CN102430151A - Tissue engineering bone cartilage composite bracket and integrated photocuringable forming method thereof - Google Patents
Tissue engineering bone cartilage composite bracket and integrated photocuringable forming method thereof Download PDFInfo
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- CN102430151A CN102430151A CN2011102605306A CN201110260530A CN102430151A CN 102430151 A CN102430151 A CN 102430151A CN 2011102605306 A CN2011102605306 A CN 2011102605306A CN 201110260530 A CN201110260530 A CN 201110260530A CN 102430151 A CN102430151 A CN 102430151A
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Abstract
The invention discloses a tissue engineering bone cartilage composite bracket and an integrated photocuringable forming method thereof. The tissue engineering bone cartilage composite bracket serves as a ceramic bracket, wherein the ceramic bracket is served as a bone-repair part, and a porous structure is arranged on the surface of the ceramic bracketbone-repair part of the porous structure; and the ceramic bracket is fixed on a supporting plate of a photocuringable quick forming machine. A laser scanning path is driven through a computer aided design (CAD) model; and laser directly exposes and cures a hydrogel bracket and a pure hydrogel bracket which contain a ceramic component onto the ceramic bracket sequentially to form a three-layer composite bracket. Therefore, quick and fine preparation of a three-dimensional composite bracket of bone cartilage-like tissue histomorphometry is realized; uncontrollable structures and low efficiency because of handwork in the preparation process of a traditional composite bracket are avoided; the preparation efficiency is improved; and a calcified cartilage-like layer bracket and a hydrogel cartilage bracket with subtle structures can be bonded and compounded on the surface of the ceramic bracket by means of a rivet and a two-phase material.
Description
Technical field
The present invention relates to biological manufacturing technology field, particularly tissue engineered bone cartilage compound rest and integrated photocuring forming method thereof.
Background technology
Because the self-reparing capability of adult's articular cartilage is limited, be directed against the damaged of articular cartilage and bone clinically, need surgical intervention usually, comprise little fracture art, the autotransplantation of bone cartilage etc. under cleaning art, the mirror under the arthroscope.Defectives such as it is poor that above-mentioned means exist repairing effect, is subject to patient age and damaged area, and the graft source is limited.Through the research of in recent years the artificial bone cartilage defect being repaired, the osteochondral tissue engineering has had more deep development, and demonstrates the tremendous potential of using clinically.
The osteochondral tissue engineering rack includes simple bone (cartilage) support; Bone cartilage compound rest and the kinds such as bone cartilage compound rest that comprise the calcified cartilage layer; Present most of bone cartilage compound rest mainly relies on manual suture, mode such as bonding to prepare, complicated operating process, and automatization and customization degree are low; And cause the structural instability of compound rest; After support is implanted, be easy to generate delamination, situation such as peel off, can't for cambium grow into and the fusion of support and surrounding tissue provides a good mechanical back-up environment.In addition; Has one deck calcified cartilage layer between the natural bone cartilage; It plays the effect of supporting that cartilage pressure carries and stops vascular invasion; This transition structure of preparation calcified cartilage layer support is not considered in the preparation of conventional stent, and it is relatively poor to adopt the hierarchy support of the method preparation of 3 D-printing to exist adhesion, support problem such as subside easily after implanting.
Summary of the invention
In order to overcome the defective of above-mentioned prior art; The object of the present invention is to provide tissue engineered bone cartilage compound rest and integrated photocuring forming method thereof; Can prepare the osteochondral tissue engineering MULTILAYER COMPOSITE support that customizes profile fast, compound rest has the calcification layer of similar calcified cartilage layer function, relies on the bonding effect on the surface of hole and the colloid of ceramic bone surface; Can effectively improve the adhesive strength between the compound rest; Strengthen the stability after support is implanted, for growing into of cell and tissue provides a good mechanical back-up environment, this method for preparing has precision height, simple to operate, the cycle short, repeatability is high advantage.
