CN103520387A - Chinese herba preparation for treating acute mastitis and preparation method thereof - Google Patents
Chinese herba preparation for treating acute mastitis and preparation method thereof Download PDFInfo
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Abstract
The invention provides a Chinese herba preparation for treating acute mastitis and a preparation method thereof. The Chinese herba preparation comprises the following raw medicinal materials: fiveleaf akebia fruit, citrus reticulata leaf, viola philippica, loosestrife, youngia japonica, field sowthistle herb, rhizoma bolbostemmae, shuteria pampaniniana, the root of red-rooted salvia, prinsepia utilis, hemistepta lyrata, stellaria media, adiantum, nauclea officinalis and aizoon stonecrop herb. The Chinese herba preparation has effects of soothing the liver and regulating vital energy, clearing away heat and toxic materials, removing stasis, and relieving swelling and pain, has definite curative effects for acute mastitis, and has small toxic and side effects.
Description
Technical field
The present invention relates to contain the medicinal preparation that derives from plant, animal or mineral component, relate in particular to a kind of Chinese medicine preparation for the treatment of acute mastitis and preparation method thereof.
Background technology
The acute festering type that acute mastitis is caused by staphylococcus aureus mostly infects.Clinical manifestation mainly contains distending pain of the breast, fear of cold, heating, local red, swollen, hot, bitterly, touches lump, leucocytosis.Great majority have nipple damage, chap or long-pending newborn medical history.Often there is women breast-feeding their children, the especially primipara in 1-2 month puerperal in primary disease.Pathogenic bacteria generally, from nipple cut or the intrusion of chapping, also can directly be invaded and cause infection.Western medical treatment generally adopts antibiotic therapy, though there is good therapeutic effect, has certain toxic and side effects, and likely causes drug resistance.
Primary disease belongs to motherland's medical science " acute mastitis " category.The traditional Chinese medical science thinks that nipple belongs to liver, and breast belongs to stomach, at the beginning of milk unit in stomach, if stagnation of liver-QI gastric heat, depression of liver-QI, the gas of the moon of fainting is not all right and lose in catharsis and add puerperal asthenia, eating and drinking without temperance, causes depression of liver-QI, excessiveness of stomach-heat, can make row breast not smooth, qi depression to blood stasis, accumulates in pyretic toxicity and forms carbuncle, therefore treatment focuses on depressed liver-energy dispersing and QI regulating, heat-clearing and toxic substances removing, eliminating stasis and resolving masses, reducing swelling and alleviating pain.
Summary of the invention
Technical problem to be solved by this invention is, a kind of Chinese medicine preparation for the treatment of acute mastitis and preparation method thereof is provided, Chinese medicine preparation depressed liver-energy dispersing and QI regulating of the present invention, and heat-clearing and toxic substances removing, eliminating stasis and resolving masses, reducing swelling and alleviating pain, has definite curative effect to acute mastitis, and toxic and side effects is little.
In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine preparation for the treatment of acute mastitis, its raw medicinal material comprises: Fructus Akebiae, Citrus chachiensis Hort. (C. Suavissima Tanaka), Herba Violae mundae, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis), Herba youngiae japonicae, Sonchus arvensis L., Rhizoma Bolbostematis, HERBA SHUTERIAE, Radix Salviae Miltiorrhizae, Folium Prinsepiae Utilis, Herba Hemisteptae Lyratae, Herba malachii aquatici, black nylon yarn, Lignum et Radix Naucleae and Herba Galii Teneri.
In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material is as follows: 5～15 parts of Fructus Akebiaes, 30～40 parts of Citrus chachiensis Hort. (C. Suavissima Tanaka), 15～25 parts of Herba Violae mundaes, 10～20 parts of Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis), 30～40 parts of Herba youngiae japonicae, 15～25 parts of Sonchus arvensis L., 10～20 parts of Rhizoma Bolbostematiss, 10～20 parts of HERBA SHUTERIAEs, 5～15 parts of Radix Salviae Miltiorrhizaes, 15～25 parts of Folium Prinsepiae Utilis, 10～20 parts of Herba Hemisteptae Lyrataies, 5～15 parts of Herba malachii aquaticis, 5～15 parts of black nylon yarns, 10～20 parts of 10～20 parts of Lignum et Radix Naucleae and Herba Galii Teneris.
In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material can also be preferably: 5～10 parts of Fructus Akebiaes, 30～35 parts of Citrus chachiensis Hort. (C. Suavissima Tanaka), 15～20 parts of Herba Violae mundaes, 10～15 parts of Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis), 30～35 parts of Herba youngiae japonicae, 15～20 parts of Sonchus arvensis L., 10～15 parts of Rhizoma Bolbostematiss, 10～15 parts of HERBA SHUTERIAEs, 5～10 parts of Radix Salviae Miltiorrhizaes, 15～20 parts of Folium Prinsepiae Utilis, 10～15 parts of Herba Hemisteptae Lyrataies, 5～10 parts of Herba malachii aquaticis, 5～10 parts of black nylon yarns, 10～15 parts of 10～15 parts of Lignum et Radix Naucleae and Herba Galii Teneris.
In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material also can be preferably: 6 parts of Fructus Akebiaes, 34 parts of Citrus chachiensis Hort. (C. Suavissima Tanaka), 16 parts of Herba Violae mundaes, 11 parts of Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis), 31 parts of Herba youngiae japonicae, 17 parts of Sonchus arvensis L., 13 parts of Rhizoma Bolbostematiss, 12 parts of HERBA SHUTERIAEs, 8 parts of Radix Salviae Miltiorrhizaes, 17 parts of Folium Prinsepiae Utilis, 12 parts of Herba Hemisteptae Lyrataies, 7 parts of Herba malachii aquaticis, 8 parts of black nylon yarns, 12 parts of 14 parts of Lignum et Radix Naucleae and Herba Galii Teneris.
