CN103520540A - Obliterative cholangitis postoperative navel applying agent and preparation method thereof - Google Patents

Abstract

The invention discloses an obliterative cholangitis postoperative navel applying agent and a preparation method thereof, aiming at solving a treatment problem of the obliterative cholangitis. The preparation method is characterized by comprising the following steps of (1), distilling tetrapanax papyriferum, pleurotus and radix sophorae flavescentis with vapor, extracting volatile oil for future use, and reserving dregs; (2), crushing geckos and rice-grain sprouts into fine powder for future use; (3), uniformly mixing prismatomeria tetrandra, gulfweeds, poncirus barks, equisetum hiemale, ternate buttercup roots, wild mints, leaves and twigs of common claoxylon and the dregs obtained in the step (1) for alcohol extraction twice, mixing two-time alcohol extracts, filtering, recycling alcohol and decompressing and concentrating to obtain extract; and (4), adding the fine powder obtained in the step (2) into the extract obtained in the step (3), uniformly mixing, drying at 60 DEG C, crushing into fine powder, adding polysorbate-80 to prepare particles, drying, granulating, spraying the volatile oil obtained in the step (1), uniformly mixing, and sub-packaging to obtain the agent. Clinical experiment proves that the obliterative cholangitis postoperative navel applying agent has characteristics of good curative effect and high safety for bypass postoperative use of the obliterative cholangitis, and is worthy of clinical application and popularization.

Description

Postoperative deposited umbilicus agent of a kind of cholangitis,stenosing and preparation method thereof

Technical field

The present invention relates to the field of Chinese medicines, be specifically related to postoperative deposited umbilicus agent of a kind of cholangitis,stenosing and preparation method thereof.

Background technology

Narrow cholangitis is a kind of agnogenio, course of disease biliary tract pathological changes slowly.Primary disease feature is the extensive fibrosis of the inside and outside biliary tract of liver, it is significantly narrow that its tube wall obviously thickens tube chamber, clinical manifestation is except obstructive jaundice, patient fails to obtain diagnosis and treatment timely, can cause biliary cirrhosis and portal hypertension, and because of liver failure and upper gastrointestinal hemorrhage death.The cause variation of primary disease, main relevant with following factors: 1. chronic nonspecific infects: this is sick relevant with ulcerative colitis.When infectious enteropathy, intestinal bacterium is invaded biliary system from portal vein, forms chronic inflammatory disease, and bile duct wall proliferation of fibrous tissue, makes bile duct wall constriction.2. autoimmune disease: the immune complex in patients serum is often higher than normal person, and these species precipitate, when organizing, can cause local inflammation.Badenheimer measures the immune complex in patients serum, no matter whether occur together ulcerative colitis, the immune complex in their serum is all significantly higher than normal healthy controls group.With the patient of ulcerative colitis, the antinuclear antibody in serum, smooth muscle antibody all have a certain proportion of positive, have supported these patients' the morbidity view relevant with immune factor.But application hormone or immunosuppressant treatment, though can improve symptom, do not improve the pathological change of bile duct, can not change patient's the course of disease.3. other factors: this disease is relevant with factors such as congenital factor, quasi-colubriformis infection, alcoholism, lithocholic acid.

The main pathological change of primary disease, in liver, portal area bile duct wall and pericholangitis sexual cell infiltrate, it is mainly lymphocyte, rare multinuclear leucocyte, visible macrophage and eosinophilic granulocyte once in a while, along with the development of pathological changes, there are necrosis and the proliferation of fibrous tissue of focal little point-like simultaneously, bile duct epithelial cell is atrophy and disappearance gradually, occur tube wall to harden rough and thicken, finally cause the extreme fibrosis of bile duct tube wall, so that tube wall thickens and the narrow string ball sample that is of change in lumen, the thinnest person of its tube chamber is only as pencil-lead, diameter is 2mm only, extent of disease only involves choledoch-one section sometimes, but also there is choledoch-major part even left, right common hepatic duct is affected individual simultaneously.With chronic cholecystitis, adhesion becomes streak to majority of cases with hepatoduodenal ligament, is almost to can not see bile duct spline structure.There are obstructive jaundice and biliary cirrhosis simultaneously, can occur portal hypertension and liver failure late period to pathological changes.

