CN104490386B - The changing method of a kind of multi-channel electrode array and system - Google Patents

The changing method of a kind of multi-channel electrode array and system Download PDF

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Publication number
CN104490386B
CN104490386B CN201410782531.0A CN201410782531A CN104490386B CN 104490386 B CN104490386 B CN 104490386B CN 201410782531 A CN201410782531 A CN 201410782531A CN 104490386 B CN104490386 B CN 104490386B
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plating
multichannel analog
control unit
unit
analog switch
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CN104490386A (en
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鲁艺
王立平
钟成
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Shenzhen Institute of Advanced Technology of CAS
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Shenzhen Institute of Advanced Technology of CAS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system

Abstract

The present invention provides changing method and the system of a kind of multi-channel electrode array, and described method includes: control unit sends detection signal to the second multichannel analog switch；Described second multichannel analog switch switches to according to described detection signal and detects device and be connected；Described detection measurement device the first multichannel analog switch resistance value of electrod-array when current channel；Described resistance value is sent to described control unit by described detection device；Described control unit is according to the described described first multichannel analog switch of resistance value switching.The multichannel microelectrode that present invention achieves complete dynamicization is modified and is measured and interchannel automatic switchover, it is achieved that prepared by the microelectrode array under the conditions of unmanned, accelerate the preparation process of nerve electrode, it is adaptable to the production of commercialization nerve microelectrode array.

Description

The changing method of a kind of multi-channel electrode array and system
Technical field
The present invention is about electrophysiological technique field, especially with regard to electrophysiological nerve microelectrode array technology, concrete Say it is changing method and the system of a kind of multi-channel electrode array.
Background technology
At present, have the population of 1/10 just enduring the puzzlement of neuropsychiatric disease to the fullest extent in the world, every year by The treatment burden of the neuropsychiatric diseases such as epilepsy, schizophrenia, depression, drug dependence, senile dementia accounts for whole disease 13%, exceeded cardiovascular disease and cancer.And with the quickening pace of modern life with the aging of population structure, Huan Zheren Number is also gradually increasing.At present constantly the increasing of neuropsychiatric disease sickness rate in global range, makes not only to patient and society Having become white elephant, the most also treatment and research to these diseases bring unprecedented challenge.Simultaneously as brain Complexity and existing research and treatment technology between contradiction, seriously constrain people's deeply grinding neuropsychiatric disease Study carefully.
In order to study reinventing and repair mechanism of neural circuit comprehensively and in depth, the diagnosis and treatment improving neuropsychiatric disease are existing Shape, in the urgent need to studying the connection between specific behavior and specific brain regions district neurocyte coding in the animal model of clear-headed activity System.Electrophysiological technique is one of important technical realizing this purpose.By being implanted in the electricity in animal pattern specific brain regions district Pole, can recorded the electricity physiological signal under the conditions of different stimulated, and study model animal specific behavior is put with electricity physiological signal The contact of power mode.
In order to improve the spatial resolution of electrode, it is thus achieved that the coding information of more neurocytes, recorded more polyneural thin The electrical activity of born of the same parents, uses the mode of microelectrode array to carry out electrophysiological recording at present.Owing to the port number of microelectrode array leads to Often reach more than 64 passages, the most thousands of passages.Therefore, modification and the detection process of multi-channel electrode array are the most numerous Trivial.But, there is no at present and be specifically designed to the channel switching system that nerve electrode is modified and detected, be only capable of being carried out by manual type Switching.This not only consumes substantial amounts of manpower and carries out repetitive work, and it also requires there is the technical staff of certain Professional knowledge The result measured is passed judgment on and record, easily makes a mistake, and very likely improper because of state modulator or misoperation Damage electrode.
Therefore, how to develop a set of perfect multi-channel electrode array automatic switchover mechanism to solve to be currently used for electricity life Reason research nerve microelectrode array preparation and detection during between multiple instruments and multichannel switching problem be this area urgently Technical barrier to be solved.
Summary of the invention
In order to solve in prior art for electrophysiologic study nerve microelectrode array preparation and detection during many Switching problem between individual instrument and multichannel, the invention provides changing method and the system of a kind of multi-channel electrode array, passes through Control unit controls the first multichannel analog switch, the second multichannel analog switch, and combines detection device and plating dress Put, it is achieved that the multichannel microelectrode of complete dynamicization is modified and measured and interchannel automatic switchover, it is achieved that unmanned bar Prepared by the microelectrode array under part, accelerate the preparation process of nerve electrode, it is adaptable to the life of commercialization nerve microelectrode array Produce.
It is an object of the invention to provide the changing method of a kind of multi-channel electrode array, described method includes: control Unit sends detection signal to the second multichannel analog switch；The second described multichannel analog switch is according to described detection letter Number switch to and detect device and be connected；Described detection measurement device the first multichannel analog switch electrode when current channel The resistance value of array；Described resistance value is sent to described control unit by described detection device；Described control unit According to the described described first multichannel analog switch of resistance value switching.
In a preferred embodiment of the invention, described control unit is according to described resistance value switching described more than first Tunnels analogy switch includes: described control unit obtains the first impedance threshold set in advance, the second impedance threshold, and described The first impedance threshold less than described the second impedance threshold；Whether the described resistance value described in control unit judgement is less than institute Whether the first impedance threshold stated or described resistance value be more than the second described impedance threshold；When being judged as YES, described Control unit output negative-feedback signal；Described control unit is according to the first multichannel described in described negative-feedback signal switching Analog switch enters into next passage；The channel information of electrod-array described in described control unit record.
In a preferred embodiment of the invention, described control unit is according to described resistance value switching described more than first Tunnels analogy switch includes: described control unit obtains the first impedance threshold set in advance, the second impedance threshold, and described The first impedance threshold less than described the second impedance threshold；Whether the described resistance value described in control unit judgement is more than institute The first impedance threshold of stating and less than the second described impedance threshold；When being judged as YES, described control unit is to described Second multichannel analog switch sends galvanic signal；The second described multichannel analog switch is according to described galvanic signal switching To being connected with electroplanting device；Described electrod-array is electroplated by described electroplanting device；After plating terminates, described the Two multichannel analog switches switch to be connected with described detection device；Described detection measurement device the first multichannel analog Switch is when current channel, the resistance value of plating end rear electrode array；Plating is terminated rear electrode battle array by described detection device The resistance value of row sends to described control unit；Described control unit terminates the resistance of rear electrode array according to described plating The described first multichannel analog switch of anti-value switching.
In a preferred embodiment of the invention, described control unit terminates rear electrode array according to described plating The described first multichannel analog switch of resistance value switching includes: the described plating described in control unit judgement terminates rear electrode battle array Whether the resistance value of row is less than the first described impedance threshold；When being judged as YES, described control unit output positive feedback letter Number；Described control unit enters into next according to the first multichannel analog switch described in described positive feedback signal switching and leads to Road.
In a preferred embodiment of the invention, described control unit terminates rear electrode array according to described plating The described first multichannel analog switch of resistance value switching includes: the described plating described in control unit judgement terminates rear electrode battle array Whether the resistance value of row is more than the first described impedance threshold；When being judged as YES, described control unit obtains and presets Plating threshold value；Described control unit sends galvanic signal to the second described multichannel analog switch；More than described second Tunnels analogy switch switches to be connected with electroplanting device according to described galvanic signal；Described electroplanting device is to described electricity Pole array carries out electroplating threshold value time plating；After plating threshold value time plating terminates, the second described multichannel analog switch switching To being connected with described detection device；Described detection measurement device the first multichannel analog switchs when current channel, electricity Plating threshold value time plating terminates the resistance value of rear electrode array；Plating threshold value time plating is terminated rear electrode battle array by described detection device The resistance value of row sends to described control unit；Described control unit is electric after terminating according to described plating threshold value time plating The described first multichannel analog switch of resistance value switching of pole array.
In a preferred embodiment of the invention, after described control unit terminates according to described plating threshold value time plating The described first multichannel analog switch of resistance value switching of electrod-array includes: the described plating threshold described in control unit judgement Whether value time plating terminates the resistance value of rear electrode array more than the first described impedance threshold；When being judged as YES, described Control unit output negative-feedback signal；Described control unit is according to the first multichannel described in described negative-feedback signal switching Analog switch enters into next passage.
In a preferred embodiment of the invention, described control unit terminates rear electrode array according to described plating The described first multichannel analog switch of resistance value switching includes: the described plating described in control unit judgement terminates rear electrode battle array Whether the resistance value of row is more than the first described impedance threshold；When being judged as YES, described control unit obtains and presets Plating threshold value；Described control unit sends galvanic signal to the second described multichannel analog switch；More than described second Tunnels analogy switch switches to be connected with electroplanting device according to described galvanic signal；Described electroplanting device is to described electricity Pole array carries out n plating, and described n is positive integer and is less than described plating threshold value；After n plating terminates, described Second multichannel analog switch switches to be connected with described detection device；Described detection measurement device the first multichannel mould Intend switch when current channel, the resistance value of n plating end rear electrode array；N plating is terminated by described detection device The resistance value of rear electrode array sends to described control unit；After described control unit terminates according to n time described plating The described first multichannel analog switch of resistance value switching of electrod-array.
