CA2834387A1 - Novel rock inhibitors - Google Patents
Novel rock inhibitors Download PDFInfo
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- CA2834387A1 CA2834387A1 CA2834387A CA2834387A CA2834387A1 CA 2834387 A1 CA2834387 A1 CA 2834387A1 CA 2834387 A CA2834387 A CA 2834387A CA 2834387 A CA2834387 A CA 2834387A CA 2834387 A1 CA2834387 A1 CA 2834387A1
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- het1
- aryl
- heteroaryl
- 6alkyl
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| GB1107223.8 | 2011-04-29 | ||
| GBGB1107223.8A GB201107223D0 (en) | 2011-04-29 | 2011-04-29 | Novel rock inhibitors |
| PCT/EP2012/057785 WO2012146724A2 (en) | 2011-04-29 | 2012-04-27 | Novel rock inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2834387A1 true CA2834387A1 (en) | 2012-11-01 |
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| CA2834387A Pending CA2834387A1 (en) | 2011-04-29 | 2012-04-27 | Novel rock inhibitors |
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| US (1) | US9073905B2 (enExample) |
| EP (1) | EP2702053A2 (enExample) |
| JP (1) | JP2014512406A (enExample) |
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| EA (1) | EA201370230A1 (enExample) |
| GB (1) | GB201107223D0 (enExample) |
| MX (1) | MX2013012555A (enExample) |
| NZ (1) | NZ616300A (enExample) |
| WO (1) | WO2012146724A2 (enExample) |
| ZA (1) | ZA201307496B (enExample) |
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| CA2926478C (en) | 2012-10-05 | 2022-05-24 | Kadmon Corporation, Llc | Rho kinase inhibitors |
| MX362485B (es) * | 2012-10-31 | 2019-01-21 | Amakem Nv | Nuevos inhibidores de rock. |
| US9828345B2 (en) | 2013-02-28 | 2017-11-28 | Bristol-Myers Squibb Company | Phenylpyrazole derivatives as potent ROCK1 and ROCK2 inhibitors |
| TW201444798A (zh) | 2013-02-28 | 2014-12-01 | 必治妥美雅史谷比公司 | 作爲強效ｒｏｃｋ１及ｒｏｃｋ２抑制劑之苯基吡唑衍生物 |
| CN103127249A (zh) * | 2013-03-02 | 2013-06-05 | 谭习达 | 一种治阑尾炎的药 |
| WO2015196072A2 (en) | 2014-06-19 | 2015-12-23 | Whitehead Institute For Biomedical Research | Uses of kinase inhibitors for inducing and maintaining pluripotency |
| US12398118B2 (en) | 2018-11-09 | 2025-08-26 | Beijing Tide Pharmaceutical Co., Ltd. | Rho-associated protein kinase inhibitor, pharmaceutical composition comprising same, and use thereof |
| WO2020253882A1 (zh) * | 2019-06-21 | 2020-12-24 | 中山大学中山眼科中心 | 作为rock蛋白激酶抑制剂的异喹啉酮的衍生物及其应用 |
| US12371667B2 (en) | 2021-05-13 | 2025-07-29 | Washington University | Enhanced methods for inducing and maintaining naive human pluripotent stem cells |
| US20250000083A1 (en) | 2021-11-11 | 2025-01-02 | The Doshisha | Cryopreservation preparation for corneal endothelial cells and method for producing said cryopreservation preparation |
| WO2024229406A1 (en) | 2023-05-04 | 2024-11-07 | Revolution Medicines, Inc. | Combination therapy for a ras related disease or disorder |
| US20250049810A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| US20250154171A1 (en) | 2023-10-12 | 2025-05-15 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
| CN118304286B (zh) * | 2024-06-07 | 2024-09-10 | 四川省医学科学院·四川省人民医院 | 芥子碱硫氰酸盐在制备治疗视网膜新生血管相关疾病的药物中的应用 |
| WO2025255438A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
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| US6043358A (en) | 1995-11-01 | 2000-03-28 | Merck & Co., Inc. | Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases |
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| US6369087B1 (en) | 1999-08-26 | 2002-04-09 | Robert R. Whittle | Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same |
| US7217722B2 (en) | 2000-02-01 | 2007-05-15 | Kirin Beer Kabushiki Kaisha | Nitrogen-containing compounds having kinase inhibitory activity and drugs containing the same |
| US8058271B2 (en) * | 2006-05-12 | 2011-11-15 | Vertex Pharmaceuticals Incorporated | Selective inhibitors of rock protein kinase and uses thereof |
| WO2008049919A2 (en) | 2006-10-26 | 2008-05-02 | Devgen N.V. | Rho kinase inhibitors |
| US20100022517A1 (en) | 2006-12-18 | 2010-01-28 | Richards Lori A | Ophthalmic formulation of rho kinase inhibitor compound |
| US8071779B2 (en) * | 2006-12-18 | 2011-12-06 | Inspire Pharmaceuticals, Inc. | Cytoskeletal active rho kinase inhibitor compounds, composition and use |
| US20090325960A1 (en) | 2008-06-26 | 2009-12-31 | Fulcher Emilee H | Method for treating inflammatory diseases using rho kinase inhibitor compounds |
| US20090325959A1 (en) | 2008-06-26 | 2009-12-31 | Vittitow Jason L | Method for treating ophthalmic diseases using rho kinase inhibitor compounds |
| US8299096B2 (en) | 2008-06-26 | 2012-10-30 | Inspire Pharmaceuticals, Inc. | Method for treating pulmonary diseases using rho kinase inhibitor compounds |
| EP2400969A4 (en) * | 2008-12-04 | 2012-05-16 | Inspire Pharmaceuticals Inc | METHOD FOR TREATING PULMONARY DISEASES USING RHO KINASE INHIBITORY COMPOUNDS |
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- 2012-04-27 AU AU2012247455A patent/AU2012247455A1/en not_active Abandoned
- 2012-04-27 NZ NZ616300A patent/NZ616300A/en not_active IP Right Cessation
- 2012-04-27 CN CN201280020905.4A patent/CN103534249A/zh active Pending
- 2012-04-27 EA EA201370230A patent/EA201370230A1/ru unknown
-
2013
- 2013-10-08 ZA ZA2013/07496A patent/ZA201307496B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2702053A2 (en) | 2014-03-05 |
| MX2013012555A (es) | 2014-04-25 |
| BR112013027241A2 (pt) | 2016-12-27 |
| AU2012247455A1 (en) | 2013-10-24 |
| NZ616300A (en) | 2014-11-28 |
| EA201370230A1 (ru) | 2014-02-28 |
| CN103534249A (zh) | 2014-01-22 |
| WO2012146724A3 (en) | 2013-01-17 |
| WO2012146724A2 (en) | 2012-11-01 |
| ZA201307496B (en) | 2015-04-29 |
| JP2014512406A (ja) | 2014-05-22 |
| US20140057942A1 (en) | 2014-02-27 |
| GB201107223D0 (en) | 2011-06-15 |
| US9073905B2 (en) | 2015-07-07 |
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