CN103341083A - Traditional Chinese medicine composition for treating lumbar and cervical vertebra diseases and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating lumbar and cervical vertebra diseases and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating lumbar and cervical vertebra diseases, a preparation method and a use thereof. The traditional Chinese medicine composition is mainly prepared by the following raw materials in parts by weight: 10-30 parts of garter snake, 1-10 parts of processed Semen Strychni, 8-25 parts of long-noded pit viper, 5-20 parts of the seed of Job's tears, 8-25 parts of turtle shell, 8-25 parts of Pangolin Scales, 5-18 parts of large-leaved gentian, 8-25 parts of Cowherb Seed, 5-20 parts of rhizoma atractylodis, 5-20 parts of radices sileris, 8-25 parts of cortex acanthopanacis, 8-25 parts of Astragalus membranaceus, 1-10 parts of asarum, 5-25 parts of Eucommia ulmoides, 5-20 parts of radix angelicae pubescentis and 8-25 parts of Chaenomeles sinensis Koehne. The traditional Chinese medicine composition disclosed by the invention is free from irritation and toxic and side effects, high in safety, good in sameness prevention, quick effect, short in treatment cycle and low in recurrence rate, and can treat lumbar and cervical vertebra diseases by treating both manifestation and root cause of diseases. The traditional Chinese medicine composition is higher in cure rate and effective rate to lumbar and cervical vertebra diseases, and the cure rate is 97% and the effective rate is 100%.
Description
Technical field
The invention belongs to the field of Chinese medicines for the treatment of waist cervical spondylosis, particularly a kind of is Chinese medicine composition and preparation method thereof and the purposes of the diseases such as treatment prolapse of lumbar intervertebral disc, cervical spondylosis of feedstock production with the Chinese herbal medicine.
Technical background
Because occupation needs, a lot of people are long-term sitting, so the waist cervical spondylosis becomes a kind of disease occurred frequently, and refractory more, easily recurrence.The Chinese medicine for the treatment of waist cervical spondylosis has much at present, but the cost of material of medicine is higher, and treatment cycle is long, and the relapse rate height can not effect a permanent cure.Chinese patent CN101455770A discloses a kind of with Radix Achyranthis Bidentatae, Eupolyphaga Seu Steleophaga, Herba Ephedrae, Rhizoma Atractylodis, Radix Angelicae Sinensis, the Radix Paeoniae Alba, the Radix Polygoni Multiflori, Fructus Lycii, side's powder, Cortex Acanthopancis, Folium Artemisiae Argyi, DUISHANYAO, Radix Codonopsis, the Radix Astragali, Rhizoma Smilacis Glabrae, Fructus Psoraleae, Semen Cuscutae, Flos Carthami, Pericarpium Citri Reticulatae, Herba Asari, Rhizoma Acori Graminei, Radix Aconiti Lateralis Preparata, Cortex Cinnamomi, Radix Glycyrrhizae, Gecko, Semen Strychni, Olibanum, Myrrha, Scorpio and Mel etc. 30 flavor Chinese medicines are the Chinese medicine pill of the treatment prolapse of lumbar intervertebral disc that makes of raw material, this Chinese medicine pill therapeutic effect is remarkable, but raw materials used kind is many, price is expensive, and does not relate to the research for the treatment of cycle and relapse rate.Chinese patent CN101185699A discloses a kind of with Radix Saposhnikoviae 10 grams, Carapax et Plastrum Testudinis 15 grams, Rhizoma Drynariae 10 grams, Radix Angelicae Sinensis 10 grams, the Cortex Eucommiae 15 grams, Cornu Cervi Degelatinatum 15 grams, Radix Rehmanniae Preparata 10 grams, Rhizoma Chuanxiong 15 grams, Radix Clematidis 15 grams, Eupolyphaga Seu Steleophaga 15 grams, Caulis Spatholobi 15 grams, Herba Asari 3 restrain the Chinese medicine decoction of the treatment cervical spondylosis that makes for raw material, instant effect, short treating period, expense are low, but only are applicable to the treatment of cervical spondylosis.
Summary of the invention
The purpose of this invention is to provide a kind of degree of safety height, concertedness is good, treatment cycle is short, relapse rate is low, the Chinese medicine composition for the treatment of waist cervical spondylosis that can treating both the principal and secondary aspects of a disease.
Another object of the present invention provides the preparation method of this Chinese medicine composition.
The Chinese medicine composition for the treatment of waist cervical spondylosis of the present invention, the primary raw material weight portion for preparing described Chinese medicine composition consists of: Zaocys 10-30, Semen Strychni (processed) 1-10, Agkistrodon 8-25, Semen Coicis 5-20, Carapax Trionycis 8-25, big gun first 8-25, Radix Gentianae Macrophyllae 5-18, king do not stay 8-25.
The Chinese medicine composition for the treatment of waist cervical spondylosis of the present invention, the parts by weight of raw materials composition for preparing described Chinese medicine composition also comprises: Rhizoma Atractylodis 5-20, Radix Saposhnikoviae 5-20, Cortex Acanthopancis 8-25, Radix Astragali 8-25, Herba Asari 1-10, Cortex Eucommiae 5-25, Radix Angelicae Pubescentis 5-20, Fructus Chaenomelis 8-25.
The Chinese medicine composition for the treatment of waist cervical spondylosis of the present invention, the primary raw material weight portion for preparing described Chinese medicine composition consists of: Zaocys 15-25, Semen Strychni (processed) 4-6, Agkistrodon 12-20, Semen Coicis 8-15, Carapax Trionycis 12-20, big gun first 12-20, Radix Gentianae Macrophyllae 8-12, king do not stay 8-25, Rhizoma Atractylodis 8-15, Radix Saposhnikoviae 8-15, Cortex Acanthopancis 12-20, Radix Astragali 12-20, Herba Asari 4-6, Cortex Eucommiae 10-20, Radix Angelicae Pubescentis 8-15, Fructus Chaenomelis 12-20.