The natural history of cholangitis,stenosing was from 6 months～15 years, many asymptomatic cases usually when finding with liver cirrhosis and portal hypertension, belong to the very poor disease kind of prognosis in liver and gall diseases, unclear because of its cause of disease, at clinicing aspect, still lack effective processing means.For merging portal hypertension person, should suitably use portosystemic shunt.During because of portal hypertension, the portal vein pipe network anger at hepatic portal place is opened, pressure is high, and operation is often bled profusely and is difficult to carry out, therefore can adopt operation method by stages.No matter be staging operation or full portosystemic shunt, maximum post-operative complication is liver failure, and this liver failure part is derived from cholangitis,stenosing itself, and a part is from portosystemic shunt.But because this art formula can reach reduction portal venous pressure, prevent the object of portal hypertension complication, the effect of hemostasis and elimination ascites certainly, is applicable to the patient that liver function Child-Pugh C level is waited for liver transplantation.

This disease of Chinese traditional treatment is many to be controlled from " jaundice " opinion: take in early days clearing away heat-damp and promoting diuresis as main, take blood circulation promoting and blood stasis dispelling mid-term as main, take invigorating spleen for diuresis late period as main.But there is not the medicine of report for using after cholangitis,stenosing surgical bypass operation, with liver failure after reducing portosystemic shunt, occur.

Summary of the invention

Technical assignment of the present invention is for above the deficiencies in the prior art, and postoperative deposited umbilicus agent of cholangitis,stenosing that a kind of curative effect is affirmed and side effect is little and preparation method thereof is provided.

The technical scheme that the present invention solves its technical problem is: a kind of pharmaceutical composition for using after cholangitis,stenosing surgical bypass operation, is characterized in that being prepared from by the crude drug of following weight proportion: 10 ~ 30 parts of xanthorrhizas, pick up the ears 6 ~ 12 parts, 3 ~ 10 parts of Alga Sgrgassi Enervess, 6 ~ 12 parts of Cortex Ponciri trifoliatae, 3 ~ 10 parts of Radix Sophorae Flavescentiss, 6 ~ 12 parts of Herba Equiseties Hiemalis, go back 6 ~ 12 parts, bobbin, 6 ~ 12 parts of Radix Ranunculi Ternatis, 6 ~ 12 parts of Herba Dracocephalis, 1 ~ 5 part of Gecko, 3 ~ 10 parts of Folium et Ramulus Callicarpae nudiflorae, 10 ~ 25 parts of Fructus Setariae Germinatus (parched to brown).

Chinese medicine of the present invention can be prepared from by following method:

(1) will go back bobbin, pick up the ears, Radix Sophorae Flavescentis coarse powder soaks separately after 4 hours and extracts volatile oil 6 hours with vapor distillation, and mixing for standby use after collecting, medicinal residues are standby;

(2) Gecko, Fructus Setariae Germinatus (parched to brown) were pulverized to 150 mesh sieves, and became fine powder standby;

(3) gained medicinal residues in xanthorrhiza, Alga Sgrgassi Enerves, Cortex Ponciri trifoliatae, Herba Equiseti Hiemalis, Radix Ranunculi Ternati, Herba Dracocephali, Folium et Ramulus Callicarpae nudiflorae and step 1 are mixed with 5 times and measure 80% ethanol extractions 2 times, each 2 hours, merge ethanol extract twice, filter the extractum that when recovery ethanol concentrating under reduced pressure become 60 ℃, relative density is 1.25～1.30;

(4) add gained extractum in step 3 to mix gained fine powder in step 2,60 ℃ of oven dry, are ground into fine powder, add Tween-80 granulation, dry, and granulate, sprays into gained volatile oil in step 1, mix packing and get final product.

Wherein said: xanthorrhiza, for Rubiaceae Radix Prismatomeris tetrandrae platymiscium xanthorrhiza Prismatomeris tetrandra (Roxb.) K. Schum., is used as medicine with root.Property mildly bitter flavor; Cool.Merit can cooling blood for hemostasis; Dampness removing jaundice eliminating; The strong muscle of dissipating blood stasis.

