CN103394130A - Die material containing estrol and Szechwan lovage rhizome - Google Patents
Die material containing estrol and Szechwan lovage rhizome Download PDFInfo
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- CN103394130A CN103394130A CN2013103505164A CN201310350516A CN103394130A CN 103394130 A CN103394130 A CN 103394130A CN 2013103505164 A CN2013103505164 A CN 2013103505164A CN 201310350516 A CN201310350516 A CN 201310350516A CN 103394130 A CN103394130 A CN 103394130A
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- vagina
- estrol
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- lovage rhizome
- rhizoma chuanxiong
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Abstract
The invention relates to a die material containing estrol and Szechewan lovage rhizome. The die material containing estrol and Szechewan lovage rhizome is composed of methacrylic acid-formic ester resin, estrol and Szechewan lovage rhizome at a weight ratio of 20:(5-8):(1-4). The die material containing estrol and Szechewan lovage rhizome has the advantages that a vagina die containing estrogen and a traditional Chinese medicine can be used for greatly reducing the contracture rate of an artificial vagina; a methacrylic acid-formic ester resin material is combined with estrogen and the traditional Chinese medicine, and a vagina die with estrogen slow release capability is prepared, so that treatment of the vagina die and combined treatment of traditional Chinese medicine and western medicine are effectively unified; therefore, the vagina die with a slow release function has great potential in clinical application.
Description
Technical field
The present invention relates to a kind of material of mould, specifically, is the mold materials that contains female phenol and Rhizoma Chuanxiong about a kind of.
Background technology
The congenital absence of vagina patient is mostly Rokitansky-Kuster-Hauser syndrome (RKH syndrome), is the undergrown result of embryo's bilateral in period gyneduct, and karyotype is 46XX.Congenital absence of vagina patient's treatment has operative treatment and non-operative treatment.Operative treatment comprises vulvovaginoplasty (Williams method), make dibbling pico farad (McIndol method), peritoneum is for vagina method (Rothman method), Sigmoid Colon vagina method (Pratl method), amniotic membrane is rebuild vagina etc. for vagina method and novel biomaterial, and the application of vaginal stent is the very important ring of vaginoplasty post processing.Postoperatively need to place vaginal stent March to half a year, prevent the contracture of artificial vagina.For vaginal vestibule section mucosa good springiness, the table shallow depression person of existence is arranged, can adopt Frank method vagina top to press non-operative treatment.Frank proposed pole compression method non-operative treatment congenital absence of vagina in 1938, adopt the vaginal vestibule section of the pole aligning locking of different-diameter, along normal vagina direction of principal axis top, pressed, and with dilating urethra rectum gap, finally formed artificial tract.
Chinese patent application CN101352360A discloses a kind of soft bearing band with side opening reconstruction vaginal mold, comprises a body, and this body is provided with several apertures, and an end of body is the Duckbill type cecum, and another end is opening.Chinese patent application CN202078425U discloses the modified form vaginal stent, comprises cylindrical main part, and the front end of described main part is one-body molded has a taper section, the rear end of described main part to offer axial and finger-hole finger size coupling.
But, about can either greatly reducing the contracture rate of artificial vagina, can discharge again estrogenic vaginal stent and yet there are no report.
Summary of the invention
The objective of the invention is for deficiency of the prior art, a kind of mold materials that contains female phenol and Rhizoma Chuanxiong is provided.
One purpose more of the present invention is that a kind of purposes of material is provided.
For achieving the above object, the technical scheme that the present invention takes is: a kind of mold materials that contains female phenol and Rhizoma Chuanxiong, methymethacrylate resin, female phenol and Rhizoma Chuanxiong, consist of, described methymethacrylate resin, female phenol, Rhizoma Chuanxiong weight ratio are 20:(5-8): (1-4).
Described methymethacrylate resin, female phenol, Rhizoma Chuanxiong weight ratio are 20:5:1.
For realizing above-mentioned second purpose, the technical scheme that the present invention takes is: material is as the application of vaginal stent.
The invention has the advantages that: the vaginal stent that contains estrogen, Chinese medicine reduces the contracture rate of artificial vagina greatly.The present invention is by combining the methymethacrylate resin material with estrogen and Chinese medicine, the vaginal stent that preparation has the estrogen slow-release capability, thus the combine treatment of these two aspects for the treatment of of the treatment of vaginal stent and Chinese and western medicine is united effectively.Therefore, this vaginal stent with slow-release function has very large potentiality in clinical practice afterwards.
The accompanying drawing explanation
Accompanying drawing 1 is the vaginal stent structural representation that contains medicine.
Accompanying drawing 2 is the vaginal stent structural representations that do not contain medicine.
The specific embodiment
Below in conjunction with accompanying drawing, the specific embodiment provided by the invention is elaborated.
