JP5924276B2 - 流路デバイス、粒子分取装置及び粒子分取方法 - Google Patents

流路デバイス、粒子分取装置及び粒子分取方法 Download PDF

Info

Publication number
JP5924276B2
JP5924276B2 JP2013010546A JP2013010546A JP5924276B2 JP 5924276 B2 JP5924276 B2 JP 5924276B2 JP 2013010546 A JP2013010546 A JP 2013010546A JP 2013010546 A JP2013010546 A JP 2013010546A JP 5924276 B2 JP5924276 B2 JP 5924276B2
Authority
JP
Japan
Prior art keywords
electrode
flow path
branch
guide
path
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2013010546A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013231710A (ja
JP2013231710A5 (enExample
Inventor
洋一 勝本
洋一 勝本
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sony Corp
Original Assignee
Sony Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sony Corp filed Critical Sony Corp
Priority to JP2013010546A priority Critical patent/JP5924276B2/ja
Priority to US13/851,668 priority patent/US20130256197A1/en
Priority to CN201310102904.0A priority patent/CN103357506B/zh
Publication of JP2013231710A publication Critical patent/JP2013231710A/ja
Publication of JP2013231710A5 publication Critical patent/JP2013231710A5/ja
Application granted granted Critical
Publication of JP5924276B2 publication Critical patent/JP5924276B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C7/00—Separating solids from solids by electrostatic effect
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C5/00—Separating dispersed particles from liquids by electrostatic effect
    • B03C5/02—Separators
    • B03C5/022—Non-uniform field separators
    • B03C5/026—Non-uniform field separators using open-gradient differential dielectric separation, i.e. using electrodes of special shapes for non-uniform field creation, e.g. Fluid Integrated Circuit [FIC]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C5/00—Separating dispersed particles from liquids by electrostatic effect
    • B03C5/005—Dielectrophoresis, i.e. dielectric particles migrating towards the region of highest field strength
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/1023—Microstructural devices for non-optical measurement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
    • G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00—Details of magnetic or electrostatic separation
    • B03C2201/26—Details of magnetic or electrostatic separation for use in medical or biological applications

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Engineering & Computer Science (AREA)
  • Fluid Mechanics (AREA)
  • Molecular Biology (AREA)
  • Electrochemistry (AREA)
  • Electrostatic Separation (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2013010546A 2012-04-03 2013-01-23 流路デバイス、粒子分取装置及び粒子分取方法 Expired - Fee Related JP5924276B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2013010546A JP5924276B2 (ja) 2012-04-03 2013-01-23 流路デバイス、粒子分取装置及び粒子分取方法
US13/851,668 US20130256197A1 (en) 2012-04-03 2013-03-27 Flow channel device, particle sorting apparatus, and particle sorting method
CN201310102904.0A CN103357506B (zh) 2012-04-03 2013-03-27 流道装置、颗粒分选装置和颗粒分选方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2012084511 2012-04-03
JP2012084511 2012-04-03
JP2013010546A JP5924276B2 (ja) 2012-04-03 2013-01-23 流路デバイス、粒子分取装置及び粒子分取方法

Publications (3)

Publication Number Publication Date
JP2013231710A JP2013231710A (ja) 2013-11-14
JP2013231710A5 JP2013231710A5 (enExample) 2015-03-19
JP5924276B2 true JP5924276B2 (ja) 2016-05-25

Family

ID=49233444

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013010546A Expired - Fee Related JP5924276B2 (ja) 2012-04-03 2013-01-23 流路デバイス、粒子分取装置及び粒子分取方法

Country Status (3)

Country Link
US (1) US20130256197A1 (enExample)
JP (1) JP5924276B2 (enExample)
CN (1) CN103357506B (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9267873B2 (en) * 2011-03-30 2016-02-23 Empire Technology Development Llc Material sorting system and method of sorting material
JP5924077B2 (ja) 2012-03-30 2016-05-25 ソニー株式会社 微小粒子分取装置及び微小粒子分取装置における軌道方向判定方法
US9087371B2 (en) 2012-03-30 2015-07-21 Sony Corporation Microparticle sorting device and method of optimizing fluid stream therein
US9192944B2 (en) * 2012-09-30 2015-11-24 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University Methods, systems and apparatus for size-based particle separation
JP6065527B2 (ja) * 2012-11-08 2017-01-25 ソニー株式会社 微小粒子分取装置及び微小粒子分取方法
DE102013200927A1 (de) * 2013-01-22 2014-07-24 Siemens Aktiengesellschaft Verfahren zum Anreichern und Vereinzeln von Zellen mit Konzentrationen über mehrere logarithmische Stufen
JP6304034B2 (ja) 2013-01-28 2018-04-04 ソニー株式会社 微小粒子分取装置、微小粒子分取方法及びプログラム
JP6447506B2 (ja) 2013-10-16 2019-01-09 ソニー株式会社 粒子分取装置及び粒子分取方法
EP3106857B1 (en) 2014-02-13 2020-04-22 Sony Corporation Particle sorting apparatus, particle sorting method, program, and particle sorting system
US10520419B2 (en) * 2014-05-20 2019-12-31 Earlybio Gmbh Cartridge for a magnetic flow cytometer, a magnetic flow cytometer, and method for analysing a sample with such a cartridge
JP6657625B2 (ja) 2014-09-05 2020-03-04 ソニー株式会社 液滴分取装置、液滴分取方法及びプログラム
KR101702745B1 (ko) * 2014-11-13 2017-02-03 인제대학교 산학협력단 단일세포 분리장치 및 방법
EP3356792B1 (en) 2015-09-30 2020-04-29 Semen Refinement B.V. Microfluidic device for selection of semen
EP3343200B1 (en) 2015-10-19 2021-12-15 Sony Group Corporation Image processing device, microparticle separation device, and image processing method
CN113717846B (zh) * 2020-05-26 2023-08-29 中国科学院青岛生物能源与过程研究所 一种基于介电确定性位移的细胞分选芯片、装置及方法
DE102020120425A1 (de) * 2020-08-03 2022-02-03 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein Verfahren und fluidisches Mikrosystem zur dielektrophoretischen Manipulierung von suspendierten Partikeln
CN114100706B (zh) * 2021-10-18 2022-08-19 吉林大学 一种基于粒子漂移的粒子分选方法及系统
EP4201526A1 (en) * 2021-12-22 2023-06-28 Imec VZW Microfluidic device for sorting particles
WO2023244166A1 (en) * 2022-06-17 2023-12-21 Nanyang Technological University Method and system for label-free microfluidic sorting