The Chinese medicine composition for the treatment of waist cervical spondylosis of the present invention, the primary raw material weight portion for preparing described Chinese medicine composition consists of: Zaocys 20, Semen Strychni (processed) 5, Agkistrodon 15, Semen Coicis 12, Carapax Trionycis 15, big gun first 15, Radix Gentianae Macrophyllae 10, king do not stay 15, Rhizoma Atractylodis 12, Radix Saposhnikoviae 12, Cortex Acanthopancis 15, the Radix Astragali 15, Herba Asari 5, the Cortex Eucommiae 14, Radix Angelicae Pubescentis 12, Fructus Chaenomelis 15.
The Chinese medicine composition for the treatment of waist cervical spondylosis of the present invention is made powder with described Chinese medicine composition, and described powder comprises Chinese medicine composition and the adjuvant that following weight portion is formed:
The Chinese medicine composition for the treatment of waist cervical spondylosis of the present invention is made electuary with described Chinese medicine composition, and described electuary comprises Chinese medicine composition and the adjuvant that following weight portion is formed:
The Chinese medicine composition for the treatment of waist cervical spondylosis of the present invention is made tablet with described Chinese medicine composition, and described tablet comprises Chinese medicine composition and the adjuvant that following weight portion is formed:
The Chinese medicine composition for the treatment of waist cervical spondylosis of the present invention is made pill with described Chinese medicine composition, and described pill comprises Chinese medicine composition and the adjuvant that following weight portion is formed:
The Chinese medicine composition for the treatment of waist cervical spondylosis of the present invention is made capsule with described Chinese medicine composition, and described capsule comprises Chinese medicine composition and the adjuvant that following weight portion is formed:
The preparation method of the Chinese medicine composition for the treatment of waist cervical spondylosis of the present invention comprises the steps:
A) at first that ten Six-element Chinese medicines are clean, cutting and dry, ratio of component is weighed by weight, and is standby;
B) decocting that Zaocys, Semen Strychni (processed), Agkistrodon, Carapax Trionycis, big gun first, Wang Buliu, the Radix Astragali, Herba Asari, Radix Angelicae Pubescentis, the Fructus Chaenomelis of described components by weight percent ratio is added 3～6 times of volumes boils 3 times, to water surplus be original 1/4, it is 40～70 minutes at every turn, filter and merging filtrate, be condensed into proportion and be 1.3 extractum, add 91%～96% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry under 50～55 ℃, make extractum 1;
C) Semen Coicis, Radix Gentianae Macrophyllae, Radix Saposhnikoviae, Rhizoma Atractylodis, Cortex Acanthopancis, the Cortex Eucommiae with described components by weight percent ratio adds alcohol reflux 0.5～1.5h of 91%～96%, described ethanol consumption is 4～7 times of Six-element Chinese medicine volume, obtain extracting solution and reclaim ethanol, dry under 47～52 ℃, get dry extract 2;
D) merge extractum 1 and extractum 2, be ground into fine powder and mix homogeneously, namely make Chinese medicine composition of the present invention.
The Chinese medicine composition for the treatment of waist cervical spondylosis of the present invention, its pharmacological action is complicated and comprehensive, can adjust the allomeric function of human body.Semen Strychni is to get in the prescription to imitate critical medicine, its meridian dredging, and reducing swelling and alleviating pain reaches the power in joint thoroughly, outclass its medicine in fact." surgery is given birth to collection entirely " carries: " can search the rheumatism that muscles and bones is gone into joint, the expectorant poison that the flesh side film of dispelling condenses outward." Compendium of Material Medica Li Shizhen (1518-1593 A.D.) foreword: " shape is like company's money event name Semen Strychni of horse, and 120 kinds of diseases controlled in that person's speech, and every disease has soup to draw ", pointed out Semen Strychni to have very strong research and development and be worth.The Chinese medicine composition for the treatment of waist cervical spondylosis of the present invention, the principle of the mutual compatibility of utilization medicine can effectively be dispeled the toxic and side effects of Semen Strychni, makes medication safe and reliable.Main pharmacological has dredge the meridian passage, promoting blood circulation and stopping pain, and vigorate qi and replenish the blood, expelling wind and cold, the dehumidifying detumescence, the Shujin bone strengthening, the merit of strong nerve, its outstanding feature is at " a leading to " word.The Chinese medicine composition for the treatment of waist cervical spondylosis of the present invention is pure Chinese medicinal preparation, and it is main being conceived to effect a permanent cure, and takes without any side effectsly for a long time, and the good characteristics of late result is arranged.Sick good back is difficult for recurrence, truly has the merit of bone and muscle strengthening, the effect of replenishing kidney, strengthening waist, and both dredge the meridian passage again can promoting blood circulation and stopping pain; Both expelling wind and cold, the detumescence that can dehumidify again has tonifying YANG to control the merit of flaccidity.Harmless to health fertility cerebral nerve, after taking medicine, obviously appetite strengthening is inspired enthusiasm.The Chinese medicine composition for the treatment of waist cervical spondylosis of the present invention also has curative effect preferably to diseases such as rheumatism, rheumatoid arthritis, sciatica, waist hyperosteogeny of cervical vertebra, ankylosing spondylitis, scapulohumeral periarthritis, the soft paralysed disease of flaccidity, gouts.
The source of used primary raw material is as follows among the present invention:
Zaocys (Dioscorea opposita): Colubridae, Zaocys belong to animal.Sweet in the mouth, property is flat, and is nontoxic.Cure mainly that all wind of insensitive impediment, munbness, wind addiction pruritus, scabies, skin give birth to that leprosy, eyebrow beard come off, deafness, scrofula caused by pathogenic wind disease, swollen and rigid tongue plug, pathogenic wind toxic gas, gallbladder life nebula, lockjaw lip boil.
