CN103537329B - 微流体装置以及该微流体装置的控制方法和测试装置 - Google Patents
微流体装置以及该微流体装置的控制方法和测试装置 Download PDFInfo
- Publication number
- CN103537329B CN103537329B CN201310291257.2A CN201310291257A CN103537329B CN 103537329 B CN103537329 B CN 103537329B CN 201310291257 A CN201310291257 A CN 201310291257A CN 103537329 B CN103537329 B CN 103537329B
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0605—Metering of fluids
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0621—Control of the sequence of chambers filled or emptied
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/12—Specific details about manufacturing devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0681—Filter
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0803—Disc shape
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0803—Disc shape
- B01L2300/0806—Standardised forms, e.g. compact disc [CD] format
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/087—Multiple sequential chambers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/082—Active control of flow resistance, e.g. flow controllers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/084—Passive control of flow resistance
- B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2575—Volumetric liquid transfer
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Micromachines (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
Description
Claims (11)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR20120075711 | 2012-07-11 | ||
KR10-2012-0075711 | 2012-07-11 | ||
KR1020120085361A KR20140008976A (ko) | 2012-07-11 | 2012-08-03 | 미세유동구조물, 이를 포함하는 미세유동장치 및 그 제어방법 |
KR10-2012-0085361 | 2012-08-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103537329A CN103537329A (zh) | 2014-01-29 |
CN103537329B true CN103537329B (zh) | 2018-11-02 |
Family
ID=48783004
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310291257.2A Expired - Fee Related CN103537329B (zh) | 2012-07-11 | 2013-07-11 | 微流体装置以及该微流体装置的控制方法和测试装置 |
Country Status (5)
Country | Link |
---|---|
US (4) | US20140017806A1 (zh) |
EP (2) | EP2684608B1 (zh) |
CN (1) | CN103537329B (zh) |
CA (1) | CA2820181C (zh) |
WO (1) | WO2014010927A1 (zh) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
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DE102012202775B4 (de) * | 2012-02-23 | 2016-08-25 | Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. | Fluidikmodul, vorrichtung und verfahren zum pumpen einer flüssigkeit |
US20140017806A1 (en) | 2012-07-11 | 2014-01-16 | Samsung Electronics Co., Ltd. | Microfluidic structure, microfluidic device having the same and method of controlling the microfluidic device |
KR20160081022A (ko) * | 2014-12-30 | 2016-07-08 | 삼성전자주식회사 | 미세유동장치 및 이에 공급된 시료의 검출방법 |
CN104678115B (zh) * | 2015-02-15 | 2018-04-27 | 石家庄禾柏生物技术股份有限公司 | 一体式定量采样加试剂装置检测仪中的多光路试剂检测装置 |
DE102015204235B4 (de) * | 2015-03-10 | 2016-12-15 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Fluidikstruktur mit Halteabschnitt und Verfahren zum Vereinigen zweier Flüssigkeitsvolumina |
CN105562130A (zh) * | 2015-12-11 | 2016-05-11 | 中国科学院苏州生物医学工程技术研究所 | 微流控芯片及用其进行内毒素检测的方法 |
