powder are mixed in proportion.
Cordyceps, ganoderma lucidum powder and the manyzoned polypore bacteria powder raw material that the present invention uses all can obtain by commercially available acquisition or self-control.
Ganoderma lucidum powder, for brown color is to chocolate brown powder, has the distinctive fragrance of product, salty, the micro-hardship of taste acid, free from extraneous odour, wherein, and GL-B >=1.5g/100g.Cordyceps sinensis polysaccharide >=1.5% in cordyceps, coriolan >=4.0% in manyzoned polypore bacteria powder.Above-mentioned raw materials can also be dried to pulverize by the mycelium of liquid deep layer fermenting and be made.
Compound Chinese caterpillar fungus glossy ganoderma composition of the present invention can be made preparation with pharmaceutically acceptable auxiliary material, as: powder, granule, capsule, tablet, oral liquid or injection etc.Compound Chinese caterpillar fungus glossy ganoderma composition of the present invention can effectively improve body immunity, improve microcirculation, there is antiatherosclerosis, the anti-ageing effect of waiting for a long time, can be for the preparation of the medicine that increases immunity of organisms, can also be for the preparation of the medicine with auxiliary antineoplastic action.The present composition and cordyceps, ganoderma lucidum powder, manyzoned polypore bacteria powder one-component or both combine comparison arbitrarily, can significantly reduce dose.
By concrete test example, the present invention is further described below:
Get this compound Chinese caterpillar fungus glossy ganoderma Mixed Microbes powder with the simple cordyceps of dosage and ganoderma lucidum powder its immunity humidification relatively, have significant difference, the results are shown in Table 1, table 2 and table 3.
Test example 1: the impact on mouse thymus index (thymus gland average quality mg/ average body quality g)
This test is divided into 7 groups, every group of 20 mouse, its empty group is that basal feed is fed, simple cordyceps group is that basal feed+simple cordyceps (2g/d) is fed, simple ganoderma lucidum powder group is that basal feed+simple ganoderma lucidum powder (2g/d) is fed, embodiment 2 is that basal feed+embodiment 2 formulas (2g/d) are fed, embodiment 4 is that basal feed+embodiment 4 formulas (2g/d) are fed, embodiment 6 is that basal feed+embodiment 6 formulas (2g/d) are fed, embodiment 8 is that basal feed+embodiment 8 formulas (2g/d) are fed, the nursing time is 10d, after 10d, detect its thymus index.
Table 1
| Group | Size of animal (only) | Thymus index | P value |
| Blank group | 20 | 14.13±1.07 | / |
| Simple cordyceps group | 20 | 22.87±5.25 | ＜0.05 |
| Simple ganoderma lucidum powder group | 20 | 23.18±6.92 | ＜0.05 |
| Embodiment 2 | 20 | 33.02±8.46 | ＜0.05 |
| Embodiment 4 | 20 | 34.18±7.95 | ＜0.05 |
| Embodiment 6 | 20 | 32.92±7.67 | ＜0.05 |
| Embodiment 8 | 20 | 35.32±9.19 | ＜0.05 |
Conclusion: compare with blank group as can be seen from the above table, simple cordyceps and ganoderma lucidum powder are remarkable to mouse thymus exponent increase effect; And compare with ganoderma lucidum powder with simple cordyceps, compound Cordyceps-Ganoderma bacterium powder all has significant difference to mouse thymus exponent increase, and effect is remarkable.
Test example 2: the impact on mice spleen lymphocytes proliferation
This test is divided into 7 groups, every group of 20 mouse, its empty group is that basal feed is fed, simple cordyceps group is that basal feed+simple cordyceps (2g/d) is fed, simple ganoderma lucidum powder group is that basal feed+simple ganoderma lucidum powder (2g/d) is fed, embodiment 1 is that basal feed+embodiment 1 formula (2g/d) is fed, embodiment 3 is that basal feed+embodiment 3 formulas (2g/d) are fed, embodiment 5 is that basal feed+embodiment 5 formulas (2g/d) are fed, embodiment 7 is that basal feed+embodiment 7 formulas (2g/d) are fed, the nursing time is 10d, after 10d, detect its lymphopoiesis situation.