In order to achieve the above object, technical scheme of the present invention is achieved in that
A kind of integrated photocuring forming method of tissue engineered bone cartilage compound rest may further comprise the steps:
Step 4; Adopt light-sensitive material Polyethylene Glycol double methacrylate; The preparation hydrogel solution; According to volume ratio with the Polyethylene Glycol double methacrylate: light trigger I-1173: deionized water=(30-50): (0.3-0.5): ratio uniform mixing (50-70), adopt magnetic stirrer to stir and at the uniform velocity stir 30-60min, place type vacuum injecting and forming machine to remove bubble;
Step 5; Place rapidform machine to have on the supporting plate of regulating calibrating installation ceramics bone frame; Place the prepared hydrogel solution that contains ceramic powders of step 3, regulate ceramics bone frame and aim at, adjustment liquid level zero-bit with calcified cartilage layer support three-dimensional data profile; Carry out hot spot scanning, the straight forming three dimensional structure;
Step 6 rises supporting plate, and the hydrogel solution that will contain ceramic powders replaces with the prepared hydrogel solution of step 4; Data are replaced by hydrogel cartilage support three-dimensional data, regulate ceramics bone frame and aim at, adjustment liquid level zero-bit with calcified cartilage layer support three-dimensional data profile; Carry out hot spot scanning; The straight forming three dimensional structure makes the MULTILAYER COMPOSITE support, place deionized water repeatedly swelling, disinfect.
Described light trigger I-1173 is 2-hydroxy-2-methyl-1-phenyl-1-propyl group ketone.
Prepared tissue engineered bone cartilage MULTILAYER COMPOSITE support comprises porous ceramics bone support 1, on porous ceramics bone support 1, is solidified with the hydrogel support 2 that contains ceramic component, is solidified with pure water gel stent 3 containing on the hydrogel support 2 of ceramic component.
Porous ceramics bone support 1 surface has the pore structure on the similar natural bone surface of design in advance; The infiltration of type of helping calcified cartilage layer support in the preparation process, and compound rest is implanted back blood from the limited infiltration of ceramics bone frame to hydrogel cartilage support.
Contain the amalgam of the hydrogel support 2 of ceramic component for bioceramic and hydrogel; Can impel compound rest to implant the formation of back calcified cartilage layer tissue; Play the effect of the calcified cartilage layer that has between similar natural bone and the cartilage; Stop blood vessel from the intrusion of ceramics bone frame, impel compound rest to implant the formation of back cartilage to hydrogel cartilage support.
The present invention prepares on the basis of ceramics bone frame at rapid shaping; Proposition is substrate with the ceramics bracket surface; Utilize photocureable rapid shaping technology preparation type calcified cartilage layer support and hydrogel cartilage support; Realize the preparation of many materials of multilamellar compound rest, can prepare customization, bone cartilage MULTILAYER COMPOSITE support that bond strength is high fast, for the preparation of osteochondral tissue engineering compound rest provides customization, technology is simple, precision is high process.
Description of drawings
Fig. 1 is a process chart of the present invention.
Fig. 2 is a ceramics bracket localization machine composition.
Fig. 3 is a structural representation of the present invention, and wherein: Fig. 3 (a) is a MULTILAYER COMPOSITE support front view; Fig. 3 (b) is the compound rest normal axomometric drawing.
Fig. 4 is the implant site sketch map of bone cartilage MULTILAYER COMPOSITE support.
The specific embodiment
Below in conjunction with accompanying drawing the present invention is made further detailed description.