In a preferred embodiment of the invention, described control unit terminates rear electrode battle array according to n time described plating The described first multichannel analog switch of resistance value switching of row includes: described n plating described in control unit judgement terminates Whether the resistance value of rear electrode array is more than the first described impedance threshold；When being judged as YES, described control unit output Zero feedback signal；Described control unit switchs again according to the first multichannel analog described in zero described feedback signal switching Enter current channel.
In a preferred embodiment of the invention, described method also includes: described control unit is by described electrode The channel information of array sends to recording unit；Described record unit stores the channel information of described electrod-array.
In a preferred embodiment of the invention, described method also includes: described record unit is by described electrode array The channel information of row arrives display unit by the 3rd multichannel analog switch output；Described display unit shows described electrode array The channel information of row.
It is an object of the invention to provide the switched system of a kind of multi-channel electrode array, described system includes: Detection device, electroplanting device, described system also includes control unit；The first multichannel being connected with described control unit Analog switch, the second multichannel analog switch；Switch, with the first described multichannel analog, the electricity being connected by electrode interface Pole array；Wherein, described control unit includes: detection signal transmitting unit, for opening to the second described multichannel analog Close and send detection signal；The second described multichannel analog switch includes: first connects unit, for according to described detection letter Number switch to be connected with described detection device；Described detection device includes: the first measuring unit, is used for measuring described One multichannel analog switch resistance value of described electrod-array when current channel；First transmitting element, for by described resistance Anti-value sends to described control unit；Described control unit also includes: the first switch unit, for according to described impedance The described first multichannel analog switch of value switching.
In a preferred embodiment of the invention, the first described switch unit includes: impedance threshold acquiring unit, is used for Obtain the first impedance threshold set in advance, the second impedance threshold, and the first described impedance threshold is less than the second described resistance Anti-threshold value；First judging unit, for judging that whether described resistance value is less than the first described impedance threshold or described resistance Whether anti-value is more than the second described impedance threshold；First feedback signal output unit, for when the first described judging unit When being judged as YES, export negative-feedback signal；First passage switch unit, for according to described in described negative-feedback signal switching First multichannel analog switch enters into next passage；Channel information record unit, for recording the passage of described electrod-array Information.
In a preferred embodiment of the invention, the first described switch unit also includes: the second judging unit, is used for sentencing Whether disconnected described resistance value is more than the first described impedance threshold and less than the second described impedance threshold；First galvanic signal Transmitting element, for when the second described judging unit is judged as YES, sends electricity to the second described multichannel analog switch Plating signal；The second described multichannel analog switch also includes: second connects unit, for according to described galvanic signal switching To being connected with electroplanting device；Described electroplanting device includes: the first electroplating unit, for described electrod-array is carried out electricity Plating；First detection signal transmitting unit, for after plating terminates, sends detection letter to the second described multichannel analog switch Number；The first connection unit in second multichannel analog switch, for switching to and described inspection according to described detection signal Survey device is connected；Described detection device also includes: the second measuring unit, is used for measuring described first multichannel analog switch When current channel, the resistance value of plating end rear electrode array；Second transmitting element, for terminating rear electrode array by plating Resistance value send to the most described control unit；Described control unit also includes: the second switch unit, for according to described Plating terminates the described first multichannel analog switch of resistance value switching of rear electrode array.
In a preferred embodiment of the invention, the second described switch unit includes: the 3rd judging unit, is used for judging Whether described plating terminates the resistance value of rear electrode array less than the first described impedance threshold；Second feedback signal output is single Unit, for when the 3rd described judging unit is judged as YES, exports positive feedback signal；Second channel switch unit, for root Next passage is entered into according to the first multichannel analog switch described in described positive feedback signal switching.
In a preferred embodiment of the invention, the second described switch unit includes: the 4th judging unit, is used for judging Whether described plating terminates the resistance value of rear electrode array more than the first described impedance threshold；Plating threshold value acquiring unit, For when the 4th described judging unit is judged as YES, obtaining plating threshold value set in advance；Second galvanic signal sends single Unit, for sending galvanic signal to the second described multichannel analog switch；In described second multichannel analog switch the Two connect unit, for switching to be connected with electroplanting device according to described galvanic signal；Described electroplanting device includes: the Two electroplating units, for carrying out plating threshold value time plating to described electrod-array；Second detection signal transmitting unit, for working as After plating threshold value time plating terminates, send detection signal to the second described multichannel analog switch；Second multichannel analog is opened The first connection unit in the Central Shanxi Plain, for switching to be connected with described detection device according to described detection signal；Described Detection measurement device also includes: the 3rd measuring unit, is used for measuring described first multichannel analog and switchs when current channel, electricity Plating threshold value time plating terminates the resistance value of rear electrode array；3rd transmitting element, electricity after plating threshold value time plating is terminated The resistance value of pole array sends to described control unit；Described control unit also includes: the 3rd switch unit, for basis Described plating threshold value time plating terminates the described first multichannel analog switch of resistance value switching of rear electrode array.
In a preferred embodiment of the invention, the 3rd described switch unit includes: the 5th judging unit, is used for judging Whether described plating threshold value time plating terminates the resistance value of rear electrode array more than the first described impedance threshold；3rd feedback Signal output unit, for when the 5th described judging unit is judged as YES, exports negative-feedback signal；Third channel switching is single Unit, for entering into next passage according to the first multichannel analog switch described in described negative-feedback signal switching.
In a preferred embodiment of the invention, described electroplanting device also includes: the 3rd electroplating unit, for described Electrod-array carry out n plating, described n is positive integer and less than described plating threshold value；3rd detection signal sends single Unit, after terminating when n plating, sends detection signal to the second described multichannel analog switch；Second multichannel analog The first connection unit in switch, for switching to be connected with described detection device according to described detection signal；Described Detection measurement device also include: the 4th measuring unit, for measure first multichannel analog switch when current channel, n time Plating terminates the resistance value of rear electrode array；4th transmitting element, for sending out the resistance value that n plating terminates rear electrode array Deliver to described control unit；Described control unit also includes: the 4th switch unit, for according to n time described plating knot The described first multichannel analog switch of resistance value switching of bundle rear electrode array.
In a preferred embodiment of the invention, the 4th described switch unit includes: the 6th judging unit, is used for judging Whether n time described plating terminates the resistance value of rear electrode array more than the first described impedance threshold；4th feedback signal is defeated Go out unit, for when the 6th described judging unit is judged as YES, export zero feedback signal；Fourth lane switch unit, uses In reentering current channel according to the first multichannel analog switch described in zero described feedback signal switching.
In a preferred embodiment of the invention, described system also includes: record unit, is used for storing described control single The channel information of the described electrod-array that unit sends.
In a preferred embodiment of the invention, described system also includes: the 3rd multichannel analog switch, with described Record unit is connected；Switch, with described 3rd multichannel analog, the display unit being connected, be used for showing described electrod-array Channel information.
The beneficial effects of the present invention is, it is provided that the changing method of a kind of multi-channel electrode array and system, by control Unit processed controls the first multichannel analog switch, the second multichannel analog switch, and combines detection device and electroplanting device, The multichannel microelectrode achieving complete dynamicization is modified and is measured and interchannel automatic switchover, it is achieved that under the conditions of unmanned Microelectrode array prepare, accelerate the preparation process of nerve electrode, it is adaptable to the production of commercialization nerve microelectrode array, solve In prior art of having determined for electrophysiologic study nerve microelectrode array preparation and detection during multiple instruments and manifold Switching problem between road.
For the above and other objects, features and advantages of the present invention can be become apparent, preferred embodiment cited below particularly, And coordinate institute's accompanying drawings, it is described in detail below.
Accompanying drawing explanation
In order to be illustrated more clearly that the embodiment of the present invention or technical scheme of the prior art, below will be to embodiment or existing In having technology to describe, the required accompanying drawing used is briefly described, it should be apparent that, the accompanying drawing in describing below is only this Some embodiments of invention, for those of ordinary skill in the art, on the premise of not paying creative work, it is also possible to Other accompanying drawing is obtained according to these accompanying drawings.
