CN103525047A - Antibacterial low-temperature thermoplastic material for orthopedics department and radiotherapy - Google Patents
Antibacterial low-temperature thermoplastic material for orthopedics department and radiotherapy Download PDFInfo
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- CN103525047A CN103525047A CN201310399570.8A CN201310399570A CN103525047A CN 103525047 A CN103525047 A CN 103525047A CN 201310399570 A CN201310399570 A CN 201310399570A CN 103525047 A CN103525047 A CN 103525047A
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Abstract
The invention relates to the technical field of low-temperature thermoplastic materials, and provides an antibacterial low-temperature thermoplastic material for orthopedics department and radiotherapy. The antibacterial low-temperature thermoplastic material is prepared from the following raw materials in parts by weight: 4 to 8 parts of antibacterial agent and 1000 to 1200 parts of polycaprolactone, wherein the appearance of the thermoplastic material is beautified by adding a toner; the strength, elasticity, heat resistance and solvent resistance of the thermoplastic material are improved by adding a cross-linking agent. When a prepared low-temperature thermoplastic membrane is used, an antibacterial agent is released slowly and can last quite a long time so as to damage the growth of bacteria, so that the fecundity of bacterial cells is lost. Thus, the death of the bacterial cells occurs. Therefore, the wound of a patient is prevented from being infected, namely, the occurrence of a secondary disease is avoided.
Description
Technical field
The present invention relates to low-temp thermoplastic material technical field, is a kind of orthopaedics, the antibiotic low-temp thermoplastic material of radiotherapy.
Background technology
When carrying out radiotherapy and during orthopaedics therapy, conventionally need to carry out moulding at patient's fixed position, low temperature sheet of thermoplastic film need be pasted to 10 days with it to more than 30 days patient, on diaphragm, be easy to grow germ, low temperature sheet of thermoplastic film does not all adopt antimicrobial treatment in the market, be easy to like this grow germ, the wound of serious infected patient, causes the generation of secondary disease.
Summary of the invention
The invention provides a kind of orthopaedics, the antibiotic low-temp thermoplastic material of radiotherapy, overcome the deficiency of above-mentioned prior art, it can effectively solve the existing low temperature sheet of thermoplastic film problem of easy breed bacteria in use.
Technical scheme of the present invention realizes by following measures: the antibiotic low-temp thermoplastic material of a kind of orthopaedics, radiotherapy, raw materials by weight portion comprises 4 parts to 8 parts of antiseptic-germicides, 1000 parts to 1200 parts of polycaprolactones.
The further optimization and/or improvements to foregoing invention technical scheme below:
Above-mentioned meter by weight also comprises 1 part to 2 parts of linking agent.
Above-mentioned meter by weight also comprises 0.2 part to 2 parts of toner.
Above-mentioned antiseptic-germicide is organic antibacterial agent, the mixture that the O-phthalic benzoic acid dioctyl ester that organic antibacterial agent is 95% and the different plug azoles quinoline-3-of 2-n-octyl-4-of 5% ketone form; Or the mixture of the different plug azoles quinoline-3-of the 2-n-octyl-4-of 91% O-phthalic benzoic acid dioctyl ester and 9% ketone composition; Or the mixture of the different plug azoles quinoline-3-of the 2-n-octyl-4-of 80% O-phthalic benzoic acid dioctyl ester and 20% ketone composition; Or the mixture of the different plug azoles quinoline-3-of the 2-n-octyl-4-of 75% O-phthalic benzoic acid dioctyl ester and 25% ketone composition; Or the mixture of the different plug azoles quinoline-3-of the 2-n-octyl-4-of 55% O-phthalic benzoic acid dioctyl ester and 45% ketone composition; Or 90% ESBO and 10% 4, the mixture that the different plug azoles quinoline-3-of the chloro-2-n-octyl-4-of 5-bis-ketone forms; Or 70% ESBO and 30% 4, the mixture that the different plug azoles quinoline-3-of the chloro-2-n-octyl-4-of 5-bis-ketone forms; Or N-(trichloro-methylthio)-4-tetrahydrobenzene-1,2-bis-carbimides; Or 2,3,5,6-tetrachloro-4-(methylsulfonyl) pyridine; Or octhilinone or five chlorophenyl laurate; Or the different O-phthalic ester of tetrachloro; Or tebuconazole or different plug oxazolone; Or 10,10 '-bis oxide Fen Evil arsenic; Or N-butyl benzisoxa plug azoles quinoline.