Pick up the ears, for Mycophyta Basidiomycetes Agaricales Agaricaceae Pleurotus ostreatus (the Jacq. ex Fr.) Quel. that picks up the ears, with sporophore, be used as medicine.Nature and flavor are pungent; Sweet; Warm in nature.Return liver; Kidney channel.Merit can wind-evil dispelling and cold-evil expelling; Relaxing muscles and tendons and activating QI and blood in the collateral; Kidney invigorating and YANG supporting.

Alga Sgrgassi Enerves is Sargassaceae plant Alga Sgrgassi Enerves Sargassum enerve C.Ag., Heng Shi Alga Sgrgassi Enerves Sargassum henslowianum C.Ag., sargassum thunbergii Sargassum thunbergii(Mert.) O.Kuntze or Sargassum phyllocystum Tseng et Lu,Sargassum horneri (Turn.) C. Ag. (Fucus horneri (Turn.)C.Ag.,Spongocarpus horneri Kutz.) argassum horneri(Turn.) frond of C. Ag.Nature and flavor are salty; Cold.Return liver; Stomach; Kidney channel.Merit can hard masses softening and resolving; Removing heat-phlegm.

Cortex Ponciri trifoliatae is bark bits or the peel bits of rutaceae Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) Poncirus tuifoliata (L.) Raf..Nature and flavor are pungent; Temperature.Return liver; Kidney channel.Merit can endogenous wind stopping relieving convulsion; Eleminating phlegm and freeing channels.

Radix Sophorae Flavescentis is the dry root of leguminous plant Radix Sophorae Flavescentis Sophora flavescens Ait..Nature and flavor are bitter, cold.Return liver, liver, stomach, large intestine, urinary bladder channel.Merit can heat clearing and damp drying, parasite killing, diuresis.

Herba Equiseti Hiemalis is the dry aerial parts of Equisetaceae plant Herba Equiseti Hiemalis Equisetum hiemale L..Nature and flavor are sweet, bitter, flat.Return lung, Liver Channel.The merit wind heat of can faling apart, moves back corneal nebula.

Also bobbin, is the fruit of orchid Rhizoma Gastrodiae Gastrodia elata Bl..Sweet in the mouth; Cold in nature.Merit can tonify deficiency subduing the wind syndrome.Main dizzy; Pupil; Wind syndrome of head headache; Weak breath consumption of essence; Early whitening of beard and hair.

Radix Ranunculi Ternati is the dried root of the little Herba Ranunculi Japonici Ranunculus of ranunculaceae plant ternatus Thunb..Nature and flavor sweet, acrid, warm.Return liver, lung meridian.Merit can eliminating stagnation, detumescence.

Herba Dracocephali, is the herb of Labiatae dragonhead Herba Dracocephali Dracocephalum moldavica L., and nature and flavor are pungent, bitter, cool.Merit can wind and heat dispersing; Smooth throat to stop cough; Cool liver hemostasis.

Gecko is the dry body of Gekkonidae animal Gecko Gekko gecko Linnaeus.Nature and flavor are salty, flat.Return lung, kidney channel.Merit can invigorating the lung and the kidney, improving inspiration by invigorating kidney-QI Dingchuan, supporing yang benefit essence.

Folium et Ramulus Callicarpae nudiflorae is the leaf with twig of Verbenaceae Callicarpa nudiflora Callicarpa nudiflora Hook. Et Arn..Nature and flavor are puckery, micro-pungent, bitter, flat.Return Liver Channel.Merit can be stopped blooding by dissipating blood stasis; Removing toxic substances and promoting subsidence of swelling.

Fructus Setariae Germinatus (parched to brown), dry through germinateing for the mature fruit of grass foxtail millet Setaria italica (L.) Beauv., according to frying method, fry to burnt brown.Nature and flavor are sweet, temperature.Return spleen, stomach warp.Merit can help digestion and in, spleen benefiting and stimulating the appetite.

