CN103417205B - Neural information detecting system - Google Patents
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- CN103417205B CN103417205B CN201210162336.9A CN201210162336A CN103417205B CN 103417205 B CN103417205 B CN 103417205B CN 201210162336 A CN201210162336 A CN 201210162336A CN 103417205 B CN103417205 B CN 103417205B
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Abstract
The invention discloses a neural information detecting system which comprises an electrophysiology module, a data acquisition module, an analog switch array and a central processing module. The electrophysiology module comprises N electrophysiology signal channels; the data acquisition module is connected with the electrophysiology module and is used for sampling electrophysiology data acquired by the N electrophysiology signal channels of the electrophysiology module and performing analog-digital conversion on the data; the analog switch array comprises N analog switch channels, each analog switch channel comprises an electrophysiology signal switch, the front end of each electrophysiology signal switch is connected to a micro-electrode, and the rear end of each electrophysiology signal switch is connected to the corresponding electrophysiology signal channel; the central processing module is connected with the analog switch array and the data acquisition module and is used for controlling on and off of the electrophysiology signal switch of each analog switch channel. The neural information detecting system has the advantage that the problem that a neural information detecting instrument with a fixed quantity of channels is incompatible with micro-electrode arrays with different quantities of channels is solved.
Description
Technical field
The present invention relates to electron trade signal detection field, particularly relate to a kind of nerve information detection system.
Background technology
The release of the pulsed discharge of neurocyte and neurotransmitter (chemical substance) is the process of a fast transient, nerve information detects the process of catching pulsed discharge and neurotransmitter regulator at synchronous high-speed in real time, and nationality has important scientific meaning and clinical value with the aspect such as pathogeny, nerve signal transmission, drug reaction studying some disease.The response of organism for extraneous event simultaneously and each process of information processing, all need the combined effect relating to many neurocytes, thus to the bioelectrical activity of multiple cranial nerve cell detect simultaneously be in Neuroscience Research a kind of easily, the information getting method of normality.
Owing to often will use the microelectrode array of various different port number when detecting polyneural cellular electrophysiologicalsensor information, Fig. 1 is the structural representation of prior art nerve information detection system.As shown in Figure 1, this nerve information detection system comprises electro physiology module, data acquisition module, central processing module, USB module and buffer memory etc.But, electro physiology module is certain to the communication channel number of microelectrode array, and therefore it can only be connected with the microelectrode array of special modality number, and incompatible to the microelectrode array of other port numbers, thus the Exploitative potential of instrument can not be given full play to, meet clinical and needs that are scientific research.Therefore, design can have very important significance for reduction Neuroscience Research cost, raising scientific research efficiency etc. with the nerve information detecting instrument of the microelectrode array compatibility of various port number.
Summary of the invention
(1) technical problem that will solve
For solving above-mentioned one or more problems, the invention provides a kind of nerve information detection system, the problem that can not match with the microelectrode array of various port number with the nerve information detecting instrument solving stationary conduit number.
(2) technical scheme
The invention discloses a kind of nerve information detection system, comprising: electro physiology module, comprise the electricity physiological signal passage on N road; Data acquisition module, is connected with electricity physiological signal module, for sampling and analog digital conversion to the electric physiological data of N road electricity physiological signal channel acquisition in electro physiology module; Analog switch array, comprise the analog switch passage on N road, each analog switch passage in this N path analoging switch passage comprises: electricity physiological signal switch, and its front end is connected to a microelectrode, and its rear end is connected to electricity physiological signal passage Zhong mono-road, N road electricity physiological signal passage; Central processing module, is connected with data acquisition module with analog switch array, closing and opening for electricity physiological signal switch in each the analog switch passage in control N path analoging switch passage.
(3) beneficial effect
From technique scheme, nerve information detection system of the present invention has following beneficial effect:
(1) in nerve information detection system of the present invention, analog switch array inside is divided into four groups, often group has 18 interfaces to plug with microelectrode array to be connected, often organize analog switch array can be connected with microelectrode array separately, make system can be configured to 16,32,48 and 64 passages respectively, and use for different microelectrode arrays, ensure that the microelectrode array of instrument energy and various port number is compatible;
(2) in nerve information detection system of the present invention, comprise electro physiology module, electrochemical module and data acquisition module simultaneously, and analog switch array can configure the mode of each electrode access instrument, make electrod-array simultaneously for measuring electricity physiological signal and electrochemical signals, can ensure that instrument energy synchronous high-speed catches pulsed discharge and neurotransmitter regulator process in real time.
