CN103535825A - Tumor postoperation healthy drink prepared by utilizing enzymolysis for extracting scallop glycoprotein - Google Patents
Tumor postoperation healthy drink prepared by utilizing enzymolysis for extracting scallop glycoprotein Download PDFInfo
- Publication number
- CN103535825A CN103535825A CN201310469142.8A CN201310469142A CN103535825A CN 103535825 A CN103535825 A CN 103535825A CN 201310469142 A CN201310469142 A CN 201310469142A CN 103535825 A CN103535825 A CN 103535825A
- Authority
- CN
- China
- Prior art keywords
- glycoprotein
- scallop
- tumor
- chinese medicine
- postoperation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000003886 Glycoproteins Human genes 0.000 title claims abstract description 51
- 108090000288 Glycoproteins Proteins 0.000 title claims abstract description 51
- 241000237509 Patinopecten sp. Species 0.000 title claims abstract description 50
- 235000020637 scallop Nutrition 0.000 title claims abstract description 50
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 42
- 239000003814 drug Substances 0.000 claims abstract description 28
- 235000021552 granulated sugar Nutrition 0.000 claims abstract description 9
- 235000013361 beverage Nutrition 0.000 claims description 20
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 9
- 239000000284 extract Substances 0.000 claims description 8
- 238000000605 extraction Methods 0.000 claims description 8
- 244000189799 Asimina triloba Species 0.000 claims description 5
- 235000006264 Asimina triloba Nutrition 0.000 claims description 5
- 241000132012 Atractylodes Species 0.000 claims description 5
- 235000009467 Carica papaya Nutrition 0.000 claims description 5
- 239000009636 Huang Qi Substances 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 10
- 230000005764 inhibitory process Effects 0.000 abstract description 5
- 230000035622 drinking Effects 0.000 abstract description 3
- 238000004393 prognosis Methods 0.000 abstract description 3
- 238000000034 method Methods 0.000 abstract description 2
- 210000004881 tumor cell Anatomy 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 description 10
- 238000002512 chemotherapy Methods 0.000 description 9
- 210000002784 stomach Anatomy 0.000 description 7
- 238000002271 resection Methods 0.000 description 5
- 238000001959 radiotherapy Methods 0.000 description 4
- 210000000952 spleen Anatomy 0.000 description 4
- 230000000259 anti-tumor effect Effects 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 238000005538 encapsulation Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000029058 respiratory gaseous exchange Effects 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000004064 dysfunction Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000237852 Mollusca Species 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 201000010260 leiomyoma Diseases 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 238000005374 membrane filtration Methods 0.000 description 1
- 230000031864 metaphase Effects 0.000 description 1
- 230000000505 pernicious effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 201000000498 stomach carcinoma Diseases 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation containing fruit or vegetable juices
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/66—Proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention belongs to the technical field of health care products, and provides tumor postoperation healthy drink in order to give fully play to the inhibition effects of scallop glycoprotein I and scallop glycoprotein II on tumor cells. The tumor postoperation healthy drink is characterized by being prepared by adding the scallop glycoprotein I, the scallop glycoprotein II and granulated sugar to a traditional Chinese medicine extracting solution, wherein the weight of the traditional Chinese medicine extracting solution is used as the benchmark, the scallop glycoprotein I accounts for is 12-15wt%, the scallop glycoprotein II accounts for 15-20wt%, and the granulated sugar accounts for 8-12wt%. The tumor postoperation healthy drink is scientific in formula, has relatively mouth feel and can give fully play to effects in the prognosis health care process of tumor patients suffering tumor excision. The drinking of lots of tumor patients proves that the effective rate of the tumor postoperation healthy drink reaches above 85%.
Description
?
Technical field
The invention belongs to health product technology field, be specifically related to a kind of tumor post-operation health beverages that utilizes scallop zymolyte to prepare.
Background technology
At present; it is first-selected method that early metaphase tumour adopts operation excision; chemotherapy after tumor resection, radiotherapy are to control the further effective means of diffusion of cancer cell; but although radiotherapy, chemotherapy have stronger lethal effect to cancer cell; but " fail to differentiate between the enemy and ourselves ", when fighting the enemy, also greatly damaged the normal function of human body.After local tumor excision simultaneously, body is in insufficiency of vital energy and blood, the state of dysfunction of spleen and stomach, the chemotherapy now adopting, a lot of patients' of radiotherapy means physical qualification can not bear, and the phenomenon that therefore causes at present a lot of patients to occur that it is poorer that chemotherapy, radiotherapy time are more grown up situation occurs.
