CN103494206A - Preparation process of soft capsule containing peony seed essential oil and peony petal isoflavone - Google Patents
Preparation process of soft capsule containing peony seed essential oil and peony petal isoflavone Download PDFInfo
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- CN103494206A CN103494206A CN201310506224.5A CN201310506224A CN103494206A CN 103494206 A CN103494206 A CN 103494206A CN 201310506224 A CN201310506224 A CN 201310506224A CN 103494206 A CN103494206 A CN 103494206A
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- peony
- soft capsule
- peony petal
- essential oil
- petal
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- 241000736199 Paeonia Species 0.000 title claims abstract description 122
- 235000006484 Paeonia officinalis Nutrition 0.000 title claims abstract description 122
- 239000007901 soft capsule Substances 0.000 title claims abstract description 57
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 title claims abstract description 47
- 235000008696 isoflavones Nutrition 0.000 title claims abstract description 47
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- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- GOMNOOKGLZYEJT-UHFFFAOYSA-N isoflavone Chemical compound C=1OC2=CC=CC=C2C(=O)C=1C1=CC=CC=C1 GOMNOOKGLZYEJT-UHFFFAOYSA-N 0.000 title abstract 6
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- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 208000018152 Cerebral disease Diseases 0.000 description 1
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- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 1
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- 230000004054 inflammatory process Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- -1 linoleic acid, leukotrienes Chemical class 0.000 description 1
- 229960004488 linolenic acid Drugs 0.000 description 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 208000001491 myopia Diseases 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
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- 238000000926 separation method Methods 0.000 description 1
- JAJWGJBVLPIOOH-IZYKLYLVSA-M sodium taurocholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS([O-])(=O)=O)C)[C@@]2(C)[C@@H](O)C1 JAJWGJBVLPIOOH-IZYKLYLVSA-M 0.000 description 1
- 238000012109 statistical procedure Methods 0.000 description 1
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- 239000013589 supplement Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
- A23L29/37—Sugar alcohols
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
- A23P10/35—Encapsulation of particles, e.g. foodstuff additives with oils, lipids, monoglycerides or diglycerides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P20/00—Coating of foodstuffs; Coatings therefor; Making laminated, multi-layered, stuffed or hollow foodstuffs
- A23P20/20—Making of laminated, multi-layered, stuffed or hollow foodstuffs, e.g. by wrapping in preformed edible dough sheets or in edible food containers
- A23P20/25—Filling or stuffing cored food pieces, e.g. combined with coring or making cavities
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/02—Recovery or refining of essential oils from raw materials
- C11B9/025—Recovery by solvent extraction
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention mainly relates to a soft capsule containing peony seed essential oil and peony petal isoflavone. The soft capsule containing the peony seed essential oil and the peony petal isoflavone has the functions of reducing blood pressure, blood fat and cholesterol, antithrombosis, promoting cell regeneration, reducing wrinkles, delaying skin aging, clearing bowels and moistening dryness, expelling noxious substance and improving looks, and calming the nerves and maintaining mental tranquility, is remarkable in effect and free of side effect, and is particularly suitable for people who have the problems of loose and rough kin, more wrinkles and color mottles, fatness, mental stress, emotional instability, very high blood fat and the like. According to a preparation process of the soft capsule containing the peony seed essential oil and the peony petal isoflavone, since a biological method is used for extracting the peony petal isoflavone, the extraction purity is quite high, and the extraction efficiency is quite high compared with a solvent method, column chromatography and the like; according to the preparation process, since a spraying method is used for mixing the peony seed essential oil and the peony petal isoflavone, mixing is uniform, and work efficiency is effectively improved.
Description
Technical field
The invention belongs to health product technology field, relate generally to a kind of preparation technology of the soft capsule containing peony seeds essential oil and peony petal isoflavones.