Accompanying drawing explanation
Fig. 1 is the structural representation of prior art nerve information detection system;
Fig. 2 is the structural representation of embodiment of the present invention nerve information detection system;
Fig. 3 is the structural representation of a certain analog switch passage in embodiment of the present invention nerve information detection system analog switch array;
Fig. 4 is the circuit diagram of electro physiology module in embodiment of the present invention nerve information detection system;
Fig. 5 is the circuit diagram of electrochemical module in embodiment of the present invention nerve information detection system;
Fig. 6 is the structural representation of data acquisition module in embodiment of the present invention nerve information detection system.
Detailed description of the invention
For making the object, technical solutions and advantages of the present invention clearly understand, below in conjunction with specific embodiment, and with reference to accompanying drawing, the present invention is described in more detail.
It should be noted that, in accompanying drawing or description describe, similar or identical part all uses identical figure number.And in the accompanying drawings, embodiment is to simplify or convenient sign.Moreover the element not illustrating in accompanying drawing or describe or implementation are form known to a person of ordinary skill in the art in art.In addition, although herein can providing package containing the demonstration of the parameter of particular value, parameter without the need to definitely equaling corresponding value, but can be similar to corresponding value in acceptable error margin or design constraint.
In one exemplary embodiment of the present invention, propose a kind of nerve information detection system.Fig. 2 is the structural representation of embodiment of the present invention nerve information detection system.As shown in Figure 2, the present embodiment nerve information detection system comprises: central processing module, analog switch array, electrical stimulation module, electro physiology module, electrochemical module, data acquisition module, cache module, USB transport module and upper computer module.Below respectively each ingredient is described in detail.In figure, the hollow arrow of each band oblique line represents a bus, the number of the data wire that this bus packet of the numeral below oblique line contains.
Central processing module, for the state of each analog switch passage in control simulation switch arrays, receives the data of data collecting module collected simultaneously, and is transferred to cache module by USB interface after data are encoded.
Upper computer module, belongs to upper computer software, and it realizes the configuration to analog switch array, data acquisition module, electrical stimulation module etc. by central processing module; The electricity physiological signal and electrochemical signals that can realize being stored in cache module carries out synchronous mark, stores synchronized; Selectivity storage can be carried out to the signal measured, to reduce memory data output simultaneously.
Analog switch array, its control end is connected with central processing module, comprise 64 path analoging switch passages, for each analog switch passage, its front end connects a microelectrode in microelectrode array, and of being connected in following circuit is selected in its rear end: an electricity physiological signal passage of electro physiology module, an electrochemical signals passage of electrochemical module, an electricity irritation passage in electrical stimulation module, or ground, this analog switch array is for configuring the mode of microelectrode access instrument.Herein, 64 tunnels are common set-up mode, those skilled in the art can according to oneself need the analog switch port number that analog switch array comprises is set.
For a part of analog switch passage wherein, it can comprise four switches, and the annexation of itself and electrode and each circuit as shown in Figure 3.By central processing module, analog switch is arranged, each electrode can be made to be chosen as different purposes, make it to be connected respectively to electricity physiological signal passage, electrochemical signals passage, electrical stimulation circuit, reference or ground, thus can according to concrete experiment demand, indiscriminately ad. as one wishes change the arrangement mode of microelectrode array, especially, it coordinates electro physiology module, electrochemical module and data acquisition module, can realize the configurable electrochemical signals of detection site and electricity physiological signal synchronous detecting.The state being controlled each switch by central processing module can also interconnected between realizing circuit, when carrying out electricity irritation, electricity physiological signal passage and electrochemical signals passage are connected to the ground especially, electricity physiological signal passage and electrochemistry amplifying circuit can be avoided to enter saturation by the impact of electricity irritation, thus mutual interference when avoiding electrode multiplexing between circuit, greatly improve the performance of system.
Herein, for convenience of explanation, electricity physiological signal switch, electrochemical signals switch, electrical stimulation signal switch and reference/ground switch has been included in an analog switch branch road.But, it will be understood by those skilled in the art that, for another part analog switch passage, it also can comprise three switches, such as electricity physiological signal switch, electrochemical signals switch and electrical stimulation signal switch etc.; Also two switches can be comprised, such as electricity physiological signal switch and electrical stimulation signal switch, or electricity physiological signal switch and reference/ground etc.; Only can certainly comprise a physiological signal switch.