Table 2
| Group | Size of animal (only) | Optical density difference | P value |
| Blank group | 20 | 0.0517±0.0235 | / |
| Simple cordyceps group | 20 | 0.2753±0.0897 | ＜0.05 |
| Simple ganoderma lucidum powder group | 20 | 0.2688±0.0769 | ＜0.05 |
| Embodiment 1 | 20 | 0.5047±0.0572 | ＜0.05 |
| Embodiment 3 | 20 | 0.5381±0.0497 | ＜0.05 |
| Embodiment 5 | 20 | 0.5649±0.0539 | ＜0.05 |
| Embodiment 7 | 20 | 0.6014±0.0329 | ＜0.05 |
Conclusion: compare with blank group as can be seen from the above table, simple cordyceps and ganoderma lucidum powder are remarkable to mice spleen lymphocytes proliferation effect; And compare with ganoderma lucidum powder with simple cordyceps, compound Cordyceps-Ganoderma bacterium powder is remarkable to mice spleen lymphocytes proliferation effect.
Test example 3: the impact on mouse macrophage phagocytic activity
This test is divided into 7 groups, every group of 20 mouse, its empty group is that basal feed is fed, simple cordyceps group is that basal feed+simple cordyceps (2g/d) is fed, simple ganoderma lucidum powder group is that basal feed+simple ganoderma lucidum powder (2g/d) is fed, embodiment 2 is that basal feed+embodiment 2 formulas (2g/d) are fed, embodiment 3 is that basal feed+embodiment 3 formulas (2g/d) are fed, embodiment 4 is that basal feed+embodiment 4 formulas (2g/d) are fed, embodiment 9 is that basal feed+embodiment 9 formulas (2g/d) are fed, the nursing time is 10d, after 10d, detect its macrophage phagocytic index.
Table 3
| Group | Size of animal (only) | Phagocytic index | P value |
| Blank group | 20 | 22.54±7.62 | / |
| Simple cordyceps group | 20 | 30.72±8.91 | ＜0.05 |
| Simple ganoderma lucidum powder group | 20 | 32.15±7.39 | ＜0.05 |
| Embodiment 2 | 20 | 35.38±5.64 | ＜0.05 |
| Embodiment 3 | 20 | 35.29±4.39 | ＜0.05 |
| Embodiment 4 | 20 | 36.64±5.86 | ＜0.05 |
| Embodiment 9 | 20 | 37.09±4.85 | ＜0.05 |
Conclusion: compare with blank group as can be seen from the above table, simple cordyceps and ganoderma lucidum powder are remarkable to mouse macrophage phagocytic activity effect; And compare with ganoderma lucidum powder with simple cordyceps, compound Cordyceps-Ganoderma bacterium powder is remarkable to mouse macrophage phagocytic activity effect.
Hence one can see that, the increase immunity of organisms of the present composition, has the simple addition that auxiliary antineoplastic action is not each constituent function, is the synergistic function of each constituent.In addition, the present composition is placed about 6 months under normal temperature condition, and its active constituent content is substantially constant.
The specific embodiment:
By specific embodiment, further illustrate the present invention below.But the detail of embodiment only, for explaining the present invention, should not be construed as limited overall technical solution.
Cordyceps deep liquid fermentation process:
Cordyceps bacterial strain: Cordyceps Militaris-Paecilomyces hepiali chen (Paecilomyces hepiali chen) Cs-4, buys in Chinese Academy of Sciences's microorganism fungus kind preservation center.