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4143573C2 (de) * 1991-08-19 1996-07-04 Fraunhofer Ges Forschung Vorrichtung zur Trennung von Gemischen mikroskopisch kleiner, in einer Flüssigkeit oder einem Gel suspendierter, dielektrischer Teilchen
US5489506A (en) * 1992-10-26 1996-02-06 Biolife Systems, Inc. Dielectrophoretic cell stream sorter
US6641708B1 (en) * 1996-01-31 2003-11-04 Board Of Regents, The University Of Texas System Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation
JP4093740B2 (ja) * 2001-09-27 2008-06-04 独立行政法人科学技術振興機構 微粒子分別マイクロチップと微粒子分別装置
DE10311716A1 (de) * 2003-03-17 2004-10-14 Evotec Oai Ag Verfahren und Vorrichtung zur Trennung von Partikeln in einer Flüssigkeitsströmung
US7390387B2 (en) * 2004-03-25 2008-06-24 Hewlett-Packard Development Company, L.P. Method of sorting cells in series
JP4760330B2 (ja) * 2005-11-25 2011-08-31 富士ゼロックス株式会社 微粒子の分級方法及び分級装置
KR100787234B1 (ko) * 2006-02-17 2007-12-21 한국기계연구원 입자 분리 장치 및 입자 분리 방법
TW200940987A (en) * 2008-03-21 2009-10-01 Univ Nat Taiwan Microparticle sorting chip system and operating method thereof
JP5047034B2 (ja) * 2008-04-03 2012-10-10 キヤノン株式会社 粒子の分離方法及び分離装置
JP5604862B2 (ja) * 2009-01-09 2014-10-15 ソニー株式会社 流路デバイス、複素誘電率測定装置及び誘電サイトメトリー装置
JP2011237201A (ja) * 2010-05-06 2011-11-24 Sony Corp 微小粒子分取装置、マイクロチップ及びマイクロチップモジュール

Also Published As

Publication number Publication date
US20130256197A1 (en) 2013-10-03
JP2013231710A (ja) 2013-11-14
CN103357506B (zh) 2017-06-30
CN103357506A (zh) 2013-10-23

Similar Documents

Publication Publication Date Title
JP5924276B2 (ja) 流路デバイス、粒子分取装置及び粒子分取方法
US9429276B2 (en) Flow channel device, particle sorting apparatus, particle outflow method, and particle sorting method
JP5732816B2 (ja) 細胞分取装置及び細胞分取チップ
JP6584422B2 (ja) 電磁ソレノイドを用いた細胞分別システム
US8702945B2 (en) Time-varying flows for microfluidic particle separation
Tsutsui et al. Cell separation by non-inertial force fields in microfluidic systems
Jiang et al. High-throughput continuous dielectrophoretic separation of neural stem cells
US20140262970A1 (en) Sorting apparatus and sorting method
CN102564920B (zh) 细胞分选器和细胞分选方法
JP2005037346A (ja) マイクロ流体制御システム
KR101133288B1 (ko) 미세입자 분리 장치 및 방법
US7070684B1 (en) Electrode arrangement for generating functional field barriers in microsystems
JP7188506B2 (ja) マイクロチップ及び微小粒子分取装置
CN104031819A (zh) 流道设备和分选装置
Kentsch et al. Microdevices for separation, accumulation, and analysis of biological micro-and nanoparticles
Elvington et al. Label-free isolation and enrichment of cells through contactless dielectrophoresis
US20070131554A1 (en) Multi-sample microfluidic dielectrophoresis separating device and method thereof
CN100457239C (zh) 多样品微流体介电泳分离装置
JP2005049273A (ja) マイクロ流体制御システム
CN116286336A (zh) 细胞分选装置及分选方法
JP2005043301A (ja) 液滴生成方法及びマイクロ流体制御システム
CN101430942B (zh) 一种具有微粒抬升装置的光钳装置
KR100872497B1 (ko) 연속적 입자 분류기
JP2017136583A (ja) 粒子分取装置及び粒子分取方法
Moon et al. Modeling and Analysis of a Microfluidic Biosensor for Selective Cell Control in Lab-on-Chip Applications

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150202

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20150202

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20151120

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20151201

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160119

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20160322

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20160404

R151 Written notification of patent or utility model registration

Ref document number: 5924276

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R151

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees