CN103495207A - Double-pipeline organic polymer/biological ceramic composite bone scaffold and preparation method thereof - Google Patents
Double-pipeline organic polymer/biological ceramic composite bone scaffold and preparation method thereof Download PDFInfo
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Abstract
The invention provides a double-pipeline organic polymer/biological ceramic composite bone scaffold and a preparation method thereof. The preparation method comprises the following steps: preparing a negative model of a biological ceramic scaffold; inputting data of the negative model of the biological ceramic scaffold into a stereolithography apparatus to prepare a negative resin die for the scaffold and preparing a double-pipeline biological ceramic scaffold by using a gelcasting method; fusing a high-molecular organic polymer; filling the fused high-molecular organic polymer into a secondary pipeline so as to obtain a high-molecular organic polymer-filled scaffold; and carrying out cutting so as to obtain the double-pipeline organic polymer/biological ceramic composite bone scaffold. According to the invention, the characteristics of good toughness and adjustable mechanical properties of the organic polymer are utilized, and the organic polymer is infused into the biological ceramic scaffold so as to prepare the double-pipeline organic polymer/biological ceramic composite bone scaffold, wherein a primary pipeline is used for cell adhesion, tissue ingrowth and metabolism of nutrients, and the secondary pipeline is filled with the organic polymer, thereby exerting an effect on improvement of the mechanical properties of the scaffold.
Description
Technical field
The invention belongs to the manufacturing engineering field, be specifically related to a kind of twin flue organic polymer/bioceramic Composite Bone support and preparation method thereof.
Background technology
The bone caused due to wound, infection and tumor etc. is damaged is the problem often run in Orthopedic Clinical work, and bone tissue engineer provides new approaches for the damaged reparation of bone.Bioceramic has good biocompatibility, biodegradability, osteoinductive etc., it is the biomaterial of commonly using clinically, but porous bioceramic scaffold faces the mechanical strength deficiency, the problem of the large poor toughness of fragility, be difficult to meet the mechanical property requirements of bone support.The organic polymers such as PLA have biodegradability and biocompatibility, and can regulate its mechanical property by controlling synthesis condition, there is well good toughness especially of mechanical property, but the organic polymer of bulk is implanted and is easy to be inflamed reaction.
Summary of the invention
The purpose of this invention is to provide twin flue organic polymer/bioceramic Composite Bone support and preparation method thereof, its mechanical strength is large, good toughness.
For achieving the above object, the technical solution used in the present invention is:
The preparation method of twin flue organic polymer of the present invention/bioceramic Composite Bone support comprises the following steps:
1) at first utilize Three-dimensional Design Software Pro/Engineer design bioceramic scaffold cad model, this bioceramic scaffold cad model has disconnected elementary pipeline and secondary pipeline mutually, then utilizes Boolean calculation to obtain the minus model of bioceramic scaffold;
2) by the data of the minus model of bioceramic scaffold input photocureable rapid shaping machine, make support minus resin die, then utilize the standby twin flue bioceramic scaffold that obtains of gel injection-moulding legal system;
The crucible that 3) will hold the macromolecule organic polymer is put into resistance furnace, then resistance furnace is put into to the vacuum casting machine, resistance furnace is heated up and make the fusing of macromolecule organic polymer;
4) the twin flue bioceramic scaffold is put in the crucible of the organic polymer that fills fusing, to vacuum casting machine evacuation, makes to pour in secondary pipeline the macromolecule organic polymer of fusing, obtain filled high polymer organic polymer support;
5) filled high polymer organic polymer support is cut, elementary pipeline is come out, obtained twin flue organic polymer/bioceramic Composite Bone support.
Elementary pipeline described in described step 1) and secondary pipeline are all cylindric, and diameter is 400～800 μ m.
Described step 2) in, the gel injection-moulding method is specially: the bioceramic slurry perfusion, in support minus resin die, is solidified and obtains the twin flue bioceramic scaffold by lyophilization, the demoulding, sintering.
In described step 3), the macromolecule organic polymer is polylactic acid, polyglycolic acid or polycaprolactone.