Along with the development of life science, the Chinese traditional medicine biology activity of glycoprotein is constantly revealed, and wherein in sea mollusk, the remarkable active anticancer of glycoprotein causes the concern of medical circle.The chemical composition of the article < < scallop glycoprotein that Gu Qianqun stepping on < < Chinese Sea medicine > > magazine the 3rd periodical in 1998 etc. delivers and the research > > of antitumor activity, in this article, explained in detail and how to have adopted enzyme solution from scallop, to extract scallop glycoprotein I (GCFI) and scallop glycoprotein I I(GCFII), and by small white mouse to scallop glycoprotein I (GCFI) and scallop glycoprotein I I(GCFII) antitumor activity measure, result shows, scallop glycoprotein I (GCFI) and scallop glycoprotein I I(GCFII) mouse transplantability S180 tumour is had to more significant inhibitory action.But by aforementioned known tumour patient its qi and blood after tumor resection lose greatly, dysfunction of spleen and stomach, if merely utilize scallop glycoprotein I and scallop glycoprotein I I to carry out tumour inhibition of cancer cell to patient, because its effect of weakness of health built-in function can not effectively be brought into play, therefore how to utilize the inhibition effect of giving full play to scallop glycoprotein to become the problem that art technology researcher urgently studies.
Summary of the invention
For giving full play to scallop glycoprotein I and the inhibition effect of scallop glycoprotein I I to tumour cancer cell, the present invention is by above-mentioned glycoprotein being provided provide a kind of tumor post-operation health beverages with traditional Chinese medical extract.
The technical solution used in the present invention is: a kind of tumor post-operation health beverages that utilizes enzymolysis and extraction scallop glycoprotein to prepare, it is characterized in that, this health beverages is in Chinese medicine extract, to add scallop glycoprotein I, scallop glycoprotein I I and granulated sugar to make, wherein take Chinese medicine extract weight as benchmark, the weight accounting of scallop glycoprotein I is 12-15%, and the weight accounting of scallop glycoprotein I I is that the weight accounting of 15-20%, granulated sugar is 8-12%.
The above-mentioned Chinese medicine extract mode that to be the base stock Chinese medicine that adopts following weight proportion decoct Chinese medicine through tradition is extracted its juice and is obtained after filtration, pawpaw 12-15 part, bighead atractylodes rhizome 9-12 part, Radix Astragali 9-12 part, Radix Angelicae Sinensis 6-9 part, Radix Glycyrrhizae 3-6 part, date 6-9 part.
The drinking way of this health beverages is to drink for three times morning, noon and afternoon every day, and the amount of drinking is at 100-150ml at every turn.
In the health beverages providing in this invention, its Chinese medicine extract for tumour patient its qi and blood after tumor resection lose greatly, taste imbalance situation carries out the meticulous collocation of material medicine, it selects pawpaw, the bighead atractylodes rhizome, Radix Glycyrrhizae, date in order to strengthening the spleen and stomach, the function of motion that adds persistent erection Jiao, middle Jiao is good for and transports coordination between the heart and kidney, extreme misery sexual intercourse, as flat people.In medicine, in addition the first tonifying Qi medicine Radix Astragali is in order to supplement health yang-energy again, and in addition a small amount of Radix Angelicae Sinensis, in order to tonifying yin liquid, can play the effect from cloudy yang-tonifying.Negative and positive must be mended, the strong fortune of middle Jiao, and human internal environment is improved, and now the scallop glycoprotein I in health beverages and scallop glycoprotein I I can fully be absorbed by the body, and give full play to the effect of its inhibition cancer cell.This health beverage formulation science, mouthfeel is better, in the prognosis health care to tumour patient after tumor resection, can give full play to effect, through massive tumor patient, drink, by statistics, its efficient reaching more than 85%.
The specific embodiment
Below in conjunction with embodiment, the present invention will be further described.
Being extracted in the chemical composition of article < < scallop glycoprotein that Gu Qianqun etc. delivers and the research > > of antitumor activity of scallop glycoprotein I and scallop glycoprotein I I mentioned in detail, to repeat no more in this manual, using scallop glycoprotein I and scallop glycoprotein I I as circulation product be used.
Get Chinese medicinal pawpaw 12-15 part, bighead atractylodes rhizome 9-12 part, Radix Astragali 9-12 part, Radix Angelicae Sinensis 6-9 part, Radix Glycyrrhizae 3-6 part, date 6-9 part, the mode that decocts Chinese medicine according to tradition is extracted its juice and is got its limpid concoction through membrane filtration.The weight portion of said medicine is adjusted according to patient's situation in above-mentioned scope, weakness of the spleen and the stomach person, the bighead atractylodes rhizome, pawpaw amount are large, when normalized volume little; The deficiency of yang person of breathing hard increases Radix Astragali consumption, the thirsty increasing Radix Angelicae Sinensis of deficiency of Yin consumption.
