CN103520392B - A kind of Chinese medicine composition for the treatment of xerophthalmia and preparation method thereof - Google Patents
A kind of Chinese medicine composition for the treatment of xerophthalmia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine composition for the treatment of xerophthalmia and preparation method thereof, belong to the field of Chinese medicines; With Chinese crude drug Folium fici microcarpae, Lignum Sappan, Rhizoma Bolbostematis, Folium Malvae, Flos Carthami, Herba Euphorbiae Humifusae and Medulla Junci for material combination makes active component, Chinese medicine granules or effervescent is made with common drug pharmaceutical adjunct, stifling or atomization eye during use, this Chinese medicine composition has the therapeutical effect determined to xerophthalmia.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicine composition for the treatment of xerophthalmia and preparation method thereof, belong to technical field of Chinese medicines.
Technical background
Social activity development and work and study environment change, the reading method of people also changes thereupon, xerophthalmia is one of modal disease of ophthalmology, this illness is after many factors makes eyeball surface water quality, mucus and Lipid Secretion, the tear quality and quantity disequilibrium caused and a series of syndromes occurred.
Being closely related, interdepending and do as a whole playing a role between eye superficial epithelium and tear film, instead of isolatedly to exist; Tear kinetics comprises: the generation of tear, distribution, evaporation and removing, and any one link of above Four processes occurs extremely will cause xerophthalmia, and xerophthalmia is dynamic (dynamical) abnormal and eye superficial epithelium is abnormal caused by tear.
Radiation, environmental pollution, weather, the many reasons such as medicine all bring out the generation of xerophthalmia, comprise constitutional lacrimal gland diseases, sarcoid, graft versus host disease, lachrymal gland blocks, rheumatic arthritis, systemic lupus erythematosus (sle), systemic sclerosis, sand holes, burn, cicatricial class sky herpes, neuroparalytic keratitis, facial paralysis, meibomian gland dysfunction, blepharitis, mucin lacks, to twinkle exception, margo palpebrae malposition, angle conjunctival operation otch, ultraviolet, contact lens is worn improper, tricyclic antidepressant, anti-handkerchief Jin Shi medicine, oral contraceptive, resisting hypertension and anti-arrhythmic all can cause xerophthalmia to occur.The main clinical manifestation of xerophthalmia is sensation of dryness, foreign body sensation, burning sensation, gargalesthesia, photophobia, furious, blurred vision, vision fluctuation and asthenopia etc.
Drug therapy at present with regard to xerophthalmia mainly comprises: artificial tears, glucocorticoid, immunosuppressant, autoserum, gonadal hormone and Chinese medicine etc., various medicine has respective curative effect advantage.
The traditional Chinese medical science thinks that xerophthalmia belongs to " dry disease " category, liver opening at eye, tear makes moist liver key and order; The hepatic and renal YIN deficiency, deficiecny of liver-YIN is the main cause that xerophthalmia occurs.Meanwhile, " General Treatise on the Cause and Symptoms of Diseases " is said: " husband's vital organs of the human body all have body fluid, lead in order person for tear.", " order, the time of liver also, essences of ZANG FU-organs China, high feeling pulse gather, Shang Yezhi road, its liquid person of exhausting, then order is puckery.", xerophthalmia occurs with the vital organs of the human body closely related, when the five internal organs imbalance, must cause lung, liver, kidney Tianjin wound, and xerophthalmia occurs.
