CN103357074A - Sustained-release mold preparation material - Google Patents
Sustained-release mold preparation material Download PDFInfo
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- CN103357074A CN103357074A CN2013103332165A CN201310333216A CN103357074A CN 103357074 A CN103357074 A CN 103357074A CN 2013103332165 A CN2013103332165 A CN 2013103332165A CN 201310333216 A CN201310333216 A CN 201310333216A CN 103357074 A CN103357074 A CN 103357074A
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- vagina
- silicone rubber
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- mold
- release
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Abstract
The invention relates to a sustained-release mold preparation material. The sustained-release mold preparation material comprises silicone rubber, diethylstilbestrol and ligusticum wallichii, wherein a weight ratio of silicone rubber, diethylstilbestrol to ligusticum wallichii is 20: (5-8): (1-4). A mold prepared from the sustained-release mold preparation material contains estrogen and the traditional Chinese medicines and greatly reduces an artificial vagina contracture rate. Through combination of silicone rubber, estrogen and the traditional Chinese medicines, a vagina mold having an estrogen sustained-release capability is obtained so that vagina mold treatment and combined treatment of Chinese traditional and Western medicine are effectively combined. The vagina mold having a sustained-release capability has a large potential in clinical application.
Description
Technical field
The present invention relates to a kind of material for preparing mould, specifically, is the material for preparing mould about a kind of spacetabs type.
Background technology
The congenital absence of vagina patient mostly is greatly Rokitansky-Kuster-Hauser syndrome (RKH syndrome), is the undergrown result of embryo's bilateral in period gyneduct, and karyotype is 46XX.Congenital absence of vagina patient's treatment has operative treatment and non-operative treatment.Operative treatment comprises vulvovaginoplasty (Williams method), make dibbling pico farad (McIndol method), peritoneum is for vagina method (Rothman method), Sigmoid Colon vagina method (Pratl method), amniotic membrane is rebuild vagina etc. for vagina method and novel biomaterial, and the application of vaginal stent is the very important ring of vaginoplasty post processing.Postoperative need be placed vaginal stent March to half a year, prevents the contracture of artificial vagina.For vaginal vestibule section mucosa good springiness, the table shallow depression person of existence is arranged, can adopt Frank method vagina top to press non-operative treatment.Frank proposed pole compression method non-operative treatment congenital absence of vagina in 1938, adopt the vaginal vestibule section of the pole aligning locking of different-diameter, pressed along normal vagina direction of principal axis top, with dilating urethra rectum gap, finally formed artificial tract.
Chinese patent application CN101352360A discloses a kind of soft bearing band with side opening reconstruction vaginal mold, comprises a body, and this body is provided with several apertures, and an end of body is the Duckbill type cecum, and another end is opening.Chinese patent application CN202078425U discloses the modified form vaginal stent, comprises cylindrical main part, and the front end of described main part is one-body molded to have a taper section, the rear end of described main part to offer axial and finger-hole finger size coupling.
But about can either greatly reducing the contracture rate of artificial vagina, can discharge again estrogenic vaginal stent and yet there are no report.
Summary of the invention
The objective of the invention is for deficiency of the prior art, a kind of material for preparing mould is provided.
Again one purpose of the present invention is that a kind of purposes of material is provided.
For achieving the above object, the technical scheme that the present invention takes is: a kind of material for preparing mould, formed by silicone rubber, female phenol and Rhizoma Chuanxiong, described silicone rubber, female phenol, Rhizoma Chuanxiong weight ratio are 20:(5-8): (1-4).
Described silicone rubber, female phenol, Rhizoma Chuanxiong weight ratio are 20:5:1.
For realizing above-mentioned second purpose, the technical scheme that the present invention takes is: material is as the application of vaginal stent.
The invention has the advantages that: the vaginal stent that contains estrogen, Chinese medicine reduces the contracture rate of artificial vagina greatly.The present invention is by combining silastic material with estrogen and Chinese medicine, the vaginal stent that preparation has the estrogen slow-release capability, thus the combine treatment of these two aspects for the treatment of of the treatment of vaginal stent and Chinese and western medicine is united effectively.Therefore, this vaginal stent with slow-release function has very large potentiality in the clinical practice afterwards.
Description of drawings
Accompanying drawing 1 is the vaginal stent structural representation that contains medicine.
Accompanying drawing 2 is the vaginal stent structural representations that do not contain medicine.
The specific embodiment
Below in conjunction with accompanying drawing the specific embodiment provided by the invention is elaborated.
Embodiment 1
One, medicine and preparation:
1, estrogen: female phenol crude drug; Chinese medicine: Rhizoma Chuanxiong.
2, silicone rubber compounds: be purchased from Shanghai Rubber Products Insitute.The silicone rubber that the present invention selects is two-component room-temperature-vulcanized silicone rubber, before not vulcanizing, divide two components of A, B to exist, wherein contain catalyst in the A component, contain cross-linking agent in the B component, both do not react mutually at ordinary times, mix because of catalyst and cross-linking agent after mutual blend, can carry out polyreaction.