Analog switch array inside is divided into four groups simultaneously, and often group comprises the analog switch passage on 16 tunnels.The analog switch passage on every Zu 16 tunnel, together with the referenced interface on 1 tunnel and the ground interface on 1 tunnel, totally 18 interfaces are connected with microelectrode array, as shown in Figure 2.Often organize analog switch can be connected with microelectrode array separately, make system can be configured to 16,32,48 and 64 passages respectively and use for different microelectrode arrays.In the present embodiment, pass through analog switch array, thus make system can be configured to 16 respectively, 32, 48 and 64 passages use, can be configured the purposes of each electrode simultaneously, make electrod-array can simultaneously for measuring electricity physiological signal and electrochemical signals, therefore, can realize making system can measure electricity physiological signal and electrochemical signals simultaneously, solve stationary conduit number nerve information detecting instrument and can not catch the problem of pulsed discharge and neurotransmitter regulator process in real time by synchronous high-speed, with stationary conduit number nerve information detecting instrument can not with the problem of the microelectrode array compatibility of various port number.
As shown in Figure 2, for each path analoging switch in analog switch array, can also comprise: pre-amplification circuit, be positioned at the front end of analog switch, for realizing the impedance matching with microelectrode array, anti-stop signal excessive attenuation in the process of transmission.This pre-amplification circuit is realized by emitter follower, and those skilled in the art should the design of decorrelation emitter follower, repeats no more herein.
Electro physiology module, its control end is connected with central processing module, and its input is connected with analog switch array, for amplifying electricity physiological signal, Filtering Processing, improves signal to noise ratio.Electro physiology module, comprise 64 road electricity physiological signal passages, the block diagram of each paths as shown in Figure 4, is made up of three parts, is differential amplifier circuit, low pass filter (LFP) and high pass filter (HFP) respectively by the flow direction of signal.The electricity physiological signal of input and reference signal (REF) are carried out differential amplification by differential amplifier circuit, and by signal transmission to next stage, suppress common-mode noise simultaneously.The amplification of resistance R decision-making circuit in figure, when R is set to 5.1K, the amplification of circuit is 10 times, instrument amplifier AD620R is the core devices of this circuit, its input impedance is 10G Ω, and be that common mode rejection ratio is 110db when 10 in amplification, input noise is
parameters can meet the detection needs of faint electroneurographic signal.Low pass filter (LFP) realizes amplifying (amplifying 5 times) the second level of signal, the high-frequency noise simultaneously in filtering circuit.High pass filter (HFP) realizes amplifying (amplifying 4 times) the third level of signal, the low-frequency noise simultaneously in filtering circuit, and gives data acquisition module signal transmission.Whole electricity physiological signal passage capable of being realizes the signal of microvolt level to amplify 1000 times, makes it become millivolt level and is easy to by the signal of data collecting module collected, and contain the various noises in circuit, greatly improve signal to noise ratio.It should be noted that, the electricity physiological signal passage on this 64 tunnel is also common setting, is not construed as limiting the invention.In addition, central processing module is to the size of control action major embodiment adjustable resistance in control circuit of electro physiology module, thus the amplification of control circuit, passband etc.
Electrochemical module, its control end is connected with central processing module, and its input (i.e. working electrode W) is connected with analog switch array, for generation of the permanent electromotive force that Electrochemical Detection needs, and convert electrochemical source of current signal to voltage signal, and processing and amplifying is carried out to signal.Electrochemical module, comprise 4 road electrochemical signals passages, the block diagram of each road electrochemical signals passage as shown in Figure 5, be the electrochemical signals testing circuit of a three-electrode system, its three electrodes are respectively reference electrode (R), to electrode (C) and working electrode (W).Circuit is made up of three parts, permanent potential instrument, current-to-voltage converting circuit and signal amplification circuit.Permanent potential instrument part produces the voltage waveform required for Electrochemical Detection by DAC chip MAX504, this voltage by the amplifier U7A of AD8606 and reference electrode (R), be linked in neurocyte to be measured or tissue electrode (C), and and working electrode (W) form current loop; Current-to-voltage converting circuit converts the current signal that working electrode (W) detects to voltage signal by another amplifier U7B of AD8606 and the sample resistance R16 of 100M, in circuit, the electric capacity C40 of 1000P is used for the parasitic capacitance in bucking circuit, improves the response speed of system; The voltage signal of input is carried out differential amplification by instrument amplifier AD620R by signal amplification circuit, and signal is sent into data acquisition module, and in circuit, resistance R8 determines amplification, and when R is set to 510 Europe, the amplification of circuit is 100 times.The core circuit of electrochemical signals testing circuit is current-to-voltage converting circuit.Because the electrochemical signals detected is pA magnitude, require high to required amplifier, bias current thus need be selected when type selecting low, the chip that current noise density is little.Amplifier selected by the present embodiment is AD8606, and it is that a bias current only has 0.2pA, and current noise density only has
the FET operational amplifier of low noise sound pitch open-loop gain, the needs of this instrument can be met.It should be noted that, the electrochemical signals passage on this 4 tunnel is also common setting, is not construed as limiting the invention.In addition, central processing module to the control action major embodiment of electrochemical module in the control mode of Electrochemical Scanning and the size of scanning voltage: scan mode can be electrochemistry CV method, electrochemistry IT method or quick CV method etc.; Scanning voltage arranges scope between-4V to 4V.