The flow process of the embodiment one of the changing method of a kind of multi-channel electrode array that Fig. 1 provides for the embodiment of the present invention Figure；
The flow process of the embodiment two of the changing method of a kind of multi-channel electrode array that Fig. 2 provides for the embodiment of the present invention Figure；
The flow process of the embodiment three of the changing method of a kind of multi-channel electrode array that Fig. 3 provides for the embodiment of the present invention Figure；
Fig. 4 is the particular flow sheet of the embodiment one of step S105 in Fig. 1；
Fig. 5 is the particular flow sheet of the embodiment two of step S105 in Fig. 1；
Fig. 6 is the particular flow sheet of the embodiment one of step S509 in Fig. 5；
Fig. 7 is the particular flow sheet of the embodiment two of step S509 in Fig. 5；
Fig. 8 is the particular flow sheet of step S709 in Fig. 7；
Fig. 9 is the particular flow sheet of the embodiment three of step S509 in Fig. 5；
Figure 10 is the particular flow sheet of step S909 in Fig. 9；
The knot of the embodiment one of the switched system of a kind of multi-channel electrode array that Figure 11 provides for the embodiment of the present invention Structure block diagram；
The knot of the embodiment two of the switched system of a kind of multi-channel electrode array that Figure 12 provides for the embodiment of the present invention Structure block diagram；
The knot of the embodiment three of the switched system of a kind of multi-channel electrode array that Figure 13 provides for the embodiment of the present invention Structure block diagram；
The knot of the embodiment four of the switched system of a kind of multi-channel electrode array that Figure 14 provides for the embodiment of the present invention Structure block diagram；
The knot of the embodiment five of the switched system of a kind of multi-channel electrode array that Figure 15 provides for the embodiment of the present invention Structure block diagram；
The knot of the embodiment six of the switched system of a kind of multi-channel electrode array that Figure 16 provides for the embodiment of the present invention Structure block diagram；
The knot of the embodiment seven of the switched system of a kind of multi-channel electrode array that Figure 17 provides for the embodiment of the present invention Structure block diagram；
The knot of the embodiment eight of the switched system of a kind of multi-channel electrode array that Figure 18 provides for the embodiment of the present invention Structure block diagram；
The knot of the embodiment nine of the switched system of a kind of multi-channel electrode array that Figure 19 provides for the embodiment of the present invention Structure block diagram；
The knot of the embodiment ten of the switched system of a kind of multi-channel electrode array that Figure 20 provides for the embodiment of the present invention Structure block diagram；
The schematic diagram of multi-channel electrode array automatic switchover scheme in the specific embodiment that Figure 21 provides for the present invention.
Detailed description of the invention
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is carried out clear, complete Describe, it is clear that described embodiment is only a part of embodiment of the present invention rather than whole embodiments wholely.Based on Embodiment in the present invention, it is every other that those of ordinary skill in the art are obtained under not making creative work premise Embodiment, broadly falls into the scope of protection of the invention.
In order to improve the spatial resolution of electrode, and recorded the electrical activity of more neurocyte, the most employings are micro- The mode of electrod-array carries out electrophysiological recording.Owing to the port number of microelectrode array generally reaches more than 64 passages, even Reach thousands of passage.Therefore, modification and the detection process of multi-channel electrode array are the most loaded down with trivial details.But, there is no special use at present Modify and the channel switching device of detection in nerve electrode, be therefore only capable of being switched over by manual type.This not only consumes greatly The manpower of amount carries out repetitive work, and it also requires there is the technical staff of certain Professional knowledge to comment the result measured Sentence and record, easily make a mistake, and very likely improper because of state modulator or misoperation damage electrode.
For the deficiency of such scheme, it is an object of the invention to provide a kind of multi-channel electrode array changing method and System, solves to be currently used for multiple instruments and manifold during the preparation of the nerve microelectrode array of electrophysiologic study and detection Switching problem between road.This system is particularly suited for preparation and the detection of the microelectrode array of more than 64 passages, can accelerator nerve electricity The preparation process of pole, by with electrode plating device and detection device combination, the commercialization under the conditions of unmanned can be realized The modification of nerve microelectrode array and detection.
Fig. 1 is the idiographic flow of the embodiment one of the changing method of a kind of multi-channel electrode array that the present invention proposes Figure, as shown in Figure 1, in embodiment one, described method includes:
S101: control unit sends detection signal to the second multichannel analog switch.
S102: described second multichannel analog switch switches to according to described detection signal and detects device and be connected Connect.
S103: described detection measurement device the first multichannel analog switch impedance of electrod-array when current channel Value.
S104: described resistance value is sent to described control unit by described detection device.
S105: described control unit is according to the described described first multichannel analog switch of resistance value switching.
Fig. 2 is the idiographic flow of the embodiment two of the changing method of a kind of multi-channel electrode array that the present invention proposes Figure, as shown in Figure 2, in embodiment two, described method includes:
S201: control unit sends detection signal to the second multichannel analog switch.
S202: described second multichannel analog switch switches to according to described detection signal and detects device and be connected Connect.
S203: described detection measurement device the first multichannel analog switch impedance of electrod-array when current channel Value.
S204: described resistance value is sent to described control unit by described detection device.
S205: described control unit is according to the described described first multichannel analog switch of resistance value switching.
The channel information of described electrod-array is sent to recording unit by S206: described control unit.
S207: described record unit stores the channel information of described electrod-array.
Fig. 3 is the idiographic flow of the embodiment three of the changing method of a kind of multi-channel electrode array that the present invention proposes Figure, from the figure 3, it may be seen that in embodiment three, described method includes:
S301: control unit sends detection signal to the second multichannel analog switch.
S302: described second multichannel analog switch switches to according to described detection signal and detects device and be connected Connect.
S303: described detection measurement device the first multichannel analog switch impedance of electrod-array when current channel Value.
S304: described resistance value is sent to described control unit by described detection device.
S305: described control unit is according to the described described first multichannel analog switch of resistance value switching.
The channel information of described electrod-array is sent to recording unit by S306: described control unit.
S307: described record unit stores the channel information of described electrod-array.
S308: the channel information of described electrod-array is exported by described record unit by the 3rd multichannel analog switch To display unit；
S309: described display unit shows the channel information of described electrod-array.
In a particular embodiment, the 3rd multichannel analog switch contact leads to entering directly into next after output signal Road.
Display unit is made up of the LED with electrode interface port number equal number；When receiving positive feedback, same logical The LED in road is bright；When receiving negative feedback, the LED of same passage does not works.
Fig. 4 is the particular flow sheet of the embodiment one of step S105 in Fig. 1, and as shown in Figure 4, this step includes:
S401: described control unit obtains the first impedance threshold set in advance, the second impedance threshold, and described the One impedance threshold is less than the second described impedance threshold.In a particular embodiment, the first impedance threshold set in advance is all As for 500k Ω, the second impedance threshold set in advance is such as 3000k Ω.
S402: whether the described resistance value described in control unit judgement is less than described the first impedance threshold or described Whether resistance value is more than the second described impedance threshold.
S403: when being judged as YES, described control unit output negative-feedback signal.
S404: described control unit according to the first multichannel analog described in described negative-feedback signal switching switch into Enter to next passage.
S405: the channel information of electrod-array described in described control unit record.
In the detailed description of the invention of the present invention, electrod-array is by electrode interface and the first multichannel analog switch phase Even, in actual mechanical process, first the first multichannel analog switch is switched to current channel, such as passage 1, simultaneously second Multichannel analog switch is switched to passage 1 (being i.e. connected with detection device) and starts impedance measurement.When electrod-array is at not electricity When during plating, resistance value is less than 500k Ω or is more than 3000k Ω, impedance measurements is fed back to bear, and i.e. exports negative-feedback signal.Control Unit processed controls the first multichannel analog switch by receiving feedback signal.When feedback signal is defined as negative, output is negative anti- Be fed to record unit, direct recording channel information and control first multichannel analog switch enter into next passage.
Fig. 5 is the particular flow sheet of the embodiment two of step S105 in Fig. 1, and as shown in Figure 5, this step is specifically wrapped Include:
S501: described control unit obtains the first impedance threshold set in advance, the second impedance threshold, and described the One impedance threshold is less than the second described impedance threshold.
In a particular embodiment, the first impedance threshold set in advance is such as 500k Ω, set in advance second Impedance threshold is such as 3000k Ω.
S502: whether the described resistance value described in control unit judgement is more than the first described impedance threshold and less than institute The second impedance threshold stated.
S503: when being judged as YES, described control unit sends plating letter to the second described multichannel analog switch Number；
S504: the second described multichannel analog switch switches to be connected with electroplanting device according to described galvanic signal Connect；
S505: described electrod-array is electroplated by described electroplanting device；
S506: after plating terminates, the second described multichannel analog switch switches to be connected with described detection device；
S507: described detection measurement device the first multichannel analog switchs when current channel, plating terminates rear electrode The resistance value of array；
Plating is terminated the resistance value of rear electrode array and sends to described control unit by S508: described detection device；
S509: described control unit terminates the resistance value switching described more than first of rear electrode array according to described plating Tunnels analogy switchs.
