CN103505517A - 一种安胃片的制备方法及应用 - Google Patents
一种安胃片的制备方法及应用 Download PDFInfo
- Publication number
- CN103505517A CN103505517A CN201310468362.9A CN201310468362A CN103505517A CN 103505517 A CN103505517 A CN 103505517A CN 201310468362 A CN201310468362 A CN 201310468362A CN 103505517 A CN103505517 A CN 103505517A
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- Prior art keywords
- gastralgia
- preparation
- tablet
- crude drug
- processed
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- 206010000087 Abdominal pain upper Diseases 0.000 title claims abstract description 37
- 238000002360 preparation method Methods 0.000 title claims abstract description 28
- 239000003814 drug Substances 0.000 claims abstract description 28
- 229940079593 drug Drugs 0.000 claims abstract description 17
- 238000000194 supercritical-fluid extraction Methods 0.000 claims abstract description 16
- 241000218176 Corydalis Species 0.000 claims abstract description 13
- 230000004663 cell proliferation Effects 0.000 claims abstract description 10
- 201000001441 melanoma Diseases 0.000 claims abstract description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 31
- 238000000605 extraction Methods 0.000 claims description 12
- 235000021419 vinegar Nutrition 0.000 claims description 12
- 239000000052 vinegar Substances 0.000 claims description 12
- 229920002472 Starch Polymers 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 7
- 235000019698 starch Nutrition 0.000 claims description 7
- 239000008107 starch Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 6
- 230000002401 inhibitory effect Effects 0.000 abstract description 3
- 239000004480 active ingredient Substances 0.000 abstract 1
- 229940037003 alum Drugs 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 229960004756 ethanol Drugs 0.000 description 10
- 238000002474 experimental method Methods 0.000 description 8
- 238000005242 forging Methods 0.000 description 6
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 3
- 230000010261 cell growth Effects 0.000 description 3
- 239000012531 culture fluid Substances 0.000 description 3
- 229960000935 dehydrated alcohol Drugs 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000006285 cell suspension Substances 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- WEEMDRWIKYCTQM-UHFFFAOYSA-N 2,6-dimethoxybenzenecarbothioamide Chemical compound COC1=CC=CC(OC)=C1C(N)=S WEEMDRWIKYCTQM-UHFFFAOYSA-N 0.000 description 1
- 238000002965 ELISA Methods 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- 206010020601 Hyperchlorhydria Diseases 0.000 description 1
- 206010067171 Regurgitation Diseases 0.000 description 1
- 206010040007 Sense of oppression Diseases 0.000 description 1
- 229920002334 Spandex Polymers 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000010165 autogamy Effects 0.000 description 1
- 238000010009 beating Methods 0.000 description 1
- FCPVYOBCFFNJFS-LQDWTQKMSA-M benzylpenicillin sodium Chemical compound [Na+].N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)CC1=CC=CC=C1 FCPVYOBCFFNJFS-LQDWTQKMSA-M 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 208000023652 chronic gastritis Diseases 0.000 description 1
- 238000010219 correlation analysis Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 239000012738 dissolution medium Substances 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 208000000718 duodenal ulcer Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000004900 laundering Methods 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- -1 sieve Substances 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000004759 spandex Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 229960002385 streptomycin sulfate Drugs 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201310468362.9A CN103505517B (zh) | 2013-10-10 | 2013-10-10 | 一种安胃片的制备方法及应用 |
Applications Claiming Priority (1)
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CN201310468362.9A CN103505517B (zh) | 2013-10-10 | 2013-10-10 | 一种安胃片的制备方法及应用 |
Publications (2)
Publication Number | Publication Date |
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CN103505517A true CN103505517A (zh) | 2014-01-15 |
CN103505517B CN103505517B (zh) | 2015-11-25 |
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CN201310468362.9A Expired - Fee Related CN103505517B (zh) | 2013-10-10 | 2013-10-10 | 一种安胃片的制备方法及应用 |
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CN (1) | CN103505517B (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105726645A (zh) * | 2016-02-26 | 2016-07-06 | 南京正亮医药科技有限公司 | 一种安胃胶囊的制备方法及应用 |
CN106236929A (zh) * | 2016-08-25 | 2016-12-21 | 陕西必康制药集团控股有限公司 | 一种治疗胃病的药物及其制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1365786A (zh) * | 2001-01-18 | 2002-08-28 | 杨孟君 | 纳米安胃制剂药物及其制备方法 |
CN101297869A (zh) * | 2007-04-30 | 2008-11-05 | 福建省医学科学研究所 | 安胃分散片及制备方法 |
CN101618217A (zh) * | 2009-07-27 | 2010-01-06 | 洛阳君山制药有限公司 | 一种安胃片的包衣方法 |
-
2013
- 2013-10-10 CN CN201310468362.9A patent/CN103505517B/zh not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1365786A (zh) * | 2001-01-18 | 2002-08-28 | 杨孟君 | 纳米安胃制剂药物及其制备方法 |
CN101297869A (zh) * | 2007-04-30 | 2008-11-05 | 福建省医学科学研究所 | 安胃分散片及制备方法 |
CN101618217A (zh) * | 2009-07-27 | 2010-01-06 | 洛阳君山制药有限公司 | 一种安胃片的包衣方法 |
Non-Patent Citations (2)
Title |
---|
万莉等: "延胡索生物碱化学成分及其抗肿瘤作用的研究进展", 《现代肿瘤医学》, vol. 20, no. 5, 31 May 2012 (2012-05-31), pages 1042 - 1046 * |
程建明等: "延胡索中延胡索乙素不同提取方法的比较研究", 《时珍国医国药》, vol. 17, no. 7, 31 July 2006 (2006-07-31), pages 1236 - 1238 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105726645A (zh) * | 2016-02-26 | 2016-07-06 | 南京正亮医药科技有限公司 | 一种安胃胶囊的制备方法及应用 |
CN106236929A (zh) * | 2016-08-25 | 2016-12-21 | 陕西必康制药集团控股有限公司 | 一种治疗胃病的药物及其制备方法 |
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CN103505517B (zh) | 2015-11-25 |
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C41 | Transfer of patent application or patent right or utility model | ||
CB03 | Change of inventor or designer information |
Inventor after: Li Yanliang Inventor after: Zhu Dongyuan Inventor before: The inventor has waived the right to be mentioned |
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COR | Change of bibliographic data | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20151023 Address after: Huaiyin District sunshine new road Ji'nan City, Shandong province 250000 No. 21 No. 52 No. 809 Applicant after: Li Yanliang Address before: Lishui Economic Development Zone, Nanjing City, Jiangsu province 211200 zhe Ning Road No. 369 Applicant before: Nanjing Zhengliang Medical Technology Co.,Ltd. |
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C14 | Grant of patent or utility model | ||
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TR01 | Transfer of patent right |
Effective date of registration: 20160310 Address after: Huaiyin District of Ji'nan City, Shandong province 250022 Yan Ji Road, No. 440 Patentee after: Shandong Inst. of Tumor Prevention and Cure Address before: Huaiyin District sunshine new road Ji'nan City, Shandong province 250000 No. 21 No. 52 No. 809 Patentee before: Li Yanliang |
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CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20151125 Termination date: 20171010 |