Above-mentioned antiseptic-germicide is inorganic antiseptic, and inorganic antiseptic is nano-silver ionic type inorganic antibiosis powder; Or zeolite-Yin/zinc inorganic antibiosis powder; Or zeolite-Yin/inorganic copper antimicrobial powder; Or zeolite-inorganic antibiosis powder of silver; Or zeolite-silver ions inorganic antibiosis powder; Or titanium dioxide-silver chloride inorganic antibiosis powder; Or Zinc oxide/titanium dioxide inorganic antibiosis powder.
The low temperature sheet of thermoplastic film that adopts the present invention to make, in use, antiseptic-germicide can slowly release, and can continue considerable time, and destroy the growth of bacterium, make bacterial cell lose fecundity and death, avoid infection patient's wound, the generation of stopping secondary disease.
Embodiment
The present invention is not subject to the restriction of following embodiment, can determine concrete embodiment according to technical scheme of the present invention and practical situation.
Below in conjunction with embodiment, the invention will be further described:
Embodiment 1, and this orthopaedics, radiotherapy comprise 4 parts to 8 parts of antiseptic-germicides, 1000 parts to 1200 parts of polycaprolactones by antibiotic low-temp thermoplastic material raw materials by weight portion.
Embodiment 2, and this orthopaedics, radiotherapy comprise 4 parts of antiseptic-germicides or 8 parts, 1000 parts or 1200 parts of polycaprolactones by antibiotic low-temp thermoplastic material raw materials by weight portion.
Embodiment 3, are with the difference of embodiment 1 and embodiment 2, and this orthopaedics, radiotherapy are counted by weight and also comprised 1 part to 2 parts of linking agent with antibiotic low-temp thermoplastic material.Linking agent is also solidifying agent, stiffening agent, ripening agent, it can make the macromole of line style or slight branched chain type be transformed into tridimensional network, the performances such as intensity, elasticity, thermotolerance, wear resistance, solvent resistance that improve rubber plastic product with this, can be used for foaming or foaming product not.
Embodiment 4, are with the difference of embodiment 3, and this orthopaedics, radiotherapy are counted by weight and also comprised 0.2 part to 2 parts of toner with antibiotic low-temp thermoplastic material.Toner is used for orthopaedics, radiotherapy to be deployed into required color with antibiotic low-temp thermoplastic material, as required, add the toner that needs color, make last low temperature sheet of thermoplastic film elegant in appearance, distinct colors, also plays certain regulating effect to patient's psychology simultaneously.
Embodiment 5, as embodiment 1, embodiment 2, embodiment 3 and embodiment 4 preferably, antiseptic-germicide is organic antibacterial agent, the mixture that the O-phthalic benzoic acid dioctyl ester that organic antibacterial agent is 95% and the different plug azoles quinoline-3-of 2-n-octyl-4-of 5% ketone form; Or the mixture of the different plug azoles quinoline-3-of the 2-n-octyl-4-of 91% O-phthalic benzoic acid dioctyl ester and 9% ketone composition; Or the mixture of the different plug azoles quinoline-3-of the 2-n-octyl-4-of 80% O-phthalic benzoic acid dioctyl ester and 20% ketone composition; Or the mixture of the different plug azoles quinoline-3-of the 2-n-octyl-4-of 75% O-phthalic benzoic acid dioctyl ester and 25% ketone composition; Or the mixture of the different plug azoles quinoline-3-of the 2-n-octyl-4-of 55% O-phthalic benzoic acid dioctyl ester and 45% ketone composition; Or 90% ESBO and 10% 4, the mixture that the different plug azoles quinoline-3-of the chloro-2-n-octyl-4-of 5-bis-ketone forms; Or 70% ESBO and 30% 4, the mixture that the different plug azoles quinoline-3-of the chloro-2-n-octyl-4-of 5-bis-ketone forms; Or N-(trichloro-methylthio)-4-tetrahydrobenzene-1,2-bis-carbimides; Or 2,3,5,6-tetrachloro-4-(methylsulfonyl) pyridine; Or octhilinone or five chlorophenyl laurate; Or the different O-phthalic ester of tetrachloro; Or tebuconazole or different plug oxazolone; Or 10,10 '-bis oxide Fen Evil arsenic; Or N-butyl benzisoxa plug azoles quinoline.Organic antibacterial agent is by progressing into cell with microorganism cells film surface anion binding group, or with the radical reactions such as sulfydryl of cell surface, destroy the synthesis system of protein and cytolemma, suppress the breeding of microorganism.The adventitia of microorganism cells is semi-permeable membranes, by lipid layer and protein, formed, inside and outside two-layer be protein, sandwich lipid layer, therefore will permeate biological cell membrane needs organic antibacterial agent to have wetting ability and lipophilicity, organic antibacterial agent makes the various metabolic enzyme inactivations in bacterial cell, hinders biological respiration, reaches sterilization effect.
