CN103417948A - Pharmaceutical composition for external use to treat seborrheic dermatitis - Google Patents
Pharmaceutical composition for external use to treat seborrheic dermatitis Download PDFInfo
- Publication number
- CN103417948A CN103417948A CN2013103683890A CN201310368389A CN103417948A CN 103417948 A CN103417948 A CN 103417948A CN 2013103683890 A CN2013103683890 A CN 2013103683890A CN 201310368389 A CN201310368389 A CN 201310368389A CN 103417948 A CN103417948 A CN 103417948A
- Authority
- CN
- China
- Prior art keywords
- pharmaceutical composition
- seborrheic dermatitis
- parts
- radix
- dermatitis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000008742 seborrheic dermatitis Diseases 0.000 title claims abstract description 27
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 title claims abstract description 24
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 18
- 241001116389 Aloe Species 0.000 claims abstract description 16
- 235000011399 aloe vera Nutrition 0.000 claims abstract description 16
- 239000000463 material Substances 0.000 claims abstract description 9
- 241001071795 Gentiana Species 0.000 claims abstract description 3
- 210000000582 semen Anatomy 0.000 claims description 14
- 201000004624 Dermatitis Diseases 0.000 claims description 11
- 239000002994 raw material Substances 0.000 claims description 11
- 239000006210 lotion Substances 0.000 claims description 6
- 239000002674 ointment Substances 0.000 claims description 4
- 239000000499 gel Substances 0.000 claims description 2
- 208000003251 Pruritus Diseases 0.000 abstract description 7
- 210000004761 scalp Anatomy 0.000 abstract description 7
- 206010015150 Erythema Diseases 0.000 abstract description 6
- 231100000321 erythema Toxicity 0.000 abstract description 6
- 230000028327 secretion Effects 0.000 abstract description 4
- 208000024891 symptom Diseases 0.000 abstract description 4
- 230000003266 anti-allergic effect Effects 0.000 abstract description 2
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 2
- 239000000203 mixture Substances 0.000 abstract description 2
- 210000001732 sebaceous gland Anatomy 0.000 abstract description 2
- 238000002560 therapeutic procedure Methods 0.000 abstract description 2
- 235000003805 Musa ABB Group Nutrition 0.000 abstract 1
- 240000008790 Musa x paradisiaca Species 0.000 abstract 1
- 235000015266 Plantago major Nutrition 0.000 abstract 1
- 240000004980 Rheum officinale Species 0.000 abstract 1
- 235000008081 Rheum officinale Nutrition 0.000 abstract 1
- 230000007012 clinical effect Effects 0.000 abstract 1
- 230000007774 longterm Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 25
- 238000011282 treatment Methods 0.000 description 17
- 230000000694 effects Effects 0.000 description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
- 229940079593 drug Drugs 0.000 description 12
- 239000012567 medical material Substances 0.000 description 12
- 239000000284 extract Substances 0.000 description 8
- 238000001556 precipitation Methods 0.000 description 8
- 239000006228 supernatant Substances 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 239000008280 blood Substances 0.000 description 7
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 238000011084 recovery Methods 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 6
- 210000003128 head Anatomy 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 206010000496 acne Diseases 0.000 description 5
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 4
- 230000002421 anti-septic effect Effects 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 description 4
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 4
- 238000000605 extraction Methods 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- GYCKQBWUSACYIF-UHFFFAOYSA-N o-hydroxybenzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1O GYCKQBWUSACYIF-UHFFFAOYSA-N 0.000 description 4
- 238000012856 packing Methods 0.000 description 4
- 230000001717 pathogenic effect Effects 0.000 description 4
- 239000002244 precipitate Substances 0.000 description 4
- 206010040882 skin lesion Diseases 0.000 description 4
- 231100000444 skin lesion Toxicity 0.000 description 4
- 206010010904 Convulsion Diseases 0.000 description 3
- 206010039792 Seborrhoea Diseases 0.000 description 3
- 230000036461 convulsion Effects 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 210000002374 sebum Anatomy 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 206010010774 Constipation Diseases 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 206010016807 Fluid retention Diseases 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 206010023126 Jaundice Diseases 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 208000001848 dysentery Diseases 0.000 description 2
- 239000003172 expectorant agent Substances 0.000 description 2
- 230000003419 expectorant effect Effects 0.000 description 2
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 208000037920 primary disease Diseases 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 244000144927 Aloe barbadensis Species 0.000 description 1