Background technology
In today of economic life prosperity, people require more and more higher to quality of life.Find after deliberation, in the peony seeds essential oil, containing multiple unrighted acids such as oleic acid, linoleic acid, leukotrienes, especially linolenic acid content reaches more than 50%.Leukotrienes to increasing intelligence, strengthen immunity, vision protection, reduce blood pressure, reduce blood sugar, reduce blood fat, suppress hemorrhagic cerebral disease and thrombotic diseases, generation and transfer, prevention miocardial infarction and cerebral infarction, Polyglucan disease, prevention of inflammation and the reducing human aging etc. of inhibition cancer have obvious effect.At present, generally lack leukotrienes in the population of China meals, half of the not enough world health organisation recommendations amount of daily intaking amount, this is also to cause one of China's angiocardiopathy, diabetes, near-sighted reason occurred frequently.The numerous and confused appealing of China's medical circle and the expert of nutrition educational circles supplements leukotrienes, although in the peony seeds essential oil, linolenic content is very high, but leukotrienes is unrighted acid, in oxidation environment or meet high temperature and be easy to oxidized generation trans-fatty acid, harmful on the contrary to human body.Therefore, in view of the effect that the peony seeds essential oil is brought into play in medical science and nutrition, research and development have larger value and prospect about the health-caring capsule of peony seeds essential oil.
Summary of the invention
The preparation technology who the purpose of this invention is to provide a kind of soft capsule containing peony seeds essential oil and peony petal isoflavones, that this soft capsule has is hypotensive, reducing blood lipid, reduction cholesterol, antithrombotic, promotion cytothesis, reduce wrinkle, delay skin aging, logical intestines and moisturize, toxin-expelling and face nourishing, the effect of feeling at ease to repose, and effect is remarkable, have no side effect.For cutis laxa, coarse, wrinkle, color spot increase, body obesity, stress, emotional instability, and the crowds such as Hyperlipidemia are especially applicable.
The present invention realizes that the technical scheme that above-mentioned purpose adopts is: a kind of preparation technology of the soft capsule containing peony seeds essential oil and peony petal isoflavones comprises the following steps:
Step 1, pluck fresh peony petal, take out after peony petal is placed in to the baking oven forced air drying 0.5-2.5h that temperature is 40-60 ℃, be crushed to 40 orders, obtain the peony petal raw material, standby;
The pectase equal-volume that step 2, the cellulase that is 0.2mg/mL by mass concentration and mass concentration are 0.1mg/mL mixes, add again the acetum that mass concentration is 2%, until the pH of mixed value reaches 5.0, by the mixed liquor rear standing 10-15min that stirs, obtain complex enzyme liquid, standby;
Step 3, the peony petal raw material that step 1 is obtained are put into triangular flask, and to the complex enzyme liquid that adds step 2 to obtain in triangular flask, complex enzyme liquid is 45:1 with the ratio of peony petal raw material addition, and wherein complex enzyme liquid is in milliliter, and the peony petal raw material are in gram; Triangular flask is placed under 35 ℃ of conditions after standing 20min, keeps temperature to carry out ultrasonic wave to triangular flask simultaneously and process 5min, supersonic frequency is 22 kHz, and ultrasonic being disposed moves to standing 40min under 40 ℃ of conditions by triangular flask; Then to adding in triangular flask the alcohol reflux that mass concentration is 95% to extract 1h, amount of alcohol added is 5 times of total solution weight in triangular flask, carries out centrifugation 15min after refluxing extraction, obtains supernatant; Supernatant is successively carried out to decompression distillation and heated-air drying, obtain the peony petal isoflavones, standby;
Step 4, getting peony seeds essential oil 40-60 part according to parts by weight and be placed in agitator, is to stir 20-40min under 50 ℃ of conditions in temperature, and mixing speed is 80-110r/min, stir finish after insulation, standby; Get again peony petal isoflavones 1-3 part, be placed in mill, grind 1h, obtain peony petal isoflavones powder, standby;
Step 5, the peony seeds essential oil that step 4 is obtained are placed in liquid dispensing apparatus, by in peony petal isoflavones powder spray device, then open two sprayer units simultaneously, shower nozzle points in same receiver, controls spray velocity both have been sprayed simultaneously, and spraying finishes, liquid in receiver is placed in to mill, grind 2-4h under the condition that is 50-100r/min at rotating speed, obtain the filler of soft capsule, standby;
Step 6, the process for preparing soft capsule according to routine prepare soft capsule shell, and the filler of the soft capsule after prepared by soft capsule shell, step 5 obtained carries out the capsule-filling compacting, then carry out hardened forming, shampooing is dry, completes the preparation of soft capsule.