At present, Chinese traditional treatment does not have the medicine typing for cholangitis,stenosing, but how from the pattern of syndrome of " jaundice ", to discuss and to control.The tcm syndrome differentiation and typing of " jaundice " has: take in early days clearing away heat-damp and promoting diuresis as main, take blood circulation promoting and blood stasis dispelling mid-term as main, take invigorating spleen for diuresis late period as main.But cholangitis,stenosing and " jaundice " inherent mechanism are obviously different, and the former mostly is substantive proliferation of fibrous tissue, poor prognosis; And the latter mostly is functional imbalance that other reasons causes, good prognosis.

Compared with prior art, the present invention has following characteristics:

1, set forth one's views unique: cholangitis,stenosing is controlled from positivism, is that tangible heresy blocked liver network, causes not all right and raw his change of stagnation in liver meridian, so get rid of evils as key element.But after portal vein bypass, operation wound damage healthy energy, simulataneous insufficiency and excessive, needs strengthening vital QI to eliminate pathogenic factors.

2, take xanthorrhiza, pick up the ears as monarch: xanthorrhiza cooling blood for hemostasis, dampness removing jaundice eliminating, the strong muscle of dissipating blood stasis to be to get rid of evils, the tonifying YANG righting of picking up the ears.The promoting the function of the gallbladder to alleviate jaundice medicine (as Herba Artemisiae Scopariae, Radix Curcumae, Rhizoma Coptidis etc.) that xanthorrhiza is better than other is that one medicine is multiplex, Basic pharmacology test confirms: 1. higher containing aluminum, manganese amount in xanthorrhiza, xanthorrhiza perfusate (1.5g/100ml) is the tolerance enhancing 37.82% to anoxia to isolated rat liver tissue; 2. rabbit liver cells in vitro culture studies result shows, xanthorrhiza energy the liver protecting cell film promotes the foreign body of liver to get rid of, thereby effectively suppresses the formation of liver fiber; 3. xanthorrhiza has good antibacterial action.For the various disease of this pathogenic factor of cholangitis,stenosing, many target spots are started with and are contributed to improve curative effect.Pick up the ears, warm in nature, the acidic polysaccharose of picking up the ears that it contains has immunoregulation effect, can reduce immune complex in the deposition (reducing by 27.33% compared with blank group) of liver.

3, usining the loose wind heat of Alga Sgrgassi Enerves hard masses softening and resolving, the diuresis of Radix Sophorae Flavescentis heat clearing and damp drying, Herba Dracocephali wind and heat dispersing, Cortex Ponciri trifoliatae eleminating phlegm and freeing channels, Herba Equiseti Hiemalis, Radix Ranunculi Ternati mass dissipating and swelling eliminating gets rid of evils as the auxiliary monarch drug of ministerial drug.But oxymatrine can alleviate the hepatocyte injury causing by lacking sugared anoxia, but to the hepatocyte injury unprotect effect due to ethanol, so can only help out as ministerial drug.In " accumulation of blood is both of a specified duration, also can turn to expectorant water " (" treatise on blood trouble " rolls up five) liver network, QI and blood is not all right, accumulation of phlegm retardance of a specified duration, and breath does not reach, so select Cortex Ponciri trifoliatae, Alga Sgrgassi Enerves Herba Equiseti Hiemalis, Radix Ranunculi Ternati; Herba Equiseti Hiemalis's decocting liquid (10g crude drug/kg/d) can improve the excretion rate 19.45% of high blood copper rat urine copper.

4, with Gecko invigorating the lung and the kidney, go back bobbin tonify deficiency subduing the wind syndrome assistant and help the righting of picking up the ears, the aminoacid that wherein Gecko contains and phospholipid composition can reduce the content of malonaldehyde in cell membrane (MDA), play the effect of stabilizing cell membrane.

5, low dose of Folium et Ramulus Callicarpae nudiflorae is corrigent, and resisting dredging collateral medicine in this prescription too much has the anxiety of consumption gas, and the effect of its removing toxic substances and promoting subsidence of swelling also can contribute to get rid of evils.And silicate and tannin that Herba Equiseti Hiemalis is contained have astriction, there is the meaning of receipts in loose, and under can preventing that heat-clearing and toxic substances removing medicine is cold and cool and rushing down.