Semen Strychni (Semen Strychni): Loganiaceae, Poisonnut plant.Bitter in the mouth, cold in nature, poisonous.Excited stomach invigorating, detumescence poison, removing heat from blood.Cure mainly numb limbs and tense tendons, paralysis, inappetence, mass in the abdomen, carbuncle pyogenic infections from tumour or sore, laryngopharynx swelling and pain.Semen Strychni (processed): sand is processed, oil is processed, the general designation of water Semen Strychni (processed), is the dry mature seed of Semen Strychni.Promoting blood circulation to remove obstruction in the collateral, antiphlogistic antibacterial, pain relieving, expelling the stasis for the new.
Agkistrodon (Agkistrodonacutus (Gunther)): the drying of Viperidae animal point kiss Pallas pit viper (Agkistrodon) is all.Sweet in the mouth, salty, slightly warm in nature is poisonous.Dispel the wind collateral dredging, relieving convulsion.Be used for rheumatoid arthritis stubborn, numbness contracture, middle air port is askew, hemiplegia, tic spasm, tetanus, leprosy scabies, scrofula malignant boil.
Semen Coicis (Coix lacroyma-jobi L.var.ma-yuen (Roman.) Stapf): grass family, the super family of Semen Maydis, Coix plant.Sweet in the mouth, light, cold nature.Control cold syndrome of the stomach pain, deficient qi and blood.
Carapax Trionycis (Carapax Trionycis): salty in the mouth, cold in nature.The nourishing kidney YANG hyperactivity suppressing, hard masses softening and resolving.Cure mainly hard under hectic fever due to YIN-deficiency consumptive fever, malaria with splenomegaly, the side of body, lumbago, diseases such as amenorrhea lump in the abdomen.
Big gun first (Pangolin Scales): the scute of Manidae animal Manitis.Salty in the mouth, cool in nature.The routed carbuncle of detumescence, it is active to search wind, the stimulating milk secretion of stimulating the menstrual flow.
Radix Gentianae Macrophyllae (G. macrophylla): Gentianaceae Gentiana dicotyledon.Acrid in the mouth, hardship, cold nature.Wind-damp dispelling, Shujin network, clearind deficient heat.Be used for rheumatic arthralgia, the contracture of muscle arteries and veins, joint is ached, afternoon fever, infantile malnutrition heating.
The king does not stay (Semen Vaccariae): the dry mature seed of Caryophyllaceae Vaccaria plant Vaccaria segetalis.Bitter in the mouth, property is flat.Promoting blood circulation to restore menstrual flow, the stimulating milk secretion detumescence.
Rhizoma Atractylodis (Rhizoma Atractylodis): the plant of Compositae, [WTBX.Acrid in the mouth, hardship, warm in nature.Cure mainly the fortune imbalance that the spleen being blocked by dampness causes, inappetence, vomiting is unhappy, and abdominal distention is had loose bowels, arthralgia.
Radix Saposhnikoviae (Radix Saposhnikoviae): the root of Umbelliferae herbaceos perennial Radix Saposhnikoviae.Acrid in the mouth, sweet, slightly warm in nature.Expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic.Cure mainly that affection of exogenous wind-cold, headache general pain, rheumatic arthralgia, joint are ached, stomachache is had loose bowels, discharging fresh blood stool, tetanus, rubella pruritus, skin infection from the beginning of.
Cortex Acanthopancis (.Cortex Acan thopanacis Gracilistyli): Araliaceae, acanthopanax plant.Acrid in the mouth, hardship, warm in nature.Wind-damp dispelling; Invigorating the liver and kidney; Bone and muscle strengthening; The arteries and veins of invigorating blood circulation.Be used for anemofrigid-damp arthralgia; Lumbocrural pain; The muscles and bones flaccidity is soft; Children's's walking retardation in children; Body void is frail; Traumatic injury; Fracture; Edema; Foot gas; Uncontrolled urination is itched.
The Radix Astragali (Leguminosae): pulse family, Astragalus.Radix Astragali sweet in the mouth, slightly warm in nature is returned liver, spleen, lung, kidney channel.Invigorating QI to consolidate the body surface resistance, diuretic detumescent, toxin expelling evacuation of pus, granulation promoting.
Herba Asari (Herba Asari): Aristolochiaceae, asarum plant.Acrid in the mouth; Warm in nature; Mild toxicity.Dispel the wind, cold expelling, row water is had one's ideas straightened out.Cure mainly air-cooled headache, nasal sinusitis, toothache, phlegm retention cough with dyspnea, rheumatic arthralgia.
The Cortex Eucommiae (Eucommia ulmoides): the dry bark of Eucommiaceae Cortex Eucommiae platymiscium.Sweet in the mouth, little suffering, warm in nature.Invigorating the liver and kidney, bone and muscle strengthening, adjusting blood pressure.Cure mainly lumbago due to renal deficiency, fetal movement vaginal bleeding during pregnancy, hypertension.
Radix Angelicae Pubescentis (Radix Angelicae Biseratae): the dry root of Umbelliferae, the heavy peristome Radix Angelicae Sinensis of heracleum hemsleyanum michaux plant.Acrid in the mouth, hardship, slightly warm in nature.Expelling wind and dampness; Dispersing cold for relieving pain.Be used for anemofrigid-damp arthralgia; Lumbocrural pain; Few cloudy volt wind headache, the headache toothache.
Fructus Chaenomelis (Chaenome lesspeciosa): Rosaceae, Chaenomeles shrub plant.Sour in the mouth, puckery, warm in nature, nontoxic.Help digestion, anthelmintic, heat clearing away is dispeled the wind; Cure mainly stomachache, dyspepsia, lung-heat dry cough, galactostasis, eczema, parasitic disease, diseases such as trick spasm pain.
Beneficial effect of the present invention is:
Adopt raw material mostly to be the high pure plant of degree of safety, pure animal extracts, the Chinese medicine composition of preparation is non-stimulated, have no side effect, degree of safety height, concertedness are good, instant effect, short treating period, but treating both the principal and secondary aspects of a disease, relapse rate are low, waist cervical spondylosis cure rate and effective percentage are higher, cure rate 97%, effective percentage 100%.
