CN103415291A - 利用剂量给药算法将患者的治疗方案从阿片样物质静脉内给药转换为吗啡和羟考酮口服共给药以提供止痛的方法 - Google Patents

利用剂量给药算法将患者的治疗方案从阿片样物质静脉内给药转换为吗啡和羟考酮口服共给药以提供止痛的方法 Download PDF

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Publication number
CN103415291A
CN103415291A CN2011800545718A CN201180054571A CN103415291A CN 103415291 A CN103415291 A CN 103415291A CN 2011800545718 A CN2011800545718 A CN 2011800545718A CN 201180054571 A CN201180054571 A CN 201180054571A CN 103415291 A CN103415291 A CN 103415291A
Authority
CN
China
Prior art keywords
dose
morphine
oxycodone hydrochloride
morphine sulfate
oxycodone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2011800545718A
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English (en)
Chinese (zh)
Inventor
P·T·理查森
W·C·斯特恩
L·J·门勒-高
B·D·施瓦茨
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
QRxPharma Ltd
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QRxPharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/881,728 external-priority patent/US8012990B2/en
Priority claimed from US12/881,677 external-priority patent/US7923453B1/en
Priority claimed from US13/185,016 external-priority patent/US8222267B2/en
Application filed by QRxPharma Ltd filed Critical QRxPharma Ltd
Publication of CN103415291A publication Critical patent/CN103415291A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2011800545718A 2010-09-14 2011-09-14 利用剂量给药算法将患者的治疗方案从阿片样物质静脉内给药转换为吗啡和羟考酮口服共给药以提供止痛的方法 Pending CN103415291A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US12/881,677 2010-09-14
US12/881,728 US8012990B2 (en) 2009-10-14 2010-09-14 Methods of converting a patient's treatment regimen from intravenous administration of an opioid to oral co-administration of morphine and oxycodone using a dosing algorithm to provide analgesia
US12/881,728 2010-09-14
US12/881,677 US7923453B1 (en) 2009-10-14 2010-09-14 Methods of converting a patient's treatment regimen from intravenous administration of an opioid to oral co-administration of morphine and oxycodone using a dosing algorithm to provide analgesia
US13/185,016 2011-07-18
US13/185,016 US8222267B2 (en) 2009-10-14 2011-07-18 Methods of converting a patient's treatment regimen from intravenous administration of an opioid to oral co-administration of morphine and oxycodone using a dosing algorithm to provide analgesia
PCT/US2011/051577 WO2012037239A1 (en) 2010-09-14 2011-09-14 Methods of converting a patient's treatment regimen from intravenous administration of an opioid to oral co-administration of morphine and oxycodone using a dosing algorithm to provide analgesia

Publications (1)

Publication Number Publication Date
CN103415291A true CN103415291A (zh) 2013-11-27

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN2011800545718A Pending CN103415291A (zh) 2010-09-14 2011-09-14 利用剂量给药算法将患者的治疗方案从阿片样物质静脉内给药转换为吗啡和羟考酮口服共给药以提供止痛的方法

Country Status (7)

Country Link
EP (1) EP2616075A1 (https=)
JP (1) JP2013537232A (https=)
CN (1) CN103415291A (https=)
AU (1) AU2011302137A1 (https=)
CA (1) CA2811285A1 (https=)
WO (1) WO2012037239A1 (https=)
ZA (1) ZA201302585B (https=)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090291975A1 (en) * 2008-05-20 2009-11-26 Warren Stern Dual opioid pain therapy
US20110086874A1 (en) * 2009-10-14 2011-04-14 Richards Patricia T Methods of Converting a Patient's Treatment Regimen from Intravenous Administration of an Opioid to Oral Co-Administration of Morphine and Oxycodone Using a Dosing Algorithm to Provide Analgesia
US20110086873A1 (en) * 2009-10-14 2011-04-14 Richards Patricia T Methods of Converting a Patient's Treatment Regimen from Intravenous Administration of an Opioid to Oral Co-Administration of Morphine and Oxycodone Using a Dosing Algorithm to Provide Analgesia

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPN603895A0 (en) 1995-10-19 1995-11-09 University Of Queensland, The Production of analgesic synergy by co-administration of sub-analgesic doses of two strong opioids
US20050053659A1 (en) 2003-09-10 2005-03-10 Pace Gary W. Methods and compositions for reducing the risk associated with the administration of opioid analgesics in patients with diagnosed or undiagnosed respiratory illness
US20170123700A1 (en) 2015-11-03 2017-05-04 Samsung Electronics Co., Ltd. Io redirection methods with cost estimation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090291975A1 (en) * 2008-05-20 2009-11-26 Warren Stern Dual opioid pain therapy
US20110086874A1 (en) * 2009-10-14 2011-04-14 Richards Patricia T Methods of Converting a Patient's Treatment Regimen from Intravenous Administration of an Opioid to Oral Co-Administration of Morphine and Oxycodone Using a Dosing Algorithm to Provide Analgesia
US20110086873A1 (en) * 2009-10-14 2011-04-14 Richards Patricia T Methods of Converting a Patient's Treatment Regimen from Intravenous Administration of an Opioid to Oral Co-Administration of Morphine and Oxycodone Using a Dosing Algorithm to Provide Analgesia

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J.W.HOLADAY ET AL: "Dual-Opioids TM(morphine+oxycodon）provide analgesia with reduced side effect s in acute surgical pain", 《PERIOPERATIVE MEDIZIN》 *

Also Published As

Publication number Publication date
AU2011302137A1 (en) 2013-05-02
EP2616075A1 (en) 2013-07-24
ZA201302585B (en) 2014-05-28
JP2013537232A (ja) 2013-09-30
WO2012037239A1 (en) 2012-03-22
CA2811285A1 (en) 2012-03-22

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Application publication date: 20131127