CN103463250A

CN103463250A - Medicament for treating yang-deficiency type diabetes

Info

Publication number: CN103463250A
Application number: CN 201210187488
Authority: CN
Inventors: 史克勇
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-06-08
Filing date: 2012-06-08
Publication date: 2013-12-25

Abstract

The invention relates to a traditional Chinese medicine composition for treating yang-deficiency type diabetes. The main components of the traditional Chinese medicine comprise radix aconiti carmichaeli, cinnamomum cassia, balsam pear, common fenugreek seed, epimeddium, morinda officinalis, cynomorium songaricum and mulberry leaf extract. The traditional Chinese medicine composition of the invention is used to treat yang-deficiency type diabetes and has no obvious side effect.

Description

A kind of medicine for the treatment of the deficiency of yang type diabetes

Technical field

The present invention relates to a kind of Chinese medicine composition, is a kind of Chinese medicine composition for the treatment of the deficiency of yang type diabetes specifically.

Background technology

Diabetes (diabetes) are to act on body by various virulence factors such as inherited genetic factors, immunologic function disorder, infected by microbes, free radical, Nervous and Mental Factors to cause hypoinsulinism, insulin resistant (Insulin Resistance, and a series of metabolism disorder syndromes such as the sugar caused, protein, fat, power and water Xie Zhi IR) etc., take hyperglycemia clinically as main feature, the performance such as polyuria, polydipsia, polyphagia can appear in model case, become thin, i.e. " three-many-one-little " symptom.

Diabetes spp is in traditional Chinese medical science diabetes category, and China's medical book Huangdi's Internal Classics has the earliest just been put down in writing " diabetes " this name of disease.Yang deficiency and the relation of quenching one's thirst also can be traced back to the Huangdi's Internal Classics epoch, as " Plain Questions lose consciousness opinion " said: " the heart transferring pathogenic cold to the lung, diabetes involving in upper-JIAO, the diabetes involving in upper-JIAO person, drinking one cup of water and running two cups of urine, stubbornly refuse to control." symptom that proposes diabetes involving in upper-JIAO is drinking one cup of water and running two cups of urine." Compendium of medicine diseases due to endogenous heat of ZANG FU organs door " further done explanation to the symptom of diabetes involving in upper-JIAO, " the lid the lung keeping QI in store, lung is anosis gas energy pipe take the photograph the precise and tiny of body fluid, and the precise and tiny person of body fluid adoptes the muscles and bones blood vessels, the rest is and urinates.Pneumonopathy body fluid is taken the photograph without trachea, and precise and tiny person is also with urinating down, therefore drinking one cup of water and running two cups of urine.Though " this section do not explain yang deficiency, from symptom analysis, the deficiency and coldness of yang deficiency is also bright, but not cold-evil's excess-cold.Eastern Han Dynasty's Zhang Zhongjing is established special piece of writing opinion and is quenched one's thirst in " Medical Treasures of the Golden Chamber ", and proposes: " diabetes in male, urine is anti-many, with drinking one DOU of water, one DOU of urine, the shenqi pill master it." shenqi pill is for take YANG invigorating as main tonifying both YIN and YANG agent, with side's survey card, what known we's control was yang deficiency quenches one's thirst.After this, shenqi pill becomes classics side, the side of representative that treatment yang deficiency is quenched one's thirst.The Wang Tao of Tang is at " medical secrets of official " medium cloud: " person of quenching one's thirst, former its morbidity, due to this duty is suffered from a deficiency of the kidney ..., waist kidney both cold caused by deficiency can not steam in upper, essence derived from food lower to the greatest extent for urine also, therefore sweet constant ".Point out that the diabetes pathogenesis is that waist suffers from a deficiency of the kidney cold.Song's Xu Shuwei " all antiperspirant of coughing in general Ji ability side is quenched one's thirst " points out that primary disease is " kidney-yang deficiency ", " at the bottom of still without firewood ", proposes the Therapeutic Principle of " often must temperature compensation kidney qi ".

