CN103463346A - Medicine for treating chicken respiratory disease and preparation method thereof - Google Patents

Medicine for treating chicken respiratory disease and preparation method thereof Download PDF

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CN103463346A
CN103463346A CN2013104352039A CN201310435203A CN103463346A CN 103463346 A CN103463346 A CN 103463346A CN 2013104352039 A CN2013104352039 A CN 2013104352039A CN 201310435203 A CN201310435203 A CN 201310435203A CN 103463346 A CN103463346 A CN 103463346A
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medicine
chicken
respiratory disease
preparation
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CN103463346B (en
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冯元风
林茂正
邹民发
李淑清
梁华
闫长茂
张仁河
王晓非
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GUANGDONG ZHONGNONGLIAN BIOLOGICAL PHARMACEUTICAL CO., LTD.
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DALIAN JINPENG ANIMAL HUSBANDRY SPECIALIZED COOPERATIVES
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Abstract

The invention discloses a medicine for treating chicken respiratory disease and a preparation method thereof. The medicine is prepared from the following traditional Chinese medicines as bulk pharmaceutical ingredients in parts by weight: 90-100 parts of radix isatidis, 30-40 parts of scutellaria baicalensis, 30-40 parts of radix bupleuri, 40-45 parts of ephedra sinica stapf, 20-30 parts of semen armeniacae amarae, 40-50 parts of honeysuckle, 25-30 parts of subprostrate sophora, 16-20 parts of blackberry lily, 35-40 parts of dandelion, 40-50 parts of herba violae, 20-25 parts of radix glycyrrhizae preparata, 30-35 parts of rhizoma pinelliae preparata, 30-35 parts of white poria, 50-55 parts of pericarpium citri reticulatae and 40-45 parts of rhizoma atractylodis. The medicine can be decocted for administration by drinking, and can also be ground to powder for administration by stirring. By using the medicine disclosed by the invention, the cure rate is 95%, the improvement rate is 5%, and the effective rate is 100%, while control medicines (western medicines) have the effects that the cure rate is 90%, the improvement rate is 6%, and the effective rate is 96%. Statistical analysis shows that the medicine and the control medicines have significant differences.