USD841186S1 (en) * | 2015-12-23 | 2019-02-19 | Tunghai University | Biochip |
EP3469374A4 (en) | 2016-06-08 | 2019-12-04 | The Regents of the University of California | METHOD AND DEVICE FOR PROCESSING TISSUES AND CELLS |
KR101868961B1 (ko) | 2016-06-21 | 2018-06-19 | 울산과학기술원 | 미세 유체 장치 |
CN106268994B (zh) * | 2016-09-22 | 2018-04-20 | 博奥生物集团有限公司 | 一种离心式微流控芯片 |
EP3324189B1 (en) * | 2016-11-16 | 2021-01-06 | Roche Diagnostics GmbH | Rotatable cartridge with multiple metering chambers |
CN207655161U (zh) * | 2016-12-12 | 2018-07-27 | 东莞东阳光科研发有限公司 | 全血分离微流控芯片及检测装置 |
EP3342485B1 (de) * | 2017-01-02 | 2020-07-08 | Thinxxs Microtechnology Ag | Halterung für reagenzträgerelemente |
CN107328949B (zh) * | 2017-06-27 | 2019-05-03 | 中国科学院长春光学精密机械与物理研究所 | 一种实现多份液体自发顺序流动的方法及装置 |
KR102140371B1 (ko) | 2017-11-20 | 2020-07-31 | 주식회사 엘지화학 | 회전식 디스크 시스템을 활용한 중금속 정성 및 정량 분석 디바이스 및 분석 방법 |
EP3505248B1 (en) * | 2017-12-28 | 2021-07-28 | IMEC vzw | Fast sample loading microfluidic reactor and system |
CN109187448B (zh) * | 2018-07-25 | 2021-08-13 | 西安交通大学 | 一种多目标物碟式侧流试纸芯片及其激光切割制备方法、使用方法、应用和检测装置 |
CN109718876B (zh) * | 2018-12-28 | 2021-04-02 | 路煜恒 | 一种管程可控的微流控芯片 |
CN109967147A (zh) * | 2019-04-22 | 2019-07-05 | 德莫德(苏州)机械科技有限公司 | 一种用于流体组合的装置 |
CN110320476B (zh) * | 2019-06-17 | 2020-11-13 | 中国科学院物理研究所 | 用于原位检测液态电池产气的模拟电池装置 |
CN110180611B (zh) * | 2019-07-05 | 2024-03-08 | 宋禹 | 微流控芯片组件 |
CN110568202B (zh) * | 2019-09-12 | 2022-05-24 | 重庆科技学院 | 一种自动分样定容免疫荧光定量快速检测微流控芯片 |
US20210079331A1 (en) * | 2019-09-16 | 2021-03-18 | Delta Electronics, Inc. | Biological detection cartridge and method for performing the same |
CN111530515A (zh) * | 2020-05-08 | 2020-08-14 | 北京森美希克玛生物科技有限公司 | 一种微流控芯片 |
CN113009136B (zh) * | 2020-08-21 | 2024-04-05 | 东莞东阳光医疗智能器件研发有限公司 | 小型多指标检测样本分析装置 |
CN112934279B (zh) * | 2021-01-29 | 2023-03-10 | 中新国际联合研究院 | 一种磁性数字微流体芯片及其装载结构 |
CN114505106B (zh) * | 2022-01-29 | 2023-02-03 | 南京岚煜生物科技有限公司 | 优化磁性混匀效果的主动微流控芯片及其使用方法 |
CN114618600B (zh) * | 2022-02-25 | 2023-03-24 | 南昌大学 | 微流控离心盘 |
WO2023245955A1 (zh) * | 2022-06-23 | 2023-12-28 | 浙江大学 | 核酸检测装置和方法 |
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US5160702A (en) * | 1989-01-17 | 1992-11-03 | Molecular Devices Corporation | Analyzer with improved rotor structure |
CN102177439A (zh) * | 2008-10-14 | 2011-09-07 | 三星电子株式会社 | 利用离心力的微流体装置及使用微流体装置的样品分析方法 |
GB2479139A (en) * | 2010-03-29 | 2011-10-05 | Biosurfit Sa | A liquid distribution and metering device |
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US3706413A (en) * | 1970-07-30 | 1972-12-19 | Sorvall Inc Ivan | Automatic filling apparatus for cell washing centrifuge |
US5976472A (en) * | 1997-10-15 | 1999-11-02 | Eastman Kodak Company | Integrated micro-ceramic chemical plant with insertable catalytic reaction chambers |
ATE359502T1 (de) * | 1999-07-16 | 2007-05-15 | Applera Corp | Vorrichtung und verfahren für hochdichte elektrophorese |
US20020151078A1 (en) * | 2000-05-15 | 2002-10-17 | Kellogg Gregory J. | Microfluidics devices and methods for high throughput screening |
US6791677B2 (en) * | 2001-08-28 | 2004-09-14 | Tosoh Corporation | Information measuring apparatus using a fine channel device |