6, Fructus Setariae Germinatus (parched to brown) is sweet in flavor and warm in property, returns taste warp, in one cold and cool medicine, gets and protects the meaning of sun in defending.

7, the thing homogeneous medicine multiple-effect of getting it filled in side, contributes to reduce medicament categories and consumption, does not increase Liver and kidney burden after wound.

8, medicine material consumption of the present invention is groped in a large number to sum up through inventor and is drawn, each raw material consumption is for all to have good curative effect in following weight parts scope.

9, because cholangitis,stenosing needs the medication cycle long, the burden of bringing in order to reduce Liver and kidney metabolism, applies umbilicus agent dosage form so adopt, and easy to use, compliance is good, is convenient to the consolidation of the course for the treatment of.

The specific embodiment

Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.

Embodiment 1, crude drug weight proportion: 20 parts of xanthorrhizas, pick up the ears 10 parts, 6 parts of Alga Sgrgassi Enervess, 10 parts of Cortex Ponciri trifoliatae, 6 parts of Radix Sophorae Flavescentiss, 10 parts of Herba Equiseties Hiemalis, go back 10 parts, bobbin, 10 parts of Radix Ranunculi Ternatis, 10 parts of Herba Dracocephalis, 2 parts of Geckos, 6 parts of Folium et Ramulus Callicarpae nudiflorae, 20 parts of Fructus Setariae Germinatus (parched to brown).

The preparation method of embodiment 1 is: by xanthorrhiza, pick up the ears, Alga Sgrgassi Enerves, Cortex Ponciri trifoliatae, Radix Sophorae Flavescentis, Herba Equiseti Hiemalis, go back bobbin, Radix Ranunculi Ternati, Herba Dracocephali, Gecko, Folium et Ramulus Callicarpae nudiflorae, Fructus Setariae Germinatus (parched to brown) mixing and water adding and decoct, after 30 minutes, get filtrate, medicinal residues add water continuation decoction and get filtrate after 20 minutes, twice filtrate merges, and is divided into two parts and sooner or later uses.

Embodiment 2, crude drug weight proportion: 10 parts of xanthorrhizas, pick up the ears 6 parts, 3 parts of Alga Sgrgassi Enervess, 6 parts of Cortex Ponciri trifoliatae, 3 parts of Radix Sophorae Flavescentiss, 6 parts of Herba Equiseties Hiemalis, go back 6 parts, bobbin, 6 parts of Radix Ranunculi Ternatis, 6 parts of Herba Dracocephalis, 1 part of Gecko, 3 parts of Folium et Ramulus Callicarpae nudiflorae, 10 parts of Fructus Setariae Germinatus (parched to brown).

Embodiment 3, crude drug weight proportion: 20 parts of xanthorrhizas, pick up the ears 10 parts, 6 parts of Alga Sgrgassi Enervess, 10 parts of Cortex Ponciri trifoliatae, 6 parts of Radix Sophorae Flavescentiss, 10 parts of Herba Equiseties Hiemalis, go back 10 parts, bobbin, 10 parts of Radix Ranunculi Ternatis, 10 parts of Herba Dracocephalis, 2 parts of Geckos, 6 parts of Folium et Ramulus Callicarpae nudiflorae, 20 parts of Fructus Setariae Germinatus (parched to brown).

Embodiment 4, crude drug weight proportion: 30 parts of xanthorrhizas, pick up the ears 12 parts, 10 parts of Alga Sgrgassi Enervess, 12 parts of Cortex Ponciri trifoliatae, 10 parts of Radix Sophorae Flavescentiss, 12 parts of Herba Equiseties Hiemalis, go back 12 parts, bobbin, 12 parts of Radix Ranunculi Ternatis, 12 parts of Herba Dracocephalis, 5 parts of Geckos, 10 parts of Folium et Ramulus Callicarpae nudiflorae, 25 parts of Fructus Setariae Germinatus (parched to brown).