Description

Medicine for the treatment of respiratory disease of chicken and preparation method thereof
Technical field
The present invention relates to a kind of pharmaceutical composition for the treatment of respiratory disease of chicken, particularly relate to a kind of medicine of take the treatment respiratory disease of chicken that vegetable Chinese herbal medicine makes as raw material, the invention still further relates to the preparation method of this medicine.
Background technology
The peculiar airbag structure of birds, make the respiratory system of chicken can be described as from the nose to the lung, to abdominal viscera, to the open to the outside world system of skeleton and linked groups.Such structure is easy to occur respiratory tract infection, and the infection of respiratory system is easy to diffuse to even whole body of chicken abdominal viscera.
The commercial chicken mycoplasma does not reach purification, and the chronic respiratory tract disease that mycoplasma infection causes just easily occurs.White scour of chicken pneumonia, cause pertussis to cough, and ataxia occurs more.The airsacculitis that escherichia coli cause is the pathogenetic main cause of broiler respiratory tract.Serious respiratory symptom also appears in ND, IB, IBD.In addition, mycoplasma, escherichia coli are arranged, with ND, IB, the mixed respiratory tract disease of having carried out the coffin upon burial of IBD, can cause serious airsacculitis and airway obstruction, make chicken death by suffocation.The hen house temperature is unstable is one of key factor of various diseases generation; Coop ventilation is bad, and the factors such as ammonia and concentration of hydrogen sulfide height all can be damaged the integrity of upper respiratory tract system structure, and then cause respiratory system disease.The little air drying of humidity in house, airborne dust is also too much the risk factor that causes respiratory tract disease.
The way that certain effect is arranged at present is to carry out vaccine immunity, and when doing the ND immunity, the raiser uses the Lasota Seedling substantially, doing the IB immunity, is to use H120.These two kinds of strains are all to have a liking for the respiratory tract type, and the strain (tracheal mucosa) in the chicken body of living copies, and causes the tracheal mucosa cell detachment, the respiratory response of " reversibility " occurs, within after healthy chicken occurs 3-5 days, naturally recover.But after commercial meat bird inoculation ND and IB, with self mycoplasma, escherichia coli mixed infection, there will be serious respiratory symptom, this is also one of reason of the normal respiratory tract disease of sending out of broiler.After doing the IBD immunity, can make the antibody response of chicken have a negative impact, reduced the resistance to ND, IB, mycoplasma etc.Especially, after the IBD Seedling that in using, isogonic is strong, the interference effect that ND antibody is produced is very large.The strong IBD Seedling of isogonic in some raiser's life-time service, cause respiratory tract disease to can not get for a long time controlling.Method of vaccination is as very spraying immune and the aerosol immunity of small particle all can make vaccine reaction increase the weight of improperly.
The same day or second day that the mass-sending of broiler field chicken is given birth to after respiratory tract disease show the respiratory symptom that the order of severity differs, and what have shows as snore, cough, breathes rale, and some dyspnea, dehisce to stretch neck, while breathing, all emits a shrill cry at every turn; Some respiratory symptoms are lighter, when only quiet at night, can hear.Sick chicken diarrhea, draw the water sample loose stool, and often with not digesting feedstuff completely, what have draws celadon or yellow green loose stool.The morbidity chicken appetite of mining massively obviously reduces, and drinking-water increases, and during drinking-water, constantly from bicker, throws away mucus; Spirit is depressed, and feather is fluffy and disorderly, the necking down of hanging one's head; Nasal secretion increases, stream nose liquid, nasal sinuses swelling; Conjunctival congestion, shed tears; Cephalledema, cockscomb and wattle congestion, be atropurpureus, and the one or both sides wattle thickens, hardening, and the hotness of touching increases; Without hair place, the purple ecchymosis is arranged on lower limb, indivedual chickens occur dead, the broiler growth that stops growing.Bring huge economic loss to the raiser.
Summary of the invention
The object of the present invention is to provide a kind of medicine for the treatment of respiratory disease of chicken, it eliminates the infringement of traditional Western medicine to kidney, the severe reaction of having avoided improper vaccination to cause, without obvious toxic-side effects, another object of the present invention is to provide the preparation method of this medicine.
The technical scheme that the present invention adopted for achieving the above object is:
The medicine for the treatment of respiratory disease of chicken of the present invention is to take the medicament that the Chinese medicine of following portions by weight prepares as crude drug:
Figure BDA0000385698860000021
Further, in medicine of the present invention, each crude drug preferred weight umber is:
Figure BDA0000385698860000022
Figure BDA0000385698860000031
In prescription of the present invention, Radix Isatidis has the effect of heat-clearing and toxic substances removing, removing heat from blood detumescence, sore-throat relieving.Radix Scutellariae has heat clearing and damp drying, removing heat from blood, detoxicating functions.Radix Bupleuri cold nature, bitter in the mouth, suffering, return Liver Channel, gallbladder meridian, the tool depressed liver-energy dispersing and function of gallbladder promoting, dredge gas resolving depression, loose effect of fire.Herba Ephedrae diaphoresis cold expelling, depressed lung-energy dispersing, inducing diuresis to remove edema.Semen Armeniacae Amarum has sending down the abnormal ascending QI relieving cough and asthma, loosening bowel to relieve constipation.The Flos Lonicerae heat-clearing and toxic substances removing, the sweet cold fragrance of property, clearing away heat with drugs sweet in flavor and cold in nature and not injuring one's stomach, fragrance thoroughly reaches and can be eliminating evil.The Radix Sophorae Tonkinensis Qinghuo Jiedu, reducing swelling and alleviating pain.The Rhizoma Belamcandae resolving toxin and disinhibiting the throat, removing heat-phlegm, the knot that disappears dispels the heat.The Herba Taraxaci heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Herba Violae mildly bitter flavor cold in nature, heat-clearing and toxic substances removing, removing heat from blood detumescence.Moxibustion Radix Glycyrrhizae: get clean Radix Glycyrrhizae tabellae, according to the processed with honey method, fry to yellow to buff, take out when tack-free, dry in the air cool and obtain spleen reinforcing stomach function regulating, Yiqi and vein recovery.Weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse.Rhizoma Pinelliae: Rhizoma Pinelliae and Alumen boil the Preparation process product that rear drying forms, drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass altogether.Poria eliminating dampness by diuresis spleen invigorating.The Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, in tune, dampness, reduce phlegm.Rhizoma Atractylodis are drying damp and strengthening spleen, expelling wind and cold, improving eyesight.Rhizoma Atractylodis are for distension and fullness in the abdomen, the edema of having loose bowels, beriberi flaccidity of feet with lamenness, rheumatic arthralgia, anemofrigid cold, nyctalopia.Full side coordinates, relieving cough and asthma, and reducing swelling and alleviating pain, heat-clearing and toxic substances removing, have obvious alleviation respiratory symptom and protect the liver the effect of protecting kidney.Heat clearing away, removing toxic substances, eliminating the pathogens from the lung, Dingchuan.Cure mainly viral respiratory disease.