With reference to Fig. 1, utilize photocureable rapid shaping technological according to what the present invention proposed, be substrate with ceramics bracket based on the rapid shaping technique preparation, rely on its porous surface, straight forming class calcified cartilage layer support and hydrogel cartilage support, its concrete steps comprise:
A kind of integrated photocuring forming method of tissue engineered bone cartilage compound rest may further comprise the steps:
Porous ceramics bone support 1 demand according to the support implant site is utilized three-dimensional reverse technology, extracts the joint profile; Through Geomagics and Pro/E software processes; Design porous ceramics support, its upper surface profile is derived from the pass pitch surface, and has equally distributed at least 200 μ m holes; Hole accounts for the 40-50% area, preparation prototype or minus; Class calcified cartilage layer backing thickness is 300 μ m, and hydrogel cartilage backing thickness is 1000 μ m, and threedimensional model saves as the .stl formatted file, adopts rapidform machine to prepare the ceramics bone frame minus, adopts gel casting process, the preparation biscuit of ceramics; Perhaps adopt rapid shaping technique, directly solidify ceramic size, the forming ceramic biscuit.Technologies such as warp is dry, deresination is come unstuck, high temperature sintering, the preparation ceramics bone frame, or adopt additive method, and like the 3 D-printing method of forming, preparation such as fusion sediment method ceramics bone frame.
Step 4; Adopt light-sensitive material Polyethylene Glycol double methacrylate; The preparation hydrogel solution; According to volume ratio with the Polyethylene Glycol double methacrylate: light trigger I-1173: the ratio uniform mixing of deionized water=40: 0.5: 60, adopt magnetic stirrer to stir and at the uniform velocity stir 50min, place type vacuum injecting and forming machine to remove bubble;
Step 5; Place rapidform machine to have on the supporting plate of regulating calibrating installation ceramics bone frame; Place the prepared hydrogel solution that contains ceramic powders of step 3, regulate ceramics bone frame and aim at, adjustment liquid level zero-bit with calcified cartilage layer support three-dimensional data profile; Carry out hot spot scanning, the straight forming three dimensional structure;
The specific embodiment of this step is: with reference to Fig. 2, adopt two-dimensional localization mechanism, with ceramics bone frame according to model in computer software magics the position and accurately be positioned on the rapid shaping machine supporting plate adjustment zero-bit; Place the prepared hydrogel solution that contains ceramic powders of step 3,, the scanning of type of carrying out calcified cartilage layer data, the scanning process parameter is: solid state laser wavelength 355nm; Spot diameter 0.20mm, model lift height 0.10mm fills scanning speed 2500.00mm/s; Fill vectorial spacing 0.10mm, support scanning speed 500mm/s, skip during preparation and support this step of scanning; Stride jumping speed 12000.00mm/s, profile scan speed 3000mm/s, compensation diameter 0.1mm; Worktable lifting speed 2.0mm/s, point supports 1.66ms sweep time, and structure 1.37ms sweep time tangles;
Step 6 rises supporting plate, and the hydrogel solution that will contain ceramic powders replaces with the prepared hydrogel solution of step 4; Data are replaced by hydrogel cartilage support three-dimensional data, regulate ceramics bone frame and aim at, adjustment liquid level zero-bit with calcified cartilage layer support three-dimensional data profile; Carry out hot spot scanning; The straight forming three dimensional structure makes the MULTILAYER COMPOSITE support, place deionized water repeatedly swelling, disinfect;
The specific embodiment of this step is: the rising supporting plate, solution is replaced with the prepared hydrogel solution of step 4, and data are replaced by hydrogel cartilage support three-dimensional data, regulate ceramics bone frame and aim at calcified cartilage layer support three-dimensional data profile; Adjustment liquid level zero-bit, the scanning of carrying out hydrogel cartilage support is solidified, and the scanning process parameter is: solid state laser wavelength 355nm; Spot diameter 0.20mm, model lift height 0.10mm fills scanning speed 5500.00mm/s; Fill vectorial spacing 0.10mm, support scanning speed 1000mm/s, skip during preparation and support this step of scanning; Stride jumping speed 12000.00mm/s, profile scan speed 6000mm/s, compensation diameter 0.1mm; Worktable lifting speed 2.0mm/s, point supports 0.50ms sweep time, and structure 0.50ms sweep time tangles; After the compound rest preparation is accomplished, take out, place deionized water to clean, it is carried out processing such as follow-up sterilization, carry out external implantation.Can adjust the two-dimensional localization mechanism position this moment, and the displacement ceramics bracket can repeat to prepare compound rest.