- 235000002961 Aloe barbadensis Nutrition 0.000 description 1
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 206010010726 Conjunctival oedema Diseases 0.000 description 1
- 206010011878 Deafness Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 241001135871 Gentiana scabra Species 0.000 description 1
- 241001071804 Gentianaceae Species 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000555688 Malassezia furfur Species 0.000 description 1
- 208000007101 Muscle Cramp Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 241000013557 Plantaginaceae Species 0.000 description 1
- 241000961970 Plantago depressa Species 0.000 description 1
- 241000205407 Polygonum Species 0.000 description 1
- 208000004680 Rectal Fistula Diseases 0.000 description 1
- 240000001745 Rheum palmatum Species 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 208000007712 Tinea Versicolor Diseases 0.000 description 1
- 206010044278 Trace element deficiency Diseases 0.000 description 1
- 206010046274 Upper gastrointestinal haemorrhage Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 244000273928 Zingiber officinale Species 0.000 description 1
- 235000006886 Zingiber officinale Nutrition 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 206010002156 anal fistula Diseases 0.000 description 1
- 239000003098 androgen Substances 0.000 description 1
- 230000001142 anti-diarrhea Effects 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000003756 cervix mucus Anatomy 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 208000037893 chronic inflammatory disorder Diseases 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 206010013990 dysuria Diseases 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 210000000744 eyelid Anatomy 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 235000008397 ginger Nutrition 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 210000004013 groin Anatomy 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 235000009200 high fat diet Nutrition 0.000 description 1
- 206010021198 ichthyosis Diseases 0.000 description 1
- 150000002460 imidazoles Chemical class 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 229960004125 ketoconazole Drugs 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 238000006748 scratching Methods 0.000 description 1
- 230000002393 scratching effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 210000003859 smegma Anatomy 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 206010046901 vaginal discharge Diseases 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 210000003905 vulva Anatomy 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000001841 zingiber officinale Substances 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a pharmaceutical composition for external use to treat seborrheic dermatitis. The pharmaceutical composition is prepared by the following traditional Chinese medicinal materials, by weight, 40-60 parts of rhizoma zingiberis, 10-18 parts of gentian, 10-18 parts of plantain seeds, 25-35 parts of aloe and 25-35 parts of rheum officinale. The pharmaceutical composition is obvious in clinical effect on treating seborrheic dermatitis, can obviously improve clinical symptoms of a patient and relieve scalp erythema, papula, scale and pruritus, can inhibit sebaceous gland secretion, and is anti-inflammatory and antiallergic, and a therapeutic method using the pharmaceutic composition is good in long-term efficacy and low in recurrence rate.
Description
Technical field
The invention belongs to the Chinese medicine technical field, be specifically related to a kind of pharmaceutical composition of external curing seborrheic dermatitis, relate in particular to a kind of external medicine preparation for the treatment of seborrheic dermatitis.
Background technology
Seborrheic dermatitis (seborrheic dermatitis) is the chronic inflammatory disease dermatoses occurred than multiple location at seborrhea, and the cause of disease is very unclear.Some researcheres think that primary disease is on the seborrhea basis at present, the imbalance of skin surface normal flora, and due to the Malassezia furfur growth increases, it has the characteristics such as long, the easy recurrence of the course of disease.
The brawny tetter dermatitis is commonly encountered diseases, the frequently-occurring disease of department of dermatologry, in the crowd, sickness rate can reach 2%～3%, studies have reported that the brawny tetter dermatitis is main relevant with the oval Pityrosporum orbiculare infection, secondly to immunologic function extremely, trace element deficiency, the rising of androgen, sebum secretion is vigorous and inherited genetic factors etc. is relevant.
Ketoconazole is the imidazoles antifungal drug, extensive use 2% TPIATOP washout treatment brawny tetter dermatitis in clinical treatment, respond well for scalp squama, pruritus, but for irritated inflammatory reaction unsatisfactory curative effects such as scalp erythema, pimples, and the clinical recurrence rate is high.
