CN103459430B - 生产具有高堆积密度和良好流动性的纤维素衍生物的方法 - Google Patents

生产具有高堆积密度和良好流动性的纤维素衍生物的方法 Download PDF

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Publication number
CN103459430B
CN103459430B CN201280015844.2A CN201280015844A CN103459430B CN 103459430 B CN103459430 B CN 103459430B CN 201280015844 A CN201280015844 A CN 201280015844A CN 103459430 B CN103459430 B CN 103459430B
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cellulose
cellulose derivative
gas
derivative
impact mill
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Chinese (zh)
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CN103459430A (zh
Inventor
Y.M.戈尔拉科-多特
J.赫曼斯
M.格罗斯图克
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Nutrition And Biotechnology Usa First LLC
Dow Chemical Co
DDP Specialty Electronic Materials US LLC
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Dow Global Technologies LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/12—Powdering or granulating
    • C08J3/124—Treatment for improving the free-flowing characteristics
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B11/00—Preparation of cellulose ethers
    • C08B11/20—Post-etherification treatments of chemical or physical type, e.g. mixed etherification in two steps, including purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C13/00—Disintegrating by mills having rotary beater elements ; Hammer mills
    • B02C13/26—Details
    • B02C13/288—Ventilating, or influencing air circulation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C23/00—Auxiliary methods or auxiliary devices or accessories specially adapted for crushing or disintegrating not provided for in preceding groups or not specially adapted to apparatus covered by a single preceding group
    • B02C23/18—Adding fluid, other than for crushing or disintegrating by fluid energy
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C23/00—Auxiliary methods or auxiliary devices or accessories specially adapted for crushing or disintegrating not provided for in preceding groups or not specially adapted to apparatus covered by a single preceding group
    • B02C23/18—Adding fluid, other than for crushing or disintegrating by fluid energy
    • B02C23/24—Passing gas through crushing or disintegrating zone
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B11/00—Preparation of cellulose ethers
    • C08B11/193—Mixed ethers, i.e. ethers with two or more different etherifying groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
    • C08L1/08—Cellulose derivatives
    • C08L1/26—Cellulose ethers
    • C08L1/28—Alkyl ethers
    • C08L1/284—Alkyl ethers with hydroxylated hydrocarbon radicals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C23/00—Auxiliary methods or auxiliary devices or accessories specially adapted for crushing or disintegrating not provided for in preceding groups or not specially adapted to apparatus covered by a single preceding group
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2301/00—Characterised by the use of cellulose, modified cellulose or cellulose derivatives
    • C08J2301/08—Cellulose derivatives
    • C08J2301/26—Cellulose ethers
    • C08J2301/28—Alkyl ethers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Cosmetics (AREA)
CN201280015844.2A 2011-04-06 2012-03-29 生产具有高堆积密度和良好流动性的纤维素衍生物的方法 Active CN103459430B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610585804.1A CN106188581B (zh) 2011-04-06 2012-03-29 生产具有高堆积密度和良好流动性的纤维素衍生物的方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161472225P 2011-04-06 2011-04-06
US61/472,225 2011-04-06
PCT/US2012/031111 WO2012138532A2 (en) 2011-04-06 2012-03-29 Process for producing cellulose derivatives of high bulk density and good flowability

Related Child Applications (1)

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CN201610585804.1A Division CN106188581B (zh) 2011-04-06 2012-03-29 生产具有高堆积密度和良好流动性的纤维素衍生物的方法

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CN103459430A CN103459430A (zh) 2013-12-18
CN103459430B true CN103459430B (zh) 2016-08-17

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CN201280015844.2A Active CN103459430B (zh) 2011-04-06 2012-03-29 生产具有高堆积密度和良好流动性的纤维素衍生物的方法

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Country Status (8)

Country Link
US (2) US9352330B2 (cg-RX-API-DMAC7.html)
EP (1) EP2694035B1 (cg-RX-API-DMAC7.html)
JP (1) JP5977331B2 (cg-RX-API-DMAC7.html)
KR (2) KR101960244B1 (cg-RX-API-DMAC7.html)
CN (2) CN106188581B (cg-RX-API-DMAC7.html)
BR (1) BR112013023380B1 (cg-RX-API-DMAC7.html)
MX (1) MX343509B (cg-RX-API-DMAC7.html)
WO (1) WO2012138532A2 (cg-RX-API-DMAC7.html)