The preservation bacterial classification taking out from refrigerator is connected on fresh slant medium, and culture medium prescription is: potato 8.0%, glucose 3.0%, potassium dihydrogen phosphate 0.3%, magnesium sulfate 0.15%, 1.3%, 26 ℃ of cultivation of agar 4 days.
On inclined-plane, cultured strain transfer is in shaking flask, and shaking flask culture medium is: glucose 2%, peptone 1%, potassium dihydrogen phosphate 0.1%, 0.05%, 26 ℃ of cultivation of magnesium sulfate 2 days.
After shaking flask is cultivated and finished, by strain transfer, in seeding tank, seed tank culture base is: glucose 2%, peptone 1%, potassium dihydrogen phosphate 0.1%, magnesium sulfate 0.05%, defoamer 0.1%, technological condition for fermentation is: inoculum concentration 10%, 26 ℃ ± 1 ℃ of temperature, throughput 1: 0.5vvm, tank pressure 0.03MPa.
Seeding tank fermentation was transferred to bulk fermentation after 3 days, and large tank culture medium is: glucose 1.5%, peptone 2%, potassium dihydrogen phosphate 0.05%, magnesium sulfate 0.07%, defoamer 0.1%.Zymotechnique is: inoculum concentration 10%, 26 ℃ ± 1 ℃ of cultivation temperature, ventilation 1: 0.5vvm, tank pressure 0.03MPa.
After fermentation ends, zymotic fluid is separated through horizontal spiral discharge sedimentation centrifuge, and mycelium, in vacuum drying below 70 ℃, was pulverized 100 mesh sieves and obtained cordyceps after oven dry.
Ganoderma lucidum powder deep liquid fermentation process:
Ganoderma lucidum powder bacterial strain: glossy ganoderma [Ganoderma lucidum(Curtis:Fr) P.Karst.], buy in Chinese Academy of Sciences's microorganism fungus kind preservation center.
The preservation bacterial classification taking out from refrigerator is connected on fresh slant medium, and culture medium prescription is: potato 8%, glucose 2.0%, potassium dihydrogen phosphate 0.2%, magnesium sulfate 0.08%, 1.5%, 25 ℃ of cultivation of agar 3 days.
On inclined-plane, cultured strain transfer is in shaking flask, and shaking flask culture medium is: soybean cake powder 1.0%, sucrose 3.0%, potassium dihydrogen phosphate 0.15%, magnesium sulfate 0.075%, 0.05%, 25 ℃ of cultivation of ammonium sulfate 2 days.
After shaking flask is cultivated and finished, by strain transfer, in seeding tank, seed tank culture base is: soybean cake powder 1%, glucose 2%, potassium dihydrogen phosphate 0.1%, magnesium sulfate 0.05%, defoamer 0.1%, technological condition for fermentation is: inoculum concentration 10%, 26 ℃ ± 1 ℃ of temperature, throughput 1: 0.5vvm, tank pressure 0.03MPa.
Seeding tank fermentation was transferred to bulk fermentation after 2 days, and large tank culture medium is: soybean cake powder 2.0%, dried silkworm chrysalis meal 0.5%, glucose 1%, potassium dihydrogen phosphate 0.08% magnesium sulfate 0.07%, defoamer 0.1%.Zymotechnique is: inoculum concentration 10%, 27 ℃ ± 1 ℃ of cultivation temperature, ventilation 1: 0.5vvm, tank pressure 0.03MPa.
After fermentation ends, zymotic fluid is separated through horizontal spiral discharge sedimentation centrifuge, and mycelium, in vacuum drying below 70 ℃, was pulverized 100 mesh sieves and obtained ganoderma lucidum powder after oven dry.
Manyzoned polypore bacteria powder liquid deep layer fermenting process:
Manyzoned polypore bacteria powder bacterial strain: Coriolus Versicolor [Polystictus Versicolor (L) Fr], buy in Chinese Academy of Sciences's microorganism fungus kind preservation center.