In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material also can be preferably: 8 parts of Fructus Akebiaes, 31 parts of Citrus chachiensis Hort. (C. Suavissima Tanaka), 18 parts of Herba Violae mundaes, 14 parts of Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis), 33 parts of Herba youngiae japonicae, 16 parts of Sonchus arvensis L., 12 parts of Rhizoma Bolbostematiss, 11 parts of HERBA SHUTERIAEs, 6 parts of Radix Salviae Miltiorrhizaes, 19 parts of Folium Prinsepiae Utilis, 14 parts of Herba Hemisteptae Lyrataies, 8 parts of Herba malachii aquaticis, 6 parts of black nylon yarns, 13 parts of 11 parts of Lignum et Radix Naucleae and Herba Galii Teneris.
The present invention also provides the preparation method of above-mentioned Chinese medicine preparation, and the dosage form of described Chinese medicine preparation is tablet, and its preparation method comprises the following steps:
The first step: each raw medicinal material of described Chinese medicine preparation is mixed in proportion, add the ethanol that the determining alcohol with respect to 3～5 times of mixture qualities is 80～90%, reflux 1～2 hour, extract, filter and obtain the first extracting solution, the medicinal residues that filter to obtain add the ethanol that the determining alcohol with respect to 1～3 times of medicinal residues quality is 80～90% again, reflux 35～45 minutes, extract, filter and obtain the second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure is removed alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step is obtained is placed in super micron mill to be pulverized 1～2 hour, pulverizes and sieves and obtains 200～300 object micropowders;
The 3rd step: add the microcrystalline Cellulose with respect to 0.1～0.3 times of its quality, the lactose of 0.05～0.15 times, the starch of 0.1～0.3 times in the micropowders obtaining at second step, sieve, mix homogeneously, granulate, dry, add the magnesium stearate with respect to 0.005～0.05 times of micropowders quality, granulate, tabletting, makes.
The present invention also provides the preparation method of above-mentioned Chinese medicine preparation, and the dosage form of described Chinese medicine preparation is capsule, and its preparation method comprises the following steps:
The first step, is mixed in proportion each raw medicinal material of described Chinese medicine preparation, adds the ethanol that the determining alcohol with respect to 3～5 times of mixture qualities is 80～90%, and reflux 40～60 minutes is extracted, and filters and obtains the first extracting solution; The medicinal residues that filter to obtain add the ethanol that the determining alcohol with respect to 2～3 times of medicinal residues quality is 85～90% again, and reflux 30～50 minutes, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;
Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 1～2 hour, pulverizes and sieves and obtains 200～300 object micropowders;
The 3rd step, the micropowders obtaining at second step adds the microcrystalline Cellulose with respect to 0.1～0.3 times of its quality, the starch of 0.1～0.3 times, the magnesium stearate of 0.005～0.05 times, mix processing, obtain capsule 's content, described Capsule content is incapsulated in housing, obtain capsule finished product.
The present invention also provides the preparation method of above-mentioned Chinese medicine preparation, and when the dosage form of described Chinese medicine is membranous patch, its preparation method comprises the following steps:
The first step, is mixed in proportion each raw medicinal material of described Chinese medicine preparation, is ground into 100 order～120 object powder, add the ethanol that the determining alcohol with respect to 5～8 times of mixture qualities is 85%～90%, reflux 3～5 hours, extracts, and filters and obtains the first extracting solution; The medicinal residues that filter to obtain add the ethanol that the determining alcohol with respect to 3～5 times of described medicinal residues quality is 90%～95% again, and reflux 2～4 hours, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract, and is ground into 160 order～200 object powder;
Second step, powder 8～10 weight portions prepared by the first step, polyvinyl alcohol 2～3 weight portions, the abundant mix and blend of glycerol 0.5～1 weight portion, to producing without minute bubbles, standing 45～60 minutes, makes mixing paste;
The 3rd step, mixing paste prepared by second step is evenly coated with masking with film-making machine, and under room temperature, dry postforming, cuts into strip, is placed on non-woven fabrics and fixes according to the fixing mode in both sides, containing powder sticking glass paper, obtains membranous patch.
Beneficial effect of the present invention: Chinese medicine preparation depressed liver-energy dispersing and QI regulating of the present invention, heat-clearing and toxic substances removing, eliminating stasis and resolving masses, reducing swelling and alleviating pain, has definite curative effect to acute mastitis, and toxic and side effects is little.
The specific embodiment
The invention provides a kind of Chinese medicine preparation for the treatment of acute mastitis, its raw medicinal material comprises: Fructus Akebiae, Citrus chachiensis Hort. (C. Suavissima Tanaka), Herba Violae mundae, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis), Herba youngiae japonicae, Sonchus arvensis L., Rhizoma Bolbostematis, HERBA SHUTERIAE, Radix Salviae Miltiorrhizae, Folium Prinsepiae Utilis, Herba Hemisteptae Lyratae, Herba malachii aquatici, black nylon yarn, Lignum et Radix Naucleae and Herba Galii Teneri.
In described Chinese medicine preparation, the pharmacology of each raw medicinal material is as follows:
Fructus Akebiae: micro-hardship, property is flat.Return liver, stomach warp.Liver-smoothing, qi-regulating, promoting blood circulation and stopping pain, relieving restlessness diuresis.Treating the liver peratodynia, gastric heat food is slow-witted, excessive thirst, also Hakuri, lumbago, hypochondriac pain, hernia, the tenesmus of Jing， uterus, cave." Shaanxi Chinese herbal medicine ": " Shugan Yishen, invigorating the spleen and regulating the stomach.Control dyspepsia, stomachache, dysentery, hernia, uterus tenesmus.
Citrus chachiensis Hort. (C. Suavissima Tanaka): pungent, hardship, flat.Return spleen, stomach, Liver Channel.Circulation of qi promoting the chest stuffiness relieving, dispersing the stagnated liver-QI for regulating the stomach, removing toxicity for eliminating carbuncles.Main chest and diaphragm is full vexed, distending pain over the hypochondrium, blockage of menstruation, diaphragm carbuncle, acute mastitis, breast carcinoma." it is former that book on Chinese herbal medicine is asked ": control chest and diaphragm against gas, the stagnant gas of row liver stomach, Sweeling-eliminating medicine powder poison.Acute mastitis, acute mastitis, breast carcinoma, hypochondriac pain disappear.Pass through.