Chinese medicine thinks, the brawny tetter dermatitis belongs to the seborrhea ichthyosis category, and the cause of disease is with to experience the exopathogen such as wind, wet, heat, worm relevant.In the element body, heat is arranged, the heresy of wind heat is outer attacks, and evil Yu Rijiu enters blood, wind is given birth in the heat in blood dryness-transformation, or the living endogenous wind of deficiency of YIN-blood, cause wind heat pathogenic dryness and accumulate the resistance skin, or surfeit greasy and surfeit flavour, pungent drinks etc., cause transporting and transforming function of the spleen and stomach not normal, give birth to heat of wetting, damp and hotly accumulate the steaming skin, or the evil folder of worm wind, the pathogen such as wet are attacked outward, change hot air wind producing, all can send out as primary disease.Chinese medicine is for the common special effect of agnogenic chronic disease, therefore, develops a kind of Chinese medicine evident in efficacy, treatment seborrheic dermatitis that relapse rate is low and seems necessary.
Summary of the invention
The present invention, according to Traditional Chinese medical theory, through a large amount of screenings, restructuring, the trial to the several kinds of Chinese medicinal materials raw material, makes by lot of experiments again.Therefore, the object of the invention is to by prescription again after the conventional medicament pharmacology is studied, a kind of pharmaceutical composition of evident in efficacy, external curing seborrheic dermatitis that relapse rate is low is provided.
The object of the present invention is achieved like this:
A kind of pharmaceutical composition of external curing seborrheic dermatitis, be prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Rhizoma Zingiberis 40-60 part, Radix Gentianae 10-18 part, Semen Plantaginis 10-18 part, Aloe 25-35 part, Radix Et Rhizoma Rhei 25-35 part.
Preferably, the pharmaceutical composition of above-mentioned external curing seborrheic dermatitis, be prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Rhizoma Zingiberis 45-52 part, Radix Gentianae 13-15 part, Semen Plantaginis 13-15 part, Aloe 28-32 part, Radix Et Rhizoma Rhei 28-32 part.
Further preferably, the pharmaceutical composition of above-mentioned external curing seborrheic dermatitis, be prepared from by the traditional Chinese medicinal material raw materials of following weight portion: Rhizoma Zingiberis 45-52 part, 14 parts of Radix Gentianaes, 14 parts of Semen Plantaginiss, 30 parts of Aloes, 30 parts of Radix Et Rhizoma Rhei.
Again further preferably, the pharmaceutical composition of above-mentioned external curing seborrheic dermatitis, it is lotion, ointment, ointment, gel.
Pharmaceutical composition of the present invention is applicable to the seborrheic dermatitis that treatment is fallen ill and divided in the partes corporis humani, after comprising scalp, supercilium, eyelid, nose and both sides, ear, the sebaceous gland such as neck, interscapular region, Ji Shang back, shirtfront, axillary fossa, groin, omphalos distribute and enrich position, the present invention especially is applicable to treatment brawny tetter dermatitis.
The present invention comprises the steps: for the preparation method of the lotion of external curing seborrheic dermatitis
1) get the raw materials ready: take the following Chinese crude drug cleaned up: Rhizoma Zingiberis 40-60 part, Radix Gentianae 10-18 part, Semen Plantaginis 10-18 part, Aloe 25-35 part, Radix Et Rhizoma Rhei 25-35 part are standby;
2) decoct: decoct with water, first decocts every tank adds 8-12 times that water is the medical material total amount, keeps 2-3 hour after ebuillition of heated, and extracting solution filters and enters settling tank through 200 order filters; Second decocts the water heating extraction that adds medical material amount 6-8 times, protects the 2-3 hour that boils, and extracting solution filters and enters settling tank through 200 order filters;
3) precipitation: in settling tank, the extracting solution precipitation is 24～36 hours, extracts supernatant and is filtered in triple effect evaporator through 200 order filters, and precipitate is by offal treatment;
4) concentrated: be concentrated into volume in triple effect evaporator when supernatant: the drug extract of medical material weight=1: 1, and be 0.1% to add the antiseptic ethyl hydroxybenzoate by weight percentage, last thin up, packing gets final product.
According to the Chinese medicine Historical Data Data About, the pharmacologically active of said medicine material is as follows:
Rhizoma Zingiberis: warming spleen and stomach for dispelling cold, recuperating depleted YANG is promoted blood circulation, dampness expectorant, warming the lung to resolve fluid-retention.Cure mainly coldness and pain in the epigastrium; Vomiting; Have loose bowels, YANG-depletion is fainted contrary; Cold fluid-retention is breathed with cough; Arthralgia due to cold-dampnes.Select the dry rhizome of zingiber Zingiber officinale Rosc..