The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:

(1) will go back bobbin, pick up the ears, Radix Sophorae Flavescentis coarse powder soaks separately after 4 hours and extracts volatile oil 6 hours with vapor distillation, and mixing for standby use after collecting, medicinal residues are standby;

(2) Gecko, Fructus Setariae Germinatus (parched to brown) were pulverized to 150 mesh sieves, and became fine powder standby;

(3) gained medicinal residues in xanthorrhiza, Alga Sgrgassi Enerves, Cortex Ponciri trifoliatae, Herba Equiseti Hiemalis, Radix Ranunculi Ternati, Herba Dracocephali, Folium et Ramulus Callicarpae nudiflorae and step 1 are mixed with 5 times and measure 80% ethanol extractions 2 times, each 2 hours, merge ethanol extract twice, filter the extractum that when recovery ethanol concentrating under reduced pressure become 60 ℃, relative density is 1.25～1.30;

(4) add gained extractum in step 3 to mix gained fine powder in step 2,60 ℃ of oven dry, are ground into fine powder, add Tween-80 granulation, dry, and granulate, sprays into gained volatile oil in step 1, mix packing and get final product.

During use, getting appropriate granule dresses in SHENQUE acupoint (umbilicus) and locates with vinegar, twice of every day.

Effective combination of said medicine, coordinates mutually, effectively reach the object of using for after cholangitis,stenosing surgical bypass operation, and side effect is less.The above results is that clinical data fully proves, interrelated data is as follows.

1 object and method.

1.1 object.

1.1.1 case selection: case is selected from that in March, 2006 ~ 2012 are diagnosed as cholangitis,stenosing 21 examples year March and the portal vein liver interior door cavities thanking (TIPS) and in postoperative 10 days, severe complication patient does not occur of passing through.21 examples are male, 19 ~ 41 years old age, 30.3 ± 6.5 years old mean age.Be divided at random two groups: matched group 10 examples, Chinese drug-treated group 11 examples.Before two groups of patient treatments, on age, the state of an illness, the course of disease, liver function, Surgical Operation, operating time, compare, and difference not statistically significant (P > 0.05), there is comparability.

1.1.2 diagnostic criteria: patient's clinical manifestation and lab testing are all supported following diagnostic criteria: the 1. characteristic abnormal cholangiography sign of the tool biliary tract of segmental or the popularity (change); 2. abnormal clinical, biochemical or liver histological is found.Side by side divided by lower situation: 1. biliary tract calcification (except situation) in resting stage; 2. operation on biliary tract (containing simple cholecystectomy); 3. congenital biliary tract is abnormal; 4. the biliary tract pathological changes that acquired immune deficiency syndrome (AIDS) is relevant; 5. ischemic is narrow; 6. tumor of biliary tract; 7. be exposed to and there is (as formalin) under zest chemical substance; 8. other hepatopathys (as constitutional bile duct sclerosis or chronic active hepatitis).

1.2 method.

1.2.1 Therapeutic Method: matched group: give postoperative conventional therapy (comprising the use of surgery nutrition, antibiotic, gastric mucosa protectant); Chinese drug-treated group starts to add the embodiment 1 gained decoction described in embodiment from postoperative 10d on matched group medication basis, and after medication 1m, for easy to use, use embodiment 3 gained granules instead and dress in SHENQUE acupoint, 2 times/d, 5 months service time.