Herba Violae mundae: light, cool.Return Liver Channel.Loose wind, heat clearing away, soothing the liver, detumescence.Control wind-fire acute conjunctivitis, corneal nebula hides eyeball, acute mastitis, and scrofula, furuncle is swollen." the southern regions of the Yunnan Province book on Chinese herbal medicine ": dispelling the stagnated QI blood, Shu Yu.Control the sudden and violent red pain of acute conjunctivitis, expelling wind and removing nebula, white membrane in eye, married woman's breast knot is obstructed, red hard swollen.The person's of spending in vain ophthalmology is good, pale reddish brown person's breast knot effect, Hemerocallis citrina Baroni person abdominal pain due to cold effect.
Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis): pungent, puckery, flat.Promoting blood flow to regulate menstruation, inducing diuresis to remove edema.Control menoxenia, leucorrhea, infantile malnutrition, edema, dysentery, traumatic injury, laryngalgia, acute mastitis.The doctor of Soviet Union " Chinese herbal medicine handbook ": heat-clearing and toxic substances removing.Control venom, mastitis, leukorrhagia, carbuncle furuncle, epistaxis.
Herba youngiae japonicae: sweet in the mouth, bitter in the mouth, cool in nature.Heat-clearing and toxic substances removing, inducing diuresis to remove edema, pain relieving.Cure mainly flu, pharyngalgia, eye conjunctivitis, acute mastitis, toothache, furuncle toxic swelling, venom, dysentery, cirrhotic ascites, acute nephritis, stranguria with turbid discharge, hematuria, leucorrhea, rheumatic arthritis, traumatic injury.Furuncle toxic swelling is controlled in external." the conventional identification of obscuring Chinese herbal medicine ": anti-inflammation.Control furuncle, mastitis, tonsillitis, urinary tract infection, leucorrhea, conjunctivitis, rheumatic arthritis.
Sonchus arvensis L.: hardship, cold.Heat-clearing and toxic substances removing.Appendicitis curing, dysentery, hemorrhoid, seminal emission, nebulousurine, mastitis, furuncle kind poison, burn.Guangzhou air force " conventional Chinese herbal medicine handbook ": appendicitis curing, dysentery, mastitis, furuncle and phyma.
Rhizoma Bolbostematis: hardship, is slightly cold.Return lung, spleen channel.Eliminating stagnation, detumescence, removing toxic substances.For acute mastitis, scrofula; Mastitis, lymphoid tuberculosis, chronic lymphadenitis, hypertrophic rhinitis." Shaanxi Chinese herbal medicine ": clearing heat, releasing toxin, removing swelling.Control tuberculous lymphadenitis, acute mastitis is from the beginning of, carbuncle.
HERBA SHUTERIAE: hardship, cold.Heat-clearing and toxic substances removing, detumescence.For appendicitis, mastitis, parotitis, hemoptysis of pulmonary tuberculosis.
Radix Salviae Miltiorrhizae: hardship, is slightly cold.GUIXIN, Liver Channel.Blood circulation promoting and blood stasis dispelling, mind tranquilizing and the heart calming, evacuation of pus pain relieving.Control angina pectoris, menoxenia, dysmenorrhea, amenorrhea, metrorrhagia leukorrhagia, lump in the abdomen, gathers, abdominal pain due to blood stasis, arthralgia, palpitation with fear sleeplessness, malignant boil toxic swelling." choosing of Yunnan Chinese herbal medicine ": promoting blood circulation to remove blood stasis, sedation-analgesia.Control menoxenia, dysmenorrhea, rheumatic arthralgia, metrorrhagia, spits blood, mastitis, carbuncle.
Folium Prinsepiae Utilis: hardship, pungent, cold.GUIXIN, liver, kidney channel.Heat-clearing and toxic substances removing, blood circulation promoting and dispersing pathogen accumulation.Main acute mastitis, mumps, hemorrhoid, scrofula, traumatic injury, menoxenia." the southern regions of the Yunnan Province book on Chinese herbal medicine ": " attack all sore carbuncle, have pus to lift one's head, no pus is vertical to disappear; Eliminating stagnation core, chews carefully and takes with wine.
Herba Hemisteptae Lyratae: pungent, flat.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.For mastitis, cervical lymphadenitis, carbuncle furuncle, rubella pruritus.
Herba malachii aquatici: acid, flat.Return liver, stomach warp.Clearing away heat and cooling blood, reducing swelling and alleviating pain, removing food stagnancy lactogenesis.For infantile malnutrition, toothache, dysentery, hemorrhoid toxic swelling, mastitis, galactostasis, furuncle is controlled in external.
Black nylon yarn: micro-pungent, light, flat.Cooling blood and dissolving stasis, diuresis lactogenesis, cough-relieving.Cure mainly galactostasis, mastitis, cystitis, urethritis, heating, cough, postnatal blood stasis, metrorrhagia.
Lignum et Radix Naucleae: hardship, cold.Heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Treating acute tonsillitis, pharyngolaryngitis, mastitis, enteritis, bacillary dysentery, urinary tract infection, cholecystitis, ulcer of the lower limb, tinea pedis infects, furuncle and phyma pus infections, dermatitis and eczema.
Herba Galii Teneri: bitter in the mouth, pungent, cold in nature.Heat-clearing and toxic substances removing, inducing diuresis for treating stranguria syndrome, reducing swelling and alleviating pain.Cure mainly swollen ulcer drug, mastitis, appendicitis, edema, cold, fever, dysentery, urinary tract infection, hematuria, gingival hemorrhage, knife injury is hemorrhage.Jiangxi " medical herbs handbook ": heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Control carbuncle, appendicitis, closely for for cancer.
In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material is as follows: 5～15 parts of Fructus Akebiaes, 30～40 parts of Citrus chachiensis Hort. (C. Suavissima Tanaka), 15～25 parts of Herba Violae mundaes, 10～20 parts of Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis), 30～40 parts of Herba youngiae japonicae, 15～25 parts of Sonchus arvensis L., 10～20 parts of Rhizoma Bolbostematiss, 10～20 parts of HERBA SHUTERIAEs, 5～15 parts of Radix Salviae Miltiorrhizaes, 15～25 parts of Folium Prinsepiae Utilis, 10～20 parts of Herba Hemisteptae Lyrataies, 5～15 parts of Herba malachii aquaticis, 5～15 parts of black nylon yarns, 10～20 parts of 10～20 parts of Lignum et Radix Naucleae and Herba Galii Teneris.