Radix Gentianae: heat clearing and damp drying; The eliminating pathogen in the liver arresting convulsion.Jaundice due to damp-heat; The urine leaching pain; Swelling of the vulva pudendal pruritus; Damp-heat vaginal discharge; The feeling of fullness in the head headache of liver and gall excess-fire; Conjunctival congestion and swelling pain; Deaf ear is swollen; The hypochondriac pain bitter taste; The calentura convulsion with spasms.Derive from root and the rhizome of gentianaceae plant Radix Gentianae (Gentiana scabra Bge.).
Semen Plantaginis: clearing away heat and promoting diuresis; Eliminating dampness by diuresis antidiarrheal; Improving eyesight; Eliminate the phlegm.Cure mainly: main dysuria; The stranguria with turbid discharge leukorrhagia; The edema distension; The heat-damp in summer dysentery; Conjunctival congestion is hidden from view; The expectorant heat syndrome cough is breathed heavily.Select the seed for Plantaginaceae plant Herba Plantaginis Big Semen Plantaginis and Plantago depressa Willd.
Aloe: under rushing down; Liver heat removing; Parasite killing.Main constipation with heat retention; The liver-fire headache; The conjunctival congestion infantile convulsion; Abdominal pain due to worm stagnation; Scabies; Hemorrhoid complicated by anal fistula; Solution Fructus Crotonis poison.Select foreign Aloe (barbados aloe).
Radix Et Rhizoma Rhei: purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, eliminating blood stasis and inducing menstruation.For the excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, heat in blood is told nosebleed, conjunctival congestion, pharyngeal swelling, abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire; Upper gastrointestinal hemorrhage.Be selected from the dry root and rhizome of polygonum rheum palmatum Rheum palmatum L..
Evidence: the total effective rate of externally-applied medicinal composition treatment brawny tetter dermatitis of the present invention reaches more than 95%, and the relapse rate after curing is lower than 15%.Generally speaking, adopt external medication seborrheic dermatitis of the present invention (especially brawny tetter dermatitis) clinical effectiveness remarkable, can obviously improve the patient clinical symptom, alleviate scalp erythema, pimple, squama and pruritus, and can suppress smegma, antiinflammatory and antiallergic, the Therapeutic Method late result is good, and relapse rate is low, and clinic is used for reference and promoted.
The specific embodiment
Be below specific embodiments of the invention, technical scheme of the present invention is done to further the description, but protection scope of the present invention is not limited to these embodiment.Every do not deviate from the change of the present invention design or be equal to substitute include within protection scope of the present invention.
Embodiment 1
Crude drug prescription: Rhizoma Zingiberis 480 grams, Radix Gentianae 140 grams, Semen Plantaginis 140 grams, Aloe 300 grams, Radix Et Rhizoma Rhei 300 grams.
Preparation technology:
1) get the raw materials ready: take the following Chinese crude drug cleaned up by recipe quantity: Rhizoma Zingiberis, Radix Gentianae, Semen Plantaginis, Aloe, Radix Et Rhizoma Rhei, standby;
2) decoct: decoct with water, first decocts every tank, and to add water be 10 times of medical material total amount, after ebuillition of heated, keeps 3 hours, and extracting solution filters and enters settling tank through 200 order filters; Second decocts the water heating extraction that adds 8 times of medical material amounts, protects and boils 2 hours, and extracting solution filters and enters settling tank through 200 order filters;
3) precipitation: in settling tank, the extracting solution precipitation is 24～36 hours, extracts supernatant and is filtered in triple effect evaporator through 200 order filters, and precipitate is by offal treatment;
4) concentrated: be concentrated into volume in triple effect evaporator when supernatant: the drug extract of medical material weight=1: 1, and be 0.1% to add the antiseptic ethyl hydroxybenzoate by weight percentage, finally be diluted with water to 1 liter, by every bag of 50 milliliters of packing.
Embodiment 2
Crude drug prescription: Rhizoma Zingiberis 600 grams, Radix Gentianae 120 grams, Semen Plantaginis 120 grams, Aloe 250 grams, Radix Et Rhizoma Rhei 350 grams.