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BR112013023380B1 (pt) 2011-04-06 2021-03-23 Dow Global Technologies Llc Processo para produzir um derivado de celulose particulado
EP2694110B2 (en) * 2011-04-06 2022-06-08 Dow Global Technologies LLC Novel polysaccharide derivatives and dosage forms
MX373836B (es) * 2012-02-10 2020-03-25 Nutrition & Biosciences Usa 1 Llc Composición para cuerpos cerámicos moldeados por extrusión que comprende un derivado de celulosa de determinado largo medio de partícula.
JP6039812B2 (ja) * 2012-09-25 2016-12-07 ダウ グローバル テクノロジーズ エルエルシー 冷水中で高い嵩密度、良好な流動性、および／または分散性、ならびに低い溶液色を有するセルロース誘導体の製造方法
KR102193811B1 (ko) * 2012-09-27 2020-12-22 다우 글로벌 테크놀로지스 엘엘씨 튀김 식품의 오일 및/또는 지방 흡수를 감소시키는 방법
CN110511440A (zh) 2013-03-12 2019-11-29 赫尔克里士公司 共处理的涂覆有硅石的聚合物组合物
EP3049446B1 (en) * 2013-09-23 2017-05-03 Dow Global Technologies LLC A process for recovering an esterified cellulose ether from a reaction product mixture
SG10202009484WA (en) * 2014-04-25 2020-11-27 Chugai Pharmaceutical Co Ltd Preparation containing tetracyclic compound at high dose
WO2016196153A1 (en) * 2015-06-05 2016-12-08 Dow Global Technologies Llc Cellulose ether powders
CN107636018B (zh) 2015-06-05 2020-07-10 陶氏环球技术有限责任公司 纤维素醚粉末
KR102519854B1 (ko) * 2016-10-07 2023-04-10 신에쓰 가가꾸 고교 가부시끼가이샤 히드록시알킬 알킬 셀룰로오스 및 그의 제조 방법, 및 고형 제제
KR102519850B1 (ko) * 2016-10-07 2023-04-10 신에쓰 가가꾸 고교 가부시끼가이샤 히드록시알킬 알킬 셀룰로오스 및 그의 제조 방법, 및 고형 제제
CN113117131B (zh) * 2019-12-31 2023-01-03 广州迈普再生医学科技股份有限公司 一种纳米纤维微球材料及其制备方法和应用
WO2022152760A1 (en) * 2021-01-13 2022-07-21 Nutrition & Biosciences Usa 1, Llc Improved method for the preparation of colloidal microcrystalline cellulose

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EP0384046A1 (en) * 1986-05-01 1990-08-29 The Dow Chemical Company Grinding process for high viscosity cellulose ethers
GB2262527A (en) * 1992-07-02 1993-06-23 Dow Deutschland Inc Process for grinding cellulose compounds
CN1311258A (zh) * 2000-02-28 2001-09-05 沃尔夫瓦尔斯罗德有限公司 生产粒状水溶性纤维素衍生物的方法
CN1311259A (zh) * 2000-02-28 2001-09-05 沃尔夫瓦尔斯罗德有限公司 用含蒸汽的过热气体混合物制备粒状、水溶性纤维素衍生物的方法
CN101243131A (zh) * 2005-08-16 2008-08-13 陶氏沃尔弗纤维素有限公司 制备具有更高粘度和细度的纤维素醚产品的方法
US20080039621A1 (en) * 2006-08-08 2008-02-14 Shin-Etsu Chemical Co., Ltd. Low-substituted hydroxypropylcellulose powder and method for producing the same

Also Published As

Publication number Publication date
KR20140027132A (ko) 2014-03-06
KR20180132952A (ko) 2018-12-12
CN106188581B (zh) 2019-08-16
US9352330B2 (en) 2016-05-31
WO2012138532A2 (en) 2012-10-11
CN103459430A (zh) 2013-12-18
KR101960244B1 (ko) 2019-03-21
MX2013011588A (es) 2013-12-09
MX343509B (es) 2016-11-08
US20160256390A1 (en) 2016-09-08
BR112013023380B1 (pt) 2021-03-23
CN106188581A (zh) 2016-12-07
US20140017319A1 (en) 2014-01-16
WO2012138532A3 (en) 2013-02-28
EP2694035B1 (en) 2024-11-06
EP2694035A2 (en) 2014-02-12
BR112013023380A2 (pt) 2017-04-25
JP5977331B2 (ja) 2016-08-24
JP2014510184A (ja) 2014-04-24

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