CN103520471A - Bitterness covering agent for Chinese medicine mixture - Google Patents
Bitterness covering agent for Chinese medicine mixture Download PDFInfo
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- CN103520471A CN103520471A CN201310492329.XA CN201310492329A CN103520471A CN 103520471 A CN103520471 A CN 103520471A CN 201310492329 A CN201310492329 A CN 201310492329A CN 103520471 A CN103520471 A CN 103520471A
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Abstract
The invention discloses a bitterness covering agent for Chinese medicine mixture. The Chinese medicine mixture is prepared from the following raw materials in part by weight: 180 parts of rehmannia, 160 parts of radix ophiopogonis, 260 parts of radix scrophulariae, 315 parts of fructus forsythiae, 315 parts of scutellaria baicalensis, 0.2-0.8 part of neotame and 4-12 parts of extractum glycyrrhizae. Compared with the other bitterness covering agents, the bitterness covering agent has the advantages of high matching rate, few dosage, comfortable mouthfeel, high stability and the like, and the orally-taking compliance of patients is improved to a great degree, and therefore, the bitterness covering agent brings high additional value for products.
Description
Technical field
the present invention relates to field of traditional Chinese medicine pharmacy, be specifically related to a kind of bitterness masking agent of herb mixture, and a kind of herb mixture of good mouthfeel.
Background technology
described herb mixture is by 180 parts of Chinese crude drugs, 160 parts of Radix Ophiopogonis, and 260 parts of Radix Scrophulariaes, 315 parts of 315 parts of Fructus Forsythiaes and Radix Scutellariaes are made.Having the effects such as yin nourishing, moistening and cleaning throat, removing toxic substances, is treatment limitation pharyngeal diphtheria, calomel poisoning type diphtheria, acute tonsillitis, anginal common medicine.The main effective ingredient of this mixture comprises baicalin and phillyrin etc., taste is extremely bitter, easily cause nausea and vomiting when patient takes medicine, cause patient to be difficult to accept, carrying out smoothly of impact treatment, thereby the drug compliance that has limited to a certain extent the extensive use of this mixture, particularly child and old man is poorer.Therefore, we think that the bitterness masking agent mating with it for this mixture development is very important.
Think that at present the taste masking mechanism of Chinese medicine mainly comprises following several: 1. add correctives to make taste bud produce illusion; 2. avoid bitter drug to contact with the direct of taste bud; 3. reversible and temporarily benumb taste bud; 4. by competing bitterness receptors or block it with medicine, to brain, send bitterness signal.Conventional concealing method has: 1, add sweeting agent, aromatic is covered bitter taste of drug; 2, with mucilage, cover bitter taste of drug; 3, add ion exchange resin and cover bitter taste of drug ion; When 4, the screening agent such as tannic acid, glycerol, lactic acid, citric acid, tartaric acid makes medicine dissolution, form with it difficulty soluble salt, and packaging medicine granule stops it in oral cavity, to dissolve rapidly.5, prepare microcapsule or microsphere or use coating, clathrate technology to cover bitterness; 6, with Mentholum or Herba Menthae wet goods paralysis gustatory cell, cover bitterness.In said method, method 1 is that cost is minimum, the bitterness method of covering of applicable mixture.Affect the factor more complicated of bitterness masking agent effect.On the one hand, cover the chemical composition of effect and preparation, pH value, temperature, dosage forms etc. are closely related; On the other hand, the consumption of masking agent must require to adapt with the quality of the pharmaceutical preparations, and for example masking agent is to curative effect of medication, the impact of preparation relative density, stability; In addition the threshold of perception current of bitterness is very little, and the persistent period is longer, is not easy to eliminate; Therefore develop a kind of highly with preparation matching degree, and the bitterness masking agent of good mouthfeel, is the work that challenge is higher to pharmacy work person.
summary of the invention
For improving the mouthfeel of mixture, the invention provides a kind of and this mixture matching degree high, the bitterness masking agent of good mouthfeel, also provides a kind of herb mixture with good taste simultaneously.
Technical scheme of the present invention is:
A bitterness masking agent, described herb mixture is by weight by 180 parts of Chinese crude drug Radix Rehmanniae, 160 parts of Radix Ophiopogonis, 260 parts of Radix Scrophulariaes, 315 parts of 315 parts of Fructus Forsythiaes and Radix Scutellariaes are made, and it is characterized in that: above-mentioned bitterness masking agent is by 0.2～0.8 part of neotame, 4～12 parts of compositions of Radix Glycyrrhizae extract.
Described bitterness masking agent optimum ratio is by 0.4 part of neotame, 6 parts of compositions of Radix Glycyrrhizae extract.
Described bitterness masking agent also can comprise 2～6 parts of fruity flavors.