Preparation technology:
1) get the raw materials ready: take the following Chinese crude drug cleaned up by recipe quantity: Rhizoma Zingiberis, Radix Gentianae, Semen Plantaginis, Aloe, Radix Et Rhizoma Rhei, standby;
2) decoct: decoct with water, first decocts every tank, and to add water be 12 times of medical material total amount, after ebuillition of heated, keeps 3 hours, and extracting solution filters and enters settling tank through 200 order filters; Second decocts the water heating extraction that adds 8 times of medical material amounts, protects and boils 2 hours, and extracting solution filters and enters settling tank through 200 order filters;
3) precipitation: in settling tank, the extracting solution precipitation is 24～36 hours, extracts supernatant and is filtered in triple effect evaporator through 200 order filters, and precipitate is by offal treatment;
4) concentrated: be concentrated into volume in triple effect evaporator when supernatant: the drug extract of medical material weight=1: 1, and be 0.1% to add the antiseptic ethyl hydroxybenzoate by weight percentage, finally be diluted with water to 1 liter, by every bag of 50 milliliters of packing.
Embodiment 3
Crude drug prescription: Rhizoma Zingiberis 450 grams, Radix Gentianae 180 grams, Semen Plantaginis 180 grams, Aloe 350 grams, Radix Et Rhizoma Rhei 260 grams.
Preparation technology:
1) get the raw materials ready: take the following Chinese crude drug cleaned up by recipe quantity: Rhizoma Zingiberis, Radix Gentianae, Semen Plantaginis, Aloe, Radix Et Rhizoma Rhei, standby;
2) decoct: decoct with water, first decocts every tank, and to add water be 10 times of medical material total amount, after ebuillition of heated, keeps 3 hours, and extracting solution filters and enters settling tank through 200 order filters; Second decocts the water heating extraction that adds 6 times of medical material amounts, protects and boils 2 hours, and extracting solution filters and enters settling tank through 200 order filters;
3) precipitation: in settling tank, the extracting solution precipitation is 24～36 hours, extracts supernatant and is filtered in triple effect evaporator through 200 order filters, and precipitate is by offal treatment;
4) concentrated: be concentrated into volume in triple effect evaporator when supernatant: the drug extract of medical material weight=1: 1, and be 0.1% to add the antiseptic ethyl hydroxybenzoate by weight percentage, finally be diluted with water to 1 liter, by every bag of 50 milliliters of packing.
The correct seborrheic dermatitis patient's of embodiment 4 Chinese medicine lotions effectiveness study
Brawny tetter dermatitis patient 47 examples, be divided into 2 groups at random.Test group 24 examples, male 15 examples, female's 9 examples; 16～52 years old age, average 33.6 years old; The course of disease 3 months～10 years, average 5.1 years.Matched group 23 examples, male 14 examples, female's 9 examples; 17～52 years old age, average 34.2 years old; The course of disease 2 months-9 years, average 5.3 years.Two groups of physical data comparing difference not statistically significants, have comparability.
Chinese medicine lotion 1 bag that test group adopts embodiment 1 preparation, embathe and massage head skin zone, and medicine juice retains 5 min backlash in scalp section to be washed off, massages l5～20 min at every turn, the next day 1 time.Matched group adopts 2% TPIATOP (Xian-Janssen Pharmaceutical Ltd.) to be applied in right amount on moistening hair and massage head skin zone, and medicine juice retains the 5min backlash in scalp section to be washed off, massages 15～20min at every turn, the next day 1 time.In addition, two groups are limited polysaccharide, high fat diet, diet irritable food, avoid scratching, and the daily life rule.Test group and matched group all be take 4 weeks as 1 course for the treatment of, after 1 course for the treatment of, carry out the curative effect statistics.Criterion of therapeutical effect is as follows:
Recovery from illness: the patient clinical symptom disappears fully, and it is normal that the head skin lesion recovers;
Produce effects: patient's head skin lesion erythema, pimple, squama disappear more than 70%, and pruritus obviously alleviates, and sebum secretion obviously reduces;
Effectively: patient's head skin lesion erythema, pimple, squama disappear more than 20%, and pruritus alleviates, and sebum secretion reduces to some extent;
Invalid: the patient clinical doing well,improving is not obvious or increase the weight of, and has new skin lesion to occur.
Table 1 liang group brawny tetter dermatitis patient's curative effect relatively
| Group | n | Recovery from illness | Produce effects | Effectively | Invalid | Total effective rate |
| Matched group | 23 | 11 | 7 | 2 | 3 | 86.96% |
| Test group | 24 | 15 | 6 | 2 | 1 | 95.83% |
Result of the test by table 1 can find out, the total effective rate of test group is higher than 95%, and slightly has superiority than matched group, and this illustrates the evident in efficacy of Chinese medicine lotion treatment brawny tetter dermatitis of the present invention, and clinic is promoted.