Embodiment 1
One, medicine and preparation:
1, estrogen: female phenol crude drug; Chinese medicine: Rhizoma Chuanxiong.
2, methymethacrylate resin sizing material.
Two, equipment
Pressure forming machine (product type: XLB-D400-400), rubber mixing machine (model: JTC-752A), electronic platform scale (model: TSC-6) electric drying oven with forced convection (model: 101A-1B), drying baker (model: the 101-3 type), three-roll grinder (model: the SG-150 type), Weighing display device (model: XK3130).
Three, the material preparation
Take methymethacrylate resin sizing material 100g, take female phenol 25g, Rhizoma Chuanxiong 5 g.
Three kinds of raw materials are put into to the rubber mixing machine blend, make sizing material and medicine mixing even, draw thin-pass 10 times, medicine more is evenly dispersed in sizing material.
Four, the vaginal stent preparation:
Take the 10g material, put into the mould mold pressing; 140 ℃ of temperature, time 12min, pressure 9.5MPa depanning; Take out product, deburring; Encapsulation, standby after the ethylene oxide gas sterilization.The finished product that makes is dispersed in equally distributed tiny female phenol, Rhizoma Chuanxiong drug particles (seeing Fig. 1) as seen.
Embodiment 2
One, medicine and preparation: with embodiment 1.
Two, equipment: with embodiment 1.
Three, material preparation: take methymethacrylate resin sizing material 100g, take female phenol 30g, Rhizoma Chuanxiong 10 g the other the same as in Example 1.
Four, vaginal stent preparation: with embodiment 1.
Embodiment 3
One, medicine and preparation: with embodiment 1.
Two, equipment: with embodiment 1.
Three, material preparation: take methymethacrylate resin sizing material 100g, take female phenol 50g, Rhizoma Chuanxiong 8 g the other the same as in Example 1.
Four, vaginal stent preparation: with embodiment 1.
Embodiment 4
One, medicine and preparation: with embodiment 1.
Two, equipment: with embodiment 1.
Three, material preparation: take methymethacrylate resin sizing material 100g, take female phenol 40g, Rhizoma Chuanxiong 20g the other the same as in Example 1.
Four, vaginal stent preparation: with embodiment 1.
Embodiment 5
One, preparation:
1, methymethacrylate resin sizing material.
Two, equipment
Pressure forming machine (product type: XLB-D400-400), rubber mixing machine (model: JTC-752A), electronic platform scale (model: TSC-6) electric drying oven with forced convection (model: 101A-1B), drying baker (model: the 101-3 type), three-roll grinder (model: the SG-150 type), Weighing display device (model: XK3130).
Three, material is prepared
Take methymethacrylate resin sizing material 100g.
Four, the vaginal stent preparation:
Take the 10g material, put into the mould mold pressing; 140 ℃ of temperature, time 12min, pressure 9.5MPa depanning; Take out product, deburring; Encapsulation, standby after the ethylene oxide gas sterilization.The finished product that makes is shown in Fig. 2.
Embodiment 6
Laboratory animal is set up model
Laboratory animal absence of vagina model preparation method, rebuild experiment and the clinical research thesis for the doctorate of vagina and set up model according to the obstetrics and gynecology Zhou Huimei of the China Concord Medical Science University organizational project medical bio sticking patch of 2008
One, laboratory animal adopts 12 of Chinese Small-sized pigs, male and female, and the 4-6 monthly age, sexual maturity, unpregnancy does not produce, the about 25kg of body weight.
Two, Animal Anesthesia and preparation
Three, the full vagina resection of Chinese Small-sized pig causes the absence of vagina model.
Embodiment 7
By embodiment
6The laboratory animal that is successfully established is after 1 week of rest, more capable vagina anaplasty.12 Chinese miniature pig groupings after the vagina anaplasty are grouped as follows:
Group 1: 4 Chinese miniature pigs after the vagina anaplasty (group 1-1 pig, group 1-2 pig, group 1-3 pig, group 1-4 pig).
Group 2: after the vagina anaplasty, the vaginal stent that embodiment 5 is obtained is positioned over (group 2-1 pig, group 2-2 pig, group 2-3 pig, pig group 2-4 pig) in cave, artificial vagina chamber.
Group 3: after the vagina anaplasty, the vaginal stent that embodiment 1 is obtained is positioned over (group 3-1 pig, group 3-2 pig, group 3-3 pig, group 3-4 pig) in cave, artificial vagina chamber.