Described fruity flavor is orange taste or Fructus Fragariae Ananssae taste essence.
With respect to prior art, beneficial effect of the present invention is mainly reflected in:
1. the matching degree of bitterness masking agent of the present invention and this mixture medicinal liquid is high, and low concentration can cover institute
The numb feeling in the tongue of stating the bitterness in mixture medicinal liquid and being produced by preservative sodium benzoate; And entrance, stay mouthful without bitterness, sweet taste is moderate.Add after fruity flavor, can set off fruit aroma, comfortable taste, is applicable to more crowd, particularly child's old people garment use, makes the compliance that patient takes medicine obtain improving largely.
2. bitterness masking agent stability of the present invention is high, and consumption is few, does not produce untoward reaction and affects curative effect of medication and other quality index with this mixture medicinal liquid.
3.the raw material of bitterness masking agent of the present invention is easy to get inexpensive, and preparing process is simple, so production cost is lower, because mouthfeel improvement is obvious, for product brings higher added value.
4, the experiment proved that: the herb mixture that adds bitterness masking agent of the present invention to make not only has good mouthfeel, and the indices such as Chinese medicine adjuvant change all meets national standard and China's medicine registration management way regulation.
The specific embodiment
One, preparation mixture medicinal liquid of the present invention.
1. write out a prescription
315 grams of Radix Scutellariaes, 180 grams of Radix Rehmanniae, 160 grams of Radix Ophiopogonis, 260 grams of Radix Scrophulariaes, 315 grams of Fructus Forsythiaes.
2, preparation method
Get the Chinese medicine of the five flavours in above-mentioned prescription, be ground into coarse powder, with 57% ethanol, make solvent, flood after 24 hours, with the speed of about 1ml per minute percolation slowly, collect the about 6000ml of liquid that filters, decompression recycling ethanol is also concentrated into about 1400ml, adds water 800ml, boil 30 minutes, standing 48 hours, filter a small amount of water washing of filtering residue, washing liquid is incorporated in filtrate, is evaporated to 1000ml, adds sodium benzoate 3g, stirs evenly, standing 24 hours, filter, get filtrate, add water and make into 1000ml, stir evenly, obtain.
Two, contain the preparation of bitterness masking agent medicinal liquid sample
Get above-mentioned mixture medicinal liquid 1000ml, add in proportion bitterness masking agent of the present invention to be mixed with test specimen, the concrete proportioning of described masking agent and evaluation are listed in Table 1.
Reagent:
1. neotame, market can be bought, food stage, purity > 95%.
2. Radix Glycyrrhizae extract, food stage, every gram of Radix Glycyrrhizae extract is equivalent to 1g Radix Glycyrrhizae crude drug, by commercially available purchase, can obtain.
3. fruity flavor
(1) orange taste essence, product type is 98AF1415, has the function that increases orange taste local flavor, by purchase, obtains.
(2) Fructus Fragariae Ananssae taste essence, has the function that increases Fructus Fragariae Ananssae taste local flavor, by purchase, obtains.
Three, bitterness masking agent screening test of the present invention.
Sample preparation: get this mixture appropriate, add respectively different odor masks by EXPERIMENTAL DESIGN, after dissolving completely, be settled to 1L with this mixture medicinal liquid.
Screening technique: choose respectively the conventional bitterness masking agent of neotame, sucralose and 3 kinds of safe medical products of Radix Glycyrrhizae extract, and sodium citrate, orange taste essence, strawberry essence, the bitterness masking agent formula and this mixture medicinal liquid that by one-component, two component, three components, are combined into a plurality of proportionings are deployed into test specimen.
Adopt single blind method, ask the experimenter at 50 10 years old to 60 years old ages to carry out integrated taste evaluation to each formula sample, evaluation methodology is the most frequently used in the industry " three-point assay method ", evaluates respectively entrance mouthfeel, stays a mouthful mouthfeel, 3 leading indicators of numb feeling in the tongue.Using majority's suggestion as final appraisal results.
Taste appraisal divides four grades, is respectively poor (Yi “ – " represent), can accept ("+" represents), good (with " ++ ", representing), fine (with " +++ ", representing).
Sample quality checks: by " can accept " above grade formula being carried out to quality examination under the drug standard item of state approval, inspection item comprises pH value, relative density, content of baicalin etc.
Table 1
Analyze: from the experimental result of table 1, inventor is surprised to find that, the formula effect being comprised of neotame 0.2～0.8g and Radix Glycyrrhizae extractum 4～12g is best, is secondly the three component formulas that above-mentioned formula adds appropriate fruity flavor or sodium citrate.Above-mentioned sample is through quality examination, and the three component formula relative densities of adding sodium citrate are defective, do not consider.The prescription of the samples met medicine of all the other formulas, the bitterness masking agent that can be used as this mixture is used.The bitterness of the low dosage compound recipe formula being comprised of neotame and Radix Glycyrrhizae extractum is covered one-component formula and other compound recipes that successful is better than high dose and is filled a prescription, and we infer may be to have produced concerted reaction between its component.