Be warming up to above 10～30 ℃ of macromolecule organic polymer fusing point in described step 3).
After described step 3) fusing, the viscosity of macromolecule organic polymer is less than or equal to 2Pas.
In described step 4), be evacuated down to vacuum Wei ?0.02MPa～?0.04MPa, and keep 1～3min under this vacuum.
Twin flue organic polymer/bioceramic Composite Bone support, this Composite Bone support comprises disconnected elementary pipeline and secondary pipeline mutually, elementary pipeline is grown into and nutrient metabolism for cell attachment, tissue, and the macromolecule organic polymer poured in secondary pipeline is for improving the mechanical property of support.
With respect to prior art, the beneficial effect that the present invention has: the present invention is using bioceramic as matrix, using the macromolecule organic polymer as wild phase and the compound mechanical property that can improve bioceramic scaffold of bioceramic.The present invention utilizes macromolecule organic polymer good toughness, the characteristics that mechanical property is adjustable, it is poured in bioceramic scaffold, prepare twin flue organic polymer/bioceramic Composite Bone support, wherein elementary pipeline is for cell attachment, tissue is grown into and nutrient metabolism, perfusion macromolecule organic polymer in secondary pipeline, play the effect that improves the support mechanical property, the twin flue organic polymer of preparation/bioceramic Composite Bone support has better mechanical property than simple bioceramic scaffold, overcome in prior art bioceramic scaffold fragility large, the problem of poor toughness.
The accompanying drawing explanation
Fig. 1 is twin flue bioceramic scaffold illustraton of model, and wherein Fig. 1 (a) is axonometric drawing, and Fig. 1 (b) and Fig. 1 (c) are respectively along the A of Fig. 1 (a) and the profile of B direction;
Fig. 2 is the organic polymer that obtains of the present invention/bioceramic Composite Bone support, and wherein Fig. 2 (a) is axonometric drawing, and Fig. 2 (b) is profile.
Wherein, 1 is secondary pipeline, and 2 is elementary pipeline.
The specific embodiment
Below in conjunction with accompanying drawing, the present invention is described in further detail.It is the patent of CN102327648B that the compound method of the bioceramic slurry in the present invention refers to Granted publication number.
Referring to Fig. 1, preparation method of the present invention is as follows:
1) at first utilize Three-dimensional Design Software Pro/Engineer design to there is the bioceramic scaffold cad model (as Fig. 1) that is not communicated with mutually elementary pipeline and secondary pipeline, then utilize Boolean calculation to obtain the minus model of bioceramic scaffold; Wherein, the concrete structure of disconnected elementary pipeline and secondary pipeline is mutually: elementary pipeline only extends to outside at a face of bioceramic scaffold cad model, the elementary pipeline of other parts all is hidden in ceramics bracket cad model inside, and secondary pipeline extends to ceramics bracket cad model outside on each face of ceramics bracket cad model; Elementary pipeline and secondary pipeline are the cylindric of diameter 400～800 μ m.
2) by the data of bioceramic scaffold minus model input photocureable rapid shaping machine, make support minus resin die, then utilize the gel injection-moulding legal system to make the twin flue bioceramic scaffold; Wherein, the gel injection-moulding method is specially the bioceramic slurry perfusion that will prepare in bioceramic scaffold minus resin die, solidifies and obtains the twin flue bioceramic scaffold by lyophilization, the demoulding, sintering.
The cannon pot resistance furnace that 3) will be contained with the macromolecule organic polymer is put into vacuum casting machine the inside, open resistance furnace and be warming up to above 10～30 ℃ of macromolecule organic polymer fusing point, keep half an hour, the macromolecule organic polymer is melted at this temperature, guarantee that the viscosity of macromolecule organic polymer is not more than 2Pas; Wherein, the macromolecule organic polymer is polylactic acid, polyglycolic acid or polycaprolactone.