Beneficial effect of the present invention
That one, the soft capsule that contains peony seeds essential oil and peony petal isoflavones provided by the invention have is hypotensive, reducing blood lipid, reduction cholesterol, antithrombotic, promotion cytothesis, reduce wrinkle, delay skin aging, logical intestines and moisturize, toxin-expelling and face nourishing, the effect of feeling at ease to repose, and effect is remarkable, have no side effect.For cutis laxa, coarse, wrinkle, color spot increase, body obesity, stress, emotional instability, and the crowds such as Hyperlipidemia are especially applicable.
They are two years old, in the present invention, the peony seeds essential oil has hypotensive, reducing blood lipid, suppress platelet aggregation, antithrombotic, promote cytothesis, beautifying face and moistering lotion, reduce wrinkle, extend skin senescence, the effect that logical intestines are moisturized and lost weight, the peony seeds essential oil is combined with the peony petal isoflavones, nutrition and drug effect scope have not only been enlarged, also mutually promoted nutrition and drug action effect, the effect of the reduction cholesterol of peony petal isoflavones combines with peony seed oil, promoted hypotensive, reducing blood lipid, suppress the performance of the effect of platelet aggregation, prevent that the thrombosis effect is remarkable, the more important thing is that the peony petal isoflavones can protect the peony seeds essential oil not oxidized, himself have antisepsis, not only extended the term of validity of capsule, and do not need to add other anticorrisive agents, all-natural product, have no side effect.
Three, in preparation technology provided by the invention, the peony petal isoflavones adopts bioanalysis to be extracted, and DNA purity is higher, compares the extraction efficiencies such as solvent method, post partition method very fast; This preparation technology adopts spray-on process that peony seeds essential oil and peony petal isoflavones are mixed, and not only mixes, and has effectively improved operating efficiency.
The specific embodiment
A kind of preparation technology of the soft capsule that contains peony seeds essential oil and peony petal isoflavones comprises the following steps:
Step 1, pluck fresh peony petal, take out after peony petal is placed in to the baking oven forced air drying 0.5-2.5h that temperature is 40-60 ℃, be crushed to 40 orders, obtain the peony petal raw material, standby;
The pectase equal-volume that step 2, the cellulase that is 0.2mg/mL by mass concentration and mass concentration are 0.1mg/mL mixes, add again the acetum that mass concentration is 2%, until the pH of mixed value reaches 5.0, by the mixed liquor rear standing 10-15min that stirs, obtain complex enzyme liquid, standby;
Step 3, the peony petal raw material that step 1 is obtained are put into triangular flask, and to the complex enzyme liquid that adds step 2 to obtain in triangular flask, complex enzyme liquid is 45:1 with the ratio of peony petal raw material addition, and wherein complex enzyme liquid is in milliliter, and the peony petal raw material are in gram; Triangular flask is placed under 35 ℃ of conditions after standing 20min, keeps temperature to carry out ultrasonic wave to triangular flask simultaneously and process 5min, supersonic frequency is 22 kHz, and ultrasonic being disposed moves to standing 40min under 40 ℃ of conditions by triangular flask; Then to adding in triangular flask the alcohol reflux that mass concentration is 95% to extract 1h, amount of alcohol added is 5 times of total solution weight in triangular flask, carries out centrifugation 15min after refluxing extraction, obtains supernatant; Supernatant is successively carried out to decompression distillation and heated-air drying, obtain the peony petal isoflavones, standby;
Step 4, getting peony seeds essential oil 40-60 part according to parts by weight and be placed in agitator, is to stir 20-40min under 50 ℃ of conditions in temperature, and mixing speed is 80-110r/min, stir finish after insulation, standby; Get again peony petal isoflavones 1-3 part, be placed in mill, grind 1h, obtain peony petal isoflavones powder, standby;
Step 5, the peony seeds essential oil that step 4 is obtained are placed in liquid dispensing apparatus, by in peony petal isoflavones powder spray device, then open two sprayer units simultaneously, shower nozzle points in same receiver, controls spray velocity both have been sprayed simultaneously, and spraying finishes, liquid in receiver is placed in to mill, grind 2-4h under the condition that is 50-100r/min at rotating speed, obtain the filler of soft capsule, standby;
Step 6, the process for preparing soft capsule according to routine prepare soft capsule shell, and the filler of the soft capsule after prepared by soft capsule shell, step 5 obtained carries out the capsule-filling compacting, then carry out hardened forming, shampooing is dry, completes the preparation of soft capsule.