Light trigger I-1173 described in the above-mentioned steps is 2-hydroxy-2-methyl-1-phenyl-1-propyl group ketone.
With reference to Fig. 3; Prepared tissue engineered bone cartilage MULTILAYER COMPOSITE support; Comprise porous ceramics bone support 1, on porous ceramics bone support 1, be solidified with the hydrogel support 2 that contains ceramic component, be solidified with pure water gel stent 3 containing on the hydrogel support 2 of ceramic component.
Fig. 4 is the DF position sketch map that the present invention implants new zealand rabbit, shows rack surface and articular surface SURFACES MATCHING among the figure.
Claims (4)
1. the integrated photocuring forming method of a tissue engineered bone cartilage compound rest is characterized in that, may further comprise the steps:
Step 1, employing gel injection-moulding or photocuring forming technique or prepared by other porous ceramics bone support 1, the surperficial uniform distribution of porous ceramics bone support (1) aperture is not less than the hole of 200 μ m;
Step 2, according to the ceramics bone frame size, calcified cartilage layer support and cartilage frame threedimensional model that design matches, and be converted into the .stl formatted file, handle through delamination software, with data importing photocureable rapid shaping machine;
Step 3; Adopt light-sensitive material Polyethylene Glycol double methacrylate; Preparation contains the hydrogel solution of ceramic powders; According to volume ratio with ceramic powders: Polyethylene Glycol double methacrylate: light trigger I-1173: deionized water=90: (30-50): (0.3-0.5): ratio uniform mixing (50-70), adopted the ball mill ball milling 2-3 hour, place type vacuum injecting and forming machine to remove bubble;
Step 4; Adopt light-sensitive material Polyethylene Glycol double methacrylate; The preparation hydrogel solution; According to volume ratio with the Polyethylene Glycol double methacrylate: light trigger I-1173: deionized water=(30-50): (0.3-0.5): ratio uniform mixing (50-70), adopt magnetic stirrer to stir and at the uniform velocity stir 30-60min, place type vacuum injecting and forming machine to remove bubble;
Step 5; Place rapidform machine to have on the supporting plate of regulating calibrating installation ceramics bone frame (1); Place the prepared hydrogel solution that contains ceramic powders of step 3, regulate ceramics bone frame and aim at, adjustment liquid level zero-bit with calcified cartilage layer support three-dimensional data profile; Carry out hot spot scanning, the straight forming three dimensional structure;
Step 6 rises supporting plate, and the hydrogel solution that will contain ceramic powders replaces with the prepared hydrogel solution of step 4; Data are replaced by hydrogel cartilage support three-dimensional data, regulate ceramics bone frame and aim at, adjustment liquid level zero-bit with calcified cartilage layer support three-dimensional data profile; Carry out hot spot scanning; The straight forming three dimensional structure makes the MULTILAYER COMPOSITE support, place deionized water repeatedly swelling, disinfect.
2. the integrated photocuring forming method of a kind of tissue engineered bone cartilage compound rest according to claim 1 is characterized in that, may further comprise the steps:
Step 1, employing gel injection-moulding or photocuring forming technique or prepared by other porous ceramics bone support 1, porous ceramics bone support 1 surperficial uniform distribution aperture is not less than the hole of 200 μ m;
Porous ceramics bone support (1) utilizes three-dimensional reverse technology according to the demand of support implant site, extracts the joint profile; Through Geomagics and Pro/E software processes; Design porous ceramics support, its upper surface profile is derived from the pass pitch surface, and has equally distributed at least 200 μ m holes; Hole accounts for the 40-50% area, preparation prototype or minus; Class calcified cartilage layer backing thickness is 300 μ m, and hydrogel cartilage backing thickness is 1000 μ m, and threedimensional model saves as the .stl formatted file, adopts rapidform machine to prepare the ceramics bone frame minus, adopts gel casting process, the preparation biscuit of ceramics; Perhaps adopt rapid shaping technique, directly solidify ceramic size, the forming ceramic biscuit.Technologies such as warp is dry, deresination is come unstuck, high temperature sintering, the preparation ceramics bone frame, or adopt additive method, and like the 3 D-printing method of forming, preparation such as fusion sediment method ceramics bone frame.