In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material can be preferably: 5～10 parts of Fructus Akebiaes, 30～35 parts of Citrus chachiensis Hort. (C. Suavissima Tanaka), 15～20 parts of Herba Violae mundaes, 10～15 parts of Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis), 30～35 parts of Herba youngiae japonicae, 15～20 parts of Sonchus arvensis L., 10～15 parts of Rhizoma Bolbostematiss, 10～15 parts of HERBA SHUTERIAEs, 5～10 parts of Radix Salviae Miltiorrhizaes, 15～20 parts of Folium Prinsepiae Utilis, 10～15 parts of Herba Hemisteptae Lyrataies, 5～10 parts of Herba malachii aquaticis, 5～10 parts of black nylon yarns, 10～15 parts of 10～15 parts of Lignum et Radix Naucleae and Herba Galii Teneris.
In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material also can be preferably: 6 parts of Fructus Akebiaes, 34 parts of Citrus chachiensis Hort. (C. Suavissima Tanaka), 16 parts of Herba Violae mundaes, 11 parts of Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis), 31 parts of Herba youngiae japonicae, 17 parts of Sonchus arvensis L., 13 parts of Rhizoma Bolbostematiss, 12 parts of HERBA SHUTERIAEs, 8 parts of Radix Salviae Miltiorrhizaes, 17 parts of Folium Prinsepiae Utilis, 12 parts of Herba Hemisteptae Lyrataies, 7 parts of Herba malachii aquaticis, 8 parts of black nylon yarns, 12 parts of 14 parts of Lignum et Radix Naucleae and Herba Galii Teneris.
In described Chinese medicine preparation, the ratio of weight and number of each raw medicinal material also can be preferably: 8 parts of Fructus Akebiaes, 31 parts of Citrus chachiensis Hort. (C. Suavissima Tanaka), 18 parts of Herba Violae mundaes, 14 parts of Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis), 33 parts of Herba youngiae japonicae, 16 parts of Sonchus arvensis L., 12 parts of Rhizoma Bolbostematiss, 11 parts of HERBA SHUTERIAEs, 6 parts of Radix Salviae Miltiorrhizaes, 19 parts of Folium Prinsepiae Utilis, 14 parts of Herba Hemisteptae Lyrataies, 8 parts of Herba malachii aquaticis, 6 parts of black nylon yarns, 13 parts of 11 parts of Lignum et Radix Naucleae and Herba Galii Teneris.
Chinese medicine preparation of the present invention can be prepared into various dosage forms as required, is preferably tablet, capsule and membranous patch.
The present invention also provides the preparation method of above-mentioned Chinese medicine preparation, and the dosage form of described Chinese medicine preparation is tablet, and its preparation method comprises the following steps:
The first step: each raw medicinal material of described Chinese medicine preparation is mixed in proportion, add the ethanol that the determining alcohol with respect to 3～5 times of mixture qualities is 80～90%, reflux 1～2 hour, extract, filter and obtain the first extracting solution, the medicinal residues that filter to obtain add the ethanol that the determining alcohol with respect to 1～3 times of medicinal residues quality is 80～90% again, reflux 35～45 minutes, extract, filter and obtain the second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure is removed alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step is obtained is placed in super micron mill to be pulverized 1～2 hour, pulverizes and sieves and obtains 200～300 object micropowders;
The 3rd step: add the microcrystalline Cellulose with respect to 0.1～0.3 times of its quality, the lactose of 0.05～0.15 times, the starch of 0.1～0.3 times in the micropowders obtaining at second step, sieve, mix homogeneously, granulate, dry, add the magnesium stearate with respect to 0.005～0.05 times of micropowders quality, granulate, tabletting, makes.
The present invention also provides the preparation method of above-mentioned Chinese medicine preparation, and the dosage form of described Chinese medicine preparation is capsule, and its preparation method comprises the following steps:
The first step, is mixed in proportion each raw medicinal material of described Chinese medicine preparation, adds the ethanol that the determining alcohol with respect to 3～5 times of mixture qualities is 80～90%, and reflux 40～60 minutes is extracted, and filters and obtains the first extracting solution; The medicinal residues that filter to obtain add the ethanol that the determining alcohol with respect to 2～3 times of medicinal residues quality is 85～90% again, and reflux 30～50 minutes, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;
Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 1～2 hour, pulverizes and sieves and obtains 200～300 object micropowders;
The 3rd step, the micropowders obtaining at second step adds the microcrystalline Cellulose with respect to 0.1～0.3 times of its quality, the starch of 0.1～0.3 times, the magnesium stearate of 0.005～0.05 times, mix processing, obtain capsule 's content, described Capsule content is incapsulated in housing, obtain capsule finished product.
The present invention also provides the preparation method of above-mentioned Chinese medicine preparation, and when the dosage form of described Chinese medicine is membranous patch, its preparation method comprises the following steps:
The first step, is mixed in proportion each raw medicinal material of described Chinese medicine preparation, is ground into 100 order～120 object powder, add the ethanol that the determining alcohol with respect to 5～8 times of mixture qualities is 85%～90%, reflux 3～5 hours, extracts, and filters and obtains the first extracting solution; The medicinal residues that filter to obtain add the ethanol that the determining alcohol with respect to 3～5 times of described medicinal residues quality is 90%～95% again, and reflux 2～4 hours, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract, and is ground into 160 order～200 object powder;
Second step, powder 8～10 weight portions prepared by the first step, polyvinyl alcohol 2～3 weight portions, the abundant mix and blend of glycerol 0.5～1 weight portion, to producing without minute bubbles, standing 45～60 minutes, makes mixing paste;
The 3rd step, mixing paste prepared by second step is evenly coated with masking with film-making machine, and under room temperature, dry postforming, cuts into strip, is placed on non-woven fabrics and fixes according to the fixing mode in both sides, containing powder sticking glass paper, obtains membranous patch.