Two, equipment
Pressure forming machine (product type: XLB-D400-400), rubber mixing machine (model: JTC-752A), electronic platform scale (model: TSC-6) electric drying oven with forced convection (model: 101A-1B), drying baker (model: the 101-3 type), three-roll grinder (model: the SG-150 type), Weighing display device (model: XK3130).
Three, the material preparation
Take by weighing silicone rubber compounds 100g, take by weighing female phenol 25g, Rhizoma Chuanxiong 5 g.
Three kinds of raw materials are put into the rubber mixing machine blend, make sizing material and medicine mixing even, draw thin-pass 10 times, medicine more is evenly dispersed in the sizing material.
Four, the vaginal stent preparation:
Take by weighing the 10g material, put into the mould mold pressing; 140 ℃ of temperature, time 12min, pressure 9.5MPa depanning; Take out product, deburring; Encapsulation, for subsequent use after the ethylene oxide gas sterilization.As seen the finished product that makes is dispersed in equally distributed tiny female phenol, Rhizoma Chuanxiong drug particles (seeing Fig. 1).
Embodiment 2
One, medicine and preparation: with embodiment 1.
Two, equipment: with embodiment 1.
Three, material preparation: take by weighing silicone rubber compounds 100g, take by weighing female phenol 30g, Rhizoma Chuanxiong 10 g the other the same as in Example 1.
Four, vaginal stent preparation: with embodiment 1.
Embodiment 3
One, medicine and preparation: with embodiment 1.
Two, equipment: with embodiment 1.
Three, material preparation: take by weighing silicone rubber compounds 100g, take by weighing female phenol 50g, Rhizoma Chuanxiong 8 g the other the same as in Example 1.
Four, vaginal stent preparation: with embodiment 1.
Embodiment 4
One, medicine and preparation: with embodiment 1.
Two, equipment: with embodiment 1.
Three, material preparation: take by weighing silicone rubber compounds 100g, take by weighing female phenol 40g, Rhizoma Chuanxiong 20g the other the same as in Example 1.
Four, vaginal stent preparation: with embodiment 1.
Embodiment 5
One, preparation:
1, silicone rubber compounds: be purchased from Shanghai Rubber Products Insitute.The silicone rubber that the present invention selects is two-component room-temperature-vulcanized silicone rubber, before not vulcanizing, divide two components of A, B to exist, wherein contain catalyst in the A component, contain cross-linking agent in the B component, both do not react mutually at ordinary times, mix because of catalyst and cross-linking agent after mutual blend, can carry out polyreaction.
Two, equipment
Pressure forming machine (product type: XLB-D400-400), rubber mixing machine (model: JTC-752A), electronic platform scale (model: TSC-6) electric drying oven with forced convection (model: 101A-1B), drying baker (model: the 101-3 type), three-roll grinder (model: the SG-150 type), Weighing display device (model: XK3130).
Three, material is prepared
Take by weighing silicone rubber compounds 100g.
Four, the vaginal stent preparation:
Take by weighing the 10g material, put into the mould mold pressing; 140 ℃ of temperature, time 12min, pressure 9.5MPa depanning; Take out product, deburring; Encapsulation, for subsequent use after the ethylene oxide gas sterilization.The finished product that makes is seen Fig. 2.
Embodiment 6
Laboratory animal is set up model
Laboratory animal absence of vagina model preparation method is rebuild experiment and the clinical research thesis for the doctorate of vagina and is set up model according to the obstetrics and gynecology Zhou Huimei of China Concord Medical Science University organizational project medical bio sticking patch in 2008
One, laboratory animal adopts 12 of Chinese Small-sized pigs, male and female, and the 4-6 monthly age, sexual maturity, unpregnancy does not produce, the about 25kg of body weight.
Two, Animal Anesthesia and preparation
Three, the full vagina resection of Chinese Small-sized pig causes the absence of vagina model.
Embodiment 7
With embodiment
6The laboratory animal that is successfully established was had a rest after 1 week, went the vagina anaplasty again.12 Chinese miniature pig groupings after the vagina anaplasty are grouped as follows:
Group 1: 4 Chinese miniature pigs after the vagina anaplasty (group 1-1 pig, group 1-2 pig, group 1-3 pig, group 1-4 pig).
Group 2: after the vagina anaplasty, the vaginal stent that embodiment 5 is obtained is positioned over (group 2-1 pig, group 2-2 pig, group 2-3 pig, pig group 2-4 pig) in the cave, artificial vagina chamber.
Group 3: after the vagina anaplasty, the vaginal stent that embodiment 1 is obtained is positioned over (group 3-1 pig, group 3-2 pig, group 3-3 pig, group 3-4 pig) in the cave, artificial vagina chamber.