For this situation is described, existing to further specify effect of the present invention as follows by testing example:
Test example 1 intervertebral disc prolapse:
30 examples are organized in treatment, 20～55 years old age, average 36 years old, the course of disease 3～18 months.
Take mode: the treatment group: the oral oral formulations that is made by Chinese medicine composition of the present invention, sooner or later respectively take once after the meal every day half an hour, takes after mixing it with water with hydromel, takes two courses for the treatment of continuously, around be a course for the treatment of.Matched group: oral YAOTONGNING JIAONANG (composition: Semen Strychni Pulveratum, Eupolyphaga Seu Steleophaga, Herba Ephedrae, Olibanum, Myrrha, Radix Cyathulae, Scorpio, Bombyx Batryticatus, Rhizoma Atractylodis, Radix Glycyrrhizae), every day, each once took two courses for the treatment of continuously sooner or later, and be eight weeks a course for the treatment of.
Observation index: which disease has change before and after observing treatment, treatment back symptom, and sign disappears or alleviates; X line plain film shows that intervertebral space recovers normal, and it is normal that spinal column recovers; CT examination shows that former diseased region recovers normal; MRI checks that the recovery of lesions showed position is normal.
Curative effect determinate standard: which aspect and which degree change have taken place before and after the treatment just belonged to recovery from illness, effective, improvement; Clinical recovery: intervertebral space recovers normal, and it is normal that spinal column recovers, and it is normal that former diseased region recovers; Produce effects: the symptom of narrowing of intervertebral space has bigger recovery, and the skoliosis symptom also has bigger recovery; Effectively: the symptom of narrowing of intervertebral space is recovered to some extent, and the skoliosis symptom is also recovered to some extent; Invalid: intervertebral space is narrow, skoliosis.
Result of the test is as follows:
Efficacy evaluation: in the clinical trial of intervertebral disk hernia, it is 29 examples, produce effects person's 30 examples, improvement person's 30 examples, nonresponder's 0 example, obvious effective rate 100%, cure rate 97% that the treatment group is taken the oral formulations healing person who is made by Chinese medicine composition of the present invention; And matched group to take YAOTONGNING JIAONANG healing person be 15 examples, produce effects person's 26 examples, improvement person's 28 examples, nonresponder's 2 examples, obvious effective rate 87%, cure rate 50%.The effect for the treatment of group and matched group comparison shows that higher to treatment effective percentage and the cure rate of intervertebral disk hernia by the oral formulations that Chinese medicine composition of the present invention makes, cure rate reaches 97%, and treatment cycle is short.The patient who fully recovers in the treatment group is paid a return visit, and finding did not have the recidivist in 3 years.
Test example 2 cervical spondylosiss:
30 examples are organized in treatment, 25～60 years old age, average 39 years old, the course of disease 3～18 months.
Take mode: the treatment group: the oral oral formulations that is made by Chinese medicine composition of the present invention, sooner or later respectively take once after the meal every day half an hour, takes after mixing it with water with hydromel, takes two courses for the treatment of continuously, around be a course for the treatment of.Matched group: oral 'Gu Jin Wan ' capsule (composition: Olibanum, Myrrha, the Radix Paeoniae Alba, Rhizoma Corydalis (vinegar system), Radix Notoginseng, the Radix Aucklandiae, Flos Carthami, Radix Curcumae, Radix Angelicae Pubescentis, Radix Achyranthis Bidentatae, Radix Gentianae Macrophyllae, Ramulus Cinnamomi, Sanguis Draxonis, Semen Strychni (system)), every day sooner or later respectively once, take three courses for the treatment of continuously, around be a course for the treatment of.
Observation index: which disease has change before and after examining treatment, treatment back symptom, and sign disappears or alleviates;
The cervical vertebra X-ray film: cervical vertebra normal physiological curvature disappears or anti-opening, stenosis of disc space, and spinal canal stenosis, vertebral body trailing edge hyperosteogeny forms, and extends through to bend on the bit slice in the mistake of cervical vertebra and can also observe cervical vertebra segmental instability.
Cervical vertebra CT: the hypertrophy calcification of cervical vertebra.
Cervical vertebra MRI: intervertebral disc protrusion of cervical vertebra compressing spinal cord.
Curative effect determinate standard: which aspect and which degree change have taken place before and after the treatment just belonged to recovery from illness, effective, improvement; Clinical recovery: cervical curvature is normal, and intervertebral space, canalis spinalis are normal, and vertebral body trailing edge hyperosteogeny disappears, and cervical vertebra is stable, cervical vertebra calcification, the outstanding disappearance; Produce effects: cervical curvature recovers to some extent, and intervertebral space, spinal canal stenosis alleviate to some extent, and vertebral body trailing edge hyperosteogeny disappears substantially, and cervical vertebra is basicly stable, and the cervical vertebra calcification takes a turn for the better to some extent, outstanding basic the disappearance; Effectively: cervical curvature slightly recovers, and intervertebral space, spinal canal stenosis have the tendency of alleviating, and vertebral body trailing edge hyperosteogeny has disappearance trend, the cervical vertebra instability, and the cervical vertebra calcification takes a turn for the better to some extent; Invalid: cervical vertebra normal physiological curvature disappears or anti-opening, stenosis of disc space, spinal canal stenosis, vertebral body trailing edge hyperosteogeny, cervical vertebra instability, hyperosteogeny calcification, intervertebral disc protrusion of cervical vertebra compressing spinal cord.
Result of the test is as follows:
Efficacy evaluation: in the clinical trial of cervical spondylosis, it is 29 examples, produce effects person's 30 examples, improvement person's 30 examples, nonresponder's 0 example, obvious effective rate 97%, cure rate 90% that the treatment group is taken the oral formulations healing person who is made by Chinese medicine composition of the present invention, and matched group to take 'Gu Jin Wan ' capsule healing person be 20 examples, produce effects person's 26 examples, improvement person's 29 examples, nonresponder's 1 example, obvious effective rate 87%, cure rate 67%.The effect for the treatment of group and matched group comparison shows that higher to treatment effective percentage and the cure rate of cervical spondylosis by the oral formulations that Chinese medicine composition of the present invention makes, cure rate reaches 97%, and treatment cycle is short.The patient who fully recovers in the treatment group is paid a return visit, and finding did not have the recidivist in 3 years.