4) by step 2) the twin flue bioceramic scaffold be put in the crucible that step 3) fills fusing macromolecule organic polymer, assurance is exposed to one of outside by the elementary pipeline of twin flue bioceramic scaffold and faces up, with the macromolecule organic polymer of fusing, do not contact, vacuum casting office is closed to sealing, open vacuum pump and start evacuation, make to pour in the secondary pipeline of twin flue bioceramic scaffold the macromolecule organic polymer of fusing, when reaching ?0.02MPa～?0.04MPa, vacuum stops evacuation, keep 1～3min under this vacuum after, crucible is taken out, obtain filled high polymer organic polymer support,
5) by cooling after the taking-up of filled high polymer organic polymer support, then filled high polymer organic polymer support is cut, allow elementary pipeline come out, obtained twin flue organic polymer/bioceramic Composite Bone support.
Below by specific embodiment, be elaborated.
1) at first utilize Three-dimensional Design Software Pro/Engineer design to there is the bioceramic scaffold cad model (as Fig. 1) that is not communicated with mutually elementary pipeline and secondary pipeline, then utilize Boolean calculation to obtain the minus model of bioceramic scaffold; Wherein, the concrete structure of disconnected elementary pipeline and secondary pipeline is mutually: elementary pipeline only extends to outside at a face of bioceramic scaffold cad model, the elementary pipeline of other parts all is hidden in ceramics bracket cad model inside, and secondary pipeline extends to ceramics bracket cad model outside on each face of ceramics bracket cad model; Elementary pipeline and secondary pipeline are the cylindric of diameter 600 μ m.
2) by the data of bioceramic scaffold minus model input photocureable rapid shaping machine, make support minus resin die, then utilize the gel injection-moulding legal system to make the twin flue bioceramic scaffold; Wherein, the gel injection-moulding method is specially the bioceramic slurry perfusion that will prepare in bioceramic scaffold minus resin die, solidifies and obtains the twin flue bioceramic scaffold by lyophilization, the demoulding, sintering.
3) the cannon pot resistance furnace is put into to vacuum casting machine the inside, opened resistance furnace and be warming up to 190 ℃, put into resistance furnace after polylactic acid (PLA) is placed in to crucible, keep half an hour, PLA is melted at this temperature, survey its viscosity and be about 1.7Pas;
4) by step 2) the twin flue bioceramic scaffold be put into step 3) fill the fusing PLA crucible in, assurance is exposed to one of outside by the elementary pipeline of twin flue bioceramic scaffold and faces up, with the PLA of fusing, do not contact, vacuum casting office is closed to sealing, open vacuum pump and start evacuation, make to pour in the secondary pipeline of twin flue bioceramic scaffold the PLA of fusing, when reaching ?0.03MPa, vacuum stops evacuation, keep after one minute, crucible being taken out under this vacuum, obtain filled high polymer organic polymer support;
5) by cooling after the taking-up of filled high polymer organic polymer support, then filled high polymer organic polymer support is cut, allow elementary pipeline come out, obtained twin flue organic polymer/bioceramic Composite Bone support.
1) at first utilize Three-dimensional Design Software Pro/Engineer design to there is the bioceramic scaffold cad model (as Fig. 1) that is not communicated with mutually elementary pipeline and secondary pipeline, then utilize Boolean calculation to obtain the minus model of bioceramic scaffold; Wherein, the concrete structure of disconnected elementary pipeline and secondary pipeline is mutually: elementary pipeline only extends to outside at a face of bioceramic scaffold cad model, the elementary pipeline of other parts all is hidden in ceramics bracket cad model inside, and secondary pipeline extends to ceramics bracket cad model outside on each face of ceramics bracket cad model; Elementary pipeline and secondary pipeline are the cylindric of diameter 400 μ m.
2) by the data of bioceramic scaffold minus model input photocureable rapid shaping machine, make support minus resin die, then utilize the gel injection-moulding legal system to make the twin flue bioceramic scaffold; Wherein, the gel injection-moulding method is specially the bioceramic slurry perfusion that will prepare in bioceramic scaffold minus resin die, solidifies and obtains the twin flue bioceramic scaffold by lyophilization, the demoulding, sintering.