Yang deficiency is quenched one's thirst and is discussed the most detailed Ming Dynasty's Zhang Jingyue that surely belongs to, " the Jing Yue's complete work three types of diabetes is very thirsty " cloud: " card that disappears has negative and positive, especially must examine ..., all this persons, how due to fire, fire is contained the deficiency of YIN, be card that all sun disappears also.The justice disappeared as for the moon, do not have the person who knows.The lid person of disappearing, disappearing bright also also consumes also, the genus of all negative and positive vim and vigour the vanquished that day by day disappears, disappearing of meaning all, therefore can not take to the greatest extent fire syndrome as speech." hence one can see that, it is disappearing due to yang deficiency that the moon disappears.Sick position, pathogenesis that he further disappears to the moon again are described." internal organs that the husband gate of vitality is extreme misery, all water loses card admittedly can be for disappearing for yearningly, and fire lose card also can for disappear for thirsty person what also? ... be insufficiency of kidney-YANG all, fire loses in purgation and disappears card also." be that the moon disappears disease position the gate of vitality, " sun is activating QI crystal's cloth not not, and water must not fire has and falls without rising, the drinking one cup of water and running two cups of urine so directly enter bladder." Zhao Yangkui agrees the viewpoint of Zhang Jingyue, he also says in " Thorough Knowledge of Medicine ": " decline of the fire from the gate of life can not cook water paddy, and essential substances from water and cereals can not be fumigated and moisten in lung, as at the bottom of still without firewood, therefore pot cover is dry thirsty ".Speak for the treatment of, Zhang Jingyue is thought, " disappearing of yang deficiency, meaning should be mended fire ".But concrete side's medicine is not proposed.Zhao Yangkui also says: " grow its kidney qi, and thirsty from stopping ".Clear Zhang Lu " the Zhang Shi doctor is logical " cloud: " thirsty family mistake is controlled as fire, and the medicine of a cold nature is disorderly thrown, short people's life ".Zhou Xueting says in " three fingers buddhist ": " more than taste that to control be card, the occurring in YANG part of the body person, ten occupy two or three, the occurring in YIN part of the body person, ten occupy seven or eight, with osmanthus attached several jin and person more, heated water is risen and yearningly certainly stopped ", further emphasized the critical role of yang deficiency in diabetes.

Disappearing of the deficiency of YIN is no doubt multiple, and disappearing of yang deficiency is also very important." Plain Questions vital QI of the body connecting with natural QI opinion " cloud: " the yang-energy person, if day with day, lose its institute, have the allotted portion of life reduced by having or getting more than one deserves and clear, therefore God's will is when with day light." cloud again: " wanting of all negative and positive, sun is close is solid." emphasized the importance of yang-energy to human body.The treatment disappeared of yang deficiency should adopt tonifying both YIN and YANG.The moon is the base of sun, and sun is the use of the moon, and the two interdependent and mutually promoting of negative and positive is inseparable, and as " Jing Yue's complete work new side eight gusts ", institute says: " kind nourishing YIN person, must be in treating YIN within YANG, cloudy positive helping, and source is inexhaustible; Kind YANG invigorating person, must be in treating YANG within YIN, positive cloudy helping, and biochemical infinite." and take the YANG invigorating method as wanting, the shenqi pill of Zhang Zhongjing, Zhang Jingyue it " meaning should be mended fire ", illustrate this point invariably.To the not aobvious person of yang deficiency, sun is not forgotten in nourishing YIN, and YANG invigorating is to join the moon; To yang deficiency the person of opinion, tonifying both YIN and YANG; To the obvious person of yang deficiency, take the YANG invigorating method as main on the basis of tonifying both YIN and YANG.Constantly note regulating equilibrium between yin and yang, this is the requirement for the treatment of must aim at the pathogenesis of disease.

Modern doctor has also made Primary Study to disappearing of yang deficiency.Wang Yie (the journal .1996 of Changchun Traditional Chinese Medical College; 3:3-4) research is found, quench one's thirst factor body yang deficiency also arranged, from the beginning of have the deficiency of vital energy or yang deficiency person concurrently simultaneously, and think the card of upper dry thirsty, lower frequent micturition now be fire decline can not rising aqueous vapor due to.Tension and relaxation (Jilin Chinese medicine .1998; 5:8-9) in to 35 routine diabetics etiological analysis, find, the body deficiency of YIN of not only being always or usually as specified, also see innate deficiency of YANG in the body is arranged, plain body deficiency of both YIN and YANG person.Wherein the plain body deficiency of YIN, plain body deficiency of both YIN and YANG person are more common in type 1 diabetes, and the innate deficiency of YANG in the body person is more common in type 2 diabetes mellitus.Niu Aijun etc. (the Lv Renhe chief editor. the diabetes tcm diagnosis and treatment is assembled. the Chinese Medicine science and technology .1999 of publishing house; 217) think, current clinical diabetes patient, most courses of disease are longer, pathology take that kidney yin kidney yang two is lost so that all empty persons of the five internal organs as many, wherein take insufficiency of kidney-YANG as outstanding, it treats type 2 diabetes mellitus patient 60 examples with homemade Testudinis deer Hypolycemic pellet, effective percentage reaches 86.6%.Jiang Ying etc. (the Lv Renhe chief editor. the diabetes tcm diagnosis and treatment is assembled. the Chinese Medicine science and technology .1999 of publishing house; 307) think, the generation of this disease of diabetes and complication, all relevant with yang deficiency.The distinguished veteran doctors of TCM road will full professor also think, yang deficiency is the key factor that diabetes produces, Radix Aconiti Lateralis Preparata soup commonly used, Yougui Wan, the kidney-Yang-Reinforcing Bolus treatment.