Model case 1:
Lee, man, 50 years old.The main suit: buttocks distending pain 2 years, the numb distending pain in the lumbosacral region companion shank outside 1 year, walking 200 meters namely occurs walking lamely, and the state of an illness increases the weight of before 1 month, can not independently leave the bed, and pain is hard to bear.By institute going to a doctor to me.Have a medical check-up: vital sign is steady, sanity, and the cooperation of having a medical check-up, lumbar vertebra CT shows L4/5 intervertebral disc outstanding about 0.78cm backward, dural sac and root compression, on every side little joint hyperplasia; The waist mobility is seriously limited, tenderness between the L4/5/S1 sour jujube, and straight-leg raising test L65 ° of (-) R18 ° (+), waist side bend test (+), Achilles tendon reflex L (+) R (-), lower-limb muscular strength obviously descends.Treatment: by the oral formulations that the Chinese medicine composition of taking the course for the treatment of by treatment waist cervical spondylosis of the present invention makes, instructions of taking for early, after the dinner half an hour respectively take 1 dose, take after mixing it with water with hydromel, 4 weeks were 1 course for the treatment of.After treating 1 course for the treatment of, the former pain malaise symptoms of patient disappears substantially, and it is normal substantially to walk, and CT examination shows that the symptom of narrowing of intervertebral space has bigger recovery, and skoliosis reduces; After treating 2 courses for the treatment of, the former pain malaise symptoms of patient disappears, and walking is normal, and it is normal that intervertebral space recovers, and outstanding position disappears, and it is normal that spinal column recovers, and it is normal that former diseased region recovers.Pay a return visit after 3 years, patient's recovery situation is good, does not have recurrence.
Model case 2:
Zhang, woman, 32 years old.The main suit: neck and shoulder part pain companion right upper extremity numb pain 1 year, during take the other drug treatment, alleviation is arranged, but easily recurrence increased the weight of before 5 days, neck and shoulder pain and right upper extremity fiber crops pain increase the weight of numbness of the fingers.By institute going to a doctor to me.Have a medical check-up: vital sign is steady, sanity, and the cooperation of having a medical check-up, CT shows C5-6 intervertebral disk hernia 0.65cm; The muscle spasm of neck shoulder, sour jujube ligament anxiety, tenderness (+), the other tenderness (+) of C5-6 vertebra, intervertebral foramina squeeze test (+), brachial plexus nerve distraction test (+), RHG weakens.Treatment: by the oral formulations that the Chinese medicine composition of taking the course for the treatment of by treatment waist cervical spondylosis of the present invention makes, instructions of taking for early, after the dinner half an hour respectively take 1 dose, take after mixing it with water with hydromel, 4 weeks were 1 course for the treatment of.After treating 1 course for the treatment of, the former malaise symptoms of patient disappears substantially, points normally substantially, and CT examination shows that the symptom of narrowing of intervertebral space has bigger recovery, and skoliosis reduces; After treating 2 courses for the treatment of, the former pain malaise symptoms of patient disappears, and it is normal that intervertebral space recovers, and outstanding position disappears, and it is normal that spinal column recovers, and finger recovers flexibly.Pay a return visit after 3 years, patient's recovery situation is good, does not have recurrence.
Model case 3:
Liu, woman, 38 years old.The main suit: the cervical region companion that aches was revolved obstacle 1 year behind the right limb, increased the weight of before 1 month, pain unbearably, upper limb numbness.By institute going to a doctor to me.Have a medical check-up: vital sign is steady, sanity, and the cooperation of having a medical check-up, the cervical vertebra X-ray film shows that cervical vertebra normal physiological curvature disappears, stenosis of disc space, vertebral body trailing edge have hyperosteogeny to form; Cervical vertebra CT shows cervical vertebra degeneration, cervical vertebra 4/5, cervical vertebra 5/6 annuler bulge; Cervical vertebra MRI shows intervertebral disc protrusion of cervical vertebra compressing spinal cord; Cervical region tenderness (+), the other tenderness (+) of C5-6 vertebra, distraction test (±), pressure measurement by compression of neck (±).Treatment: by the oral formulations that the Chinese medicine composition of taking the course for the treatment of by treatment waist cervical spondylosis of the present invention makes, instructions of taking for early, after the dinner half an hour respectively take 1 dose, take after mixing it with water with hydromel, 4 weeks were 1 course for the treatment of.After treating 1 course for the treatment of, the former malaise symptoms of patient disappears substantially, and upper limb numbness disappears substantially, cervical curvature recovers to some extent, and intervertebral space, spinal canal stenosis alleviate to some extent, and vertebral body trailing edge hyperosteogeny disappears substantially, cervical vertebra is basicly stable, and the cervical vertebra calcification takes a turn for the better to some extent, outstanding basic the disappearance; After treating 2 courses for the treatment of, the former pain malaise symptoms of patient disappears, upper limb numbness disappears, and cervical curvature is normal, and intervertebral space, canalis spinalis are normal, and vertebral body trailing edge hyperosteogeny disappears, and cervical vertebra is stable, cervical vertebra calcification, the outstanding disappearance.Pay a return visit after 3 years, patient's recovery situation is good, does not have recurrence.