1.2.2 observation item: occur situation with examining the liver failure of two groups of patients of record in the time of 3 months, 6 months, 12 months.Liver failure diagnostic criteria is comply with Chinese Medical Association in 2006 and is infected " the liver failure practice guidelines " that disease credit meeting liver failure and the heavy hepatopathy of artificial liver Xue Zu, Chinese Medical Association hepatopathy credit meeting and artificial liver group are promulgated: (1) acute hepatic failure: Acute onset, in 2 weeks, there is II degree and above hepatic encephalopathy, jaundice can be less than 10 times of Upper Limit of Normal Values, in a short time the intensification of carrying out property of jaundice; Have a medical check-up or ultrasonic carrying out property of prompting liver is dwindled.(2) subacute liver failure: onset is more anxious, period of disease is limited to 15～26 weeks, jaundice is deepened rapidly, require to be greater than 10 times of Upper Limit of Normal Values or every day rising >=17.1umol/L.(3) slow extra urgaent dispatch (subacute) liver failure: on chronic hepatopathy basis, above-mentioned acute (subacute) liver function occurs in a short time and lose compensatory performance, chemical examination TBIL >=171umol/L, simultaneously PTA≤40%.(4) chronic liver failure: on liver cirrhosis basis, carrying out property of liver function goes down and loses compensatory.Diagnostic point is: 1. have ascites or other portal hypertensions performance (hemogram reduction, digestive tract hemorrhage etc.); 2. can there is hepatic encephalopathy; 3. serum total bilirubin raises (can be less than 10 times of Upper Limit of Normal Values), and albumin obviously reduces; 4. must there is coagulation disorders, PTA≤40%.

1.2.3 statistical analysis: SPSS 13.0 carries out statistical analysis.Enumeration data χ ²check, sample number is less than 40, uses Fisher ' s check.

2 results.

There is number of cases in the liver failure in 2.1 liang of group patients 3 months, 6 months, 12 months: as shown in the table;

Group	Number of cases	3 months	6 months	12 months
					Matched group	10	4	5	6
Chinese drug-treated group	11	1	2	4

Result demonstration, 3 months, 6 months points of Chinese drug-treated group, have statistical significance (P<0.05) with matched group comparing difference; 12 months points, Chinese drug-treated group liver failure occurs that number of cases is less than matched group, but difference not statistically significant (P>0.05).

2.2 liang of group adverse reactions of patients incidence rates comparison: two groups all do not occur obvious adverse reaction record.

3. conclusion.

This result of study shows, use after Chinese drug-treated group of the present invention, the incidence rate of liver failure is starkly lower than matched group, and there is not obvious adverse reaction record, illustrate that deposited umbilicus agent use after cholangitis,stenosing surgical bypass operation prepared by the inventive method has good effect, the lighter advantage of untoward reaction.

Claims (1)

1. postoperative deposited umbilicus agent of cholangitis,stenosing and preparation method thereof, it is characterized in that, by the crude drug of following weight proportion, be prepared from: 10 ~ 30 parts of xanthorrhizas, pick up the ears 6 ~ 12 parts, 3 ~ 10 parts of Alga Sgrgassi Enervess, 6 ~ 12 parts of Cortex Ponciri trifoliatae, 3 ~ 10 parts of Radix Sophorae Flavescentiss, 6 ~ 12 parts of Herba Equiseties Hiemalis, go back 6 ~ 12 parts, bobbin, 6 ~ 12 parts of Radix Ranunculi Ternatis, 6 ~ 12 parts of Herba Dracocephalis, 1 ~ 5 part of Gecko, 3 ~ 10 parts of Folium et Ramulus Callicarpae nudiflorae, 10 ~ 25 parts of Fructus Setariae Germinatus (parched to brown); By following steps, formed:

(1) will go back bobbin, pick up the ears, Radix Sophorae Flavescentis coarse powder soaks separately after 4 hours and extracts volatile oil oil 6 hours with vapor distillation, and mixing for standby use after collecting, medicinal residues are standby;

(2) Gecko, Fructus Setariae Germinatus (parched to brown) were pulverized to 150 mesh sieves, and became fine powder standby;

(3) gained medicinal residues in xanthorrhiza, Alga Sgrgassi Enerves, Cortex Ponciri trifoliatae, Herba Equiseti Hiemalis, Radix Ranunculi Ternati, Herba Dracocephali, Folium et Ramulus Callicarpae nudiflorae and step 1 are mixed with 5 times and measure 80% ethanol extractions 2 times, each 2 hours, merge ethanol extract twice, filter the extractum that when recovery ethanol concentrating under reduced pressure become 60 ℃, relative density is 1.25～1.30;

(4) add gained extractum in step 3 to mix gained fine powder in step 2,60 ℃ of oven dry, are ground into fine powder, add Tween-80 granulation, dry, and granulate, sprays into gained volatile oil in step 1, mix packing and get final product.