Embodiment 1
A tumor post-operation health beverages prepared by enzymolysis and extraction scallop glycoprotein, gets above-mentioned 500g Chinese medicine juice, and then in Chinese medicine juice, adds scallop glycoprotein I 60g, scallop glycoprotein I I100g, granulated sugar 40g, through sterilization, encapsulation, makes.
Embodiment 2
A tumor post-operation health beverages prepared by enzymolysis and extraction scallop glycoprotein, gets above-mentioned 500g Chinese medicine juice, and then in Chinese medicine juice, adds scallop glycoprotein I 75g, scallop glycoprotein I I75g, granulated sugar 60g, through sterilization, encapsulation, makes.
Embodiment 3
A tumor post-operation health beverages prepared by enzymolysis and extraction scallop glycoprotein, gets above-mentioned 500g Chinese medicine juice, and then in Chinese medicine juice, adds scallop glycoprotein I 65g, scallop glycoprotein I I85g, granulated sugar 50g, through sterilization, encapsulation, makes.
Model case
Case 1
Lee, 60 years old, man, the stomach that gets a cancer of the stomach the year before excision 2/3, postoperative, lassitude, order sets hypologia, and body is heavily liked sleeping, distastes for food.After February, check, find that stomach has new cancer cell to occur, the doctor advised excision of again perform the operation, agreement, when using chemotherapy instead, this takes health beverages provided by the invention.Take continuously after 6 months, check, has no cancer cell again, continues to take so far, and dietary amount continues to increase, and spirit takes a turn for the better, suitably stroll activity after meal, and check before January, stomach has no canceration.
Case 2
Wei, female, 42 years old, before half a year, be diagnosed as pernicious fibroid and excise, the limit chemotherapy of taking medicine of the one month inner edge after excision, but complexion is bluish white without god, yellowish fur, do not feel like eating, vexed breathing hard.After chemotherapy treatment finishes, take health beverages of the present invention so far, have rosy cheeks, diet is normal, the vexed symptom of breathing hard disappears, and hospital's further consultation has no new canceration and occurs.
Case 3
Temperature certain, man, 65 years old, before 3 years due to thyroid gland malignant tumor excision, after end of chemotherapy, long-term self-induction is uncomfortable in chest breathes hard, do not feel like eating, and vexed, diarrhoea, takes multi-medicament invalid, before 1 year, new cancer cell is found in check, but patient no longer coordinates and carry out chemotherapy, adheres to developing as one pleases.By household, persuade with health beverages of the present invention so far, conscious health is greatly improved, hospital's check before January, and cancer cell disappears, still holds on and takes at present.
Provided by the inventionly utilize tumor post-operation health beverages prepared by enzymolysis and extraction scallop glycoprotein through the taking of 92 routine tumor resection patients, Time of Administration is more than 6 months, 83 examples that self-induction health takes a turn for the better, and unchanged 7 examples, 2 examples feel that health continues to worsen.Through hospital's check, 79 examples are not reproduced new canceration, and new canceration appears in 3 examples, and 10 examples are apprised of and are returned to one's perfect health.Through above-mentioned statistics, this health beverages is to the prognosis of tumour patient its efficient reaching more than 85% that keep healthy.
Claims (2)
1. a tumor post-operation health beverages that utilizes enzymolysis and extraction scallop glycoprotein to prepare, it is characterized in that, this health beverages is in Chinese medicine extract, to add scallop glycoprotein I, scallop glycoprotein I I and granulated sugar to make, wherein take Chinese medicine extract weight as benchmark, the weight accounting of scallop glycoprotein I is 12-15%, and the weight accounting of scallop glycoprotein I I is that the weight accounting of 15-20%, granulated sugar is 8-12%.