Chinese invention patent publication number CN102824547A discloses " Traditional Chinese medicine ultrasonic atomization agent for the treatment of xerophthalmia and preparation method thereof ", and the raw material of Chinese medicine of this Traditional Chinese medicinal aerosol comprises Radix Ophiopogonis, Radix Adenophorae (Radix Glehniae), Radix Bupleuri, the Radix Angelicae Dahuricae, Flos Chrysanthemi, Fructus Lycii, Herba Dendrobii, Folium Mori, Radix Saposhnikoviae, Fructus Viticis, Herba Menthae composition; Chinese invention patent publication number CN10102973842A discloses " a kind of Chinese medicine for the treatment of xerophthalmia smokes washing liquid ", and the raw material of Chinese medicine that this Chinese medicine smokes washing liquid comprises Herba Senecionis Scandentis, Indigo Naturalis, Herba Eragrostidis Poaeoidis, Herba Clinopodii megalanthi, Radix Paeoniae Rubra, Folium Vaccinii Fragilis, Semen Vaccariae, Rhizoma Polygonati Odorati, Fructus Ligustri Lucidi, Semen Cuscutae, Semen Coicis composition.Chinese invention patent publication number CN101632781B discloses " application of a kind of Chinese medicine composition in preparation treatment dry eye drugs ", and this Chinese medicine composition comprises Radix Ginseng, Radix Ophiopogonis, Fructus Corni, Radix Salviae Miltiorrhizae, Semen Ziziphi Spinosae, Herba Taxilli, Radix Paeoniae Rubra, Eupolyphaga Seu Steleophaga, Radix Et Rhizoma Nardostachyos composition.The Chinese medicine composition of current report treatment xerophthalmia is mainly based on the rule for the treatment of of replenishing YIN and removing heat legislation prescription.
The present invention screens the Chinese medicine composition with heat clearing and blood circulation promoting effect obtained from Chinese crude drug, play heat clearing and blood circulation promoting effect, adopt suitable external method, as outer smoked, atomization etc., thus improve the effect of patient's xerophthalmia, overcome the detrimental effect of antiseptic in artificial tears.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition, under guidance of traditional Chinese medicine theory, by the rational proportion of each medical material, synergism, the effect for the treatment of xerophthalmia is played in external; Another one object of the present invention is to provide the preparation method of this Chinese medicine composition.This cataplasma steady quality, reliability is strong, good with skin-compatible, stimulates little, and technique is rationally advanced, workable.
The Chinese medicine composition for the treatment of xerophthalmia of the present invention, Folium fici microcarpae, Lignum Sappan, Rhizoma Bolbostematis, Folium Malvae, Flos Carthami, Herba Euphorbiae Humifusae, Medulla Junci is selected to be raw material, wherein Folium fici microcarpae heat-clearing and toxic substances removing, Lignum Sappan blood circulation promoting and blood stasis dispelling, Rhizoma Bolbostematis heat-clearing and toxic substances removing, Folium Malvae heat-clearing and toxic substances removing, Flos Carthami blood circulation promoting and blood stasis dispelling, Herba Euphorbiae Humifusae heat-clearing and toxic substances removing, Medulla Junci heat clearing away, each Chinese medicine composition compatibility, plays heat clearing and blood circulation promoting effect.
The raw material dosage preparing medicine activity component of the present invention is: Folium fici microcarpae 10-30 part, Lignum Sappan 5-20 part, Rhizoma Bolbostematis 10-20 part, Folium Malvae 10-20 part, Flos Carthami 3-10 part, Herba Euphorbiae Humifusae 10-30 part, Medulla Junci 5-20 part; Be preferably Folium fici microcarpae 12 parts, Lignum Sappan 9 parts, Rhizoma Bolbostematis 12 parts, Folium Malvae 12 parts, 5 parts, Flos Carthami, Herba Euphorbiae Humifusae 12 parts, Medulla Junci 9 parts.
Chinese medicine composition of the present invention can adopt Chinese medicine preparation conventional method to be prepared into conventional formulation, can be effervescent tablet, granule etc., dissolves during clinical practice with high-temperature-hot-water, stifling eye; Also can pass through ultrasonic atomizatio equipment, carry out atomized medicine introducing.