Below adopt embodiment to describe embodiments of the present invention in detail, fully understand whereby how application technology means solve technical problem in the present invention, reach technique effect and implement according to this.
Embodiment 1: tablet
Get Fructus Akebiae 60g, Citrus chachiensis Hort. (C. Suavissima Tanaka) 340g, Herba Violae mundae 160g, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 110g, Herba youngiae japonicae 310g, Sonchus arvensis L. 170g, Rhizoma Bolbostematis 130g, HERBA SHUTERIAE 120g, Radix Salviae Miltiorrhizae 80g, Folium Prinsepiae Utilis 170g, Herba Hemisteptae Lyratae 120g, Herba malachii aquatici 70g, black nylon yarn 80g, Lignum et Radix Naucleae 140g and Herba Galii Teneri 120g;
Preparation according to the following steps:
The first step: each raw medicinal material of described Chinese medicine preparation is mixed, add the ethanol that the determining alcohol with respect to 5 times of mixture qualities is 90%, reflux 2 hours, extract, filter to obtain the first extracting solution, filter the medicinal residues that obtain and add again the ethanol that the determining alcohol with respect to 2 times of medicinal residues quality is 90%, reflux 45 minutes, extract, filter and obtain the second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure is removed alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step is obtained is placed in super micron mill to be pulverized 2 hours, pulverizes and sieves and obtains 300 object micropowders;
The 3rd step: add the microcrystalline Cellulose with respect to 0.2 times of its quality, the lactose of 0.1 times, the starch of 0.2 times in the micropowders obtaining at second step, sieve, mix homogeneously, granulate, dry, add the magnesium stearate with respect to 0.02 times of micropowders quality, granulate, tabletting, makes
Embodiment 2: capsule
Get Fructus Akebiae 80g, Citrus chachiensis Hort. (C. Suavissima Tanaka) 310g, Herba Violae mundae 180g, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 140g, Herba youngiae japonicae 330g, Sonchus arvensis L. 160g, Rhizoma Bolbostematis 120g, HERBA SHUTERIAE 110g, Radix Salviae Miltiorrhizae 60g, Folium Prinsepiae Utilis 190g, Herba Hemisteptae Lyratae 140g, Herba malachii aquatici 80g, black nylon yarn 60g, Lignum et Radix Naucleae 110g and Herba Galii Teneri 130g;
Preparation according to the following steps:
The first step, mixes each raw medicinal material of described Chinese medicine preparation, adds the ethanol that the determining alcohol with respect to 4 times of mixture qualities is 90%, and reflux 60 minutes, extracts, and filters and obtains the first extracting solution; The medicinal residues that filter to obtain add the ethanol that the determining alcohol with respect to 3 times of medicinal residues quality is 90% again, and reflux 30 minutes, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;
Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 2 hours, pulverizes and sieves and obtains 300 object micropowders;
The 3rd step, the micropowders obtaining at second step adds the microcrystalline Cellulose with respect to 0.2 times of its quality, the starch of 0.2 times, the magnesium stearate of 0.02 times, mixes processing, obtains capsule 's content, described Capsule content is incapsulated in housing, obtain capsule finished product.
Embodiment 3: membranous patch
Get Fructus Akebiae 120g, Citrus chachiensis Hort. (C. Suavissima Tanaka) 380g, Herba Violae mundae 230g, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 120g, Herba youngiae japonicae 390g; Sonchus arvensis L. 210g, Rhizoma Bolbostematis 180g, HERBA SHUTERIAE 170g, Radix Salviae Miltiorrhizae 110g, Folium Prinsepiae Utilis 160g; Herba Hemisteptae Lyratae 170g, Herba malachii aquatici 130g, black nylon yarn 150g, Lignum et Radix Naucleae 180g and Herba Galii Teneri 160g;
Its preparation method comprises the following steps:
The first step, is mixed in proportion each raw medicinal material of described Chinese medicine preparation, is ground into 120 object powder, adds the ethanol that the determining alcohol with respect to 6 times of mixture qualities is 85%, and reflux 3 hours is extracted, and filters and obtains the first extracting solution; The medicinal residues that filter to obtain add the ethanol that the determining alcohol with respect to 4 times of described medicinal residues quality is 95% again, and reflux 2 hours, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract, and is ground into 200 object powder;
Second step, powder 9 weight portions prepared by the first step, polyvinyl alcohol 2 weight portions, the abundant mix and blend of glycerol 1 weight portion, to producing without minute bubbles, standing 60 minutes, makes mixing paste;
The 3rd step, mixing paste prepared by second step is evenly coated with masking with film-making machine, and under room temperature, dry postforming, cuts into strip, is placed on non-woven fabrics and fixes according to the fixing mode in both sides, containing powder sticking glass paper, obtains membranous patch.
Toxicity test:
Acute toxicity testing: 60 of application mices, male and female half and half, body weight 28～38g, carries out acute toxicity test.Mice is divided into two groups at random, be matched group and administration group, before experiment, fasting is 12 hours, and the Chinese medicinal tablet of embodiments of the invention 1 preparation is dissolved in water, (concentration is 7.42g crude drug/ml, maximum concentration) gavage, gavage volume is that 5ml/kg(is that single-dose dosage is 37.1 crude drugs/kg), matched group gives equivalent normal saline, administration in one day 2 times, delivery time 6 hours, after administration, Continuous Observation is 14 days, and record mice toxic reaction and death toll.Experimental result shows: with matched group comparison, after administration, mice has no notable difference, experiment Continuous Observation 14 days, and mice overall health of patients, diet, drinking-water, body weight gain are all normal.Mice oral administration gavage tablet of the present invention is LD50 > 37.1 crude drugs/kg, every day, maximum dosage-feeding was 74.2 crude drugs/kg/ day.Chinese medicine preparation clinical application amount of the present invention is 4.8g crude drug/day/people, becomes body weight for humans in 60KG, and average dosage is 0.08g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight take 33g) oral administration gavage Chinese medicine preparation of the present invention is quantity 928 times.Therefore Chinese medicine preparation acute toxicity of the present invention is extremely low, clinical drug safety.