In the detailed description of the invention of the present invention, electrod-array is by electrode interface and the first multichannel analog switch phase Even, in actual mechanical process, first the first multichannel analog switch is switched to current channel, such as passage 1, simultaneously second Multichannel analog switch is switched to passage 1 (being i.e. connected with detection device) and starts impedance measurement.When electrod-array is at not electricity When resistance value is more than 500k Ω and is less than 3000k Ω during plating, switch the second multichannel analog and switch passage 2 (i.e. with plating dress Put and be connected) and start plating, after plating terminates, (after such as 5 seconds) automatically jump back to passage 2 and (are i.e. connected with detection device Connect) carry out impedance measurement.
Fig. 6 is the particular flow sheet of the embodiment one of step S509 in Fig. 5, it will be appreciated from fig. 6 that this step is specifically wrapped Include:
Whether S601: the described plating described in control unit judgement terminates the resistance value of rear electrode array less than described First impedance threshold.
S602: when being judged as YES, described control unit output positive feedback signal；
S603: described control unit according to the first multichannel analog described in described positive feedback signal switching switch into Enter to next passage.
That is, in the detailed description of the invention of the present invention, electrod-array is switched by electrode interface and the first multichannel analog It is connected, in actual mechanical process, first the first multichannel analog switch is switched to current channel, such as passage 1, simultaneously the Two multichannel analog switches are switched to passage 1 (being i.e. connected with detection device) and start impedance measurement.When electrod-array is not When resistance value is more than 500k Ω and is less than 3000k Ω during plating, switch the second multichannel analog and switch passage 2 (i.e. with plating Device is connected) and start plating, after plating terminates, (after such as 5 seconds) automatically jump back to passage 2 and (are i.e. connected with detection device Connect) carry out impedance measurement.When measuring resistance value less than 500k Ω, switch the first multichannel analog and switch next passage.Also When i.e. electrod-array resistance value after plating is less than 500k Ω, output signal is just defined as, and i.e. exports positive feedback signal.Control single Unit controls the first multichannel analog switch by receiving feedback signal, when feedback signal is defined as timing, exports positive and negative being fed to Record unit, and control first multichannel analog switch enter into next passage.
Fig. 7 is the particular flow sheet of the embodiment two of step S509 in Fig. 5, and as shown in Figure 7, this step includes:
Whether S701: the described plating described in control unit judgement terminates the resistance value of rear electrode array more than described First impedance threshold.
S702: when being judged as YES, described control unit obtains plating threshold value set in advance.Concrete embodiment party In formula, plating threshold value is such as 5.
S703: described control unit sends galvanic signal to the second described multichannel analog switch；
S704: the second described multichannel analog switch switches to be connected with electroplanting device according to described galvanic signal Connect.
Described electrod-array is carried out electroplating threshold value time plating by S705: described electroplanting device；
S706: after plating threshold value time plating terminates, the second described multichannel analog switch switches to and described inspection Survey device is connected；
S707: described detection measurement device the first multichannel analog switchs when current channel, plating threshold value time plating Terminate the resistance value of rear electrode array；
S708: the resistance value that plating threshold value time plating terminates rear electrode array is sent to described by described detection device Control unit；
S709: described control unit terminates the resistance value switching of rear electrode array according to described plating threshold value time plating Described first multichannel analog switch.
That is, in the detailed description of the invention of the present invention, electrod-array is switched by electrode interface and the first multichannel analog It is connected, in actual mechanical process, first the first multichannel analog switch is switched to current channel, such as passage 1, simultaneously the Two multichannel analog switches are switched to passage 1 (being i.e. connected with detection device) and start impedance measurement.When electrod-array is not When resistance value is more than 500k Ω and is less than 3000k Ω during plating, switch the second multichannel analog and switch passage 2 (i.e. with plating Device is connected) and start plating, after plating terminates, (after such as 5 seconds) automatically jump back to passage 2 and (are i.e. connected with detection device Connect) carry out impedance measurement.When measure resistance value more than 500k Ω time, switch the second multichannel analog switch passage (i.e. with Electroplanting device is connected) again electroplate.After repeating to electroplate threshold value time plating (being such as 5 times), detection measurement device is now Resistance value.Control unit switches described first multichannel analog switch according to resistance value now.
Fig. 8 is the particular flow sheet of step S709 in Fig. 7, and as shown in Figure 8, this step specifically includes:
S801: whether the resistance value of the described plating threshold value time plating end rear electrode array described in control unit judgement More than the first described impedance threshold；
S802: when being judged as YES, described control unit output negative-feedback signal；
S803: described control unit according to the first multichannel analog described in described negative-feedback signal switching switch into Enter to next passage.
That is, in the detailed description of the invention of the present invention, electrod-array is switched by electrode interface and the first multichannel analog It is connected, in actual mechanical process, first the first multichannel analog switch is switched to current channel, such as passage 1, simultaneously the Two multichannel analog switches are switched to passage 1 (being i.e. connected with detection device) and start impedance measurement.When electrod-array is not When resistance value is more than 500k Ω and is less than 3000k Ω during plating, switch the second multichannel analog and switch passage 2 (i.e. with plating Device is connected) and start plating, after plating terminates, (after such as 5 seconds) automatically jump back to passage 2 and (are i.e. connected with detection device Connect) carry out impedance measurement.When measure resistance value more than 500k Ω time, switch the second multichannel analog switch passage (i.e. with Electroplanting device is connected) again electroplate.After repeating to electroplate threshold value time plating (being such as 5 times), detection measurement device is now Resistance value.When resistance value now is more than 500k Ω, direct recording channel information also switches the first multichannel analog and switchs Next passage.When after now electrod-array circulates 5 times after plating, resistance value is still greater than 500k Ω, output signal is defined as bearing, I.e. export negative-feedback signal.Control unit controls the first multichannel analog switch by receiving feedback signal.Work as feedback signal When being defined as negative, output negative feedback is to record unit, and controls the first multichannel analog and switch and enter into next passage.
Fig. 9 is the particular flow sheet of the embodiment three of step S509 in Fig. 5, and as shown in Figure 9, this step is specifically wrapped Include:
Whether S901: the described plating described in control unit judgement terminates the resistance value of rear electrode array more than described First impedance threshold；
S902: when being judged as YES, described control unit obtains plating threshold value set in advance；
S903: described control unit sends galvanic signal to the second described multichannel analog switch；
S904: the second described multichannel analog switch switches to be connected with electroplanting device according to described galvanic signal Connect；
S905: described electroplanting device carries out n plating to described electrod-array, and described n is positive integer and is less than Described plating threshold value；
S906: after n plating terminates, the second described multichannel analog switch switches to and described detection device phase Connect；
S907: described detection measurement device the first multichannel analog switchs when current channel, n plating is electric after terminating The resistance value of pole array；
S908: the resistance value that n plating terminates rear electrode array is sent to described control list by described detection device Unit；
S909: described control unit terminates the resistance value switching of rear electrode array described the according to described n plating One multichannel analog switch.
That is, in the detailed description of the invention of the present invention, electrod-array is switched by electrode interface and the first multichannel analog It is connected, in actual mechanical process, first the first multichannel analog switch is switched to current channel, such as passage 1, simultaneously the Two multichannel analog switches are switched to passage 1 (being i.e. connected with detection device) and start impedance measurement.When electrod-array is not When resistance value is more than 500k Ω and is less than 3000k Ω during plating, switch the second multichannel analog and switch passage 2 (i.e. with plating Device is connected) and start plating, after plating terminates, (after such as 5 seconds) automatically jump back to passage 2 and (are i.e. connected with detection device Connect) carry out impedance measurement.When measure resistance value more than 500k Ω time, switch the second multichannel analog switch passage (i.e. with Electroplanting device is connected) again electroplate.After repeating n plating (being such as 1,2,3,4 times), detect measurement device resistance now Anti-value.
Figure 10 is the particular flow sheet of step S909 in Fig. 9, and as shown in Figure 10, this step specifically includes:
S1001: whether described n plating described in control unit judgement terminates the resistance value of rear electrode array more than institute The first impedance threshold stated；
S1002: when being judged as YES, described control unit exports zero feedback signal；
S1003: described control unit is according to the first multichannel analog switch described in zero described feedback signal switching Reenter current channel.