Model case 4:
Cui, man, 49 years old.The main suit: neck portion pain 1 year, the two upper limb numbness of the pain companion of neck portion appear in no obvious inducement before February, obey the pain relief of blood-activating analgesic collare napex certainly, and two upper limb numbness improve not obvious, recur after the drug withdrawal.By just precious to my institute.Have a medical check-up: vital sign is steady, sanity, and the cooperation of having a medical check-up, the c spine ap ﹠ lat sheet shows the cervical vertebra degenerative change; Cervical vertebra MRI shows that the C6-7 intervertebral disc is slightly outstanding; It is straight that cervical curvature becomes, and musculi colli is stiff, and the cervical vertebra activity is slightly limited, tenderness (+) between neck 3-neck 5 sour jujubes, and bilateral intervertebral foramina squeeze test (-) is kowtowed top test (-), and neck test (±) is revolved in brachial plexus distraction test left side (+), right side (+).Treatment: by the oral formulations that the Chinese medicine composition of taking the course for the treatment of by treatment waist cervical spondylosis of the present invention makes, instructions of taking for early, after the dinner half an hour respectively take 1 dose, take after mixing it with water with hydromel, 4 weeks were 1 course for the treatment of.After treating 1 course for the treatment of, the former malaise symptoms of patient disappears substantially, and upper limb numbness disappears substantially, cervical curvature recovers to some extent, and intervertebral space, spinal canal stenosis alleviate to some extent, and vertebral body trailing edge hyperosteogeny disappears substantially, cervical vertebra is basicly stable, and the cervical vertebra calcification takes a turn for the better to some extent, outstanding basic the disappearance; After treating 2 courses for the treatment of, the former pain malaise symptoms of patient disappears, upper limb numbness disappears, and cervical curvature is normal, and intervertebral space, canalis spinalis are normal, and vertebral body trailing edge hyperosteogeny disappears, and cervical vertebra is stable, cervical vertebra calcification, the outstanding disappearance.Pay a return visit after 3 years, patient's recovery situation is good, does not have recurrence.
The specific embodiment
The invention will be further described below in conjunction with embodiment:
Embodiment 1 powder
Prescription:
Zaocys 20g, Semen Strychni (processed) 5g, Agkistrodon 15g, Semen Coicis 12g, Carapax Trionycis 15g, big gun first 15g, Radix Gentianae Macrophyllae 10g, king do not stay 15g, Rhizoma Atractylodis 12g, Radix Saposhnikoviae 12g, Cortex Acanthopancis 15g, Radix Astragali 15g, Herba Asari 5g, Cortex Eucommiae 14g, Radix Angelicae Pubescentis 12g, Fructus Chaenomelis 15g; Lactose 20.7g, microcrystalline Cellulose 8.3g, carboxymethyl starch sodium 12.4g, Polyethylene Glycol-40004.1g.
Method for making:
A) at first that ten Six-element Chinese medicines are clean, cutting and dry is weighed by described weight, and is standby;
B) will claim Zaocys, Semen Strychni (processed), Agkistrodon, Carapax Trionycis, big gun first, Wang Buliu, the Radix Astragali, Herba Asari, Radix Angelicae Pubescentis, the Fructus Chaenomelis decocting that adds 5 times of volumes boil 3 times, to water surplus be original 1/4, it is 55 minutes at every turn, filter and merging filtrate, be condensed into proportion and be 1.3 extractum, add 93% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry under 53 ℃, make extractum 1;
C) will claim Semen Coicis, Radix Gentianae Macrophyllae, Radix Saposhnikoviae, Rhizoma Atractylodis, Cortex Acanthopancis, the Cortex Eucommiae add 94% alcohol reflux 1h, described ethanol consumption is 5 times of Six-element Chinese medicine volume, obtain extracting solution and reclaim ethanol, 50 ℃ down dry, get dry extract 2;
D) merge extractum 1 and extractum 2, be ground into fine powder and mix homogeneously, namely make 20.7g Chinese medicine composition of the present invention.
E) add lactose, microcrystalline Cellulose, carboxymethyl starch sodium and the Polyethylene Glycol-4000 of described weight in the 20.7g that the makes Chinese medicine composition of the present invention, the Chinese medicine composition of this invention is made powder.
Embodiment 2 electuaries
Prescription:
Zaocys 10g, Semen Strychni (processed) 1g, Agkistrodon 8g, Semen Coicis 5g, Carapax Trionycis 8g, big gun first 8g, Radix Gentianae Macrophyllae 5g, king do not stay 8g, Rhizoma Atractylodis 5g, Radix Saposhnikoviae 5g, Cortex Acanthopancis 8g, Radix Astragali 8g, Herba Asari 1g, Cortex Eucommiae 5g, Radix Angelicae Pubescentis 5g, Fructus Chaenomelis 8g; Lactose 9.8g, starch slurry 10g, low-substituted hydroxypropyl cellulose 5g, magnesium laurylsulfate 2g.
Method for making:
A) at first that ten Six-element Chinese medicines are clean, cutting and dry is weighed by described weight, and is standby;
B) will claim Zaocys, Semen Strychni (processed), Agkistrodon, Carapax Trionycis, big gun first, Wang Buliu, the Radix Astragali, Herba Asari, Radix Angelicae Pubescentis, the Fructus Chaenomelis decocting that adds 3 times of volumes boil 3 times, to water surplus be original 1/4, it is 40 minutes at every turn, filter and merging filtrate, be condensed into proportion and be 1.3 extractum, add 91% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry under 50 ℃, make extractum 1;
C) will claim Semen Coicis, Radix Gentianae Macrophyllae, Radix Saposhnikoviae, Rhizoma Atractylodis, Cortex Acanthopancis, the Cortex Eucommiae add 91% alcohol reflux 0.5h, described ethanol consumption is 4 times of Six-element Chinese medicine volume, obtain extracting solution and reclaim ethanol, 47 ℃ down dry, get dry extract 2;
D) merge extractum 1 and extractum 2, be ground into fine powder and mix homogeneously, namely make 9.8g Chinese medicine composition of the present invention
E) add lactose, starch slurry, low-substituted hydroxypropyl cellulose and the magnesium laurylsulfate of described weight in the 9.8g that the makes Chinese medicine composition of the present invention, the Chinese medicine composition of this invention is made electuary.