Step 2, according to the ceramics bone frame size, calcified cartilage layer support and cartilage frame threedimensional model that design matches, and be converted into the .stl formatted file, handle through delamination software, with data importing photocureable rapid shaping machine;
Step 3; Adopt light-sensitive material Polyethylene Glycol double methacrylate; Preparation contains the hydrogel solution of ceramic powders; According to volume ratio with ceramic powders: Polyethylene Glycol double methacrylate: light trigger I-1173: deionized water=90: 40: 0.5: 60 ratio uniform mixing, adopted the ball mill ball milling 3 hours, place type vacuum injecting and forming machine to remove bubble;
Step 4; Adopt light-sensitive material Polyethylene Glycol double methacrylate; The preparation hydrogel solution; According to volume ratio with the Polyethylene Glycol double methacrylate: light trigger I-1173: the ratio uniform mixing of deionized water=40: 0.5: 60, adopt magnetic stirrer to stir and at the uniform velocity stir 50min, place type vacuum injecting and forming machine to remove bubble;
Step 5; Place rapidform machine to have on the supporting plate of regulating calibrating installation ceramics bone frame; Place the prepared hydrogel solution that contains ceramic powders of step 3, regulate ceramics bone frame and aim at, adjustment liquid level zero-bit with calcified cartilage layer support three-dimensional data profile; Carry out hot spot scanning, the straight forming three dimensional structure;
The specific embodiment of this step is: adopt two-dimensional localization mechanism, with ceramics bone frame according to model in computer software magics the position and accurately be positioned on the rapid shaping machine supporting plate, the adjustment zero-bit places the prepared hydrogel solution that contains ceramic powders of step 3;, the scanning of type of carrying out calcified cartilage layer data, the scanning process parameter is: solid state laser wavelength 355nm; Spot diameter 0.20mm, model lift height 0.10mm fills scanning speed 2500.00mm/s; Fill vectorial spacing 0.10mm, support scanning speed 500mm/s, skip during preparation and support this step of scanning; Stride jumping speed 12000.00mm/s, profile scan speed 3000mm/s, compensation diameter 0.1mm; Worktable lifting speed 2.0mm/s, point supports 1.66ms sweep time, and structure 1.37ms sweep time tangles.
Step 6 rises supporting plate, and the hydrogel solution that will contain ceramic powders replaces with the prepared hydrogel solution of step 4; Data are replaced by hydrogel cartilage support three-dimensional data, regulate ceramics bone frame and aim at, adjustment liquid level zero-bit with calcified cartilage layer support three-dimensional data profile; Carry out hot spot scanning; The straight forming three dimensional structure makes the MULTILAYER COMPOSITE support, place deionized water repeatedly swelling, disinfect.
The specific embodiment of this step is: the rising supporting plate, solution is replaced with the prepared hydrogel solution of step 4, and data are replaced by hydrogel cartilage support three-dimensional data, regulate ceramics bone frame and aim at calcified cartilage layer support three-dimensional data profile; Adjustment liquid level zero-bit, the scanning of carrying out hydrogel cartilage support is solidified, and the scanning process parameter is: solid state laser wavelength 355nm; Spot diameter 0.20mm, model lift height 0.10mm fills scanning speed 5500.00mm/s; Fill vectorial spacing 0.10mm, support scanning speed 1000mm/s, skip during preparation and support this step of scanning; Stride jumping speed 12000.00mm/s, profile scan speed 6000mm/s, compensation diameter 0.1mm; Worktable lifting speed 2.0mm/s, point supports 0.50ms sweep time, and structure 0.50ms sweep time tangles; After the compound rest preparation is accomplished, take out, place deionized water to clean, it is carried out processing such as follow-up sterilization, carry out external implantation.Can adjust the two-dimensional localization mechanism position this moment, and the displacement ceramics bracket can repeat to prepare compound rest.