The filler of the soft capsule that the present invention also can obtain step 5 is transferred in the sterile cryogenic thermostatic mixer, be stirred to peony seed oil under-10 ℃ of conditions and fully condense being no more than, then squeeze out the filler of the soft capsule that is adapted to the capsule capacity through squeezer, and be filled in capsule shells compacting envelope capsule.
Below in conjunction with specific embodiment, the present invention will be further described:
Embodiment 1:
A kind of preparation technology of the soft capsule that contains peony seeds essential oil and peony petal isoflavones comprises the following steps:
Step 1, pluck fresh peony petal, take out after peony petal is placed in to the baking oven forced air drying 0.5h that temperature is 40 ℃, be crushed to 40 orders, obtain the peony petal raw material, standby;
The pectase equal-volume that step 2, the cellulase that is 0.2mg/mL by mass concentration and mass concentration are 0.1mg/mL mixes, add again the acetum that mass concentration is 2%, until the pH of mixed value reaches 5.0, by the mixed liquor rear standing 10min that stirs, obtain complex enzyme liquid, standby;
Step 3, the peony petal raw material that step 1 is obtained are put into triangular flask, and to the complex enzyme liquid that adds step 2 to obtain in triangular flask, complex enzyme liquid is 45:1 with the ratio of peony petal raw material addition, and wherein complex enzyme liquid is in milliliter, and the peony petal raw material are in gram; Triangular flask is placed under 35 ℃ of conditions after standing 20min, keeps temperature to carry out ultrasonic wave to triangular flask simultaneously and process 5min, supersonic frequency is 22 kHz, and ultrasonic being disposed moves to standing 40min under 40 ℃ of conditions by triangular flask; Then to adding in triangular flask the alcohol reflux that mass concentration is 95% to extract 1h, amount of alcohol added is 5 times of total solution weight in triangular flask, carries out centrifugation 15min after refluxing extraction, obtains supernatant; Supernatant is successively carried out to decompression distillation and heated-air drying, obtain the peony petal isoflavones, standby;
Step 4, getting 40 parts of peony seeds essential oils according to parts by weight and be placed in agitator, is to stir 20min under 50 ℃ of conditions in temperature, and mixing speed is 80r/min, stir finish after insulation, standby; Get again 1 part of peony petal isoflavones, be placed in mill, grind 1h, obtain peony petal isoflavones powder, standby;
Step 5, the peony seeds essential oil that step 4 is obtained are placed in liquid dispensing apparatus, by in peony petal isoflavones powder spray device, then open two sprayer units simultaneously, shower nozzle points in same receiver, controls spray velocity both have been sprayed simultaneously, and spraying finishes, liquid in receiver is placed in to mill, grind 2h under the condition that is 50r/min at rotating speed, obtain the filler of soft capsule, standby;
Step 6, the process for preparing soft capsule according to routine prepare soft capsule shell, and the filler of the soft capsule after prepared by soft capsule shell, step 5 obtained carries out the capsule-filling compacting, then carry out hardened forming, shampooing is dry, completes the preparation of soft capsule.