Long term toxicity test: Chinese medicine preparation embodiment 1 tablet of the present invention to mice by 12.95,21.86 and 15 weeks (1.0ml/100g body weight of 37.98g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 3 weeks, result shows: Chinese medicine preparation of the present invention all has no significant effect indexs such as the hair of mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that toxicity is little after Chinese medicine preparation of the present invention is to mice long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.
Clinical data:
Case selection: whole 100 routine cases are my Out-patient Department patient of in August, 2009～2012 year June.Be primipara, all not irritated to penicillin, 23～35 years old age, 84 routine one-sided mammary gland morbidities, 16 routine bilateral breasts morbidities, course of disease a few hours to 3 day, 37.5～40.1 ℃ of body temperature, above person 90 people of blood examination numeration of leukocyte 10 * 109/L.Be divided at random treatment group and matched group, treatment group 50 people wherein, 24～35 years old age; Matched group 50 people, 23～33 years old age.Two groups in age, sex, the course of disease, and the aspects such as clinical manifestation are Epidemiological Analysis there was no significant difference (p > 0.05) by statistics.
Diagnostic criteria: with reference to the diagnostic criteria of acute mastitis in " practical obstetrics and gynecology ": (1) patient is women breast-feeding their children, take the primipara of full moon not especially as many; (2) from the beginning of there being painful lump in breast, companion's milk ejection is not smooth, and when abscess forms, breast swell and pain increases the weight of, and lump deliquescing, has fluctuation; (3) often there is lymphadenectasis companion pain patient oxter; (4) whole body has aversion to cold more, heating, and headache, the whole body is uncomfortable, and numeration of leukocyte increases.
Therapeutic Method:
Treatment group: give 1 tablet every day of the embodiment of the present invention 3 times, each 3, treat 7 days;
Matched group: intravenous infusion of penicillin treatment, 3 times/d, 25% magnesium sulfate is in breast local swelling hot compress, and breast milk is inhaled to sky completely with humalactor, treats 7 days.
Curative effect judging standard: whole efficacy evaluation reference " new Chinese medicine guideline of clinical investigations " relevant criterion: cure: transference cure, lump dissipates, and milk ejection is normally unobstructed, and blood testing leukocyte is normal.Effective: transference cure, lump dwindles, and milk ejection part is unobstructed, and blood testing leukocyte is normal.Invalid: symptom is without changing or increasing the weight of.
Therapeutic outcome: treat respectively after 1 course for the treatment of for two groups, statistical result is referring to table 1 and table 2.As can be seen from Table 1, adopt treatment by Chinese herbs acute mastitis of the present invention, with respect to Western medicine, on therapeutic effect, there is significant improvement; As can be seen from Table 2, adopt treatment by Chinese herbs acute mastitis of the present invention, with respect to Western medicine, treating significantly shortening on the course for the treatment of.
After table 1 liang group is treated respectively 1 course for the treatment of, Clinical efficacy comparison is routine
| Group | n | Cure | Effectively | Invalid | Effectively total |
| Treatment group | 50 | 42 | 7 | 1 | 49（98.00%） |
| Matched group | 50 | 26 | 15 | 9 | 41（82.00%） |
Table 2 liang group is treated respectively recovery from illness number and time comparative example (%) after 1 course for the treatment of
| Group | Number of cases | Medication 3 days | Medication 5 days | Medication 7 days |
| Treatment group | 42 | 5(11.9%) | 23(54.8%) | 14(33.3%) |
| Matched group | 26 | 0(0%) | 11(42.3%) | 15(57.7%) |
Known according to the clinical statistics in above table, that Chinese medicine provided by the invention has is rapid-action, effective percentage is high, determined curative effect, safe, the advantage that has no side effect; The 26 routine patients that the 42 routine patients that simultaneously treatment group cured and matched group are cured follow up a case by regular visits to half a year respectively, result statistics, and treatment group is without recurrence, and relapse rate is 0%; The routine patient of matched group 26, recurs 4 people, relapse rate 15.4%.
Concrete case: Lee, women, 30 years old.Primipara, has painful lump companion milk ejection not smooth in breast, fever with aversion to cold, and headache, the whole body is uncomfortable, 38.7 ℃ of body temperature, numeration of leukocyte 11.1 * 109/L.Be diagnosed as acute mastitis.Take 1 tablet every day of Chinese medicine preparation embodiment of the present invention 3 times, each 3, to treat after 7 days, recovery from illness, follows up a case by regular visits to not recurrence in 1 month.
The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (10)
1. a Chinese medicine preparation for the treatment of acute mastitis, is characterized in that, each raw medicinal material of described Chinese medicine preparation comprises: Fructus Akebiae, Citrus chachiensis Hort. (C. Suavissima Tanaka), Herba Violae mundae, Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis), Herba youngiae japonicae, Sonchus arvensis L., Rhizoma Bolbostematis, HERBA SHUTERIAE, Radix Salviae Miltiorrhizae, Folium Prinsepiae Utilis, Herba Hemisteptae Lyratae, Herba malachii aquatici, black nylon yarn, Lignum et Radix Naucleae and Herba Galii Teneri.
2. Chinese medicine preparation as claimed in claim 1, is characterized in that, the ratio of weight and number of described each raw medicinal material of Chinese medicine preparation is as follows: 5～15 parts of Fructus Akebiaes, 30～40 parts of Citrus chachiensis Hort. (C. Suavissima Tanaka), 15～25 parts of Herba Violae mundaes, 10～20 parts of Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis), 30～40 parts of Herba youngiae japonicae, 15～25 parts of Sonchus arvensis L., 10～20 parts of Rhizoma Bolbostematiss, 10～20 parts of HERBA SHUTERIAEs, 5～15 parts of Radix Salviae Miltiorrhizaes, 15～25 parts of Folium Prinsepiae Utilis, 10～20 parts of Herba Hemisteptae Lyrataies, 5～15 parts of Herba malachii aquaticis, 5～15 parts of black nylon yarns, 10～20 parts of 10～20 parts of Lignum et Radix Naucleae and Herba Galii Teneris.