Below in conjunction with embodiment, the invention will be further elaborated
Embodiment 1 effervescent tablet preparation of the present invention
Each crude drug is taken: Folium fici microcarpae 120 grams, Lignum Sappan 90 grams, Rhizoma Bolbostematis 120 grams, Folium Malvae 120 grams, 50 grams, Flos Carthami, Herba Euphorbiae Humifusae 120 grams, Medulla Junci 90 grams are for subsequent use by following weight; The Folium fici microcarpae of above-mentioned weight, Lignum Sappan, Rhizoma Bolbostematis, Folium Malvae, Flos Carthami, Herba Euphorbiae Humifusae, Medulla Junci mixing, add 6 times amount water soaking 2 hours, heating decoction 1.5 hours, filter, medicinal residues add 5 times of water gaging heating decoctions 1 hour again, filter, merge twice filtrate, leave standstill 1 hour, pour out supernatant; Relative density 1.10 clear paste during supernatant concentration to 60 DEG C, 60 DEG C of vacuum dryings, obtain solid content 70 grams; Pulverize dry solid content, obtain fine powder after sieving, add conventional effervescent tablet adjuvant and make granule, dry, tabletting.
Embodiment 2 granule preparation of the present invention
Each crude drug is taken: Folium fici microcarpae 150 grams, Lignum Sappan 200 grams, Rhizoma Bolbostematis 100 grams, Folium Malvae 100 grams, 100 grams, Flos Carthami, Herba Euphorbiae Humifusae 150 grams, Medulla Junci 200 grams are for subsequent use by following weight; The Folium fici microcarpae of above-mentioned weight, Lignum Sappan, Rhizoma Bolbostematis, Folium Malvae, Flos Carthami, Herba Euphorbiae Humifusae, Medulla Junci mixing, add 5 times amount water soaking 1.5 hours, heating decoction 1 hour, filter, medicinal residues add 4 times of water gaging heating decoctions 1 hour again, filter, merge twice filtrate, leave standstill 1 hour, pour out supernatant; Relative density 1.08 clear paste during supernatant concentration to 60 DEG C, 60 DEG C of vacuum dryings, obtain solid content 100 grams; Pulverize dry solid content, obtain fine powder after sieving, add conventional granulates agent adjuvant, make granule.
Embodiment 3 granule preparation of the present invention
Each crude drug is taken: Folium fici microcarpae 300 grams, Lignum Sappan 50 grams, Rhizoma Bolbostematis 200 grams, Folium Malvae 200 grams, 30 grams, Flos Carthami, Herba Euphorbiae Humifusae 300 grams, Medulla Junci 50 grams are for subsequent use by following weight; The Folium fici microcarpae of above-mentioned weight, Lignum Sappan, Rhizoma Bolbostematis, Folium Malvae, Flos Carthami, Herba Euphorbiae Humifusae, Medulla Junci mixing, add 5 times amount water soaking 1.5 hours, heating decoction 1 hour, filter, medicinal residues add 4 times of water gaging heating decoctions 1 hour again, filter, merge twice filtrate, leave standstill 1 hour, pour out supernatant; Relative density 1.08 clear paste during supernatant concentration to 60 DEG C, 60 DEG C of vacuum dryings, obtain solid content 110 grams; Pulverize dry solid content, obtain fine powder after sieving, add conventional granulates agent adjuvant, make granule.
Experimental example 1
1. data and method
1.1 physical data
Select xerophthalmia patients 67 example (134 eyeballs), symptom be eyes dry and astringent, have foreign body sensation, can not watching for a long time, eyestrain etc., all meet the diagnostic criteria of xerophthalmia after diagnosing.Wherein, male 48 example, women 19 example, 43.5 ± 7.9 years old age.All patients are the xerophthalmia caused by long-term eye, get rid of the patients with dry eye that other cause because of operated eye, autoimmune disease, ophthalmic diseases.
1.2 case groupings
Case is divided into two groups according to the principle of random packet: matched group and herbal fumigation group (Chinese medicine composition of the present invention).Wherein, matched group 33 example (66 eyeball), atomization group 34 example (68 eyeball); Two groups of patients compare there was no significant difference in case load, age, sex, have comparability (p > 0.05).
1.3 Therapeutic Method
Matched group uses carbomer eye drop, every day 4 times, each 1, in instillation eyelid; After Chinese drug-treated group uses medicine of the present invention more than 80 DEG C hot water to wash open, medicinal liquid produces steam and fumigates eye, is advisable not stimulate eye socket peripheral skin temperature.