3) the cannon pot resistance furnace is put into to vacuum casting machine the inside, opened resistance furnace and be warming up to 240 ℃, put into resistance furnace after polyglycolic acid is placed in to crucible, keep half an hour, polyglycolic acid is melted at this temperature, survey its viscosity and be less than 2Pas.
4) by step 2) the twin flue bioceramic scaffold be put into step 3) fill the fusing polyglycolic acid crucible in, assurance is exposed to one of outside by the elementary pipeline of twin flue bioceramic scaffold and faces up, with the polyglycolic acid of fusing, do not contact, vacuum casting office is closed to sealing, open vacuum pump and start evacuation, make to pour in the secondary pipeline of twin flue bioceramic scaffold the polyglycolic acid of fusing, when reaching ?0.02MPa, vacuum stops evacuation, keep after 2 minutes, crucible being taken out under this vacuum, obtain filled high polymer organic polymer support;
5) by cooling after the taking-up of filled high polymer organic polymer support, then filled high polymer organic polymer support is cut, allow elementary pipeline come out, obtained twin flue organic polymer/bioceramic Composite Bone support.
Embodiment 3
1) at first utilize Three-dimensional Design Software Pro/Engineer design to there is the bioceramic scaffold cad model (as Fig. 1) that is not communicated with mutually elementary pipeline and secondary pipeline, then utilize Boolean calculation to obtain the minus model of bioceramic scaffold; Wherein, the concrete structure of disconnected elementary pipeline and secondary pipeline is mutually: elementary pipeline only extends to outside at a face of bioceramic scaffold cad model, the elementary pipeline of other parts all is hidden in ceramics bracket cad model inside, and secondary pipeline extends to ceramics bracket cad model outside on each face of ceramics bracket cad model; Elementary pipeline and secondary pipeline are the cylindric of diameter 800 μ m.
2) by the data of bioceramic scaffold minus model input photocureable rapid shaping machine, make support minus resin die, then utilize the gel injection-moulding legal system to make the twin flue bioceramic scaffold; Wherein, the gel injection-moulding method is specially the bioceramic slurry perfusion that will prepare in bioceramic scaffold minus resin die, solidifies and obtains the twin flue bioceramic scaffold by lyophilization, the demoulding, sintering.
3) the cannon pot resistance furnace is put into to vacuum casting machine the inside, opened resistance furnace and be warming up to 70 ℃, put into resistance furnace after polycaprolactone is placed in to crucible, keep half an hour, polycaprolactone is melted at this temperature, survey its viscosity and be less than 2Pas.
4) by step 2) the twin flue bioceramic scaffold be put into step 3) fill the fusing polycaprolactone crucible in, assurance is exposed to one of outside by the elementary pipeline of twin flue bioceramic scaffold and faces up, with the polycaprolactone of fusing, do not contact, vacuum casting office is closed to sealing, open vacuum pump and start evacuation, make to pour in the secondary pipeline of twin flue bioceramic scaffold the polycaprolactone of fusing, when reaching ?0.04MPa, vacuum stops evacuation, keep after 3 minutes, crucible being taken out under this vacuum, obtain filled high polymer organic polymer support;
5) by cooling after the taking-up of filled high polymer organic polymer support, then filled high polymer organic polymer support is cut, allow elementary pipeline come out, obtained twin flue organic polymer/bioceramic Composite Bone support.
In step 1) of the present invention, the elementary pipeline of bioceramic scaffold cad model is hidden in internal stent, consider the manufacturing process of support, elementary pipeline need to come out on a face of bioceramic scaffold cad model, and secondary pipeline comes out on each face of bioceramic scaffold cad model.
In the present invention, the macromolecule organic polymer is that polylactic acid (PLA), polyglycolic acid (PGA) or polycaprolactone (PCL) etc. have definite fusing point, and has the macromolecule organic polymer of biocompatibility and biodegradability.
The Composite Bone support that said method of the present invention makes comprises disconnected elementary pipeline and secondary pipeline mutually, elementary pipeline is grown into and nutrient metabolism for cell attachment, tissue, and the organic polymer poured in secondary pipeline is for improving the mechanical property of support.