Embodiment 6, as embodiment 1, embodiment 2, embodiment 3 and embodiment 4 preferably, antiseptic-germicide is inorganic antiseptic, inorganic antiseptic is nano-silver ionic type inorganic antibiosis powder; Or zeolite-Yin/zinc inorganic antibiosis powder; Or zeolite-Yin/inorganic copper antimicrobial powder; Or zeolite-inorganic antibiosis powder of silver; Or zeolite-silver ions inorganic antibiosis powder; Or titanium dioxide-silver chloride inorganic antibiosis powder; Or Zinc oxide/titanium dioxide inorganic antibiosis powder.Inorganic antiseptic is spectrum antiseptic-germicide, belong to ion stripping contact-type antiseptic-germicide, its anti-microbial effect is passive type, the mechanism of action of the inorganic antiseptic of metal ion type has 2:(1) contact reacts mechanism: metal ion contact microorganism, make microprotein structure deteriorate, cause microbial death or produce dysfunction; (2) active oxygen mechanism: add after antiseptic-germicide, material surface distributing trace metallic element, can play the effect of catalytic active center.The energy of this active centre energy absorbing environmental, activates and is adsorbed on the air of material surface or the oxygen in water, produces hydroxy radical qiao and active oxygen ion, they have very strong redox ability, can destroy the multiplication capacity of bacterial cell, suppress or kill bacteria, produce anti-microbial property.
Adopt the low temperature sheet of thermoplastic film that the present invention makes aspect bacterial micro-organism, to detect contrast with at present common low temperature sheet of thermoplastic film, detect data mean value as shown in table 1.
Table 1
| Bacterial micro-organism | Intestinal bacteria ATCC25922 | Streptococcus aureus ATCC6538 |
| Current common low temperature sheet of thermoplastic film (cfu/ sheet) | 1.6×10 7 | 2.2×10 5 |
| The low temperature sheet of thermoplastic film (cfu/ sheet) that adopts the present invention to make | ＜50 | ＜50 |
| The low temperature sheet of thermoplastic film antibiotic rate (%) that the present invention makes | 98.53 | 98.91 |
By table 1 data, can be found out, the low temperature sheet of thermoplastic film that adopts the present invention to make, in use, slow release by antiseptic-germicide also can continue considerable time, can effectively destroy the growth of bacterium, make bacterial cell lose fecundity and death, the patient's that avoids infection wound, the generation of stopping secondary disease.
Above technical characterictic has formed most preferred embodiment of the present invention, and it has stronger adaptability and best implementation result, can increase and decrease according to actual needs non-essential technical characterictic, meets the demand of different situations.
Claims (5)
1. the antibiotic low-temp thermoplastic material of orthopaedics, radiotherapy, is characterized in that raw materials by weight portion comprises 4 parts to 8 parts of antiseptic-germicides, 1000 parts to 1200 parts of polycaprolactones.
2. the antibiotic low-temp thermoplastic material of orthopaedics according to claim 1, radiotherapy, is characterized in that counting by weight and also comprises 1 part to 2 parts of linking agent.
3. the antibiotic low-temp thermoplastic material of orthopaedics according to claim 2, radiotherapy, is characterized in that counting by weight and also comprises 0.2 part to 2 parts of toner.