Vagina ultrastructure by pig after the above-mentioned vagina anaplasty of electron microscopic observation, the results are shown in Table 1
Table 1: vagina anaplasty each pig vagina contracture situation (each pig vagina contracture area accounts for the percentage ratio of artificial vagina area) after two weeks
| ? | No. 1 pig | No. 2 pigs | No. 3 pigs | No. 4 pigs |
| Group 1 | 50% | 55% | 52% | 50% |
| Group 2 | 12% | 10% | 11% | 13% |
| Group 3 | 3% | 5% | 2% | 1% |
After vaginoplasty, do not place vaginal stent, the contracture rate of artificial vagina is very high; After vaginoplasty, place vaginal stent, can reduce the contracture rate of artificial vagina; The vaginal stent that contains estrogen, Chinese medicine reduces the contracture rate of artificial vagina greatly.
The present invention is by combining the methymethacrylate resin material with estrogen and Chinese medicine, the vaginal stent that preparation has the estrogen slow-release capability, thus the combine treatment of these two aspects for the treatment of of the treatment of vaginal stent and Chinese and western medicine is united effectively.Therefore, this vaginal stent with slow-release function has very large potentiality in clinical practice afterwards.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the inventive method; can also make some improvement and supplement, these improvement and supplement and also should be considered as protection scope of the present invention.
Claims (4)
1. one kind contains the application of the mold materials of female phenol and Rhizoma Chuanxiong as vaginal stent, described material is comprised of methymethacrylate resin, female phenol and Rhizoma Chuanxiong, and described methymethacrylate resin, female phenol, Rhizoma Chuanxiong weight ratio are 20:(5-8): (1-4).
2. application according to claim 1, described methymethacrylate resin, female phenol, Rhizoma Chuanxiong weight ratio are 20:5:1.
3. mold materials that contains female phenol and Rhizoma Chuanxiong, described material is comprised of methymethacrylate resin, female phenol and Rhizoma Chuanxiong, it is characterized in that, described methymethacrylate resin, female phenol, Rhizoma Chuanxiong weight ratio are 20:(5-8): (1-4).
4. material according to claim 3, is characterized in that, described methymethacrylate resin, female phenol, Rhizoma Chuanxiong weight ratio are 20:5:1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013103505164A CN103394130A (en) | 2013-08-13 | 2013-08-13 | Die material containing estrol and Szechwan lovage rhizome |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013103505164A CN103394130A (en) | 2013-08-13 | 2013-08-13 | Die material containing estrol and Szechwan lovage rhizome |
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| CN103394130A true CN103394130A (en) | 2013-11-20 |
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| CN2013103505164A Pending CN103394130A (en) | 2013-08-13 | 2013-08-13 | Die material containing estrol and Szechwan lovage rhizome |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101007188A (en) * | 2007-01-26 | 2007-08-01 | 李荣秀 | Drug-releasing vagina obstruction composition and preparation thereof |
| CN101152102A (en) * | 2007-09-13 | 2008-04-02 | 李风 | Cunt shaping expanding device |
| CN101351188A (en) * | 2005-08-12 | 2009-01-21 | 药物技术公司 | Estrogen compositions and therapeutic methods of use thereof |
| CN101352360A (en) * | 2008-09-05 | 2009-01-28 | 中国医学科学院整形外科医院 | Soft bearing band with side opening reconstruction vaginal mold |
| CN101361937A (en) * | 2008-07-31 | 2009-02-11 | 西安三八妇乐健康产业有限公司 | Medicinal pad with antibiosis, itching-relieving, wind-dispelling and dampness-eliminating function |
| US20090318401A1 (en) * | 2007-06-25 | 2009-12-24 | Italfarmaco, S.A. | Use of estriol in low doses |
| CN103394127A (en) * | 2013-08-02 | 2013-11-20 | 苏州市马尔泰新材料有限公司 | Vaginal mould material containing traditional Chinese medicine and western medicine |
-
2013
- 2013-08-13 CN CN2013103505164A patent/CN103394130A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101351188A (en) * | 2005-08-12 | 2009-01-21 | 药物技术公司 | Estrogen compositions and therapeutic methods of use thereof |
| CN101007188A (en) * | 2007-01-26 | 2007-08-01 | 李荣秀 | Drug-releasing vagina obstruction composition and preparation thereof |
| US20090318401A1 (en) * | 2007-06-25 | 2009-12-24 | Italfarmaco, S.A. | Use of estriol in low doses |
| CN101152102A (en) * | 2007-09-13 | 2008-04-02 | 李风 | Cunt shaping expanding device |
| CN101361937A (en) * | 2008-07-31 | 2009-02-11 | 西安三八妇乐健康产业有限公司 | Medicinal pad with antibiosis, itching-relieving, wind-dispelling and dampness-eliminating function |
| CN101352360A (en) * | 2008-09-05 | 2009-01-28 | 中国医学科学院整形外科医院 | Soft bearing band with side opening reconstruction vaginal mold |
| CN103394127A (en) * | 2013-08-02 | 2013-11-20 | 苏州市马尔泰新材料有限公司 | Vaginal mould material containing traditional Chinese medicine and western medicine |
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Application publication date: 20131120 |