Embodiment 3 tablets
Prescription:
Zaocys 30g, Semen Strychni (processed) 10g, Agkistrodon 25g, Semen Coicis 20g, Carapax Trionycis 25g, big gun first 25g, Radix Gentianae Macrophyllae 18g, king do not stay 25g, Rhizoma Atractylodis 20g, Radix Saposhnikoviae 20g, Cortex Acanthopancis 25g, Radix Astragali 25g, Herba Asari 10g, Cortex Eucommiae 25g, Radix Angelicae Pubescentis 20g, Fructus Chaenomelis 25g; Mannitol 52.2g, corn starch 69.6g, alginic acid 34.8g, Polyethylene Glycol-600013.9g.
Method for making:
A) at first that ten Six-element Chinese medicines are clean, cutting and dry is weighed by described weight, and is standby;
B) will claim Zaocys, Semen Strychni (processed), Agkistrodon, Carapax Trionycis, big gun first, Wang Buliu, the Radix Astragali, Herba Asari, Radix Angelicae Pubescentis, the Fructus Chaenomelis decocting that adds 6 times of volumes boil 3 times, to water surplus be original 1/4, it is 70 minutes at every turn, filter and merging filtrate, be condensed into proportion and be 1.3 extractum, add 96% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry under 55 ℃, make extractum 1;
C) will claim Semen Coicis, Radix Gentianae Macrophyllae, Radix Saposhnikoviae, Rhizoma Atractylodis, Cortex Acanthopancis, the Cortex Eucommiae add 96% alcohol reflux 1.5h, described ethanol consumption is 7 times of Six-element Chinese medicine volume, obtain extracting solution and reclaim ethanol, 52 ℃ down dry, get dry extract 2;
D) merge extractum 1 and extractum 2, be ground into fine powder and mix homogeneously, namely make 34.8g Chinese medicine composition of the present invention
E) add mannitol, corn starch, alginic acid, the Polyethylene Glycol-6000 of described weight in the 34.8g that the makes Chinese medicine composition of the present invention, the Chinese medicine composition of this invention is made tablet.
Embodiment 4 pills
Prescription:
Zaocys 15g, Semen Strychni (processed) 4g, Agkistrodon 12g, Semen Coicis 8g, Carapax Trionycis 12g, big gun first 12g, Radix Gentianae Macrophyllae g, king do not stay 8g, Rhizoma Atractylodis 8g, Radix Saposhnikoviae 8g, Cortex Acanthopancis 12g, Radix Astragali 12g, Herba Asari 4g, Cortex Eucommiae 10g, Radix Angelicae Pubescentis 8g, Fructus Chaenomelis 12g; Dextrin 15.3g, corn starch 24.8g, polyvinylpolypyrrolidone 8.3g, Pulvis Talci 8.3g.
Method for making:
A) at first that ten Six-element Chinese medicines are clean, cutting and dry is weighed by described weight, and is standby;
B) will claim Zaocys, Semen Strychni (processed), Agkistrodon, Carapax Trionycis, big gun first, Wang Buliu, the Radix Astragali, Herba Asari, Radix Angelicae Pubescentis, the Fructus Chaenomelis decocting that adds 4 times of volumes boil 3 times, to water surplus be original 1/4, it is 50 minutes at every turn, filter and merging filtrate, be condensed into proportion and be 1.3 extractum, add 93% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry under 53 ℃, make extractum 1;
C) will claim Semen Coicis, Radix Gentianae Macrophyllae, Radix Saposhnikoviae, Rhizoma Atractylodis, Cortex Acanthopancis, the Cortex Eucommiae add 93% alcohol reflux 0.7h, described ethanol consumption is 5 times of Six-element Chinese medicine volume, obtain extracting solution and reclaim ethanol, 49 ℃ down dry, get dry extract 2;
D) merge extractum 1 and extractum 2, be ground into fine powder and mix homogeneously, namely make 15.3g Chinese medicine composition of the present invention
E) add dextrin, corn starch, polyvinylpolypyrrolidone, the Pulvis Talci of described weight in the 15.3g that the makes Chinese medicine composition of the present invention, the Chinese medicine composition of this invention is made pill.
Embodiment 5 capsules
Prescription:
Zaocys 25g, Semen Strychni (processed) 6g, Agkistrodon 20g, Semen Coicis 15g, Carapax Trionycis 20g, big gun first 20g, Radix Gentianae Macrophyllae 12g, king do not stay 25g, Rhizoma Atractylodis 15g, Radix Saposhnikoviae 15g, Cortex Acanthopancis 20g, Radix Astragali 20g, Herba Asari 6g, Cortex Eucommiae 20g, Radix Angelicae Pubescentis 15g, Fructus Chaenomelis 20g; Starch 13.7, dextrin slurry 13.7, sodium alginate 27.4, micropowder silica gel 5.5.
Method for making:
A) at first that ten Six-element Chinese medicines are clean, cutting and dry, ratio of component is weighed by weight, and is standby;
B) decocting that Zaocys, Semen Strychni (processed), Agkistrodon, Carapax Trionycis, big gun first, Wang Buliu, the Radix Astragali, Herba Asari, Radix Angelicae Pubescentis, the Fructus Chaenomelis of described components by weight percent ratio is added 5 times of volumes boils 3 times, to water surplus be original 1/4, it is 60 minutes at every turn, filter and merging filtrate, be condensed into proportion and be 1.3 extractum, add 95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry under 54 ℃, make extractum 1;
C) Semen Coicis, Radix Gentianae Macrophyllae, Radix Saposhnikoviae, Rhizoma Atractylodis, Cortex Acanthopancis, the Cortex Eucommiae with described components by weight percent ratio adds 95% alcohol reflux 1.2h, and described ethanol consumption is 6 times of Six-element Chinese medicine volume, obtains extracting solution and reclaims ethanol, and be dry under 51 ℃, gets dry extract 2;
D) merge extractum 1 and extractum 2, be ground into fine powder and mix homogeneously, namely make 27.4g Chinese medicine composition of the present invention
E) add starch, dextrin slurry, sodium alginate, the micropowder silica gel of described weight in the 27.4g that the makes Chinese medicine composition of the present invention, the Chinese medicine composition of this invention is made pill.