The bitterness of the mixture the present invention relates to is mainly derived from Fructus Forsythiae and the Radix Scutellariae in formula.Press tcm theory, inventor thinks, bitterness masking agent of the present invention is covered applicable to the bitterness of the Chinese medicine preparation containing Fructus Forsythiae and Radix Scutellariae, containing the Chinese medicine preparation of Fructus Forsythiae and Radix Scutellariae as used bitterness masking agent of the present invention also should fall into protection scope of the present invention.
Claims (5)
1. the bitterness masking agent of a herb mixture, described herb mixture is by weight by 180 parts of Chinese crude drug Radix Rehmanniae, 160 parts of Radix Ophiopogonis, 260 parts of Radix Scrophulariaes, 315 parts of 315 parts of Fructus Forsythiaes and Radix Scutellariaes are made, it is characterized in that: above-mentioned bitterness masking agent is by 0.2～0.8 part of neotame 4～12 parts of compositions of Radix Glycyrrhizae extract.
2. bitterness masking agent as claimed in claim 1, is characterized in that: described bitterness masking agent is by 0.4 part of neotame, 6 parts of compositions of Radix Glycyrrhizae extract.
3. bitterness masking agent as claimed in claim 1 or 2, is characterized in that: described bitterness masking agent also comprises 2～6 parts of fruity flavors.
4. bitterness masking agent as claimed in claim 3, is characterized in that: described fruity flavor is orange taste or Fructus Fragariae Ananssae taste essence.
5. a herb mixture, described herb mixture is by 180 parts of Chinese crude drug Radix Rehmanniae, 160 parts of Radix Ophiopogonis, 260 parts of Radix Scrophulariaes, 4～12 parts of 315 parts of Fructus Forsythiaes, 315 parts of Radix Scutellariaes, 0.2～0.8 part of neotame and Radix Glycyrrhizae extracts are made.
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| CN201310492329.XA CN103520471B (en) | 2013-10-21 | 2013-10-21 | A kind of bitter taste masking agent of herb mixture |
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| CN201310492329.XA CN103520471B (en) | 2013-10-21 | 2013-10-21 | A kind of bitter taste masking agent of herb mixture |
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| CN103520471A true CN103520471A (en) | 2014-01-22 |
| CN103520471B CN103520471B (en) | 2016-05-04 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108113962A (en) * | 2018-02-23 | 2018-06-05 | 成都中医药大学 | A kind of method for reducing the oral preparation of Chinese traditional medicinal astringent taste containing polyphenol |
| CN112870372A (en) * | 2021-04-09 | 2021-06-01 | 陕西中财润德医药科技有限公司 | Traditional Chinese medicine composition for improving bad taste of traditional Chinese medicine decoction and preparation method |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101095827A (en) * | 2007-07-03 | 2008-01-02 | 玄振玉 | Chinese traditional medicine preparations for treating laryngopharynx disease and method for preparing the same |
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- 2013-10-21 CN CN201310492329.XA patent/CN103520471B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101095827A (en) * | 2007-07-03 | 2008-01-02 | 玄振玉 | Chinese traditional medicine preparations for treating laryngopharynx disease and method for preparing the same |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108113962A (en) * | 2018-02-23 | 2018-06-05 | 成都中医药大学 | A kind of method for reducing the oral preparation of Chinese traditional medicinal astringent taste containing polyphenol |
| CN112870372A (en) * | 2021-04-09 | 2021-06-01 | 陕西中财润德医药科技有限公司 | Traditional Chinese medicine composition for improving bad taste of traditional Chinese medicine decoction and preparation method |
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| CN103520471B (en) | 2016-05-04 |
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Address after: 570311 No. 6, Yaogu Third Road, Yaogu Industrial Park, national high tech Industrial Development Zone, Haikou City, Hainan Province Patentee after: HAINAN HONZ PHARMACEUTICAL Co.,Ltd. Patentee after: SHENYANG KANGZHI PHARMACEUTICAL Co.,Ltd. Patentee after: HEBEI KANGZHI PHARMACEUTICAL Co.,Ltd. Address before: 570311 No. 6, Yaogu Third Road, Yaogu Industrial Park, national high tech Industrial Development Zone, Haikou City, Hainan Province Patentee before: Honz Pharmaceutical Co.,Ltd. Patentee before: SHENYANG KANGZHI PHARMACEUTICAL Co.,Ltd. Patentee before: HEBEI KANGZHI PHARMACEUTICAL Co.,Ltd. |
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