The preservation bacterial classification taking out from refrigerator is connected on fresh slant medium, and culture medium prescription is: potato 10.0%, glucose 2.0%, potassium dihydrogen phosphate 0.3%, magnesium sulfate 0.15%, 1.3%, 26 ℃ of cultivation of agar 5 days.
On inclined-plane, cultured strain transfer is in shaking flask, and shaking flask culture medium is: soybean cake powder 1.0%, glucose 2%, peptone 0.5%, potassium dihydrogen phosphate 0.1%, 0.05%, 26 ℃ of cultivation of magnesium sulfate 3 days.
After shaking flask is cultivated and finished, by strain transfer, in seeding tank, seed tank culture base is: glucose 2%, peptone 1%, sodium dihydrogen phosphate 0.1%, magnesium sulfate 0.05%, defoamer 0.1%, technological condition for fermentation is: inoculum concentration 10%, 26 ℃ ± 1 ℃ of temperature, throughput 1: 0.5vvm, tank pressure 0.03MPa.
Seeding tank fermentation was transferred to bulk fermentation after 3 days, and large tank culture medium is: glucose 2%, soybean cake powder 2%, peptone 1%, sodium dihydrogen phosphate 0.4%, magnesium sulfate 0.05%, defoamer 0.1%, zymotechnique is: inoculum concentration 15%, 26 ℃ ± 1 ℃ of cultivation temperature, throughput 1: 0.5vvm; Tank pressure 0.03MPa.
After fermentation ends, zymotic fluid is separated through horizontal spiral discharge sedimentation centrifuge, and mycelium, in vacuum drying below 70 ℃, was pulverized 100 mesh sieves and obtained manyzoned polypore bacteria powder after oven dry.
Its material quality index of cordyceps, ganoderma lucidum powder and manyzoned polypore bacteria powder is as follows:
Embodiment 1
Cordyceps 100mg, ganoderma lucidum powder 220mg, manyzoned polypore bacteria powder 180mg; Three kinds of components are mixed and get final product.
Embodiment 2
Cordyceps 100mg, ganoderma lucidum powder 180mg, manyzoned polypore bacteria powder 220mg; Three kinds of components are mixed and get final product.
Embodiment 3
Cordyceps 150mg, ganoderma lucidum powder 150mg, manyzoned polypore bacteria powder 200mg; Three kinds of components are mixed and get final product.
Embodiment 4
Cordyceps 150mg, ganoderma lucidum powder 200mg, manyzoned polypore bacteria powder 150mg; Three kinds of components are mixed and get final product.
Embodiment 5
Cordyceps 200mg, ganoderma lucidum powder 150mg, manyzoned polypore bacteria powder 150mg; Three kinds of components are mixed and get final product.
Embodiment 6
Cordyceps 250mg, ganoderma lucidum powder 100mg, manyzoned polypore bacteria powder 150mg; Three kinds of components are mixed and get final product.
Embodiment 7
Cordyceps 250mg, ganoderma lucidum powder 150mg, manyzoned polypore bacteria powder 100mg; Three kinds of components are mixed and get final product.
Embodiment 8
Cordyceps 250mg, ganoderma lucidum powder 100mg, manyzoned polypore bacteria powder 150mg; Three kinds of components are mixed and get final product.
Embodiment 9
Cordyceps 300mg, ganoderma lucidum powder 100mg, manyzoned polypore bacteria powder 100mg; Three kinds of components are mixed and get final product.
Claims (10)
1. a compound Chinese caterpillar fungus glossy ganoderma composition, is characterized in that the weight portion of each composition in said composition is:
Cordyceps 100-300 weight portion ganoderma lucidum powder 100-220 weight portion manyzoned polypore bacteria powder 100-220 weight portion.
2. compound Chinese caterpillar fungus glossy ganoderma composition according to claim 1, is characterized in that the weight portion of each composition in said composition is:
Cordyceps 100-250 weight portion ganoderma lucidum powder 150-220 weight portion manyzoned polypore bacteria powder 100-200 weight portion.