At first the present invention prepares and has mutual disconnected twin flue bioceramic scaffold, this twin flue is referred to as elementary pipeline and secondary pipeline, then the twin flue bioceramic scaffold is immersed in the organic polymer of high temperature melting, allow the organic polymer of perfusion fusing in secondary pipeline, through post processing, can obtain twin flue organic polymer/bioceramic Composite Bone support.The present invention utilizes organic polymer good toughness, characteristics that mechanical property is adjustable, it is poured in bioceramic scaffold, prepare twin flue organic polymer/bioceramic Composite Bone support, wherein elementary pipeline is grown into and nutrient metabolism for cell attachment, tissue, be difficult for causing inflammation, be perfused with organic polymer in secondary pipeline, play the effect that improves the support mechanical property, the present invention has better mechanical property than simple bioceramic scaffold, has overcome that bioceramic scaffold fragility in the prior art is large, the problem of poor toughness.
Claims (8)
1. the preparation method of twin flue organic polymer/bioceramic Composite Bone support, is characterized in that, comprises the following steps:
1) at first utilize Three-dimensional Design Software Pro/Engineer design bioceramic scaffold cad model, this bioceramic scaffold cad model has disconnected elementary pipeline and secondary pipeline mutually, then utilizes Boolean calculation to obtain the minus model of bioceramic scaffold;
2) by the data of the minus model of bioceramic scaffold input photocureable rapid shaping machine, make support minus resin die, then utilize the standby twin flue bioceramic scaffold that obtains of gel injection-moulding legal system;
The crucible that 3) will hold the macromolecule organic polymer is put into resistance furnace, then resistance furnace is put into to the vacuum casting machine, resistance furnace is heated up and make the fusing of macromolecule organic polymer;
4) the twin flue bioceramic scaffold is put in the crucible of the organic polymer that fills fusing, to vacuum casting machine evacuation, makes to pour in secondary pipeline the macromolecule organic polymer of fusing, obtain filled high polymer organic polymer support;
5) filled high polymer organic polymer support is cut, elementary pipeline is come out, obtained twin flue organic polymer/bioceramic Composite Bone support.
2. the preparation method of twin flue organic polymer according to claim 1/bioceramic Composite Bone support, is characterized in that, elementary pipeline described in described step 1) and secondary pipeline are all cylindric, and diameter is 400～800 μ m.
3. the preparation method of twin flue organic polymer according to claim 1/bioceramic Composite Bone support, it is characterized in that, described step 2) in, the gel injection-moulding method is specially: the bioceramic slurry perfusion, in support minus resin die, is solidified and obtains the twin flue bioceramic scaffold by lyophilization, the demoulding, sintering.
4. the preparation method of twin flue organic polymer according to claim 1/bioceramic Composite Bone support, is characterized in that, in described step 3), the macromolecule organic polymer is polylactic acid, polyglycolic acid or polycaprolactone.
5. the preparation method of twin flue organic polymer according to claim 1/bioceramic Composite Bone support, is characterized in that, is warming up to above 10～30 ℃ of macromolecule organic polymer fusing point in described step 3).
6. the preparation method of twin flue organic polymer according to claim 1/bioceramic Composite Bone support, is characterized in that, after described step 3) fusing, the viscosity of macromolecule organic polymer is less than or equal to 2Pas.
7. the preparation method of twin flue organic polymer according to claim 1/bioceramic Composite Bone support, is characterized in that, in described step 4), be evacuated down to vacuum Wei ?0.02MPa～?0.04MPa, and keep 1～3min under this vacuum.
8. the twin flue organic polymer that method makes according to claim 1/bioceramic Composite Bone support, it is characterized in that, this Composite Bone support comprises disconnected elementary pipeline and secondary pipeline mutually, elementary pipeline is grown into and nutrient metabolism for cell attachment, tissue, and the macromolecule organic polymer poured in secondary pipeline is for improving the mechanical property of support.
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