Embodiment 2:
A kind of preparation technology of the soft capsule that contains peony seeds essential oil and peony petal isoflavones comprises the following steps:
Step 1, pluck fresh peony petal, take out after peony petal is placed in to the baking oven forced air drying 2.5h that temperature is 60 ℃, be crushed to 40 orders, obtain the peony petal raw material, standby;
The pectase equal-volume that step 2, the cellulase that is 0.2mg/mL by mass concentration and mass concentration are 0.1mg/mL mixes, add again the acetum that mass concentration is 2%, until the pH of mixed value reaches 5.0, by the mixed liquor rear standing 15min that stirs, obtain complex enzyme liquid, standby;
Step 3, the peony petal raw material that step 1 is obtained are put into triangular flask, and to the complex enzyme liquid that adds step 2 to obtain in triangular flask, complex enzyme liquid is 45:1 with the ratio of peony petal raw material addition, and wherein complex enzyme liquid is in milliliter, and the peony petal raw material are in gram; Triangular flask is placed under 35 ℃ of conditions after standing 20min, keeps temperature to carry out ultrasonic wave to triangular flask simultaneously and process 5min, supersonic frequency is 22 kHz, and ultrasonic being disposed moves to standing 40min under 40 ℃ of conditions by triangular flask; Then to adding in triangular flask the alcohol reflux that mass concentration is 95% to extract 1h, amount of alcohol added is 5 times of total solution weight in triangular flask, carries out centrifugation 15min after refluxing extraction, obtains supernatant; Supernatant is successively carried out to decompression distillation and heated-air drying, obtain the peony petal isoflavones, standby;
Step 4, getting 60 parts of peony seeds essential oils according to parts by weight and be placed in agitator, is to stir 40min under 50 ℃ of conditions in temperature, and mixing speed is 110r/min, stir finish after insulation, standby; Get again 3 parts of peony petal isoflavones, be placed in mill, grind 1h, obtain peony petal isoflavones powder, standby;
Step 5, the peony seeds essential oil that step 4 is obtained are placed in liquid dispensing apparatus, by in peony petal isoflavones powder spray device, then open two sprayer units simultaneously, shower nozzle points in same receiver, controls spray velocity both have been sprayed simultaneously, and spraying finishes, liquid in receiver is placed in to mill, grind 4h under the condition that is 100r/min at rotating speed, obtain the filler of soft capsule, standby;
Step 6, the process for preparing soft capsule according to routine prepare soft capsule shell, and the filler of the soft capsule after prepared by soft capsule shell, step 5 obtained carries out the capsule-filling compacting, then carry out hardened forming, shampooing is dry, completes the preparation of soft capsule.
Embodiment 3:
A kind of preparation technology of the soft capsule that contains peony seeds essential oil and peony petal isoflavones comprises the following steps:
Step 1, pluck fresh peony petal, take out after peony petal is placed in to the baking oven forced air drying 1.5h that temperature is 50 ℃, be crushed to 40 orders, obtain the peony petal raw material, standby;
The pectase equal-volume that step 2, the cellulase that is 0.2mg/mL by mass concentration and mass concentration are 0.1mg/mL mixes, add again the acetum that mass concentration is 2%, until the pH of mixed value reaches 5.0, by the mixed liquor rear standing 13min that stirs, obtain complex enzyme liquid, standby;
Step 3, the peony petal raw material that step 1 is obtained are put into triangular flask, and to the complex enzyme liquid that adds step 2 to obtain in triangular flask, complex enzyme liquid is 45:1 with the ratio of peony petal raw material addition, and wherein complex enzyme liquid is in milliliter, and the peony petal raw material are in gram; Triangular flask is placed under 35 ℃ of conditions after standing 20min, keeps temperature to carry out ultrasonic wave to triangular flask simultaneously and process 5min, supersonic frequency is 22 kHz, and ultrasonic being disposed moves to standing 40min under 40 ℃ of conditions by triangular flask; Then to adding in triangular flask the alcohol reflux that mass concentration is 95% to extract 1h, amount of alcohol added is 5 times of total solution weight in triangular flask, carries out centrifugation 15min after refluxing extraction, obtains supernatant; Supernatant is successively carried out to decompression distillation and heated-air drying, obtain the peony petal isoflavones, standby;
Step 4, getting 50 parts of peony seeds essential oils according to parts by weight and be placed in agitator, is to stir 30min under 50 ℃ of conditions in temperature, and mixing speed is 95r/min, stir finish after insulation, standby; Get again 2 parts of peony petal isoflavones, be placed in mill, grind 1h, obtain peony petal isoflavones powder, standby;
Step 5, the peony seeds essential oil that step 4 is obtained are placed in liquid dispensing apparatus, by in peony petal isoflavones powder spray device, then open two sprayer units simultaneously, shower nozzle points in same receiver, controls spray velocity both have been sprayed simultaneously, and spraying finishes, liquid in receiver is placed in to mill, grind 3h under the condition that is 75r/min at rotating speed, obtain the filler of soft capsule, standby;
Step 6, the process for preparing soft capsule according to routine prepare soft capsule shell, and the filler of the soft capsule after prepared by soft capsule shell, step 5 obtained carries out the capsule-filling compacting, then carry out hardened forming, shampooing is dry, completes the preparation of soft capsule.