In addition, the variation statistics curative effect of clinical symptoms (erythema, pimple, oils and fats, pruritus etc.) before and after two groups of patient treatments of observation and comparison, and the patient treatment of two groups of recoveries from illness is paid a return visit to observation and comparison recovery from illness patient's relapse rate after 4 weeks.After 4 weeks, two groups of recovery from illness patients pay a return visit result and show, test group 15 examples of fully recovering, recur 2 examples, relapse rate 13.33%; Matched group 11 examples of fully recovering, recur 9 examples, relapse rate 81.81%.Two groups of recovery from illness Patients on Recurrence rate comparing differences have statistical significance (P<0.05), and the recovery from illness Patients on Recurrence rate of test group is starkly lower than matched group.
Claims (5)
1. the pharmaceutical composition of an external curing seborrheic dermatitis, it is characterized in that: the traditional Chinese medicinal material raw materials by following weight portion is prepared from: Rhizoma Zingiberis 40-60 part, Radix Gentianae 10-18 part, Semen Plantaginis 10-18 part, Aloe 25-35 part, Radix Et Rhizoma Rhei 25-35 part.
2. the pharmaceutical composition of external curing seborrheic dermatitis according to claim 1, it is characterized in that: the traditional Chinese medicinal material raw materials by following weight portion is prepared from: Rhizoma Zingiberis 45-52 part, Radix Gentianae 13-15 part, Semen Plantaginis 13-15 part, Aloe 28-32 part, Radix Et Rhizoma Rhei 28-32 part.
3. the pharmaceutical composition of external curing seborrheic dermatitis according to claim 1, it is characterized in that: the traditional Chinese medicinal material raw materials by following weight portion is prepared from: Rhizoma Zingiberis 45-52 part, 14 parts of Radix Gentianaes, 14 parts of Semen Plantaginiss, 30 parts of Aloes, 30 parts of Radix Et Rhizoma Rhei.
4. according to the pharmaceutical composition of claim 1 or 2 or 3 described external curing seborrheic dermatitis, it is characterized in that: described pharmaceutical composition is lotion, ointment, ointment, gel.
5. according to the pharmaceutical composition of claim 1 or 2 or 3 described external curing seborrheic dermatitis, it is characterized in that: described seborrheic dermatitis is the brawny tetter dermatitis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310368389.0A CN103417948B (en) | 2013-08-22 | 2013-08-22 | Pharmaceutical composition for external use to treat seborrheic dermatitis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310368389.0A CN103417948B (en) | 2013-08-22 | 2013-08-22 | Pharmaceutical composition for external use to treat seborrheic dermatitis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103417948A true CN103417948A (en) | 2013-12-04 |
| CN103417948B CN103417948B (en) | 2014-12-10 |
Family
ID=49643688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310368389.0A Active CN103417948B (en) | 2013-08-22 | 2013-08-22 | Pharmaceutical composition for external use to treat seborrheic dermatitis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103417948B (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1671404A (en) * | 2002-04-22 | 2005-09-21 | 松浦药业株式会社 | Compositions for preventing or treating pollenosis, allergic nephritis, atopic dermatitits, asthma or urticaria |
| CN1739719A (en) * | 2005-09-17 | 2006-03-01 | 郭丽萍 | Dermatosis treating Chinese medicine prepn |
-
2013
- 2013-08-22 CN CN201310368389.0A patent/CN103417948B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1671404A (en) * | 2002-04-22 | 2005-09-21 | 松浦药业株式会社 | Compositions for preventing or treating pollenosis, allergic nephritis, atopic dermatitits, asthma or urticaria |
| CN1739719A (en) * | 2005-09-17 | 2006-03-01 | 郭丽萍 | Dermatosis treating Chinese medicine prepn |
Non-Patent Citations (1)
| Title |
|---|
| 王萍: "经典中成药在皮肤科的应用", 《中华中医药学会皮肤科分会第六次学术年会、赵炳南学术思想研讨会、全国皮肤科中医外治高级研修班论文集》, 31 December 2009 (2009-12-31), pages 255 - 257 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103417948B (en) | 2014-12-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102228603B (en) | Chinese medicine for treating retention of urine | |
| CN105535694A (en) | Traditional Chinese medicine composition for treating hyperuricemia | |
| CN103301400B (en) | A kind of Chinese medicine composition and preparation method for the treatment of chronic atrophic gastritis | |
