CN103458911B - 肽组合物和用于治疗患者的方法 - Google Patents

肽组合物和用于治疗患者的方法 Download PDF

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Publication number
CN103458911B
CN103458911B CN201280008561.5A CN201280008561A CN103458911B CN 103458911 B CN103458911 B CN 103458911B CN 201280008561 A CN201280008561 A CN 201280008561A CN 103458911 B CN103458911 B CN 103458911B
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China
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peptide
diapin
glucose
terminus
amino acid
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CN201280008561.5A
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English (en)
Chinese (zh)
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CN103458911A (zh
Inventor
Y·E·陈
C·薛
J·张
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University of Michigan Ann Arbor
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University of Michigan Ann Arbor
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Priority to CN201610034403.7A priority Critical patent/CN105617351A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CN201280008561.5A 2011-02-11 2012-02-10 肽组合物和用于治疗患者的方法 Active CN103458911B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610034403.7A CN105617351A (zh) 2011-02-11 2012-02-10 肽组合物和用于治疗患者的方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161441748P 2011-02-11 2011-02-11
US61/441,748 2011-02-11
PCT/US2012/024684 WO2012109561A2 (en) 2011-02-11 2012-02-10 Peptide compositions and methods for treating patients

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201610034403.7A Division CN105617351A (zh) 2011-02-11 2012-02-10 肽组合物和用于治疗患者的方法

Publications (2)

Publication Number Publication Date
CN103458911A CN103458911A (zh) 2013-12-18
CN103458911B true CN103458911B (zh) 2016-02-24

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CN201280008561.5A Active CN103458911B (zh) 2011-02-11 2012-02-10 肽组合物和用于治疗患者的方法
CN201610034403.7A Pending CN105617351A (zh) 2011-02-11 2012-02-10 肽组合物和用于治疗患者的方法

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US (2) US8664177B2 (enExample)
EP (1) EP2683393B1 (enExample)
JP (3) JP5946473B2 (enExample)
CN (2) CN103458911B (enExample)
AU (1) AU2012214283B2 (enExample)
CA (1) CA2827029C (enExample)
DK (1) DK2683393T3 (enExample)
ES (1) ES2673672T3 (enExample)
HU (1) HUE038787T2 (enExample)
MX (1) MX353301B (enExample)
WO (1) WO2012109561A2 (enExample)

Families Citing this family (11)

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MX353301B (es) 2011-02-11 2018-01-08 The Regents The Univ Of Michigan Composiciones tripeptidicas y metodos para tratamiento de diabetes.
US9456916B2 (en) 2013-03-12 2016-10-04 Medibotics Llc Device for selectively reducing absorption of unhealthy food
US9067070B2 (en) 2013-03-12 2015-06-30 Medibotics Llc Dysgeusia-inducing neurostimulation for modifying consumption of a selected nutrient type
US9011365B2 (en) 2013-03-12 2015-04-21 Medibotics Llc Adjustable gastrointestinal bifurcation (AGB) for reduced absorption of unhealthy food
US20180074053A1 (en) * 2015-04-03 2018-03-15 Zhongmin Ma Treatment of diabetes using agonists of the mas-related gpcr d
KR101909052B1 (ko) 2017-02-09 2018-10-17 강원대학교산학협력단 인슐린의 a 사슬로부터 유래된 펩타이드 단편 및 이를 포함하는 당뇨병 또는 당뇨병성 창상의 예방 또는 치료용 약학 조성물
WO2018237010A2 (en) 2017-06-20 2018-12-27 The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Vaccine compositions and methods of using the same
JP7068942B2 (ja) * 2018-06-25 2022-05-17 サンスター株式会社 トリペプチド含有組成物
EP3833373A4 (en) * 2018-08-10 2022-05-04 Diapin Therapeutics LLC TRIPEPTIDES AND TREATMENT OF METABOLIC, CARDIOVASCULAR AND INFLAMMATORY DISEASES
WO2022040222A1 (en) * 2020-08-18 2022-02-24 The Regents Of The University Of Michigan N-acyl amino acid products and uses
CN115252758A (zh) * 2022-08-16 2022-11-01 中国科学院南海海洋研究所 线性小分子肽类似物在制备抗肥胖和降糖药物中应用

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WO2003024995A1 (en) * 2001-09-19 2003-03-27 Tripep Ab Molecules that block viral infectivity and methods of use thereof
EP2047848A1 (en) * 2006-07-05 2009-04-15 The University of Tokyo Method of treating genetic disease caused by nonsense mutation
WO2011010769A1 (ko) * 2009-07-23 2011-01-27 월드웨이(주) 실크 펩타이드를 유효성분으로 하는 당뇨 치료 또는 예방용 조성물

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WO2000068695A2 (en) 1999-05-12 2000-11-16 Univ Oklahoma State Reagent and process for peptide/protein differentiation using circular dichroism detection
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WO1999045941A1 (en) * 1998-03-13 1999-09-16 Mrs, Llc Peptide compositions and formulations and use of same
WO2003024995A1 (en) * 2001-09-19 2003-03-27 Tripep Ab Molecules that block viral infectivity and methods of use thereof
EP2047848A1 (en) * 2006-07-05 2009-04-15 The University of Tokyo Method of treating genetic disease caused by nonsense mutation
WO2011010769A1 (ko) * 2009-07-23 2011-01-27 월드웨이(주) 실크 펩타이드를 유효성분으로 하는 당뇨 치료 또는 예방용 조성물

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Also Published As

Publication number Publication date
NZ614080A (en) 2016-05-27
JP2018131446A (ja) 2018-08-23
EP2683393A2 (en) 2014-01-15
JP2016179992A (ja) 2016-10-13
WO2012109561A3 (en) 2013-01-17
MX2013009223A (es) 2014-01-23
US20140148382A1 (en) 2014-05-29
DK2683393T3 (en) 2018-07-23
AU2012214283A1 (en) 2013-08-29
HUE038787T2 (hu) 2018-11-28
US8664177B2 (en) 2014-03-04
ES2673672T3 (es) 2018-06-25
WO2012109561A2 (en) 2012-08-16
CA2827029C (en) 2019-07-02
MX353301B (es) 2018-01-08
CN103458911A (zh) 2013-12-18
US20120208748A1 (en) 2012-08-16
AU2012214283B2 (en) 2016-01-28
CN105617351A (zh) 2016-06-01
CA2827029A1 (en) 2012-08-16
JP6412897B2 (ja) 2018-10-24
JP5946473B2 (ja) 2016-07-06
EP2683393B1 (en) 2018-04-11
US9062093B2 (en) 2015-06-23
NZ719672A (en) 2018-12-21
JP2014506579A (ja) 2014-03-17

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