the lipopenicillinase experimental study
1. given the test agent
The resulting soft capsule sample of embodiment 1.
animal subject and raising condition
Male mouse of kunming, 30, clean level, body weight 22 ± 2 g, effluent south University of Science and Technology Experimental Animal Center provides.
The experimental animal feeding condition: the barrier system Animal House, 22 ± 2 ℃ of temperature, relative humidity 40% ~ 60%, controlling lighting hours is 14 h, sub-cage rearing, every group of 2 cages, ad lib and drinking-water, change bedding and padding in time, fixed time cleaning mouse cage and water bottle etc.Mouse starts experiment after adapting to one week.
feed
Basal feed, high lipid food (85% basal feed+4% cholesterol+10% lard+1% sodium taurocholate), the Experimental Animal Center preparation of effluent south University of Science and Technology provides.
reagent
T-CHOL (TC) kit, triglycerides (TG) kit, HDL-C (HDL-C) kit, LDL-C (LDL-C) kit.
instrument
Kjeldahl apparatus, ELIASA, Laser Scanning Confocal Microscope, ultraviolet-uisible spectrophotometer, Rotary Evaporators, electronic analytical balance.
the reducing blood lipid weight-reducing experiment
30 mouse are divided into six groups at random, 10 every group; Be respectively Normal group, hyperlipidemia model group, administration group.Normal group feeding basal feed, all the other respectively organize the feeding high lipid food; Normal group and hyperlipidemia model group every day early 9 fill with and feed physiological saline, the administration group every day early 9 respectively with 15 mg/ dosage only fill with and feed soft capsule.
the reducing blood lipid weight-reducing experiment detects index
(1) changes of weight trend
Each organizes mouse all with basal feed feeding one week, adapts to laboratory environment.Start afterwards according to drug dosage schedule, each organizes the feeding corresponding feed.Test eight weeks by a definite date, on every Mondays, weighing Thursday Mouse Weight.Record and analyze weight data.
(2) serum TC, TG, HDL-C, LDL-C content
Raised for the 8th weekend mouse, water 12 h are can't help in fasting, and eyeball is got blood, 4 ℃ of standing 1.5 h of whole blood, low-temperature centrifugation 15 min, separation of serum, enzymatic assays serum TC, TG, HDL-C and LDL-C.
(3) liver heavily reaches the liver index, the total fat in abdominal cavity heavily reaches fat index
After getting blood, the dislocation of mouse cervical vertebra is put to death, and takes out liver, and with the physiological saline washing, filter paper blots the physiological saline of remained on surface, and the liver weight of every mouse is recorded in weighing immediately.Claim to obtain Mouse Weight before killing mouse, with liver anharmonic ratio body weight, calculate the Mouse Liver index.
After taking out liver, the abdominal cavity fat of mouse is carefully peeled off out, comprise all fat of stomach fat, perirenal fat and epididymis.Blot accurately weighing immediately with physiological saline washing filter paper.With abdominal cavity total fat anharmonic ratio body weight, calculate the fat index of every mouse.
. statistical procedures
All the data SAS are analyzed, and result means with (x ± s), compares group difference.
experimental result
(1) changes of weight
Before and after table 1 experiment, Mouse Weight changes
(2) serum TC, TG, HDL-C, LDL-C content
Table 2 is respectively organized the lipid of mice level
#P<0.01, model group and normal group are relatively; * P<0.01, administration group and model group are relatively.