In addition, in order to realize electricity irritation function, the present embodiment nerve information detection system also comprises: electrical stimulation module, for realizing neurocyte and organizing the function stimulated, now: central processing module, also for configuring electrical stimulation module.
Electrical stimulation module, comprises 4 road electrical stimulation signal circuit for generatings, and each road signal generating circuit adopts the high-precision AD conversion chip of dual power supply, can produce amplitude, frequency-adjustable, the self-defining bipolar voltage of waveform or current waveform.This bipolar waveform can make the net charge on stimulation rear electrode be zero, can reduce the damage to neurocyte and tissue like this, residual charge can be avoided the electrolysis of electrode simultaneously, extends the service life of electrode.Its either-or switch that can control to adopt by central processing module realizes the function selecting bipolar voltage or current waveform.It is in conjunction with analog switch array and electro physiology module, and two-way (detect and the stimulate) function that can realize electrode switches.
, in order to realize the high speed acquisition of data, also comprise in nerve information detection system: data acquisition module, for gathering through the electricity physiological signal of electro physiology module and electrochemical module process and electrochemical signals meanwhile.As shown in Figure 6, this data acquisition module comprises: I/O interface, variable connector, sampling parameter configuration submodule and analog digital conversion control (ADC) submodule two parts.Sampling parameter configuration submodule, its control end is connected with central processing module, for input connected mode, sample rate and measuring range etc. during allocating and measuring.I/O interface is connected with electrochemical module with electro physiology module, receives the 64 road electricity physiological signals and 4 road electrochemical signals that pass over.Variable connector, for 64 described road electricity physiological signals and 4 road electrochemical signals are one by one passed to analog-to-digital conversion module, realizes the time division multiplex to analog-to-digital conversion module.Analog-to-digital conversion module, its control end is connected with sampling parameter configuration module, and its input is connected with variable connector, and outfan is connected with central processing module, for realizing the data acquisition to electricity physiological signal and electrochemical signals.The precision of ADC module reaches 16, and total sample rate is up to 1.25MS/s.Select the total speed of any way analog input can be configured to up to 1.25MS/s, can configure especially electrochemical signals detect time respectively rate reach more than 0.1ms, realize to cell neurotransmitter release detection.
In addition, in the present embodiment, cache module is connected with central processing module, for carrying out buffer memory to the data collected; USB transmission circuit is connected with central processing module, be connected with upper computer module by USB port, for the data in cache module are delivered to upper computer module, send the instruction of upper computer module to central processing module simultaneously, realize the control of upper computer module to instrument.In addition, upper computer module, also for the signal showing, store, process, analysis to measure arrives, is implemented to control to instrument simultaneously.
It should be noted that, the above-mentioned definition to each element is not limited in the various concrete structure or shape mentioned in embodiment, those of ordinary skill in the art can replace it with knowing simply, such as: (1) electro physiology module filtered circuit can also first high-pass filtering, the form of then low-pass filtering again; (2) the AD8606 chip that electrochemical module uses can replace with TLC2262 chip.