That is, in the detailed description of the invention of the present invention, electrod-array is switched by electrode interface and the first multichannel analog It is connected, in actual mechanical process, first the first multichannel analog switch is switched to current channel, such as passage 1, simultaneously the Two multichannel analog switches are switched to passage 1 (being i.e. connected with detection device) and start impedance measurement.When electrod-array is not When resistance value is more than 500k Ω and is less than 3000k Ω during plating, switch the second multichannel analog and switch passage 2 (i.e. with plating Device is connected) and start plating, after plating terminates, (after such as 5 seconds) automatically jump back to passage 2 and (are i.e. connected with detection device Connect) carry out impedance measurement.When measure resistance value more than 500k Ω time, switch the second multichannel analog switch passage (i.e. with Electroplanting device is connected) again electroplate.After repeating to electroplate threshold value time plating (being such as 1,2,3,4 times), detect measurement device Resistance value now.When resistance value now is more than 500k Ω, output signal is defined as zero, i.e. exports zero feedback signal.When When feedback signal is defined as zero, control unit controls the first multichannel analog switch and reenters former passage.
As it has been described above, be the changing method of a kind of multi-channel electrode array that the present invention provides, it is possible to achieve Quan Donghua Multichannel microelectrode modify and measure, and interchannel automatic switchover.Realize the microelectrode array under the conditions of unmanned Preparation, the preparation process of accelerator nerve electrode, it is adaptable to the production of commercialization nerve microelectrode array.
Patent of the present invention is intended, by a kind of multi-channel electrode array automatic switchover system, solving to be currently used for electro physiology and grinding Switching problem between multiple instruments and multichannel during the preparation of the nerve microelectrode array studied carefully and detection.This system is especially suitable The preparation of the microelectrode array more than 64 passages and detection, can the preparation process of accelerator nerve electrode, unmanned can be realized Under the conditions of the modification of commercialization nerve microelectrode array and detection.
The knot of the embodiment one of the switched system of a kind of multi-channel electrode array that Figure 11 provides for the embodiment of the present invention Structure block diagram, as shown in Figure 11, in embodiment one, described system includes detecting device 108, electroplanting device 107, also wraps Include: control unit 100；First multichannel analog switch the 101, second multichannel analog being connected with described control unit is opened Close 109；Switch, with the first described multichannel analog, the electrod-array 103 being connected by electrode interface 102.
Wherein, described control unit 100 includes:
Detection signal transmitting unit 11, for sending detection signal to the second multichannel analog switch.
The second described multichannel analog switch 109 includes: first connects unit 91, for according to described detection signal Switch to and detect device and be connected.
Described detection device 108 includes:
First measuring unit 81, for measuring first multichannel analog switch impedance of electrod-array when current channel Value.
First transmitting element 82, for sending described resistance value to described control unit.
Described control unit also includes: the first switch unit 12, for according to described resistance value switching described first Multichannel analog switchs.
The knot of the embodiment two of the switched system of a kind of multi-channel electrode array that Figure 12 provides for the embodiment of the present invention Structure block diagram, as shown in Figure 12, in embodiment two, described system also includes:
Record unit 104, for storing the channel information of the described electrod-array that described control unit sends.
The knot of the embodiment three of the switched system of a kind of multi-channel electrode array that Figure 13 provides for the embodiment of the present invention Structure block diagram, as shown in Figure 13, in embodiment three, described system also includes:
3rd multichannel analog switch 105, is connected with described record unit；
The display unit 106 being connected is switched, for showing the logical of described electrod-array with described 3rd multichannel analog Road information.
In a particular embodiment, the 3rd multichannel analog switch contact leads to entering directly into next after output signal Road.
Display unit is made up of the LED with electrode interface port number equal number；When receiving positive feedback, same logical The LED in road is bright；When receiving negative feedback, the LED of same passage does not works.
The switched system of the multi-channel electrode array that the present invention provides includes control unit 100 and described control unit First multichannel analog switch the 101, second multichannel analog switch 109 of being connected, by electrode interface 102 and described the One multichannel analog switch be connected electrod-array 103, electrode interface 102, record unit the 104, the 3rd multichannel analog open Pass, display unit 106.
Wherein, control unit 100 switchs and the second multichannel analog switch 109 for controlling the first multichannel analog, and And be transported to record unit 104 by the channel information of electrod-array 103；First multichannel analog switch 101 connection electrode interface 102, for the switching of electrode interface 102 passage；Electrode interface 102 connects electrod-array 103, is used for and electrod-array 103 Conducting；Second multichannel analog switch 109 connection electroplanting device 107 and detection device 108, for electroplanting device 107 and detection Switching between device 108；Detection device 108 is connected with control unit 100, and feedback impedance detection signal is to control unit 100； Record unit 104 is for the storage of electrode channel information, and by multichannel analog switch C105, result is exported display Unit 106；3rd multichannel analog switch 105 is for the switching of display unit 106 passage, and display unit 106 leads to for electrode The display of road information.
Second multichannel analog switch 109 comprises two passages, is connected with electroplanting device 107 and measurement apparatus 108 respectively Connect.Control unit 100 is connected with the second multichannel analog switch 109, for the second multichannel analog switch 109 at electroplanting device 107 and measurement apparatus 108 in switching.
Detection device 108 is connected with control unit 100, is used for electrod-array 103 impedance measurements at 1 khz Feed back to control unit 100.
Impedance measurements be fed back to positive and negative or zero in one.Wherein, it is more than when electrode resistance value when not electroplating 500k Ω and less than 3000k Ω or electrode resistance value after plating less than 500k Ω time, output signal is just defined as；Work as electrode When not electroplating resistance value less than 500k Ω or more than 3000k Ω time, or electrode circulate 5 times after plating after resistance value be more than During 500k Ω, output signal is defined as bearing；Electrode is when plating cycle is less than 5 times, if resistance value is more than 500k Ω, output letter Number it is defined as zero.
Control unit 100 controls the first multichannel analog switch 101 by receiving feedback signal；When feedback signal defines For timing, export the positive and negative label unit 104 that is fed to, and control the first multichannel analog switch 101 and enter into next passage；When instead When feedback signal is defined as negative, output negative feedback is to record unit 104, and controls the first multichannel analog and switch 101 and enter into down One passage；When feedback signal is defined as zero, controls the first multichannel analog switch 101 and reenter former passage.
Control unit controls the first multichannel analog switch 101 and the second multichannel analog switch 109 simultaneously, single when controlling When unit's control the first multichannel analog switch 101 enters into new tunnel or reenters old passage, the same time control of control unit 100 Make the second multichannel analog switch 109 and reset to passage 1.Passage 1 and detection device 108 in second multichannel analog switch 109 Being connected, passage 2 is connected with electroplanting device 107.After electrode detection completes, control unit 100 receives measurement signal and controls Second multichannel analog switch 109 is switched to passage 2, and switches back into passage 1 within the time specified.
Feedback signal can manually trigger, or is triggered by detection device 108.
The knot of the embodiment four of the switched system of a kind of multi-channel electrode array that Figure 14 provides for the embodiment of the present invention Structure block diagram, as shown in Figure 14, the first described switch unit 12 includes:
Impedance threshold acquiring unit 121, is used for obtaining the first impedance threshold set in advance, the second impedance threshold, and institute The first impedance threshold stated is less than the second described impedance threshold.In a particular embodiment, the first impedance set in advance Threshold value is such as 500k Ω, and the second impedance threshold set in advance is such as 3000k Ω.
First judging unit 122, for judging that whether described resistance value is less than described the first impedance threshold or described Resistance value whether more than the second described impedance threshold.
First feedback signal output unit 123, for when the first described judging unit is judged as YES, exports negative feedback Signal.
First passage switch unit 124, for according to the first multichannel analog described in described negative-feedback signal switching Switch enters into next passage.
Channel information record unit 125, for recording the channel information of described electrod-array.
In the detailed description of the invention of the present invention, electrod-array is by electrode interface and the first multichannel analog switch phase Even, in actual mechanical process, first the first multichannel analog switch is switched to current channel, such as passage 1, simultaneously second Multichannel analog switch is switched to passage 1 (being i.e. connected with detection device) and starts impedance measurement.When electrod-array is at not electricity When during plating, resistance value is less than 500k Ω or is more than 3000k Ω, impedance measurements is fed back to bear, and i.e. exports negative-feedback signal.Control Unit processed controls the first multichannel analog switch by receiving feedback signal.When feedback signal is defined as negative, output is negative anti- Be fed to record unit, direct recording channel information and control first multichannel analog switch enter into next passage.
The knot of the embodiment five of the switched system of a kind of multi-channel electrode array that Figure 15 provides for the embodiment of the present invention Structure block diagram, as shown in Figure 15, the first described switch unit 12 also includes:
Second judging unit 126, for judging whether described resistance value is more than the first described impedance threshold and is less than The second described impedance threshold.