(3) liver heavily reaches the liver index, the total fat in abdominal cavity heavily reaches fat index
Table 3 is respectively organized mouse liver exponential sum fat index
#P<0.01, model group and normal group are relatively; * P<0.05, administration group and model group comparison.
By research, can find out, by being administered systemically, the soft capsule that contains peony seeds essential oil and peony petal isoflavones has obvious effect for reducing fat.
the pilot survey data
The capsule that will make according to above-described embodiment 1 is as test sample, 120 experimenters that are ready to take this test sample of random selection in street corner, Luoyang City and community, test group has respectively cutis laxa, coarse, wrinkle, color spot increase, body obesity, stress, emotional instability, the symptoms such as Hyperlipidemia, and the experimenter does not take other similar health products with during being intended to use this sample.
Instructions of taking: experimenter every day 1-2 time, each 1, take 1 month " Invest, Then Investigate " statistics result of use;
Effect standard:
Produce effects: body obesity, stress, emotional instability, the symptoms such as Hyperlipidemia obviously alleviate, and the rear skin smooth of use moistens, compacts flexible, and color spot obviously reduces, and mood is gentle, and body weight slightly alleviates, and blood fat is normal, is produce effects;
Effectively: cutis laxa, coarse, wrinkle, color spot increase, body obesity, stress, emotional instability, the sx↓s such as Hyperlipidemia, after using, flexible, the color spot of skin smooth alleviates, and mood is stable, and blood fat is normal, for effectively;
Invalid: cutis laxa, coarse, wrinkle, color spot increase, body obesity, stress, emotional instability, the symptoms such as Hyperlipidemia do not improve, for invalid;
By statistics, result is as shown in table 4:
Table 4:
As shown in Table 4: in 120 routine experimenters, 118 examples are arranged, 98.3% experimenter, think that this capsule is effective, and 69 examples, and 57.5% experimenter thinks that effect is remarkable, and the total effective rate of this capsule is 98.3%.Illustrate thus that a kind of soft capsule that contains peony seeds essential oil and peony petal isoflavones provided by the invention has hypotensive, reducing blood lipid, reduction cholesterol, antithrombotic, promotion cytothesis, reduces wrinkle, delay skin aging, logical intestines moisturize, toxin-expelling and face nourishing, the effect of feeling at ease to repose, and effect is remarkable, have no side effect.For cutis laxa, coarse, wrinkle, color spot increase, body obesity, stress, emotional instability, and the crowds such as Hyperlipidemia are especially applicable.
The type testing example:
1, Lee, the female, 40 years old, take front cutis laxa, coarse, wrinkle, color spot are more, and after using, flexible, the color spot of skin smooth alleviates;
2, Liu, the female, 28 years old, take front body obesity, stress, emotional instability, after using, mental relaxation is stablized, and body weight slightly alleviates;
3, Wang, the female, 51 years old, take front condensed blood lipid, cholesterol is high, body obesity, take rear blood fat and decrease, and is tending towards normal, loses weight 2 kilograms;
4, Lee, the man, 40 years old, take front blood pressure higher, health is micro-fat, and the constipation situation is serious, and take rear blood pressure and be down to normally, the constipation condition improved, enteron aisle is unobstructed.