Claims (10)
1. Chinese medicine composition for the treatment of the waist cervical spondylosis, it is characterized in that the primary raw material weight portion for preparing described Chinese medicine composition consists of: Zaocys 10-30, Semen Strychni (processed) 1-10, Agkistrodon 8-25, Semen Coicis 5-20, Carapax Trionycis 8-25, big gun first 8-25, Radix Gentianae Macrophyllae 5-18, king do not stay 8-25.
2. the Chinese medicine composition for the treatment of waist cervical spondylosis according to claim 1, it is characterized in that the parts by weight of raw materials composition for preparing described Chinese medicine composition also comprises: Rhizoma Atractylodis 5-20, Radix Saposhnikoviae 5-20, Cortex Acanthopancis 8-25, Radix Astragali 8-25, Herba Asari 1-10, Cortex Eucommiae 5-25, Radix Angelicae Pubescentis 5-20, Fructus Chaenomelis 8-25.
3. the Chinese medicine composition for the treatment of waist cervical spondylosis according to claim 2, it is characterized in that the primary raw material weight portion for preparing described Chinese medicine composition consists of: Zaocys 15-25, Semen Strychni (processed) 4-6, Agkistrodon 12-20, Semen Coicis 8-15, Carapax Trionycis 12-20, big gun first 12-20, Radix Gentianae Macrophyllae 8-12, king do not stay 8-25, Rhizoma Atractylodis 8-15, Radix Saposhnikoviae 8-15, Cortex Acanthopancis 12-20, Radix Astragali 12-20, Herba Asari 4-6, Cortex Eucommiae 10-20, Radix Angelicae Pubescentis 8-15, Fructus Chaenomelis 12-20.
4. the Chinese medicine composition for the treatment of waist cervical spondylosis according to claim 2, it is characterized in that the primary raw material weight portion for preparing described Chinese medicine composition consists of: Zaocys 20, Semen Strychni (processed) 5, Agkistrodon 15, Semen Coicis 12, Carapax Trionycis 15, big gun first 15, Radix Gentianae Macrophyllae 10, king do not stay 15, Rhizoma Atractylodis 12, Radix Saposhnikoviae 12, Cortex Acanthopancis 15, the Radix Astragali 15, Herba Asari 5, the Cortex Eucommiae 14, Radix Angelicae Pubescentis 12, Fructus Chaenomelis 15.
5. according to the Chinese medicine composition of described each treatment waist cervical spondylosis of claim 1～4, it is characterized in that described Chinese medicine composition is made powder, and described powder comprises Chinese medicine composition and the adjuvant that following weight portion is formed:
6. according to the Chinese medicine composition of described each treatment waist cervical spondylosis of claim 1～4, it is characterized in that described Chinese medicine composition is made electuary, and described electuary comprises Chinese medicine composition and the adjuvant that following weight portion is formed:
7. according to the Chinese medicine composition of described each treatment waist cervical spondylosis of claim 1～4, it is characterized in that described Chinese medicine composition is made tablet, and described tablet comprises Chinese medicine composition and the adjuvant that following weight portion is formed:
8. according to the Chinese medicine composition of described each treatment waist cervical spondylosis of claim 1～4, it is characterized in that described Chinese medicine composition is made pill, and described pill comprises Chinese medicine composition and the adjuvant that following weight portion is formed:
9. according to the Chinese medicine composition of described each treatment waist cervical spondylosis of claim 1～4, it is characterized in that described Chinese medicine composition is made capsule, and described capsule comprises Chinese medicine composition and the adjuvant that following weight portion is formed:
10. treat the preparation method of the Chinese medicine composition of waist cervical spondylosis according to described each of claim 2～4, it is characterized in that described method comprises the steps:
A) at first that ten Six-element Chinese medicines are clean, cutting and dry, ratio of component is weighed by weight, and is standby;
B) decocting that Zaocys, Semen Strychni (processed), Agkistrodon, Carapax Trionycis, big gun first, Wang Buliu, the Radix Astragali, Herba Asari, Radix Angelicae Pubescentis, the Fructus Chaenomelis of described components by weight percent ratio is added 3～6 times of volumes boils 3 times, to water surplus be original 1/4, it is 40～70 minutes at every turn, filter and merging filtrate, be condensed into proportion and be 1.3 extractum, add 91%～96% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry under 50～55 ℃, make extractum 1;
C) Semen Coicis, Radix Gentianae Macrophyllae, Radix Saposhnikoviae, Rhizoma Atractylodis, Cortex Acanthopancis, the Cortex Eucommiae with described components by weight percent ratio adds alcohol reflux 0.5～1.5h of 91%～96%, described ethanol consumption is 4～7 times of Six-element Chinese medicine volume, obtain extracting solution and reclaim ethanol, dry under 47～52 ℃, get dry extract 2;
D) merge extractum 1 and extractum 2, be ground into fine powder and mix homogeneously, namely make Chinese medicine composition of the present invention.
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| CN201310292337.XA CN103341083B (en) | 2013-07-12 | 2013-07-12 | Traditional Chinese medicine composition for treating lumbar and cervical vertebra diseases and preparation method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1895642A (en) * | 2005-07-12 | 2007-01-17 | 侯保君 | Traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain and preparation method thereof |
| CN102247585A (en) * | 2010-05-20 | 2011-11-23 | 潘治宇 | Chinese medicinal composition for treating rheumatism, preparation thereof and preparation method thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1895642A (en) * | 2005-07-12 | 2007-01-17 | 侯保君 | Traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain and preparation method thereof |
| CN102247585A (en) * | 2010-05-20 | 2011-11-23 | 潘治宇 | Chinese medicinal composition for treating rheumatism, preparation thereof and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 李昭敏等: "颈椎病中药内治研究进展", 《中医药研究》, no. 5, 31 December 1994 (1994-12-31), pages 60 - 61 * |
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