Preferably following two kinds of the preparation methoies of medicine of the present invention, respectively:
1, decoct drink-service.The section of above-mentioned raw materials medicine is mixed and pours in pot, the water that adds 10-15 times of volume, soak 20-30 minute, decoct 2 times, first pass decocts one and a half hours, medicine soup is poured in container, the decocting second time one hour that adds again 10-15 times of weight, the decoction of decocting for twice mixes to chicken and adds water (according to chicken body size age in days, determining amount of drinking water), and medicament is watered drink-service, in 5-6 hour, drunk, continuously drink-service 3-5 day.
Described decoction is used the duration and degree of heating known to ordinary skill in the art to get final product, but the intense fire effect is better.
2, breaking into the medicated powder spice takes.All medicament mixed in formula are polished into to powder together, mix to mix thoroughly by one day feedstuff consumption of chicken and dosage and feed, take continuously 3-5 days.
Characteristics of the present invention are:
The medicine for the treatment of respiratory disease of chicken of the present invention is applicable to the respiratory tract disease of chicken group discovery, and large-scale application proves, curative effect is fast, good effect, its curative effect and Western medicine clinafloxacin, exhale smooth, feel peaceful etc. and compare, drug effect is remarkable.Medicine of the present invention belongs to pure Chinese medicinal preparation, with Western medicine, compares no drug residue, has no side effect.The severe reaction of having avoided improper vaccination to cause, can be used as the succedaneum of traditional Western medicine.
The clinical practice result of the test is as follows:
2012, a kind of respiratory tract disease that is reduced to feature with cough, sneeze, trachea gong sound, feed intake occurred in Dalian part chicken house and broiler breeding family.
After finding the state of an illness, all Chinese herbal medicine decoction drink-services in filling a prescription immediately, also can spray Chinese medicine powder and be stirred in feedstuff and feed.Dosage is: every total consumption of crude drug that the average every consumption per day 0.25-0.3g(of chicken refers to every chicken).Take this medicine 3-5 days, the rehabilitation of chicken body stable disease.
It is subjects that the chicken house of take has been made a definite diagnosis 3000 ill chickens, wherein takes medicine of the present invention for 1500, takes control drug (being that every 500 chickens take respectively the Western medicine clinafloxacin, exhale freely, feel peaceful) for another 1500; Be used in conjunction 5 days.Observation and comparison trial drug and the control drug therapeutic effect to respiratory disease of chicken.
The treatment standard:
(1) cure: with sick pertussis, cough, sneeze, chickling stream nose liquid, the laying hen egg production reduces, and it is standard that respiratory mucosa is the transference cures such as serosity, catarrhal inflammation.
(2) take a turn for the better: with sick pertussis, cough, sneeze, chickling stream nose liquid, the laying hen egg production reduces, and it is standard that respiratory mucosa is the remissions such as serosity, catarrhal inflammation.
The sick chicken number of cure rate=healing/sick chicken sum * 100%; Effective percentage=(the sick chicken number of the sick chicken number of healing+improvement)/sick chicken sum * 100%.
Result of the test is as follows:
Clinical practice experiment showed, that the cure rate of medicine of the present invention reaches 95%, and improvement rate reaches 5%, and effective percentage reaches 100%, with control drug (using Western medicine) cure rate, reaches 90%, and improvement rate reaches 6%, and effective percentage reaches 96%. Epidemiological Analysis comparisons by statistics, significant difference.
The specific embodiment
Embodiment 1
The medicine for the treatment of respiratory disease of chicken is to take the medicament that the Chinese medicine of following portions by weight prepares as crude drug:
Figure BDA0000385698860000041
The section of above-mentioned raw materials medicine is mixed and pours in pot, the water that adds 10 times of volumes, soak 30 minutes, decoct 2 times, first pass decocts one and a half hours, medicine soup is poured in container, the decocting second time one hour that adds again 10 times of weight, the decoction of decocting for twice mixes to chicken and adds water (according to chicken body size age in days, determining amount of drinking water), and medicament is watered drink-service, in 6 hours, drunk, drink-service is 3 continuously.
Embodiment 2
The medicine for the treatment of respiratory disease of chicken is to take the medicament that the Chinese medicine of following portions by weight prepares as crude drug:
The section of above-mentioned raw materials medicine is mixed and pours in pot, the water that adds 15 times of volumes, soak 20 minutes, decoct 2 times, first pass decocts one and a half hours, medicine soup is poured in container, the decocting second time one hour that adds again 15 times of weight, the decoction of decocting for twice mixes to chicken and adds water (according to chicken body size age in days, determining amount of drinking water), and medicament is watered drink-service, in 5 hours, drunk, drink-service is 5 continuously.
Embodiment 3
The medicine for the treatment of respiratory disease of chicken is to take the medicament that the Chinese medicine of following portions by weight prepares as crude drug:
Figure BDA0000385698860000052
The section of above-mentioned raw materials medicine is mixed and pours in pot, the water that adds 12 times of volumes, soak 25 minutes, decoct 2 times, first pass decocts one and a half hours, medicine soup is poured in container, the decocting second time one hour that adds again 12 times of weight, the decoction of decocting for twice mixes to chicken and adds water (according to chicken body size age in days, determining amount of drinking water), and medicament is watered drink-service, in 6 hours, drunk, drink-service is 4 continuously.
Embodiment 4
The medicine for the treatment of respiratory disease of chicken is to take the medicament that the Chinese medicine of following portions by weight prepares as crude drug:
Figure BDA0000385698860000053
Figure BDA0000385698860000061
The section of above-mentioned raw materials medicine is mixed and pours in pot, the water that adds 12 times of volumes, soak 22 minutes, decoct 2 times, first pass decocts one and a half hours, medicine soup is poured in container, the decocting second time one hour that adds again 10-15 times of weight, the decoction of decocting for twice mixes to chicken and adds water (according to chicken body size age in days, determining amount of drinking water), and medicament is watered drink-service, 5.5 drunk in hour, drink-service is 4 continuously.