4. according to the antibiotic low-temp thermoplastic material of orthopaedics, radiotherapy described in claim 1 or 2 or 3, it is characterized in that antiseptic-germicide is organic antibacterial agent, the mixture that the O-phthalic benzoic acid dioctyl ester that organic antibacterial agent is 95% and the different plug azoles quinoline-3-of 2-n-octyl-4-of 5% ketone form; Or the mixture of the different plug azoles quinoline-3-of the 2-n-octyl-4-of 91% O-phthalic benzoic acid dioctyl ester and 9% ketone composition; Or the mixture of the different plug azoles quinoline-3-of the 2-n-octyl-4-of 80% O-phthalic benzoic acid dioctyl ester and 20% ketone composition; Or the mixture of the different plug azoles quinoline-3-of the 2-n-octyl-4-of 75% O-phthalic benzoic acid dioctyl ester and 25% ketone composition; Or the mixture of the different plug azoles quinoline-3-of the 2-n-octyl-4-of 55% O-phthalic benzoic acid dioctyl ester and 45% ketone composition; Or 90% ESBO and 10% 4, the mixture that the different plug azoles quinoline-3-of the chloro-2-n-octyl-4-of 5-bis-ketone forms; Or 70% ESBO and 30% 4, the mixture that the different plug azoles quinoline-3-of the chloro-2-n-octyl-4-of 5-bis-ketone forms; Or N-(trichloro-methylthio)-4-tetrahydrobenzene-1,2-bis-carbimides; Or 2,3,5,6-tetrachloro-4-(methylsulfonyl) pyridine; Or octhilinone or five chlorophenyl laurate; Or the different O-phthalic ester of tetrachloro; Or tebuconazole or different plug oxazolone; Or 10,10 '-bis oxide Fen Evil arsenic; Or N-butyl benzisoxa plug azoles quinoline.
5. according to the antibiotic low-temp thermoplastic material of orthopaedics, radiotherapy described in claim 1 or 2 or 3, it is characterized in that antiseptic-germicide is inorganic antiseptic, inorganic antiseptic is nano-silver ionic type inorganic antibiosis powder; Or zeolite-Yin/zinc inorganic antibiosis powder; Or zeolite-Yin/inorganic copper antimicrobial powder; Or zeolite-inorganic antibiosis powder of silver; Or zeolite-silver ions inorganic antibiosis powder; Or titanium dioxide-silver chloride inorganic antibiosis powder; Or Zinc oxide/titanium dioxide inorganic antibiosis powder.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201310399570.8A CN103525047A (en) | 2013-09-05 | 2013-09-05 | Antibacterial low-temperature thermoplastic material for orthopedics department and radiotherapy |
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| CN201310399570.8A CN103525047A (en) | 2013-09-05 | 2013-09-05 | Antibacterial low-temperature thermoplastic material for orthopedics department and radiotherapy |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107652642A (en) * | 2017-10-23 | 2018-02-02 | 安徽江淮汽车集团股份有限公司 | A kind of polycaprolactone composite material and preparation method thereof |
| CN108084676A (en) * | 2016-11-22 | 2018-05-29 | 广州天泓医疗科技有限公司 | A kind of low-temp thermoplastic material |
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| CN1546754A (en) * | 2003-12-04 | 2004-11-17 | 东南大学 | Twisted ultra-fine nanometer fiber film material and preparing method thereof |
| CN101161705A (en) * | 2006-10-13 | 2008-04-16 | 中国科学院化学研究所 | Functional polymer nano composite material and preparation method and uses thereof |
| CN101218093A (en) * | 2005-05-22 | 2008-07-09 | 美国硼砂公司 | Co-biocidal formulation for polymeric materials |
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2013
- 2013-09-05 CN CN201310399570.8A patent/CN103525047A/en active Pending
Patent Citations (3)
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|---|---|---|---|---|
| CN1546754A (en) * | 2003-12-04 | 2004-11-17 | 东南大学 | Twisted ultra-fine nanometer fiber film material and preparing method thereof |
| CN101218093A (en) * | 2005-05-22 | 2008-07-09 | 美国硼砂公司 | Co-biocidal formulation for polymeric materials |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108084676A (en) * | 2016-11-22 | 2018-05-29 | 广州天泓医疗科技有限公司 | A kind of low-temp thermoplastic material |
| CN107652642A (en) * | 2017-10-23 | 2018-02-02 | 安徽江淮汽车集团股份有限公司 | A kind of polycaprolactone composite material and preparation method thereof |
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Application publication date: 20140122 |