CN103534249A - 新的rock抑制剂 - Google Patents

新的rock抑制剂 Download PDF

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Publication number
CN103534249A
CN103534249A CN201280020905.4A CN201280020905A CN103534249A CN 103534249 A CN103534249 A CN 103534249A CN 201280020905 A CN201280020905 A CN 201280020905A CN 103534249 A CN103534249 A CN 103534249A
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alkyl
het
aryl
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compound
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Chinese (zh)
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D·雷森
O·戴非尔特
S·波兰德
J·阿兰
A·P·J·布兰
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A Makemu Limited-Liability Co
Amakem NV
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  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
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CN201280020905.4A 2011-04-29 2012-04-27 新的rock抑制剂 Pending CN103534249A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1107223.8 2011-04-29
GBGB1107223.8A GB201107223D0 (en) 2011-04-29 2011-04-29 Novel rock inhibitors
PCT/EP2012/057785 WO2012146724A2 (en) 2011-04-29 2012-04-27 Novel rock inhibitors

Publications (1)

Publication Number Publication Date
CN103534249A true CN103534249A (zh) 2014-01-22

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CN201280020905.4A Pending CN103534249A (zh) 2011-04-29 2012-04-27 新的rock抑制剂

Country Status (13)

Country Link
US (1) US9073905B2 (enExample)
EP (1) EP2702053A2 (enExample)
JP (1) JP2014512406A (enExample)
CN (1) CN103534249A (enExample)
AU (1) AU2012247455A1 (enExample)
BR (1) BR112013027241A2 (enExample)
CA (1) CA2834387A1 (enExample)
EA (1) EA201370230A1 (enExample)
GB (1) GB201107223D0 (enExample)
MX (1) MX2013012555A (enExample)
NZ (1) NZ616300A (enExample)
WO (1) WO2012146724A2 (enExample)
ZA (1) ZA201307496B (enExample)

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WO2020094111A1 (zh) * 2018-11-09 2020-05-14 北京泰德制药股份有限公司 Rho相关蛋白激酶抑制剂、包含其的药物组合物及其用途
CN113906017A (zh) * 2019-06-21 2022-01-07 广州润尔眼科生物科技有限公司 作为rock蛋白激酶抑制剂的异喹啉酮的衍生物及其应用

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US9828345B2 (en) 2013-02-28 2017-11-28 Bristol-Myers Squibb Company Phenylpyrazole derivatives as potent ROCK1 and ROCK2 inhibitors
TW201444798A (zh) 2013-02-28 2014-12-01 必治妥美雅史谷比公司 作爲強效ｒｏｃｋ１及ｒｏｃｋ２抑制劑之苯基吡唑衍生物
CN103127249A (zh) * 2013-03-02 2013-06-05 谭习达 一种治阑尾炎的药
WO2015196072A2 (en) 2014-06-19 2015-12-23 Whitehead Institute For Biomedical Research Uses of kinase inhibitors for inducing and maintaining pluripotency
US12371667B2 (en) 2021-05-13 2025-07-29 Washington University Enhanced methods for inducing and maintaining naive human pluripotent stem cells
US20250000083A1 (en) 2021-11-11 2025-01-02 The Doshisha Cryopreservation preparation for corneal endothelial cells and method for producing said cryopreservation preparation
WO2024229406A1 (en) 2023-05-04 2024-11-07 Revolution Medicines, Inc. Combination therapy for a ras related disease or disorder
US20250049810A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
US20250154171A1 (en) 2023-10-12 2025-05-15 Revolution Medicines, Inc. Ras inhibitors
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors
CN118304286B (zh) * 2024-06-07 2024-09-10 四川省医学科学院·四川省人民医院 芥子碱硫氰酸盐在制备治疗视网膜新生血管相关疾病的药物中的应用
WO2025255438A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder

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WO2008049919A2 (en) * 2006-10-26 2008-05-02 Devgen N.V. Rho kinase inhibitors
CN101583361A (zh) * 2006-12-18 2009-11-18 印斯拜尔药品股份有限公司 细胞骨架活性rho激酶抑制剂化合物、组合物和用途
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020094111A1 (zh) * 2018-11-09 2020-05-14 北京泰德制药股份有限公司 Rho相关蛋白激酶抑制剂、包含其的药物组合物及其用途
CN112969694A (zh) * 2018-11-09 2021-06-15 北京泰德制药股份有限公司 Rho相关蛋白激酶抑制剂、包含其的药物组合物及其用途
CN112969694B (zh) * 2018-11-09 2023-06-13 北京泰德制药股份有限公司 Rho相关蛋白激酶抑制剂、包含其的药物组合物及其用途
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CN113906017A (zh) * 2019-06-21 2022-01-07 广州润尔眼科生物科技有限公司 作为rock蛋白激酶抑制剂的异喹啉酮的衍生物及其应用
CN113906017B (zh) * 2019-06-21 2024-07-02 广州润尔眼科生物科技有限公司 作为rock蛋白激酶抑制剂的异喹啉酮的衍生物及其应用

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NZ616300A (en) 2014-11-28
EA201370230A1 (ru) 2014-02-28
CA2834387A1 (en) 2012-11-01
WO2012146724A3 (en) 2013-01-17
WO2012146724A2 (en) 2012-11-01
ZA201307496B (en) 2015-04-29
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US20140057942A1 (en) 2014-02-27
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US9073905B2 (en) 2015-07-07

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