CN103357506B - 流道装置、颗粒分选装置和颗粒分选方法 - Google Patents

流道装置、颗粒分选装置和颗粒分选方法 Download PDF

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Publication number
CN103357506B
CN103357506B CN201310102904.0A CN201310102904A CN103357506B CN 103357506 B CN103357506 B CN 103357506B CN 201310102904 A CN201310102904 A CN 201310102904A CN 103357506 B CN103357506 B CN 103357506B
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China
Prior art keywords
electrode
flow channel
sorting
branch
particles
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Expired - Fee Related
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CN201310102904.0A
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English (en)
Chinese (zh)
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CN103357506A (zh
Inventor
胜本洋
胜本洋一
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Sony Corp
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Sony Corp
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C7/00—Separating solids from solids by electrostatic effect
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C5/00—Separating dispersed particles from liquids by electrostatic effect
    • B03C5/02—Separators
    • B03C5/022—Non-uniform field separators
    • B03C5/026—Non-uniform field separators using open-gradient differential dielectric separation, i.e. using electrodes of special shapes for non-uniform field creation, e.g. Fluid Integrated Circuit [FIC]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C5/00—Separating dispersed particles from liquids by electrostatic effect
    • B03C5/005—Dielectrophoresis, i.e. dielectric particles migrating towards the region of highest field strength
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/1023—Microstructural devices for non-optical measurement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
    • G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/26—Details of magnetic or electrostatic separation for use in medical or biological applications

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Clinical Laboratory Science (AREA)
  • Fluid Mechanics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Electrochemistry (AREA)
  • Molecular Biology (AREA)
  • Electrostatic Separation (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN201310102904.0A 2012-04-03 2013-03-27 流道装置、颗粒分选装置和颗粒分选方法 Expired - Fee Related CN103357506B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2012-084511 2012-04-03
JP2012084511 2012-04-03
JP2013-010546 2013-01-23
JP2013010546A JP5924276B2 (ja) 2012-04-03 2013-01-23 流路デバイス、粒子分取装置及び粒子分取方法

Publications (2)

Publication Number Publication Date
CN103357506A CN103357506A (zh) 2013-10-23
CN103357506B true CN103357506B (zh) 2017-06-30

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CN201310102904.0A Expired - Fee Related CN103357506B (zh) 2012-04-03 2013-03-27 流道装置、颗粒分选装置和颗粒分选方法

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Country Link
US (1) US20130256197A1 (enExample)
JP (1) JP5924276B2 (enExample)
CN (1) CN103357506B (enExample)

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WO2012129591A1 (en) * 2011-03-30 2012-10-04 Empire Technology Development Llc Material sorting system and method of sorting material
WO2013145905A1 (ja) 2012-03-30 2013-10-03 ソニー株式会社 微小粒子分取装置及び該装置における流体ストリーム最適化方法
JP5924077B2 (ja) 2012-03-30 2016-05-25 ソニー株式会社 微小粒子分取装置及び微小粒子分取装置における軌道方向判定方法
US9192944B2 (en) * 2012-09-30 2015-11-24 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University Methods, systems and apparatus for size-based particle separation
JP6065527B2 (ja) * 2012-11-08 2017-01-25 ソニー株式会社 微小粒子分取装置及び微小粒子分取方法
DE102013200927A1 (de) * 2013-01-22 2014-07-24 Siemens Aktiengesellschaft Verfahren zum Anreichern und Vereinzeln von Zellen mit Konzentrationen über mehrere logarithmische Stufen
WO2014115409A1 (ja) 2013-01-28 2014-07-31 ソニー株式会社 微小粒子分取装置、微小粒子分取方法及びプログラム
WO2015056516A1 (ja) 2013-10-16 2015-04-23 ソニー株式会社 粒子分取装置、粒子分取方法及びプログラム
EP3106857B1 (en) 2014-02-13 2020-04-22 Sony Corporation Particle sorting apparatus, particle sorting method, program, and particle sorting system
CN106461686B (zh) * 2014-05-20 2018-06-12 尔利生物有限公司 用于磁流式细胞仪的盒、磁流式细胞仪及用于利用这样的盒分析样本的方法
JP6657625B2 (ja) 2014-09-05 2020-03-04 ソニー株式会社 液滴分取装置、液滴分取方法及びプログラム
KR101702745B1 (ko) * 2014-11-13 2017-02-03 인제대학교 산학협력단 단일세포 분리장치 및 방법
CA2999683A1 (en) 2015-09-30 2017-04-06 Semen Refinement B.V. Microfluidic device for selection of semen
JP6729597B2 (ja) 2015-10-19 2020-07-22 ソニー株式会社 画像処理装置、微小粒子分取装置及び画像処理方法
CN113717846B (zh) * 2020-05-26 2023-08-29 中国科学院青岛生物能源与过程研究所 一种基于介电确定性位移的细胞分选芯片、装置及方法
DE102020120425A1 (de) * 2020-08-03 2022-02-03 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein Verfahren und fluidisches Mikrosystem zur dielektrophoretischen Manipulierung von suspendierten Partikeln
CN114100706B (zh) * 2021-10-18 2022-08-19 吉林大学 一种基于粒子漂移的粒子分选方法及系统
EP4201526A1 (en) * 2021-12-22 2023-06-28 Imec VZW Microfluidic device for sorting particles
WO2023244166A1 (en) * 2022-06-17 2023-12-21 Nanyang Technological University Method and system for label-free microfluidic sorting

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DE4127405C2 (de) * 1991-08-19 1996-02-29 Fraunhofer Ges Forschung Verfahren zur Trennung von Gemischen mikroskopisch kleiner, in einer Flüssigkeit oder einem Gel suspendierter dielektrischer Teilchen und Vorrichtung zur Durchführung des Verfahrens
US5489506A (en) * 1992-10-26 1996-02-06 Biolife Systems, Inc. Dielectrophoretic cell stream sorter
US6641708B1 (en) * 1996-01-31 2003-11-04 Board Of Regents, The University Of Texas System Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation
JP4093740B2 (ja) * 2001-09-27 2008-06-04 独立行政法人科学技術振興機構 微粒子分別マイクロチップと微粒子分別装置
DE10311716A1 (de) * 2003-03-17 2004-10-14 Evotec Oai Ag Verfahren und Vorrichtung zur Trennung von Partikeln in einer Flüssigkeitsströmung
US7390387B2 (en) * 2004-03-25 2008-06-24 Hewlett-Packard Development Company, L.P. Method of sorting cells in series
JP4760330B2 (ja) * 2005-11-25 2011-08-31 富士ゼロックス株式会社 微粒子の分級方法及び分級装置
KR100787234B1 (ko) * 2006-02-17 2007-12-21 한국기계연구원 입자 분리 장치 및 입자 분리 방법
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JP5047034B2 (ja) * 2008-04-03 2012-10-10 キヤノン株式会社 粒子の分離方法及び分離装置
JP5604862B2 (ja) * 2009-01-09 2014-10-15 ソニー株式会社 流路デバイス、複素誘電率測定装置及び誘電サイトメトリー装置
JP2011237201A (ja) * 2010-05-06 2011-11-24 Sony Corp 微小粒子分取装置、マイクロチップ及びマイクロチップモジュール

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JP5924276B2 (ja) 2016-05-25
JP2013231710A (ja) 2013-11-14
US20130256197A1 (en) 2013-10-03
CN103357506A (zh) 2013-10-23

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