First galvanic signal transmitting element 127, is used for when the second described judging unit is judged as YES, described control Unit sends galvanic signal to the second described multichannel analog switch；
The second described multichannel analog switch 109 also includes: second connects unit 92, for according to described plating letter Number switch to be connected with electroplanting device；
Described electroplanting device 107 includes: the first electroplating unit 71, for electroplating described electrod-array；
First detection signal transmitting unit 72, for after plating terminates, sends out to the second described multichannel analog switch Signal is surveyed in censorship；
The first connection unit 91 in second multichannel analog switch, for switching to and institute according to described detection signal The detection device stated is connected；
Described detection device 108 also includes: the second measuring unit 83, is working as measuring the first multichannel analog switch During prepass, electroplate the resistance value terminating rear electrode array；
Second transmitting element 84, sends to described control unit for plating terminates the resistance value of rear electrode array；
Described control unit 100 also includes: the second switch unit 13, for terminating rear electrode battle array according to described plating The described first multichannel analog switch of resistance value switching of row.
In the detailed description of the invention of the present invention, electrod-array is by electrode interface and the first multichannel analog switch phase Even, in actual mechanical process, first the first multichannel analog switch is switched to current channel, such as passage 1, simultaneously second Multichannel analog switch is switched to passage 1 (being i.e. connected with detection device) and starts impedance measurement.When electrod-array is at not electricity When resistance value is more than 500k Ω and is less than 3000k Ω during plating, switch the second multichannel analog and switch passage 2 (i.e. with plating dress Put and be connected) and start plating, after plating terminates, (after such as 5 seconds) automatically jump back to passage 2 and (are i.e. connected with detection device Connect) carry out impedance measurement.
The knot of the embodiment six of the switched system of a kind of multi-channel electrode array that Figure 16 provides for the embodiment of the present invention Structure block diagram, as shown in Figure 16, the second switch unit 13 includes:
3rd judging unit 131, for judging that whether described plating terminates the resistance value of rear electrode array less than described The first impedance threshold.
Second feedback signal output unit 132, is used for when the 3rd described judging unit is judged as YES, described control Unit output positive feedback signal；
Second channel switch unit 133, for described control unit according to described in described positive feedback signal switching First multichannel analog switch enters into next passage.
That is, in the detailed description of the invention of the present invention, electrod-array is switched by electrode interface and the first multichannel analog It is connected, in actual mechanical process, first the first multichannel analog switch is switched to current channel, such as passage 1, simultaneously the Two multichannel analog switches are switched to passage 1 (being i.e. connected with detection device) and start impedance measurement.When electrod-array is not When resistance value is more than 500k Ω and is less than 3000k Ω during plating, switch the second multichannel analog and switch passage 2 (i.e. with plating Device is connected) and start plating, after plating terminates, (after such as 5 seconds) automatically jump back to passage 2 and (are i.e. connected with detection device Connect) carry out impedance measurement.When measuring resistance value less than 500k Ω, switch the first multichannel analog and switch next passage.Also When i.e. electrod-array resistance value after plating is less than 500k Ω, output signal is just defined as, and i.e. exports positive feedback signal.Control single Unit controls the first multichannel analog switch by receiving feedback signal, when feedback signal is defined as timing, exports positive and negative being fed to Record unit, and control first multichannel analog switch enter into next passage.
The knot of the embodiment seven of the switched system of a kind of multi-channel electrode array that Figure 17 provides for the embodiment of the present invention Structure block diagram, as shown in Figure 17, the second described switch unit 13 includes:
4th judging unit 134, for judging that whether described plating terminates the resistance value of rear electrode array more than described The first impedance threshold.
Plating threshold value acquiring unit 135, is used for when the 4th described judging unit is judged as YES, described control unit Obtain plating threshold value set in advance.In a particular embodiment, plating threshold value is such as 5.
Second galvanic signal transmitting element 136, for sending galvanic signal to the second described multichannel analog switch；
Described the second connection unit 92 in the second multichannel analog switch 109, for according to described galvanic signal Switch to be connected with electroplanting device.
Described electroplanting device 107 includes: the second electroplating unit 73, for described electrod-array carries out plating threshold value Secondary plating；
Second detection signal transmitting unit 74, after terminating when plating threshold value time plating, to the second described multichannel Analog switch sends detection signal；
The first connection unit 91 in second multichannel analog switch, for switching to and institute according to described detection signal The detection device stated is connected；
Described detection measurement device 108 also includes: the 3rd measuring unit 85, for measuring the first multichannel analog switch When current channel, the resistance value of plating threshold value time plating end rear electrode array；
3rd transmitting element 86, sends to described for plating threshold value time plating terminates the resistance value of rear electrode array Control unit；
Described control unit also includes: the 3rd switch unit 14, for terminating according to described plating threshold value time plating The described first multichannel analog switch of resistance value switching of rear electrode array.
That is, in the detailed description of the invention of the present invention, electrod-array is switched by electrode interface and the first multichannel analog It is connected, in actual mechanical process, first the first multichannel analog switch is switched to current channel, such as passage 1, simultaneously the Two multichannel analog switches are switched to passage 1 (being i.e. connected with detection device) and start impedance measurement.When electrod-array is not When resistance value is more than 500k Ω and is less than 3000k Ω during plating, switch the second multichannel analog and switch passage 2 (i.e. with plating Device is connected) and start plating, after plating terminates, (after such as 5 seconds) automatically jump back to passage 2 and (are i.e. connected with detection device Connect) carry out impedance measurement.When measure resistance value more than 500k Ω time, switch the second multichannel analog switch passage (i.e. with Electroplanting device is connected) again electroplate.After repeating to electroplate threshold value time plating (being such as 5 times), detection measurement device is now Resistance value.Control unit switches described first multichannel analog switch according to resistance value now.
The knot of the embodiment eight of the switched system of a kind of multi-channel electrode array that Figure 18 provides for the embodiment of the present invention Structure block diagram, as shown in Figure 18, the 3rd described switch unit 14 includes:
5th judging unit 141, for judging that described plating threshold value time plating terminates the resistance value of rear electrode array and is No more than the first described impedance threshold；
3rd feedback signal output unit 142, is used for when the 5th described judging unit is judged as YES, described control Unit output negative-feedback signal；
Third channel switch unit 143, for according to the first multichannel analog described in described negative-feedback signal switching Switch enters into next passage.
That is, in the detailed description of the invention of the present invention, electrod-array is switched by electrode interface and the first multichannel analog It is connected, in actual mechanical process, first the first multichannel analog switch is switched to current channel, such as passage 1, simultaneously the Two multichannel analog switches are switched to passage 1 (being i.e. connected with detection device) and start impedance measurement.When electrod-array is not When resistance value is more than 500k Ω and is less than 3000k Ω during plating, switch the second multichannel analog and switch passage 2 (i.e. with plating Device is connected) and start plating, after plating terminates, (after such as 5 seconds) automatically jump back to passage 2 and (are i.e. connected with detection device Connect) carry out impedance measurement.When measure resistance value more than 500k Ω time, switch the second multichannel analog switch passage (i.e. with Electroplanting device is connected) again electroplate.After repeating to electroplate threshold value time plating (being such as 5 times), detection measurement device is now Resistance value.When resistance value now is more than 500k Ω, direct recording channel information also switches the first multichannel analog and switchs Next passage.When after now electrod-array circulates 5 times after plating, resistance value is still greater than 500k Ω, output signal is defined as bearing, I.e. export negative-feedback signal.Control unit controls the first multichannel analog switch by receiving feedback signal.Work as feedback signal When being defined as negative, output negative feedback is to record unit, and controls the first multichannel analog and switch and enter into next passage.
The knot of the embodiment nine of the switched system of a kind of multi-channel electrode array that Figure 19 provides for the embodiment of the present invention Structure block diagram, as shown in Figure 19:
Described electroplanting device 107 also includes: the 3rd electroplating unit 75, for described electrod-array carries out n electricity Plating, described n is positive integer and is less than described plating threshold value；
3rd detection signal transmitting unit 76, after terminating when n plating, to the second described multichannel analog switch Send detection signal；
The first connection unit 91 in second multichannel analog switch, for switching to and institute according to described detection signal The detection device stated is connected；
Described detection device 108 also includes: the 4th measuring unit 87, is working as measuring the first multichannel analog switch During prepass, electroplate the resistance value terminating rear electrode array n time；
4th transmitting element 88, sends to described control list for n plating terminates the resistance value of rear electrode array Unit；
Described control unit also includes: the 4th switch unit 15, for terminating rear electrode battle array according to n time described plating The described first multichannel analog switch of resistance value switching of row.