1.4 evaluation index
1.4.1 dry eye symptoms scoring
Asymptomatic person, idol have symptom, often have symptom, have manifest symptom to count 0 point, 0.5 point, 1 point and 2 points respectively.Treatment Patients Before And After self-appraisal score.
1.4.2 Schimer's test
Adopt lacrimal secretion Schirmer test, cure: lacrimal secretion is more than or equal to 10mm/5min; Effective: tear amount increases more than 3mm/min; Take a turn for the better: tear amount increases more than 1mm/min; Invalid: tear amount is unchanged.Detection record before and after treatment.Total effective rate=cure rate+obvious effective rate.
1.5 data statistics
Measurement data represents with means standard deviation.Data SPSS13.0 software kit is added up, and between group, measurement data adopts t inspection, enumeration data x
2inspection.P < 0.05 is for there being significant difference.
2. result
2.1 dry eye symptoms appraisal result
Before two groups of treatments, dry eye condition are substantially identical, comparatively all have clear improvement before treatment after treatment, after two groups of treatments symptom score with treat before mark to compare there is significant difference p < 0.05; After Chinese drug-treated group treatment, scoring is marked to compare with matched group and is had significant difference p < 0.05, and prompting Chinese drug-treated group curative effect is better than artificial tears's treatment, and before and after two groups of treatments, symptom score the results are shown in Table 1.
Table 1 liang group patient dry eye symptoms appraisal result
Compare with before treatment after # treatment, p < 0.05; * Chinese drug-treated group compares with matched group, p < 0.05
2.2 Schimer's test results
After two groups of treatments, matched group total effective rate is 84.8%, Chinese drug-treated group total effective rate is 97.1%, two groups of total effective rates compare and have significant difference (p < 0.05), and prompting Chinese drug-treated group curative effect is better than artificial tears's treatment, and two groups of Schimer's tests the results are shown in Table 2.
Table 2 liang group Schimer's test result
* Chinese drug-treated group compares with matched group, p < 0.05.
Claims (4)
1. treat a Chinese medicine composition for xerophthalmia, it is characterized in that its active component is made up of the crude drug of following weight portion: Folium fici microcarpae 10-30 part, Lignum Sappan 5-20 part, Rhizoma Bolbostematis 10-20 part, Folium Malvae 10-20 part, Flos Carthami 3-10 part, Herba Euphorbiae Humifusae 10-30 part, Medulla Junci 5-20 part.
2. Chinese medicine composition according to claim 1, wherein the consumption of each crude drug is: Folium fici microcarpae 12 parts, Lignum Sappan 9 parts, Rhizoma Bolbostematis 12 parts, Folium Malvae 12 parts, 5 parts, Flos Carthami, Herba Euphorbiae Humifusae 12 parts, Medulla Junci 9 parts.
3. the preparation method of Chinese medicine composition according to claim 1 or 2, comprises the steps:
1) take each crude drug Folium fici microcarpae, Lignum Sappan, Rhizoma Bolbostematis, Folium Malvae, Flos Carthami, Herba Euphorbiae Humifusae, Medulla Junci are for subsequent use;
2) by the Folium fici microcarpae of above-mentioned weight proportion, Lignum Sappan, Rhizoma Bolbostematis, Folium Malvae, Flos Carthami, Herba Euphorbiae Humifusae, Medulla Junci mixing, add 5-6 times amount water soaking 1-2 hour, heating decoction 1.5 hours, filter, medicinal residues add 3-5 times of water gaging heating decoction 1 hour again, filter, merge twice filtrate, leave standstill 1 hour, pour out supernatant; Relative density 1.05-1.10 clear paste during supernatant concentration to 60 DEG C, 60 DEG C of vacuum dryings; Pulverize dry solid content, after sieving, obtain fine powder, the i.e. active component of this Chinese medicine composition.
4. preparation method according to claim 3, by step 2) active component and the pharmaceutical preparation that obtain commonly uses adjuvant and mixes, and is prepared into effervescent tablet, granule.
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| CN105853645A (en) * | 2016-06-08 | 2016-08-17 | 广州国宇医药科技有限公司 | Traditional Chinese medicine composition for treating dry eye syndrome |
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