3. Chinese medicine preparation as claimed in claim 1 or 2, is characterized in that, the ratio of weight and number of described each raw medicinal material of Chinese medicine preparation is as follows: 5～10 parts of Fructus Akebiaes, 30～35 parts of Citrus chachiensis Hort. (C. Suavissima Tanaka), 15～20 parts of Herba Violae mundaes, 10～15 parts of Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis), 30～35 parts of Herba youngiae japonicae, 15～20 parts of Sonchus arvensis L., 10～15 parts of Rhizoma Bolbostematiss, 10～15 parts of HERBA SHUTERIAEs, 5～10 parts of Radix Salviae Miltiorrhizaes, 15～20 parts of Folium Prinsepiae Utilis, 10～15 parts of Herba Hemisteptae Lyrataies, 5～10 parts of Herba malachii aquaticis, 5～10 parts of black nylon yarns, 10～15 parts of 10～15 parts of Lignum et Radix Naucleae and Herba Galii Teneris.
4. the Chinese medicine preparation as described in claims 1 to 3, is characterized in that, the ratio of weight and number of described each raw medicinal material of Chinese medicine preparation is as follows: 6 parts of Fructus Akebiaes, 34 parts of Citrus chachiensis Hort. (C. Suavissima Tanaka), 16 parts of Herba Violae mundaes, 11 parts of Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis), 31 parts of Herba youngiae japonicae, 17 parts of Sonchus arvensis L., 13 parts of Rhizoma Bolbostematiss, 12 parts of HERBA SHUTERIAEs, 8 parts of Radix Salviae Miltiorrhizaes, 17 parts of Folium Prinsepiae Utilis, 12 parts of Herba Hemisteptae Lyrataies, 7 parts of Herba malachii aquaticis, 8 parts of black nylon yarns, 12 parts of 14 parts of Lignum et Radix Naucleae and Herba Galii Teneris.
5. the Chinese medicine preparation as described in claims 1 to 3, is characterized in that, the ratio of weight and number of described each raw medicinal material of Chinese medicine preparation is as follows: 8 parts of Fructus Akebiaes, 31 parts of Citrus chachiensis Hort. (C. Suavissima Tanaka), 18 parts of Herba Violae mundaes, 14 parts of Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis), 33 parts of Herba youngiae japonicae, 16 parts of Sonchus arvensis L., 12 parts of Rhizoma Bolbostematiss, 11 parts of HERBA SHUTERIAEs, 6 parts of Radix Salviae Miltiorrhizaes, 19 parts of Folium Prinsepiae Utilis, 14 parts of Herba Hemisteptae Lyrataies, 8 parts of Herba malachii aquaticis, 6 parts of black nylon yarns, 13 parts of 11 parts of Lignum et Radix Naucleae and Herba Galii Teneris.
6. the Chinese medicine preparation as described in claim 1 to 5, is characterized in that, when the dosage form of described Chinese medicine preparation is tablet, its preparation method comprises the following steps:
The first step: each raw medicinal material of described Chinese medicine preparation is mixed in proportion, add the ethanol that the determining alcohol with respect to 3～5 times of mixture qualities is 80～90%, reflux 1～2 hour, extract, filter and obtain the first extracting solution, the medicinal residues that filter to obtain add the ethanol that the determining alcohol with respect to 1～3 times of medicinal residues quality is 80～90% again, reflux 35～45 minutes, extract, filter and obtain the second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure is removed alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step is obtained is placed in super micron mill to be pulverized 1～2 hour, pulverizes and sieves and obtains 200～300 object micropowders;
The 3rd step: add the microcrystalline Cellulose with respect to 0.1～0.3 times of its quality, the lactose of 0.05～0.15 times, the starch of 0.1～0.3 times in the micropowders obtaining at second step, sieve, mix homogeneously, granulate, dry, add the magnesium stearate with respect to 0.005～0.05 times of micropowders quality, granulate, tabletting, makes.
7. the Chinese medicine preparation as described in claim 1 to 5, is characterized in that, when the dosage form of described Chinese medicine preparation is capsule, its preparation method comprises the following steps:
The first step, is mixed in proportion each raw medicinal material of described Chinese medicine preparation, adds the ethanol that the determining alcohol with respect to 3～5 times of mixture qualities is 80～90%, and reflux 40～60 minutes is extracted, and filters and obtains the first extracting solution; The medicinal residues that filter to obtain add the ethanol that the determining alcohol with respect to 2～3 times of medicinal residues quality is 85～90% again, and reflux 30～50 minutes, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;
Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 1～2 hour, pulverizes and sieves and obtains 200～300 object micropowders;
The 3rd step, the micropowders obtaining at second step adds the microcrystalline Cellulose with respect to 0.1～0.3 times of its quality, the starch of 0.1～0.3 times, the magnesium stearate of 0.005～0.05 times, mix processing, obtain capsule 's content, described Capsule content is incapsulated in housing, obtain capsule finished product.
8. the preparation method of Chinese medicine preparation described in a claim 1 to 5.It is characterized in that, the dosage form of described Chinese medicine preparation is tablet, and its preparation method comprises the following steps:
The first step: each raw medicinal material of described Chinese medicine preparation is mixed in proportion, add the ethanol that the determining alcohol with respect to 3～5 times of mixture qualities is 80～90%, reflux 1～2 hour, extract, filter and obtain the first extracting solution, the medicinal residues that filter to obtain add the ethanol that the determining alcohol with respect to 1～3 times of medicinal residues quality is 80～90% again, reflux 35～45 minutes, extract, filter and obtain the second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure is removed alcohol solvent, dry, obtain and get dry extract;
Second step: the dry cream that the first step is obtained is placed in super micron mill to be pulverized 1～2 hour, pulverizes and sieves and obtains 200～300 object micropowders;
The 3rd step: add the microcrystalline Cellulose with respect to 0.1～0.3 times of its quality, the lactose of 0.05～0.15 times, the starch of 0.1～0.3 times in the micropowders obtaining at second step, sieve, mix homogeneously, granulate, dry, add the magnesium stearate with respect to 0.005～0.05 times of micropowders quality, granulate, tabletting, makes.