That is, in the detailed description of the invention of the present invention, electrod-array is switched by electrode interface and the first multichannel analog It is connected, in actual mechanical process, first the first multichannel analog switch is switched to current channel, such as passage 1, simultaneously the Two multichannel analog switches are switched to passage 1 (being i.e. connected with detection device) and start impedance measurement.When electrod-array is not When resistance value is more than 500k Ω and is less than 3000k Ω during plating, switch the second multichannel analog and switch passage 2 (i.e. with plating Device is connected) and start plating, after plating terminates, (after such as 5 seconds) automatically jump back to passage 2 and (are i.e. connected with detection device Connect) carry out impedance measurement.When measure resistance value more than 500k Ω time, switch the second multichannel analog switch passage (i.e. with Electroplanting device is connected) again electroplate.After repeating n plating (being such as 1,2,3,4 times), detect measurement device resistance now Anti-value.
The knot of the embodiment ten of the switched system of a kind of multi-channel electrode array that Figure 20 provides for the embodiment of the present invention Structure block diagram, as shown in Figure 20, the 4th switch unit 15 includes:
6th judging unit 151, for judging that whether n time described plating terminates the resistance value of rear electrode array more than institute The first impedance threshold stated；
4th feedback signal output unit 152, is used for when the 6th described judging unit is judged as YES, described control Unit exports zero feedback signal；
Fourth lane switch unit 153, for according to the first multichannel analog described in zero described feedback signal switching Switch reenters current channel.
That is, in the detailed description of the invention of the present invention, electrod-array is switched by electrode interface and the first multichannel analog It is connected, in actual mechanical process, first the first multichannel analog switch is switched to current channel, such as passage 1, simultaneously the Two multichannel analog switches are switched to passage 1 (being i.e. connected with detection device) and start impedance measurement.When electrod-array is not When resistance value is more than 500k Ω and is less than 3000k Ω during plating, switch the second multichannel analog and switch passage 2 (i.e. with plating Device is connected) and start plating, after plating terminates, (after such as 5 seconds) automatically jump back to passage 2 and (are i.e. connected with detection device Connect) carry out impedance measurement.When measure resistance value more than 500k Ω time, switch the second multichannel analog switch passage (i.e. with Electroplanting device is connected) again electroplate.After repeating to electroplate threshold value time plating (being such as 1,2,3,4 times), detect measurement device Resistance value now.When resistance value now is more than 500k Ω, output signal is defined as zero, i.e. exports zero feedback signal.When When feedback signal is defined as zero, control unit controls the first multichannel analog switch and reenters former passage.
As it has been described above, be the switched system of a kind of multi-channel electrode array that the present invention provides, come by control unit Control the first multichannel analog switch, the second multichannel analog switch, and combine detection device and electroplanting device, it is possible to achieve Prepared by the microelectrode array under the conditions of unmanned, the preparation process of accelerator nerve electrode, it is adaptable to commercialization nerve microelectrode The production of array.In specific implementation process, can the most manually set out reorganization electrode channel, or only makes Prepare and the one in electrode measurement function with electrode.
Below in conjunction with specific embodiment, technical scheme is discussed in detail.Figure 21 for the present invention provide concrete The schematic diagram of multi-channel electrode array automatic switchover scheme in embodiment.As shown in Figure 21, in this specific embodiment, electrode array Arrange to be switched by electrode interface and the first multichannel analog and be connected, in actual mechanical process, first by the first multichannel analog Switch is switched to passage 1, and the second multichannel analog switch is also switched to passage (being i.e. connected with detection device) and starts simultaneously Impedance measurement.When electrod-array is not electroplated, resistance value is less than 500k Ω or is more than 3000k Ω, direct recording channel information is also Switch the first multichannel analog and switch next passage；When electrod-array resistance value when not electroplating more than 500k Ω and is less than During 3000k Ω, switch the second multichannel analog and switch passage 2 (being i.e. connected with electroplanting device) and start plating, after 5 seconds Automatically jump back to passage 1 (being i.e. connected with detection device) and carry out impedance measurement.When measuring resistance value less than 500k Ω, switching First multichannel analog switchs next passage；When measuring resistance value more than 500k Ω, switch the second multichannel analog switch Again electroplate to passage 2 (being i.e. connected with electroplanting device)；When resistance value rear after repeating to electroplate 5 times is more than 500k Ω, directly Recording channel information also switches the first multichannel analog and switchs next passage.
In sum, the present invention proposes changing method and the system of a kind of multi-channel electrode array, passes through control unit Control the first multichannel analog switch, the second multichannel analog switch, and combine detection device and electroplanting device, it is achieved that The multichannel microelectrode of complete dynamicization is modified and is measured and interchannel automatic switchover, it is achieved that the micro-electricity under the conditions of unmanned Prepared by pole array, accelerate the preparation process of nerve electrode, it is adaptable to the production of commercialization nerve microelectrode array, solves existing Have in technology for electrophysiologic study nerve microelectrode array preparation and detection during cut between multiple instruments and multichannel Change problem.
One of ordinary skill in the art will appreciate that all or part of flow process realizing in above-described embodiment method, Ke Yitong Crossing computer program and complete to instruct relevant hardware, described program can be stored in general computer read/write memory medium In, this program is upon execution, it may include such as the flow process of the embodiment of above-mentioned each method.Wherein, described storage medium can be magnetic Dish, CD, read-only store-memory body (Read-Only Memory, ROM) or random store-memory body (Random Access Memory, RAM) etc..
Those skilled in the art are it will also be appreciated that various functions that the embodiment of the present invention is listed are by hardware or soft Part realizes depending on specifically applying the design requirement with whole system.Those skilled in the art can be specific for every kind Application, it is possible to use the function described in the realization of various methods, but this realization is understood not to protect beyond the embodiment of the present invention The scope protected.
The present invention applies specific embodiment principle and the embodiment of the present invention are set forth, above example Explanation be only intended to help to understand method and the core concept thereof of the present invention；Simultaneously for one of ordinary skill in the art, According to the thought of the present invention, the most all will change, in sum, in this specification Hold and should not be construed as limitation of the present invention.

Claims (20)

1. a changing method for multi-channel electrode array, is characterized in that, described method includes:
Control unit sends detection signal to the second multichannel analog switch；
Described second multichannel analog switch switches to according to described detection signal and detects device and be connected；
Described detection measurement device the first multichannel analog switch resistance value of electrod-array when current channel；
Described resistance value is sent to described control unit by described detection device；
Described control unit is according to the described described first multichannel analog switch of resistance value switching.
Method the most according to claim 1, is characterized in that, described control unit is according to described resistance value switching First multichannel analog switch includes:
Described control unit obtains the first impedance threshold set in advance, the second impedance threshold, and the first described impedance threshold Value is less than the second described impedance threshold；
The described resistance value described in control unit judgement whether is less than the first described impedance threshold or described resistance value is No more than the second described impedance threshold；
When being judged as YES, described control unit output negative-feedback signal；
Described control unit enters into next according to the first multichannel analog switch described in described negative-feedback signal switching Passage；
The channel information of electrod-array described in described control unit record.
Method the most according to claim 1, is characterized in that, described control unit is according to described resistance value switching First multichannel analog switch includes:
Described control unit obtains the first impedance threshold set in advance, the second impedance threshold, and the first described impedance threshold Value is less than the second described impedance threshold；
Whether the described resistance value described in control unit judgement is more than the first described impedance threshold and less than described second Impedance threshold；
When being judged as YES, described control unit sends galvanic signal to the second described multichannel analog switch；
The second described multichannel analog switch switches to be connected with electroplanting device according to described galvanic signal；
Described electrod-array is electroplated by described electroplanting device；
After plating terminates, the second described multichannel analog switch switches to be connected with described detection device；
Described detection measurement device the first multichannel analog switchs when current channel, the impedance of plating end rear electrode array Value；
Plating is terminated the resistance value of rear electrode array and sends to described control unit by described detection device；
The resistance value that described control unit terminates rear electrode array according to described plating switches described first multichannel analog Switch.
Method the most according to claim 3, is characterized in that, described control unit terminates rear electrode according to described plating The described first multichannel analog switch of resistance value switching of array includes:
Whether the described plating described in control unit judgement terminates the resistance value of rear electrode array less than the first described impedance Threshold value；
When being judged as YES, described control unit output positive feedback signal；
Described control unit enters into next according to the first multichannel analog switch described in described positive feedback signal switching Passage.
Method the most according to claim 3, is characterized in that, described control unit terminates rear electrode according to described plating The described first multichannel analog switch of resistance value switching of array includes:
Whether the described plating described in control unit judgement terminates the resistance value of rear electrode array more than the first described impedance Threshold value；
When being judged as YES, described control unit obtains plating threshold value set in advance；
Described control unit sends galvanic signal to the second described multichannel analog switch；
The second described multichannel analog switch switches to be connected with electroplanting device according to described galvanic signal；
Described electrod-array is carried out electroplating threshold value time plating by described electroplanting device；
After plating threshold value time plating terminates, the second described multichannel analog switch switches to be connected with described detection device Connect；
Described detection measurement device the first multichannel analog switchs when current channel, plating threshold value time plating terminates rear electrode The resistance value of array；
The resistance value that plating threshold value time plating terminates rear electrode array is sent to described control unit by described detection device；
Described control unit terminates the resistance value switching described first of rear electrode array according to described plating threshold value time plating Multichannel analog switchs.