2. a kind of tumor post-operation health beverages that utilizes enzymolysis and extraction scallop glycoprotein to prepare according to claim 1, it is characterized in that: the described Chinese medicine extract mode that to be the base stock Chinese medicine that adopts following weight proportion decoct Chinese medicine through tradition is extracted its juice and obtained after filtration, pawpaw 12-15 part, bighead atractylodes rhizome 9-12 part, Radix Astragali 9-12 part, Radix Angelicae Sinensis 6-9 part, Radix Glycyrrhizae 3-6 part, date 6-9 part.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310469142.8A CN103535825B (en) | 2013-10-10 | 2013-10-10 | Tumor postoperation healthy drink prepared by utilizing enzymolysis for extracting scallop glycoprotein |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310469142.8A CN103535825B (en) | 2013-10-10 | 2013-10-10 | Tumor postoperation healthy drink prepared by utilizing enzymolysis for extracting scallop glycoprotein |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103535825A true CN103535825A (en) | 2014-01-29 |
| CN103535825B CN103535825B (en) | 2015-05-20 |
Family
ID=49959987
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310469142.8A Expired - Fee Related CN103535825B (en) | 2013-10-10 | 2013-10-10 | Tumor postoperation healthy drink prepared by utilizing enzymolysis for extracting scallop glycoprotein |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103535825B (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007282506A (en) * | 2006-04-12 | 2007-11-01 | Kojo:Kk | Calcium-supplying beverage and method for producing the same |
| CN101601487A (en) * | 2009-07-09 | 2009-12-16 | 山东好当家海洋发展股份有限公司 | A kind of shellfish protein beverage and preparation method thereof |
| CN102283379A (en) * | 2011-07-13 | 2011-12-21 | 刘树平 | Health-care product and production process thereof |
| CN102293995A (en) * | 2011-07-14 | 2011-12-28 | 北京汉典中西药研究开发中心 | Spleen-invigorating the qi-replenishing particle and preparation method thereof |
-
2013
- 2013-10-10 CN CN201310469142.8A patent/CN103535825B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007282506A (en) * | 2006-04-12 | 2007-11-01 | Kojo:Kk | Calcium-supplying beverage and method for producing the same |
| CN101601487A (en) * | 2009-07-09 | 2009-12-16 | 山东好当家海洋发展股份有限公司 | A kind of shellfish protein beverage and preparation method thereof |
| CN102283379A (en) * | 2011-07-13 | 2011-12-21 | 刘树平 | Health-care product and production process thereof |
| CN102293995A (en) * | 2011-07-14 | 2011-12-28 | 北京汉典中西药研究开发中心 | Spleen-invigorating the qi-replenishing particle and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 顾谦群，等: "扇贝糖蛋白的化学组成与抗肿瘤活性的研究", 《中国海洋药物》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103535825B (en) | 2015-05-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103907723A (en) | Tea capable of nursing constitution of qi deficiency | |
| CN101607073A (en) | A kind of traditional biological technology is cultivated the method for Chinese medicine health care product Herba Swertiae davidi and healthy liquid thereof | |
| CN107213451A (en) | Improve probiotics fermention Chinese medicine preparation of microcirculation in human body obstacle and preparation method thereof | |
| CN112138108A (en) | Traditional Chinese medicine preparation for regulating human immunity and packaging structure and preparation method thereof | |
| CN100593417C (en) | Chinese traditional medicine for treating gastric cancer and bone cancer | |
| WO2022143466A1 (en) | Medicinal and edible plant-based traditional chinese medicine composition for preventing cancers | |
| CN102488200B (en) | Food composition with functions of tonifying spleen and stomach and invigorating qi, blood, yin and yang and preparation method thereof | |
| CN109105587A (en) | The tea bag and preparation method thereof of effect is relieved fatigue with strengthen immunity | |
| CN104605361B (en) | Regulate the compositions of human body sub-health status and use its method preparing beverage | |
| CN103462023B (en) | A kind of have strengthening the spleen and tonifying the lung draft food therapeutic composition of function and preparation method thereof | |
| CN103142807A (en) | Spleen arousing and children strong-keeping soup and preparation method thereof | |
| CN103272159B (en) | Chinese herbal preparation used for treating consumptive disease and preparation method thereof | |
| CN1973872B (en) | Medicine for nourishing Yin, invigorating kidney, strengthening physique and nourishing brain and its prepn | |
| CN105434679A (en) | Traditional Chinese medicine health-care preparation for reducing weight and slimming | |
| CN109157624A (en) | A kind of nutrient drug of tonifying spleen nourishing the stomach anti-aging | |
| CN103417876A (en) | Digestion and detoxification pill and preparing method thereof | |
| CN106309749A (en) | Traditional Chinese medicine for treating cervical cancer | |
| CN103535825A (en) | Tumor postoperation healthy drink prepared by utilizing enzymolysis for extracting scallop glycoprotein | |
| CN104623605A (en) | Traditional Chinese medicine capable of treating breast cancer | |
| CN104187662A (en) | Convenient food for conditioning ovarian cancer | |
| CN104799361B (en) | Health-care soup for improving postoperative immunity of tumor patient | |
| CN108721509A (en) | A kind of brain healthy, enhances composition of memory and application thereof | |
| CN103372144B (en) | One treats neurasthenic Chinese medicine preparation and preparation method | |
| CN102091155A (en) | Traditional Chinese medicine preparation for preventing and treating fatigue due to sub-health | |
| CN102188609A (en) | Formula and application of functional health-care food and Chinese medicines |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150520 Termination date: 20151010 |
|
| EXPY | Termination of patent right or utility model |