Vagina ultrastructure by pig after the above-mentioned vagina anaplasty of electron microscopic observation the results are shown in Table 1
Table 1: vagina anaplasty each pig vagina contracture situation (each pig vagina contracture area accounts for the percentage ratio of artificial vagina area) after two weeks
| ? | No. 1 pig | No. 2 pigs | No. 3 pigs | No. 4 pigs |
| Group 1 | 50% | 55% | 52% | 50% |
| Group 2 | 12% | 10% | 11% | 13% |
| Group 3 | 3% | 5% | 2% | 1% |
Do not place vaginal stent after the vaginoplasty, the contracture rate of artificial vagina is very high; Place vaginal stent after the vaginoplasty, can reduce the contracture rate of artificial vagina; The vaginal stent that contains estrogen, Chinese medicine reduces the contracture rate of artificial vagina greatly.
The present invention is by combining silastic material with estrogen and Chinese medicine, the vaginal stent that preparation has the estrogen slow-release capability, thus the combine treatment of these two aspects for the treatment of of the treatment of vaginal stent and Chinese and western medicine is united effectively.Therefore, this vaginal stent with slow-release function has very large potentiality in the clinical practice afterwards.
The above only is preferred implementation of the present invention; should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the inventive method; can also make some improvement and replenish, these improvement and replenish and also should be considered as protection scope of the present invention.
Claims (4)
1. a spacetabs type prepares the material of mould as the application of vaginal stent, and described material is comprised of silicone rubber, female phenol and Rhizoma Chuanxiong, and described silicone rubber, female phenol, Rhizoma Chuanxiong weight ratio are 20:(5-8): (1-4).
2. application according to claim 1, described silicone rubber, female phenol, Rhizoma Chuanxiong weight ratio are 20:5:1.
3. a spacetabs type prepares the material of mould, and described material is comprised of silicone rubber, female phenol and Rhizoma Chuanxiong, it is characterized in that, described silicone rubber, female phenol, Rhizoma Chuanxiong weight ratio are 20:(5-8): (1-4).
4. material according to claim 3 is characterized in that, described silicone rubber, female phenol, Rhizoma Chuanxiong weight ratio are 20:5:1.
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| CN2013103332165A CN103357074A (en) | 2013-08-02 | 2013-08-02 | Sustained-release mold preparation material |
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| CN2013103332165A CN103357074A (en) | 2013-08-02 | 2013-08-02 | Sustained-release mold preparation material |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070264309A1 (en) * | 2006-01-20 | 2007-11-15 | Chollet Janet A | Method Of Treating Atrophic Vaginitis |
| CN101351188A (en) * | 2005-08-12 | 2009-01-21 | 药物技术公司 | Estrogen compositions and therapeutic methods of use thereof |
| CN101352360A (en) * | 2008-09-05 | 2009-01-28 | 中国医学科学院整形外科医院 | Soft bearing band with side opening reconstruction vaginal mold |
| CN101361937A (en) * | 2008-07-31 | 2009-02-11 | 西安三八妇乐健康产业有限公司 | Medicinal pad with antibiosis, itching-relieving, wind-dispelling and dampness-eliminating function |
| CN101417046A (en) * | 2008-12-09 | 2009-04-29 | 曹莹莹 | Traditional Chinese medicine suppository special for gynecology colpitis and preparation method thereof |
| US20090318401A1 (en) * | 2007-06-25 | 2009-12-24 | Italfarmaco, S.A. | Use of estriol in low doses |
| CN202078425U (en) * | 2011-03-28 | 2011-12-21 | 广州仁爱天河医院有限公司 | Improved vaginal stent |
-
2013
- 2013-08-02 CN CN2013103332165A patent/CN103357074A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101351188A (en) * | 2005-08-12 | 2009-01-21 | 药物技术公司 | Estrogen compositions and therapeutic methods of use thereof |
| US20070264309A1 (en) * | 2006-01-20 | 2007-11-15 | Chollet Janet A | Method Of Treating Atrophic Vaginitis |
| US20090318401A1 (en) * | 2007-06-25 | 2009-12-24 | Italfarmaco, S.A. | Use of estriol in low doses |
| CN101361937A (en) * | 2008-07-31 | 2009-02-11 | 西安三八妇乐健康产业有限公司 | Medicinal pad with antibiosis, itching-relieving, wind-dispelling and dampness-eliminating function |
| CN101352360A (en) * | 2008-09-05 | 2009-01-28 | 中国医学科学院整形外科医院 | Soft bearing band with side opening reconstruction vaginal mold |
| CN101417046A (en) * | 2008-12-09 | 2009-04-29 | 曹莹莹 | Traditional Chinese medicine suppository special for gynecology colpitis and preparation method thereof |
| CN202078425U (en) * | 2011-03-28 | 2011-12-21 | 广州仁爱天河医院有限公司 | Improved vaginal stent |
Non-Patent Citations (2)
| Title |
|---|
| 董建雄等: "复方己烯雌酚散剂治疗萎缩性阴道炎212例", 《医药导报》, vol. 21, 31 May 2002 (2002-05-31), pages 27 * |
| 陈新谦、金有豫: "《新编药物学》", 31 March 1983, article "硅橡胶缓释避孕环", pages: 127 * |
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Application publication date: 20131023 |