3. compound Chinese caterpillar fungus glossy ganoderma composition according to claim 1, is characterized in that the weight portion of each composition in said composition is:
Cordyceps 100-250 weight portion ganoderma lucidum powder 100-200 weight portion manyzoned polypore bacteria powder 150-220 weight portion.
4. compound Chinese caterpillar fungus glossy ganoderma composition according to claim 1, is characterized in that the weight portion of each composition in said composition is:
Cordyceps 100-300 weight portion ganoderma lucidum powder 100-200 weight portion manyzoned polypore bacteria powder 100-220 weight portion.
5. according to the compound Chinese caterpillar fungus glossy ganoderma composition described in claim 1,2,3 or 4, it is characterized in that Cordyceps sinensis polysaccharide >=1.5% in cordyceps, GL-B >=1.5% in ganoderma lucidum powder, coriolan >=4.0% in manyzoned polypore bacteria powder.
6. according to the compound Chinese caterpillar fungus glossy ganoderma composition described in claim 1,2,3 or 4, it is characterized in that said composition and pharmaceutically acceptable auxiliary material make preparation.
7. compound Chinese caterpillar fungus glossy ganoderma composition according to claim 6, is characterized in that described preparation is powder, granule, capsule, tablet, oral liquid or injection.
8. according to the preparation method of the compound Chinese caterpillar fungus glossy ganoderma composition described in claim 1,2,3 or 4, it is characterized in that the method comprises the following steps: cordyceps, ganoderma lucidum powder, manyzoned polypore bacteria powder are mixed in proportion.
9. the application of the compound Chinese caterpillar fungus glossy ganoderma composition described in arbitrary claim in the medicine of preparation increase immunity of organisms in claim 1-4.
10. in claim 1-4, the compound Chinese caterpillar fungus glossy ganoderma composition described in arbitrary claim has the application in the medicine of auxiliary antineoplastic action in preparation.
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| CN104905262A (en) * | 2015-05-29 | 2015-09-16 | 湖北省农业科学院农产品加工与核农技术研究所 | Method for preparing cordyceps sinensis and lucid ganoderma compound preparation |
| CN104997815A (en) * | 2015-07-08 | 2015-10-28 | 哈尔滨瑞康源生物科技有限公司 | Cordyceps sinensis and Mythic Fungus fermentation powder composite lozenge and preparation method thereof |
| CN107184615A (en) * | 2017-07-12 | 2017-09-22 | 亳州学院 | A kind of adjuvant Chinese medicine composition and preparation method thereof |
| CN108077904A (en) * | 2017-12-21 | 2018-05-29 | 山西佰富康生物科技有限公司 | A kind of Cordyceps militaris nutrition brewed powder and preparation method thereof |
| CN115873718A (en) * | 2022-10-25 | 2023-03-31 | 江苏神华药业有限公司 | Liquid fermentation medium of armillaria mellea mycelium, and preparation method and application thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104905262A (en) * | 2015-05-29 | 2015-09-16 | 湖北省农业科学院农产品加工与核农技术研究所 | Method for preparing cordyceps sinensis and lucid ganoderma compound preparation |
| CN104997815A (en) * | 2015-07-08 | 2015-10-28 | 哈尔滨瑞康源生物科技有限公司 | Cordyceps sinensis and Mythic Fungus fermentation powder composite lozenge and preparation method thereof |
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| CN108077904A (en) * | 2017-12-21 | 2018-05-29 | 山西佰富康生物科技有限公司 | A kind of Cordyceps militaris nutrition brewed powder and preparation method thereof |
| CN115873718A (en) * | 2022-10-25 | 2023-03-31 | 江苏神华药业有限公司 | Liquid fermentation medium of armillaria mellea mycelium, and preparation method and application thereof |
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| CN103549386B (en) | 2015-09-16 |
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