3. the integrated photocuring forming method of a kind of tissue engineered bone cartilage compound rest according to claim 1 and 2 is characterized in that, the light trigger I-1173 described in the step is 2-hydroxy-2-methyl-1-phenyl-1-propyl group ketone.
4. tissue engineered bone cartilage compound rest; Comprise porous ceramics bone support (1); It is characterized in that, on porous ceramics bone support (1), be solidified with the hydrogel support (2) that contains ceramic component, be solidified with pure water gel stent (3) containing on the hydrogel support (2) of ceramic component.
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Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| CN110292659A (en) * | 2019-07-15 | 2019-10-01 | 四川大学华西医院 | A kind of biology cartilaginous tissue repairs alternative materials and preparation method thereof |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006004951A2 (en) * | 2004-06-30 | 2006-01-12 | The Board Of Trustees Of The University Of Illinois | Poly (ethylene glycol) - diacrylate- (pegda) - crosslinked hydrogels comprising adipogenic mesenchymal stem cells |
| CN101148360A (en) * | 2007-08-14 | 2008-03-26 | 西安交通大学 | Customized forming method for gradient porous structure ceramic |
| US20080103227A1 (en) * | 2006-10-27 | 2008-05-01 | Korea Institute Of Machinery & Materials | Porous material having hierarchical pore structure and preparation method thereof |
| CN101417151A (en) * | 2008-07-10 | 2009-04-29 | 中国人民解放军第三军医大学第一附属医院 | Biology source type calcified-layer containing cartilage tissue engineer bracket |
| US20110076316A1 (en) * | 2007-10-08 | 2011-03-31 | Sureshan Sivananthan | Scalable matrix for the in vivo cultivation of bone and cartilage |
-
2011
- 2011-09-05 CN CN2011102605306A patent/CN102430151B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006004951A2 (en) * | 2004-06-30 | 2006-01-12 | The Board Of Trustees Of The University Of Illinois | Poly (ethylene glycol) - diacrylate- (pegda) - crosslinked hydrogels comprising adipogenic mesenchymal stem cells |
| US20080103227A1 (en) * | 2006-10-27 | 2008-05-01 | Korea Institute Of Machinery & Materials | Porous material having hierarchical pore structure and preparation method thereof |
| CN101148360A (en) * | 2007-08-14 | 2008-03-26 | 西安交通大学 | Customized forming method for gradient porous structure ceramic |
| US20110076316A1 (en) * | 2007-10-08 | 2011-03-31 | Sureshan Sivananthan | Scalable matrix for the in vivo cultivation of bone and cartilage |
| CN101417151A (en) * | 2008-07-10 | 2009-04-29 | 中国人民解放军第三军医大学第一附属医院 | Biology source type calcified-layer containing cartilage tissue engineer bracket |
Non-Patent Citations (2)
| Title |
|---|
| 《Annals of Biomedical Engineering》 20060801 KARINA ARCAUTE ET AL. "Stereolithography of Three-Dimensional Bioactive Poly(Ethylene Glycol) Constructs with Encapsulated Cells" 第1429-1441页 1-4 第34卷, 第9期 * |
| KARINA ARCAUTE ET AL.: ""Stereolithography of Three-Dimensional Bioactive Poly(Ethylene Glycol) Constructs with Encapsulated Cells"", 《ANNALS OF BIOMEDICAL ENGINEERING》 * |
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| CN110292659A (en) * | 2019-07-15 | 2019-10-01 | 四川大学华西医院 | A kind of biology cartilaginous tissue repairs alternative materials and preparation method thereof |
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| WO2022170820A1 (en) * | 2021-02-09 | 2022-08-18 | 浙江大学 | 3d printing forming method for bionic composite scaffold for synchronously repairing soft and hard tissue defects |
| CN114129775A (en) * | 2021-12-13 | 2022-03-04 | 上海大学 | Bionic cell-containing massive osteochondral biological scaffold and preparation method thereof |
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