Summary of the invention

Purpose of the present invention just is to provide a kind of Chinese medicine composition for the treatment of diabetes, for the deficiency of yang type diabetes.

In order to realize the object of the invention, the invention provides a kind of Chinese medicine composition for the treatment of the deficiency of yang type diabetes, effective ingredient and/or pharmaceutically acceptable carrier, consist of, described effective ingredient is to be made by weight percentage by following raw materials according: 5 ~ 15 parts of Radix Aconiti Lateralis Preparatas, 25 ~ 35 parts of Cortex Cinnamomis, 5 ~ 15 parts, Fructus Momordicae charantiae, 5 ~ 10 parts of Semen Trigonellaes, 5 ~ 10 parts of Herba Epimedii, 5 ~ 15 parts of Radix Morindae Officinaliss, 5 ~ 10 parts of Herba Cynomoriis, 1 ~ 5 part of Folium Mori extract.

Preferably by following raw materials according, made by weight percentage: 10 parts of Radix Aconiti Lateralis Preparatas, 30 parts of Cortex Cinnamomis, 10 parts, Fructus Momordicae charantiae, 8 parts of Semen Trigonellaes, 8 parts of Herba Epimedii, 10 parts of Radix Morindae Officinaliss, 7 parts of Herba Cynomoriis, 3 parts of Folium Mori extracts.

We be take Radix Aconiti Lateralis Preparata as monarch drug, Radix Aconiti Lateralis Preparata acrid in the mouth, sweet, extremely hot in nature.GUIXIN, kidney, spleen channel.There is recuperating depleted YANG and rescuing the patient from collapse, mend fire supporing yang, the effect of dispersing cold for relieving pain.Minister is with acrid in the mouth, sweet, and extremely hot in nature, return kidney, spleen, the heart, Liver Channel, have mend that fire is supporing yang, the Cortex Cinnamomi of let the fire back to its origin, dispersing cold for relieving pain, promoting blood circulation to restore menstrual flow.Assistant is with Fructus Momordicae charantiae, Semen Trigonellae and Herba Epimedii, Fructus Momordicae charantiae kidney and spleen invigorating, clearing away heat and removing summer, nourishing blood and invigorating qi, Semen Trigonellae and Herba Epimedii warming and recuperating the kidney-YANG.Make with Radix Morindae Officinalis, Herba Cynomorii and Folium Mori extract the treatment that is beneficial to quench one's thirst.

The invention provides the preparation method of the Chinese medicine composition for the treatment of deficiency of yang type diabetes, comprise above-mentioned raw materials decocting together, filter, obtain the water extraction liquid of above-mentioned raw materials.Be preferably raw material is cut into to coarse grain, add 8 ~ 12 times of water gagings, 60 ~ 100 ℃ of heating, stir 1 ~ 2 hour, filter, after the filtrate high speed centrifugation, membrane filtration, filtrate is evaporated to the approximately clear paste of 0.8 ~ 1.5 (60 ℃) of relative density under the condition of 60 ~ 100 ℃ of temperature, vacuum 0.08 ~ 0.09MPa, adds right amount of auxiliary materials, 75 ~ 100 ℃ of dry materials temperature, atomizing pressure 0.06 ~ 0.09MPa, spraying frequency speed 30 ~ 40kg/h, spray drying, mixed with Folium Mori extract, obtain.

Pharmaceutical composition of the present invention can with receivable carrier pharmaceutically, such as: filler is as starch, microcrystalline Cellulose etc.; Binding agent is as vitamin derivative, starch etc.; Disintegrating agent, as sodium carboxymethyl cellulose, low-substituted hydroxypropyl cellulose etc., is taken by the mode of the oral administrations such as tablet, capsule, granule, oral liquid or pill.

Chinese medicine composition tonification kidney yang of the present invention, the strong god of benefit essence, for the treatment of deficiency of yang type diabetes, can improve thirsty, admire more, the symptoms such as polyphagia, polyuria, the irritability of becoming thin, numb limbs and tense tendons, non-evident effect.

The specific embodiment

Following examples are used for the present invention is described, but are not used for limiting the scope of the invention.

Embodiment 1 raw material forms

Radix Aconiti Lateralis Preparata 100 grams, Cortex Cinnamomi 300 grams, Fructus Momordicae charantiae 100 grams, Semen Trigonellae 80 grams, Herba Epimedii 80 grams, Radix Morindae Officinalis 100 grams, Herba Cynomorii 70 grams.Be cut into coarse grain, add 10 times of amounts of water, 90 ℃ of heating, constantly stir and extract 2 hours, coarse filtration is separated medicinal residues, the medicinal liquid high speed centrifugation, filtering with microporous membrane, the filtrate decompression dope is to the about clear paste of 1.20 (60 ℃) of relative density, take starch and dextrin as adjuvant, weight ratio by clear paste and adjuvant is 2:1, through the boiling type fluid bed, once completes spray drying, mixed with Folium Mori extract, obtain Folium Mori extract 30 grams (purchased from Xi'an Fei Da Bioisystech Co., Ltd, DNJ content is greater than 1%), encapsulated and get final product.