Claims (4)

1. the medicine for the treatment of respiratory disease of chicken is to take the medicament that the Chinese medicine of following portions by weight prepares as crude drug:
2. treat as claimed in claim 1 the medicine of respiratory disease of chicken, it is characterized in that: be to take the medicament that the Chinese medicine of following portions by weight prepares as crude drug:
Figure FDA0000385698850000012
3. the preparation method of the medicine for the treatment of respiratory disease of chicken as claimed in claim 1, is characterized in that: by the crude drug fiat pulvis misce.
4. the preparation method of the medicine for the treatment of respiratory disease of chicken as claimed in claim 1 is characterized in that:
The crude drug section is mixed and pours in pot, add the water of 10-15 times of volume, soak 20-30 minute, decoct 2 times, first pass decocts one and a half hours, and medicine soup is poured in container, add the decocting second time a hour of 10-15 times of volume, the decoction of decocting for twice mixes and gets final product again.
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104306730A (en) * 2014-11-15 2015-01-28 天农大(天津)生物科技有限公司 Traditional Chinese medicine composition for treating infectious laryngotracheitis of chickens and preparation method thereof
CN105012602A (en) * 2015-08-05 2015-11-04 郑州诺必隆生物科技有限公司 Traditional Chinese medicine composition for treating viral respiratory diseases of poultry
CN106511723A (en) * 2015-09-09 2017-03-22 谭慧敏 Drug for treating chicken infectious laryngotracheitis
CN106563064A (en) * 2015-10-13 2017-04-19 黄旺 Medicine for treating chicken streptococcosis
CN107970333A (en) * 2016-10-21 2018-05-01 钟伟权 A kind of traditional Chinese medicine oral liquid for treating fowl bacterial respiratory tract disease disease and preparation method thereof
CN110151900A (en) * 2019-07-11 2019-08-23 施瑞客(天津)生物技术有限公司 A kind of extract oral solution and preparation method thereof for poultry bronchial embolization

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104306730A (en) * 2014-11-15 2015-01-28 天农大(天津)生物科技有限公司 Traditional Chinese medicine composition for treating infectious laryngotracheitis of chickens and preparation method thereof
CN105012602A (en) * 2015-08-05 2015-11-04 郑州诺必隆生物科技有限公司 Traditional Chinese medicine composition for treating viral respiratory diseases of poultry
CN105012602B (en) * 2015-08-05 2018-06-29 郑州诺必隆生物科技有限公司 Treat the Chinese medicine composition of viral respiratory tract disease of fowl
CN106511723A (en) * 2015-09-09 2017-03-22 谭慧敏 Drug for treating chicken infectious laryngotracheitis
CN106563064A (en) * 2015-10-13 2017-04-19 黄旺 Medicine for treating chicken streptococcosis
CN107970333A (en) * 2016-10-21 2018-05-01 钟伟权 A kind of traditional Chinese medicine oral liquid for treating fowl bacterial respiratory tract disease disease and preparation method thereof
CN110151900A (en) * 2019-07-11 2019-08-23 施瑞客(天津)生物技术有限公司 A kind of extract oral solution and preparation method thereof for poultry bronchial embolization
CN110151900B (en) * 2019-07-11 2021-07-09 施瑞客(天津)生物技术有限公司 Traditional Chinese medicine oral solution for bronchial embolism of poultry and preparation method thereof

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