Above-described specific embodiment; object of the present invention, technical scheme and beneficial effect are further described; be understood that; the foregoing is only specific embodiments of the invention; be not limited to the present invention; within the spirit and principles in the present invention all, any amendment made, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (8)
1. a nerve information detection system, comprising:
Upper computer module;
Electro physiology module, comprises the electricity physiological signal passage on N road, N=64;
Electrochemical module, comprises the electrochemical signals passage on M road, described M≤N;
Electrical stimulation module, comprises the electrical stimulation signal passage on J road, described J≤N;
Data acquisition module, be connected with electrochemical module with electricity physiological signal module, for sampling and analog digital conversion to the electrochemical data of M road electrochemical signals channel acquisition in the electric physiological data of N road electricity physiological signal channel acquisition in electro physiology module and electrochemical module;
Analog switch array, comprise the analog switch passage on N road, the analog switch passage on this N road is divided into four groups, often group comprises 16 path analoging switch passages, each analog switch passage in this N path analoging switch passage comprises: electricity physiological signal switch, its front end is connected to a microelectrode, its rear end is connected to electricity physiological signal passage Zhong mono-road, described N road electricity physiological signal passage, wherein, each analog switch passage in M path analoging switch passage in this N path analoging switch passage also comprises: electrochemical signals switch, its front end is connected to a microelectrode, its rear end is connected to electrochemical signals passage Zhong mono-road, described M road electrochemical signals passage, each analog switch passage in J path analoging switch passage in described N path analoging switch passage also comprises: electrical stimulation signal switch, its front end is connected to a microelectrode, and its rear end is connected to electrical stimulation signal passage Zhong mono-road, described J road electrical stimulation signal passage, each analog switch passage of K path analoging switch passage in described N path analoging switch passage except described J path analoging switch passage also comprises: earthed switch, and its front end is connected to a microelectrode, and its rear end is connected to reference voltage or ground,
Central processing module, be connected with data acquisition module with described analog switch array, closing and opening for electrical stimulation signal switch in each the analog switch passage in electrochemical signals, J path analoging switch passage in each the analog switch passage in electricity physiological signal switch, M path analoging switch passage in each the analog switch passage in control N path analoging switch passage; Also carry out the electric physiological data after analog digital conversion and electrochemical data for receiving described data acquisition module; Wherein, be in the described electricity physiological signal switch in the analog switch passage on same road, described electrochemical signals switch, electrical stimulation signal switch can only have one of them to be in closure state, and, control when at least one path analoging switch passage in described J path analoging switch passage, electrical stimulation signal switch is in closure state, the earthed switch controlling each analog switch passage of described K path analoging switch passage is in closure state;
Cache module, is connected with central processing module, carries out buffer memory for the electricity physiological signal received central processing module;
USB transmission circuit, is connected with central processing module, is connected with upper computer module by USB port, for the data in cache module are delivered to upper computer module.
2. nerve information detection system according to claim 1, wherein, the 16 path analoging switch passages often organized, together with the referenced interface on 1 tunnel and the ground interface on 1 tunnel, totally 18 interfaces are connected with microelectrode array.
3. nerve information detection system according to claim 1, wherein, described M=4.
4. nerve information detection system according to claim 1, wherein, described J=4.
5. nerve information detection system according to claim 1, wherein,
Described central processing module, is also connected with described electrical stimulation module, for control described J road electrical stimulation signal passage in amplitude, the frequency of electrical stimulation signal, and/or waveform.
6. nerve information detection system according to claim 1, wherein, described N=64, M=4, described J=4.
7. nerve information detection system according to any one of claim 1 to 6, wherein, described upper computer module, for receiving the data acquisition parameters of user's input;
Described USB transmission circuit, is connected with central processing module, is connected by USB port with upper computer module, sends central processing module to for data acquisition parameters upper computer module received;
Described data acquisition module, also for sampling and analog digital conversion according to described data acquisition parameters to the electric physiological data of N road electricity physiological signal channel acquisition in electro physiology module.
8. nerve information detection system according to any one of claim 1 to 6, wherein, each the analog switch passage in described N path analoging switch passage also comprises:
Pre-amplification circuit, its front end is connected with a microelectrode, and its rear end is connected to the front end of corresponding electricity physiological signal switch, for realizing the impedance matching with described microelectrode.
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| CN104490386B (en) * | 2014-12-16 | 2017-01-04 | 中国科学院深圳先进技术研究院 | The changing method of a kind of multi-channel electrode array and system |
| CN106108858A (en) * | 2016-09-21 | 2016-11-16 | 中国科学院电子学研究所 | A kind of light regulation and control nerve information detecting system |
| CN106175701A (en) * | 2016-09-30 | 2016-12-07 | 中国科学院电子学研究所 | A kind of nerve information photoelectricity regulation and control and bimodulus detecting system |
| CN110013242B (en) * | 2019-04-04 | 2024-02-02 | 深圳市润谊泰益科技有限责任公司 | Myoelectric signal collector and method |
| CN111803052A (en) * | 2020-06-30 | 2020-10-23 | 天津大学 | Method for evaluating signal recording performance of neural microelectrode |
| CN114112865A (en) * | 2021-11-22 | 2022-03-01 | 中国人民解放军军事科学院军事医学研究院 | Microelectrode measuring device and measuring method thereof |
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