Embodiment 2 raw materials form

Radix Aconiti Lateralis Preparata 50 grams, Cortex Cinnamomi 150 grams, Fructus Momordicae charantiae 150 grams, Semen Trigonellae 50 grams, Herba Epimedii 100 grams, Radix Morindae Officinalis 50 grams, Herba Cynomorii 70 grams, Folium Mori extract 50 grams.

The preparation method of raw material is with embodiment 1.

Embodiment 3 raw materials form

Radix Aconiti Lateralis Preparata 150 grams, Cortex Cinnamomi 350 grams, Fructus Momordicae charantiae 50 grams, Semen Trigonellae 100 grams, Herba Epimedii 50 grams, Radix Morindae Officinalis 100 grams, Herba Cynomorii 50 grams, Folium Mori extract 10 grams.

The preparation method of raw material is with embodiment 1.

Embodiment 4 investigates the effect of Chinese medicine composition of the present invention by clinical trial

Radix Aconiti Lateralis Preparata 100 grams, Cortex Cinnamomi 300 grams, Fructus Momordicae charantiae 100 grams, Semen Trigonellae 80 grams, Herba Epimedii 80 grams, Radix Morindae Officinalis 100 grams, Herba Cynomorii 70 grams, Folium Mori extract 30 grams, make 1000 capsules by the method for embodiment 1.

Paid-in clinical feedback report result is as follows at present:

(1) the routine deficiency of spleen-YANG and kidneyYANG diabetes mellitus type of clinical data 60 is divided into two groups at random, treatment group 30 examples, and matched group 30 examples, two groups of patients, in aspect all similar such as sex, age, the course of disease and clinical manifestations, have comparability.

(2) the oral capsule of the present invention of Therapeutic Method is 3, and every day 3 times, be three months the course for the treatment of, the control group SHENQI JIANGTANG KELI 3 grams, every day 3 times.

(3) criterion of therapeutical effect is worked out with reference to new Chinese medicine treatment diabetes guideline of clinical investigations:

1. produce effects: after treatment, symptom disappears substantially, fasting glucose<7.2mmol/L (130mg/dl), 2 hours blood glucoses<8.3mmol/L (150mg/dl) after the meal, twenty-four-hour urine sugar quantitatively<10.0g, or blood glucose twenty-four-hour urine sugar quantitatively descends more than 30% before treatment.

2. effective: after treatment, symptom is obviously improved, fasting glucose<8.3mmol/L (150mg/dl), 2 hours blood glucoses<10.0mmol/L (180mg/dl) after the meal, twenty-four-hour urine sugar quantitatively<25.0g, or blood glucose, twenty-four-hour urine sugar quantitatively descend more than 10% before treatment.

3. invalid: after treatment, symptom is not improved, and blood glucose, glucose in urine descend and do not reach above-mentioned standard.

(4) in efficacy result treatment group 30 examples, produce effects 21 examples, effective 6 examples, invalid 3 examples, total effective rate 90%, matched group 30 examples, produce effects 14 examples, effective 7 examples, no effect 9, total effective rate 70%, the treatment group curative effect obviously is better than matched group (P<0.05).

Claims

1. a Chinese medicine composition for the treatment of the deficiency of yang type diabetes, it is characterized in that, effective ingredient and pharmaceutically acceptable carrier, consist of, described effective ingredient is to be made by weight percentage by following raw materials according: 5 ~ 15 parts of Radix Aconiti Lateralis Preparatas, 25 ~ 35 parts of Cortex Cinnamomis, 5 ~ 15 parts, Fructus Momordicae charantiae, 5 ~ 10 parts of Semen Trigonellaes, 5 ~ 10 parts of Herba Epimedii, 5 ~ 15 parts of Radix Morindae Officinaliss, 5 ~ 10 parts of Herba Cynomoriis, 1 ~ 5 part of Folium Mori extract.

2. treat as claimed in claim 1 the Chinese medicine composition of deficiency of yang type diabetes, it is characterized in that, described effective ingredient is to be made by weight percentage by following raw materials according: 10 parts of Radix Aconiti Lateralis Preparatas, 30 parts of Cortex Cinnamomis, 10 parts, Fructus Momordicae charantiae, 8 parts of Semen Trigonellaes, 8 parts of Herba Epimedii, 10 parts of Radix Morindae Officinaliss, 7 parts of Herba Cynomoriis, 3 parts of Folium Mori extracts.