CN103463038A - Lycojaponicumin A在促胰岛素分泌药物中的应用 - Google Patents
Lycojaponicumin A在促胰岛素分泌药物中的应用 Download PDFInfo
- Publication number
- CN103463038A CN103463038A CN2013104362492A CN201310436249A CN103463038A CN 103463038 A CN103463038 A CN 103463038A CN 2013104362492 A CN2013104362492 A CN 2013104362492A CN 201310436249 A CN201310436249 A CN 201310436249A CN 103463038 A CN103463038 A CN 103463038A
- Authority
- CN
- China
- Prior art keywords
- lycojaponicumin
- medicaments
- application
- insulinotropic hormone
- hormone excretion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- WGVQKABRYXBLGW-WUZBVLBZSA-N (1R,2S,5S,7S,10S,13S)-7-hydroxy-7-methyl-17-oxa-14-azapentacyclo[12.2.1.02,10.02,13.05,10]heptadecane-3,9-dione Chemical compound O=C([C@@]12CC3)C[C@@](C)(O)C[C@H]1CC(=O)[C@@]12[C@H]3N2CC[C@H]1O2 WGVQKABRYXBLGW-WUZBVLBZSA-N 0.000 title abstract description 30
- 239000003814 drug Substances 0.000 title abstract description 4
- 230000029142 excretion Effects 0.000 title abstract 4
- 229940088597 hormone Drugs 0.000 title abstract 4
- 239000005556 hormone Substances 0.000 title abstract 4
- 230000002473 insulinotropic effect Effects 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 claims abstract description 13
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 17
- 102000004877 Insulin Human genes 0.000 claims description 8
- 108090001061 Insulin Proteins 0.000 claims description 8
- 229940125396 insulin Drugs 0.000 claims description 8
- 230000003248 secreting effect Effects 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 229930185194 lycojaponicumin Natural products 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 abstract description 6
- 206010012601 diabetes mellitus Diseases 0.000 abstract description 2
- 230000000694 effects Effects 0.000 abstract description 2
- 230000002265 prevention Effects 0.000 abstract 1
- 230000003914 insulin secretion Effects 0.000 description 5
- 239000006228 supernatant Substances 0.000 description 5
- 210000004153 islets of langerhan Anatomy 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 230000003833 cell viability Effects 0.000 description 3
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 3
- 241000927897 Lycopodium japonicum Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 229930013930 alkaloid Natural products 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000007995 HEPES buffer Substances 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000012528 insulin ELISA Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000003716 rejuvenation Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310436249.2A CN103463038B (zh) | 2013-09-23 | 2013-09-23 | Lycojaponicumin A在制备促胰岛素分泌药物中的应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310436249.2A CN103463038B (zh) | 2013-09-23 | 2013-09-23 | Lycojaponicumin A在制备促胰岛素分泌药物中的应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103463038A true CN103463038A (zh) | 2013-12-25 |
CN103463038B CN103463038B (zh) | 2015-11-25 |
Family
ID=49788236
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310436249.2A Expired - Fee Related CN103463038B (zh) | 2013-09-23 | 2013-09-23 | Lycojaponicumin A在制备促胰岛素分泌药物中的应用 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN103463038B (zh) |
-
2013
- 2013-09-23 CN CN201310436249.2A patent/CN103463038B/zh not_active Expired - Fee Related
Non-Patent Citations (1)
Title |
---|
XIAO-JING WANG,ET AL.: ""Lycojaponicumin A-C,Three Alkaloids with an Unprecedented Skeleton from Lycopodium japonicum"", 《ORGANIC LETTERS》 * |
Also Published As
Publication number | Publication date |
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CN103463038B (zh) | 2015-11-25 |
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C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20151023 Address after: 266000 Shandong province Qingdao city Licang District Road No. 1020 Laoshan two unit 302 Applicant after: Li Shulan Address before: Metro Technology Building No. 69 Olympic Avenue in Jianye District of Nanjing city in Jiangsu province 210019 01 5 storey buildings Applicant before: Nanjing Guangkangxie Biomedical Technology Co., Ltd. |
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C56 | Change in the name or address of the patentee | ||
CP02 | Change in the address of a patent holder |
Address after: 225327 Yongan village, Yongan Town, Taizhou District, Jiangsu, China, the 4 group Patentee after: Li Shulan Address before: 266000 Shandong province Qingdao city Licang District Road No. 1020 Laoshan two unit 302 Patentee before: Li Shulan |
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C41 | Transfer of patent application or patent right or utility model | ||
CB03 | Change of inventor or designer information |
Inventor after: Sun Li Inventor after: Li Wenjun Inventor before: Jiang Chunping Inventor before: Wang Zezheng |
|
COR | Change of bibliographic data | ||
TR01 | Transfer of patent right |
Effective date of registration: 20170126 Address after: Binzhou City, Shandong province 256500 Hu Zhen Chen Boxing County wide 202 Green Road District No. 6, No. 4 Building 1 unit 502 room Patentee after: Sun Li Patentee after: Lin Lina Address before: 225327 Yongan village, Yongan Town, Taizhou District, Jiangsu, China, the 4 group Patentee before: Li Shulan |
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CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20151125 Termination date: 20170923 |