Method the most according to claim 5, is characterized in that, described control unit is according to described plating threshold value time plating The described first multichannel analog switch of resistance value switching terminating rear electrode array includes:
Whether the described plating threshold value time plating described in control unit judgement terminates the resistance value of rear electrode array more than described The first impedance threshold；
When being judged as YES, described control unit output negative-feedback signal；
Described control unit enters into next according to the first multichannel analog switch described in described negative-feedback signal switching Passage.
Method the most according to claim 3, is characterized in that, described control unit terminates rear electrode according to described plating The described first multichannel analog switch of resistance value switching of array includes:
Whether the described plating described in control unit judgement terminates the resistance value of rear electrode array more than the first described impedance Threshold value；
When being judged as YES, described control unit obtains plating threshold value set in advance；
Described control unit sends galvanic signal to the second described multichannel analog switch；
The second described multichannel analog switch switches to be connected with electroplanting device according to described galvanic signal；
Described electroplanting device carries out n plating to described electrod-array, and described n is positive integer and is less than described plating Threshold value；
After n plating terminates, the second described multichannel analog switch switches to be connected with described detection device；
Described detection measurement device the first multichannel analog switchs when current channel, n plating terminates rear electrode array Resistance value；
The resistance value that n plating terminates rear electrode array is sent to described control unit by described detection device；
The resistance value that described control unit terminates rear electrode array according to n time described plating switches described first multichannel mould Intend switch.
Method the most according to claim 7, is characterized in that, after described control unit terminates according to n time described plating The described first multichannel analog switch of resistance value switching of electrod-array includes:
Whether described n plating described in control unit judgement terminates the resistance value of rear electrode array more than the first described resistance Anti-threshold value；
When being judged as YES, described control unit exports zero feedback signal；
Described control unit reenters according to the first multichannel analog switch described in zero described feedback signal switching to be worked as Prepass.
Method the most according to claim 1 and 2, is characterized in that, described method also includes:
The channel information of described electrod-array is sent to recording unit by described control unit；
Described record unit stores the channel information of described electrod-array.
Method the most according to claim 9, is characterized in that, described method also includes:
Described record unit is single to display by the 3rd multichannel analog switch output by the channel information of described electrod-array Unit；
Described display unit shows the channel information of described electrod-array.
The switched system of 11. 1 kinds of multi-channel electrode array, is characterized in that, described system includes detecting device, electroplanting device, Described system also includes:
Control unit；
The the first multichannel analog switch, the second multichannel analog that are connected with described control unit switch；
Switch, with the first described multichannel analog, the electrod-array being connected by electrode interface；
Wherein, described control unit includes:
Detection signal transmitting unit, for sending detection signal to the second described multichannel analog switch；
Described second multichannel analog switch includes: first connects unit, for according to described detection signal switch to Described detection device is connected；
Described detection device includes:
First measuring unit, for measuring described first multichannel analog switch impedance of described electrod-array when current channel Value；
First transmitting element, for sending described resistance value to described control unit；
Described control unit also includes: the first switch unit, for switching described first multichannel according to described resistance value Analog switch.
12. systems according to claim 11, is characterized in that, the first described switch unit includes:
Impedance threshold acquiring unit, is used for obtaining the first impedance threshold set in advance, the second impedance threshold, and described first Impedance threshold is less than the second described impedance threshold；
First judging unit, for judging that whether described resistance value is less than the first described impedance threshold or described resistance value Whether more than the second described impedance threshold；
First feedback signal output unit, for when the first described judging unit is judged as YES, exports negative-feedback signal；
First passage switch unit, for entering according to the first multichannel analog switch described in described negative-feedback signal switching To next passage；
Channel information record unit, for recording the channel information of described electrod-array.
13. systems according to claim 12, is characterized in that:
The first described switch unit also includes:
Second judging unit, for judging that described resistance value is whether more than the first described impedance threshold and less than described the Two impedance threshold；
First galvanic signal transmitting element, for when the second described judging unit is judged as YES, to the second described manifold Road analog switch sends galvanic signal；
The second described multichannel analog switch also includes: second connects unit, for switching to according to described galvanic signal It is connected with electroplanting device；
Described electroplanting device includes: the first electroplating unit, for electroplating described electrod-array；
First detection signal transmitting unit, for after plating terminates, sends detection to the second described multichannel analog switch Signal；
The first connection unit in second multichannel analog switch, for switching to and described inspection according to described detection signal Survey device is connected；
Described detection device also includes: the second measuring unit, is used for measuring described first multichannel analog switch current logical During road, electroplate the resistance value terminating rear electrode array；
Second transmitting element, sends to described control unit for plating terminates the resistance value of rear electrode array；
Described control unit also includes: the second switch unit, for terminating the impedance of rear electrode array according to described plating The described first multichannel analog switch of value switching.
14. systems according to claim 13, is characterized in that, the second described switch unit includes:
3rd judging unit, for judging that whether described plating terminates the resistance value of rear electrode array less than the first described resistance Anti-threshold value；
Second feedback signal output unit, for when the 3rd described judging unit is judged as YES, exports positive feedback signal；
Second channel switch unit, for entering according to the first multichannel analog switch described in described positive feedback signal switching To next passage.
15. systems according to claim 13, is characterized in that:
The second described switch unit includes:
4th judging unit, for judging that whether described plating terminates the resistance value of rear electrode array more than the first described resistance Anti-threshold value；
Plating threshold value acquiring unit, for when the 4th described judging unit is judged as YES, obtains plating threshold set in advance Value；
Second galvanic signal transmitting element, for sending galvanic signal to the second described multichannel analog switch；
Described the second connection unit in the second multichannel analog switch, for switching to and electricity according to described galvanic signal Plating appts is connected；
Described electroplanting device includes: the second electroplating unit, for described electrod-array carries out plating threshold value time plating；
Second detection signal transmitting unit, after terminating when plating threshold value time plating, opens to the second described multichannel analog Close and send detection signal；
The first connection unit in second multichannel analog switch, for switching to and described inspection according to described detection signal Survey device is connected；
Described detection measurement device also includes: the 3rd measuring unit, is used for measuring described first multichannel analog switch and is working as During prepass, electroplate the secondary resistance value electroplating end rear electrode array of threshold value；
3rd transmitting element, sends to described control list for plating threshold value time plating terminates the resistance value of rear electrode array Unit；
Described control unit also includes: the 3rd switch unit, for terminating rear electrode according to described plating threshold value time plating The described first multichannel analog switch of resistance value switching of array.
16. systems according to claim 15, is characterized in that, the 3rd described switch unit includes:
5th judging unit, for judging that whether described plating threshold value time plating terminates the resistance value of rear electrode array more than institute The first impedance threshold stated；
3rd feedback signal output unit, for when the 5th described judging unit is judged as YES, exports negative-feedback signal；
Third channel switch unit, for entering according to the first multichannel analog switch described in described negative-feedback signal switching To next passage.
17. systems according to claim 15, is characterized in that:
Described electroplanting device also includes: the 3rd electroplating unit, for described electrod-array carries out n plating, described n For positive integer and less than described plating threshold value；
3rd detection signal transmitting unit, after terminating when n plating, sends inspection to the second described multichannel analog switch Survey signal；
The first connection unit in second multichannel analog switch, for switching to and described inspection according to described detection signal Survey device is connected；
Described detection measurement device also includes: the 4th measuring unit, for measuring the first multichannel analog switch current logical During road, electroplate the resistance value terminating rear electrode array n time；
4th transmitting element, sends to described control unit for n plating terminates the resistance value of rear electrode array；
Described control unit also includes: the 4th switch unit, for terminating the resistance of rear electrode array according to n time described plating The described first multichannel analog switch of anti-value switching.
18. systems according to claim 17, is characterized in that, the 4th described switch unit includes:
6th judging unit, for judging that described n plating terminates whether the resistance value of rear electrode array is more than described the One impedance threshold；
4th feedback signal output unit, for when the 6th described judging unit is judged as YES, exports zero feedback signal；
Fourth lane switch unit, for switching again according to the first multichannel analog described in zero described feedback signal switching Enter current channel.
19., according to the system described in claim 11 or 12, is characterized in that, described system also includes:
Record unit, for storing the channel information of the described electrod-array that described control unit sends.
20. systems according to claim 19, is characterized in that, described system also includes:
3rd multichannel analog switch, is connected with described record unit；
The display unit being connected is switched, for showing the channel information of described electrod-array with described 3rd multichannel analog.
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