9. a preparation method for Chinese medicine preparation described in claim 1 to 5, is characterized in that, the dosage form of described Chinese medicine preparation is capsule, and its preparation method comprises the following steps:
The first step, is mixed in proportion each raw medicinal material of described Chinese medicine preparation, adds the ethanol that the determining alcohol with respect to 3～5 times of mixture qualities is 80～90%, and reflux 40～60 minutes is extracted, and filters and obtains the first extracting solution; The medicinal residues that filter to obtain add the ethanol that the determining alcohol with respect to 2～3 times of medicinal residues quality is 85～90% again, and reflux 30～50 minutes, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract;
Second step, the dry cream that the first step is obtained is placed in super micron mill to be pulverized 1～2 hour, pulverizes and sieves and obtains 200～300 object micropowders;
The 3rd step, the micropowders obtaining at second step adds the microcrystalline Cellulose with respect to 0.1～0.3 times of its quality, the starch of 0.1～0.3 times, the magnesium stearate of 0.005～0.05 times, mix processing, obtain capsule 's content, described Capsule content is incapsulated in housing, obtain capsule finished product.
10. a preparation method for Chinese medicine preparation described in claim 1 to 5, is characterized in that, when the dosage form of described Chinese medicine is membranous patch, its preparation method comprises the following steps:
The first step, is mixed in proportion each raw medicinal material of described Chinese medicine preparation, is ground into 100 order～120 object powder, add the ethanol that the determining alcohol with respect to 5～8 times of mixture qualities is 85%～90%, reflux 3～5 hours, extracts, and filters and obtains the first extracting solution; The medicinal residues that filter to obtain add the ethanol that the determining alcohol with respect to 3～5 times of described medicinal residues quality is 90%～95% again, and reflux 2～4 hours, extracts, and filters and obtains the second extracting solution; The first extracting solution and the second extracting solution are merged, and concentrating under reduced pressure is removed alcohol solvent, dry, obtains and gets dry extract, and is ground into 160 order～200 object powder;
Second step, powder 8～10 weight portions prepared by the first step, polyvinyl alcohol 2～3 weight portions, the abundant mix and blend of glycerol 0.5～1 weight portion, to producing without minute bubbles, standing 45～60 minutes, makes mixing paste;
The 3rd step, mixing paste prepared by second step is evenly coated with masking with film-making machine, and under room temperature, dry postforming, cuts into strip, is placed on non-woven fabrics and fixes according to the fixing mode in both sides, containing powder sticking glass paper, obtains membranous patch.
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| CN103933347A (en) * | 2014-03-21 | 2014-07-23 | 邹晓 | Traditional Chinese medicine for treating acute mastitis and production method |
| CN104189597A (en) * | 2014-09-16 | 2014-12-10 | 姜明霞 | Traditional Chinese medicine for treating stomach hyperpyrexia type acute mastitis and preparation method thereof |
| CN104189494A (en) * | 2014-09-15 | 2014-12-10 | 江美林 | Traditional Chinese medicine for treating liver Qi stagnation type acute mastitis and nursing method |
| CN104189270A (en) * | 2014-09-16 | 2014-12-10 | 杨金灵 | Traditional Chinese medicine for treating pathogenic heat and depression syndrome type acute mastitis and preparation method thereof |
| CN104257875A (en) * | 2014-10-13 | 2015-01-07 | 夏继云 | Externally-applied traditional Chinese medicine composition for nursing acute mastitis of women |
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| CN104739988A (en) * | 2015-03-27 | 2015-07-01 | 杜彦秋 | Chinese medicament for treating pathogenic heat depression type acute mastitis and preparation method |
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| CN106266520A (en) * | 2016-08-08 | 2017-01-04 | 青岛友诚高新技术有限公司 | A kind of Chinese medicine composition treating Qi-stagnation type mastitis and preparation method thereof |
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| CN103933347A (en) * | 2014-03-21 | 2014-07-23 | 邹晓 | Traditional Chinese medicine for treating acute mastitis and production method |
| CN103933347B (en) * | 2014-03-21 | 2016-07-06 | 青岛市中心医院 | A kind of Chinese medicine treating acute mastitis and manufacture method |
| CN104189494A (en) * | 2014-09-15 | 2014-12-10 | 江美林 | Traditional Chinese medicine for treating liver Qi stagnation type acute mastitis and nursing method |
| CN104189597A (en) * | 2014-09-16 | 2014-12-10 | 姜明霞 | Traditional Chinese medicine for treating stomach hyperpyrexia type acute mastitis and preparation method thereof |
| CN104189270A (en) * | 2014-09-16 | 2014-12-10 | 杨金灵 | Traditional Chinese medicine for treating pathogenic heat and depression syndrome type acute mastitis and preparation method thereof |
| CN104189597B (en) * | 2014-09-16 | 2015-09-09 | 姜明霞 | A kind ofly treat Chinese medicine of excessiveness of stomach-heat type acute mastitis and preparation method thereof |
| CN104257875A (en) * | 2014-10-13 | 2015-01-07 | 夏继云 | Externally-applied traditional Chinese medicine composition for nursing acute mastitis of women |
| CN104644974A (en) * | 2015-01-27 | 2015-05-27 | 杜彦秋 | Traditional Chinese medicine preparation for treating liver Qi stagnation type acute mastitis and preparation method thereof |
| CN104739988A (en) * | 2015-03-27 | 2015-07-01 | 杜彦秋 | Chinese medicament for treating pathogenic heat depression type acute mastitis and preparation method |
| CN104873730A (en) * | 2015-06-11 | 2015-09-02 | 褚静萍 | Traditional Chinese medicine for treating acute mastitis with liver-qi stagnancy |
| CN106038928A (en) * | 2016-06-12 | 2016-10-26 | 夏冰 | Medicine for treating acute mastitis and preparation method |
| CN106266520A (en) * | 2016-08-08 | 2017-01-04 | 青岛友诚高新技术有限公司 | A kind of Chinese medicine composition treating Qi-stagnation type mastitis and preparation method thereof |
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