| CN108969642A (en) | A kind of Chinese medicine compound prescription external preparation that treating chronic prostatitis and its preparation process | |
| CN105213974A (en) | One treats lymphadenomatous Chinese medicine composition and application thereof | |
| CN101584849B (en) | Compound angelica-Szechuan lovage rhizome soup used for treating premenstrual catatonic syndrome | |
| CN105535822A (en) | Traditional Chinese medicine composition for treating haemorrhoids and preparation method thereof | |
| CN103860773A (en) | Traditional Chinese medicine composition for treating myocardial ischemia and preparation method thereof | |
| CN103417948B (en) | Pharmaceutical composition for external use to treat seborrheic dermatitis | |
| CN103110905A (en) | Traditional Chinese medical preparation for treating cholecystitis with stagnation of liver qi and spleen deficiency | |
| CN103768478A (en) | Traditional Chinese medicine composition for treating prostatitis and preparation method and application thereof | |
| CN103735630B (en) | A kind of Chinese medicine for the treatment of gout | |
| CN102772534A (en) | Traditional Chinese medicine ointment for treating hemorrhoids | |
| CN105106634A (en) | Traditional Chinese medicine preparation for treating acute appendicitis and application thereof | |
| CN104523942B (en) | One treats colpitic external preparation | |
| CN104997972A (en) | Traditional Chinese medicine preparation for treating radiodermatitis | |
| CN105106696A (en) | Traditional Chinese medicinal composition for treating chronic prostatitis | |
| CN104055959A (en) | Traditional Chinese medicine lotion and nursing method for treating gastrointestinal dampness-heat type seborrhoeic dermatitis | |
| CN103656312B (en) | Traditional Chinese medicinal composition for treating urinary retention after colorectal surgery | |
| CN103623286A (en) | Chinese herbal medicine for treating herpes progenitalis | |
| CN103816333B (en) | A kind of Chinese medicine umbilicus plaster for the treatment of chronic enteritis | |
| CN103157048A (en) | Traditional Chinese medicine composition for treating chronic pelvic inflammation and preparation method thereof | |
| CN105012483A (en) | Traditional Chinese medicinal composition for treating head seborrheic dermatitis and preparation method thereof | |
| CN106039236A (en) | Traditional Chinese medicine preparation for treating bone cancer and improving immunity, and preparation method of traditional Chinese medicine preparation | |
| CN105412244A (en) | Traditional Chinese medicine composition treating gynecological cervicitis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: YU FAZHOU Free format text: FORMER OWNER: ZHANG SUPING Effective date: 20140307 |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 235000 HUAIBEI, ANHUI PROVINCE TO: 235037 HUAIBEI, ANHUI PROVINCE |
|
| TA01 | Transfer of patent application right |
Effective date of registration: 20140307 Address after: 235037 Anhui Province Economic Development Zone Huaibei City Duji District Tengfei Road No. 7 Applicant after: Yu Fazhou Address before: 235000 Huaibei middle school, Lieshan District, Anhui, China, seventh Applicant before: Zhang Suping |
|
| TA01 | Transfer of patent application right | ||
| ASS | Succession or assignment of patent right |
Owner name: LI JIAN Free format text: FORMER OWNER: YU FAZHOU Effective date: 20141103 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| C53 | Correction of patent of invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Li Jian Inventor before: Zhang Suping |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: ZHANG SUPING TO: LI JIAN Free format text: CORRECT: ADDRESS; FROM: 235037 HUAIBEI, ANHUI PROVINCE TO: 241000 WUHU, ANHUI PROVINCE |
|
| TA01 | Transfer of patent application right |
Effective date of registration: 20141103 Address after: Jinghu District of Anhui city of Wuhu province Jiuhua Road 241000 No. 263 in the Department of Dermatology of Wuhu Second People's Hospital Applicant after: Li Jian Address before: 235037 Anhui Province Economic Development Zone Huaibei City Duji District Tengfei Road No. 7 Applicant before: Yu Fazhou |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20190114 Address after: 510470 Third Industrial Zone of Renzhen Aigang Village, Baiyun District, Guangzhou City, Guangdong Province Patentee after: Baicaotang pharmaceutical Limited by Share Ltd Address before: 241000 Department of Dermatology, Wuhu Second People's Hospital, 263 Jiuhua Middle Road, Jinghu District, Wuhu, Anhui Patentee before: Li Jian |
|
| TR01 | Transfer of patent right |