CN103356593B - Chukrasone B在制备促胰岛素分泌药物中的应用 - Google Patents
Chukrasone B在制备促胰岛素分泌药物中的应用 Download PDFInfo
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- CN103356593B CN103356593B CN201310278057.3A CN201310278057A CN103356593B CN 103356593 B CN103356593 B CN 103356593B CN 201310278057 A CN201310278057 A CN 201310278057A CN 103356593 B CN103356593 B CN 103356593B
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- chukrasone
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- insulinotropic hormone
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- 229930187319 chukrasone Natural products 0.000 title claims abstract description 33
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 230000029142 excretion Effects 0.000 title claims abstract description 9
- 229940088597 hormone Drugs 0.000 title claims abstract description 9
- 239000005556 hormone Substances 0.000 title claims abstract description 9
- 230000002473 insulinotropic effect Effects 0.000 title claims abstract description 9
- LVTJOONKWUXEFR-FZRMHRINSA-N protoneodioscin Natural products O(C[C@@H](CC[C@]1(O)[C@H](C)[C@@H]2[C@]3(C)[C@H]([C@H]4[C@@H]([C@]5(C)C(=CC4)C[C@@H](O[C@@H]4[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@H](CO)O4)CC5)CC3)C[C@@H]2O1)C)[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1 LVTJOONKWUXEFR-FZRMHRINSA-N 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 abstract description 7
- 230000003914 insulin secretion Effects 0.000 abstract description 6
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract description 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 6
- 239000006228 supernatant Substances 0.000 description 5
- 210000004153 islets of langerhan Anatomy 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 102000004877 Insulin Human genes 0.000 description 3
- 108090001061 Insulin Proteins 0.000 description 3
- 102000006628 Kv1.2 Potassium Channel Human genes 0.000 description 3
- 108010087141 Kv1.2 Potassium Channel Proteins 0.000 description 3
- 230000003833 cell viability Effects 0.000 description 3
- 229940125396 insulin Drugs 0.000 description 3
- 241001156380 Chukrasia tabularis Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000007995 HEPES buffer Substances 0.000 description 1
- 102000004257 Potassium Channel Human genes 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 238000012528 insulin ELISA Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 108020001213 potassium channel Proteins 0.000 description 1
- 230000003716 rejuvenation Effects 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000005204 segregation Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201310278057.3A CN103356593B (zh) | 2013-07-04 | 2013-07-04 | Chukrasone B在制备促胰岛素分泌药物中的应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN201310278057.3A CN103356593B (zh) | 2013-07-04 | 2013-07-04 | Chukrasone B在制备促胰岛素分泌药物中的应用 |
Publications (2)
Publication Number | Publication Date |
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CN103356593A CN103356593A (zh) | 2013-10-23 |
CN103356593B true CN103356593B (zh) | 2015-08-19 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201310278057.3A Active CN103356593B (zh) | 2013-07-04 | 2013-07-04 | Chukrasone B在制备促胰岛素分泌药物中的应用 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN103356593B (zh) |
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2013
- 2013-07-04 CN CN201310278057.3A patent/CN103356593B/zh active Active
Non-Patent Citations (1)
Title |
---|
"Chukrasone A and B:Poteneial Kv1.2 Potassium Channel Blockers with New Skeletons,from Chukrasia tabularis";hongbing liu etal.;《Organic Letters》;20121008;第14卷(第17期);4438-4441 * |
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Publication number | Publication date |
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CN103356593A (zh) | 2013-10-23 |
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Effective date of registration: 20171109 Address after: 401120 Chongqing Yubei District Food City Avenue 18 Chongqing advertising industrial park office space Patentee after: Chongqing San Mou science and Technology Development Co., Ltd. Address before: 210009 Gulou District, Jiangsu, Nanjing Gu Ping Kong, No. 4 Patentee before: Ding Shengyu |
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Effective date of registration: 20191106 Address after: 056699 No.17 Pingle lane, Lincheng Road, Linzhang Town, Linzhang County, Handan City, Hebei Province Patentee after: Linzhang centenary Health Management Co., Ltd Address before: 401120 Chongqing Yubei District Food City Avenue 18 Chongqing advertising industrial park office space Patentee before: Chongqing San Mou science and Technology Development Co., Ltd. |
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Effective date of registration: 20201201 Address after: 244151 Jinshan Industrial Park, Shun an town, Tongling County, Tongling, Anhui Patentee after: TONGLING RUIPU PEONY INDUSTRY DEVELOPMENT Co.,Ltd. Address before: No.17, Pingle lane, Lincheng Road, Linzhang Town, Handan City, Hebei Province Patentee before: Linzhang centenary Health Management Co.,Ltd. |
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