Claims (1)
1. the preparation technology of a soft capsule that contains peony seeds essential oil and peony petal isoflavones is characterized in that: comprise the following steps:
Step 1, pluck fresh peony petal, take out after peony petal is placed in to the baking oven forced air drying 0.5-2.5h that temperature is 40-60 ℃, be crushed to 40 orders, obtain the peony petal raw material, standby;
The pectase equal-volume that step 2, the cellulase that is 0.2mg/mL by mass concentration and mass concentration are 0.1mg/mL mixes, add again the acetum that mass concentration is 2%, until the pH of mixed value reaches 5.0, by the mixed liquor rear standing 10-15min that stirs, obtain complex enzyme liquid, standby;
Step 3, the peony petal raw material that step 1 is obtained are put into triangular flask, and to the complex enzyme liquid that adds step 2 to obtain in triangular flask, complex enzyme liquid is 45:1 with the ratio of peony petal raw material addition, and wherein complex enzyme liquid is in milliliter, and the peony petal raw material are in gram; Triangular flask is placed under 35 ℃ of conditions after standing 20min, keeps temperature to carry out ultrasonic wave to triangular flask simultaneously and process 5min, supersonic frequency is 22 kHz, and ultrasonic being disposed moves to standing 40min under 40 ℃ of conditions by triangular flask; Then to adding in triangular flask the alcohol reflux that mass concentration is 95% to extract 1h, amount of alcohol added is 5 times of total solution weight in triangular flask, carries out centrifugation 15min after refluxing extraction, obtains supernatant; Supernatant is successively carried out to decompression distillation and heated-air drying, obtain the peony petal isoflavones, standby;
Step 4, getting peony seeds essential oil 40-60 part according to parts by weight and be placed in agitator, is to stir 20-40min under 50 ℃ of conditions in temperature, and mixing speed is 80-110r/min, stir finish after insulation, standby; Get again peony petal isoflavones 1-3 part, be placed in mill, grind 1h, obtain peony petal isoflavones powder, standby;
Step 5, the peony seeds essential oil that step 4 is obtained are placed in liquid dispensing apparatus, by in peony petal isoflavones powder spray device, then open two sprayer units simultaneously, shower nozzle points in same receiver, controls spray velocity both have been sprayed simultaneously, and spraying finishes, liquid in receiver is placed in to mill, grind 2-4h under the condition that is 50-100r/min at rotating speed, obtain the filler of soft capsule, standby;
Step 6, the process for preparing soft capsule according to routine prepare soft capsule shell, and the filler of the soft capsule after prepared by soft capsule shell, step 5 obtained carries out the capsule-filling compacting, then carry out hardened forming, shampooing is dry, completes the preparation of soft capsule.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103989172A (en) * | 2014-05-26 | 2014-08-20 | 河南科技大学第一附属医院 | Soft capsule with function of reducing blood fat and blood pressure and preparation process thereof |
| CN103989171A (en) * | 2014-05-26 | 2014-08-20 | 河南科技大学第一附属医院 | Soft capsule with functions of resisting aging and maintaining beauty and keeping young and preparation process thereof |
| CN104705452A (en) * | 2015-01-19 | 2015-06-17 | 蒲绪萍 | Method for preparing scented tea by using peony petals |
| CN109394992A (en) * | 2017-08-16 | 2019-03-01 | 庄宸 | A kind of jasmine essential oil capsule and preparation method thereof |
| CN116019222A (en) * | 2021-10-26 | 2023-04-28 | 安琪纽特股份有限公司 | Soft capsule content containing active ingredients and preparation method thereof |
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| CN101647872A (en) * | 2009-09-07 | 2010-02-17 | 兰州牡丹园艺开发公司 | Peony essential oil soft capsule and preparation method thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103989172A (en) * | 2014-05-26 | 2014-08-20 | 河南科技大学第一附属医院 | Soft capsule with function of reducing blood fat and blood pressure and preparation process thereof |
| CN103989171A (en) * | 2014-05-26 | 2014-08-20 | 河南科技大学第一附属医院 | Soft capsule with functions of resisting aging and maintaining beauty and keeping young and preparation process thereof |
| CN103989172B (en) * | 2014-05-26 | 2015-10-14 | 河南科技大学第一附属医院 | A kind of have reducing blood lipid, the soft capsule of blood pressure reduction effect and preparation technology thereof |
| CN103989171B (en) * | 2014-05-26 | 2015-11-11 | 河南科技大学第一附属医院 | A kind of anti-aging beauty-care face-nourishing soft capsules and preparation technology thereof |
| CN104705452A (en) * | 2015-01-19 | 2015-06-17 | 蒲绪萍 | Method for preparing scented tea by using peony petals |
| CN109394992A (en) * | 2017-08-16 | 2019-03-01 | 庄宸 | A kind of jasmine essential oil capsule and preparation method thereof |
| CN116019222A (en) * | 2021-10-26 | 2023-04-28 | 安琪纽特股份有限公司 | Soft capsule content containing active ingredients and preparation method thereof |
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