US7125711B2 (en) * | 2002-12-19 | 2006-10-24 | Bayer Healthcare Llc | Method and apparatus for splitting of specimens into multiple channels of a microfluidic device |
DE502005002994D1 (de) * | 2005-04-04 | 2008-04-10 | Micronas Holding Gmbh | Verfahren und Vorrichtung zum Bestimmen der Konzentrationen von mindestens zwei Liganden |
CA2614180A1 (en) * | 2005-07-06 | 2007-01-11 | The Regents Of The University Of California | Apparatuses, systems, and methods for isolating and separating biological materials |
WO2008106782A1 (en) * | 2007-03-02 | 2008-09-12 | Universite Laval | Serial siphon valves for fluidic or microfluidic devices |
EP2240568A4 (en) * | 2007-12-10 | 2016-04-13 | Samsung Electronics Co Ltd | BIOLOGICAL VALVE DEVICE WITH THIN FILM AND ITS CONTROL APPARATUS |
WO2010038952A2 (en) * | 2008-10-01 | 2010-04-08 | Samsung Electronics Co., Ltd., | Centrifugal-based microfluid apparatus, method of fabricationg the same, and method of testing samples using the microfluidic apparatus |
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-
2013
- 2013-07-03 US US13/934,857 patent/US20140017806A1/en not_active Abandoned
- 2013-07-09 CA CA2820181A patent/CA2820181C/en active Active
- 2013-07-10 WO PCT/KR2013/006118 patent/WO2014010927A1/en active Application Filing
- 2013-07-11 EP EP13176051.4A patent/EP2684608B1/en active Active
- 2013-07-11 EP EP19159424.1A patent/EP3511076B1/en active Active
- 2013-07-11 CN CN201310291257.2A patent/CN103537329B/zh not_active Expired - Fee Related
-
2015
- 2015-07-20 US US14/803,161 patent/US10058864B2/en active Active
-
2018
- 2018-08-28 US US16/115,379 patent/US11110454B2/en active Active
-
2020
- 2020-11-06 US US17/091,692 patent/US11857963B2/en active Active
Patent Citations (3)
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US5160702A (en) * | 1989-01-17 | 1992-11-03 | Molecular Devices Corporation | Analyzer with improved rotor structure |
CN102177439A (zh) * | 2008-10-14 | 2011-09-07 | 三星电子株式会社 | 利用离心力的微流体装置及使用微流体装置的样品分析方法 |
GB2479139A (en) * | 2010-03-29 | 2011-10-05 | Biosurfit Sa | A liquid distribution and metering device |
Non-Patent Citations (1)
Title |
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Centrifugal microfluidics for biomedical applications;Robert Gorkin等;《Lab on a Chip》;20100528(第10期);1758-1773 * |
Also Published As
Publication number | Publication date |
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CA2820181C (en) | 2018-08-14 |
US11110454B2 (en) | 2021-09-07 |
EP2684608A2 (en) | 2014-01-15 |
EP2684608B1 (en) | 2019-02-27 |
EP2684608A3 (en) | 2015-06-24 |
EP3511076A3 (en) | 2019-10-16 |
EP3511076A2 (en) | 2019-07-17 |
CN103537329A (zh) | 2014-01-29 |
EP3511076B1 (en) | 2021-11-17 |
US20150321192A1 (en) | 2015-11-12 |
US20190091680A1 (en) | 2019-03-28 |
US10058864B2 (en) | 2018-08-28 |
US20140017806A1 (en) | 2014-01-16 |
US11857963B2 (en) | 2024-01-02 |
CA2820181A1 (en) | 2014-01-11 |
US20210053054A1 (en) | 2021-02-25 |
WO2014010927A1 (en) | 2014-01-16 |
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