CN103341083B - Traditional Chinese medicine composition for treating lumbar and cervical vertebra diseases and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating lumbar and cervical vertebra diseases and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating lumbar and cervical vertebra diseases, a preparation method and a use thereof. The traditional Chinese medicine composition is mainly prepared by the following raw materials in parts by weight: 10-30 parts of garter snake, 1-10 parts of processed Semen Strychni, 8-25 parts of long-noded pit viper, 5-20 parts of the seed of Job's tears, 8-25 parts of turtle shell, 8-25 parts of Pangolin Scales, 5-18 parts of large-leaved gentian, 8-25 parts of Cowherb Seed, 5-20 parts of rhizoma atractylodis, 5-20 parts of radices sileris, 8-25 parts of cortex acanthopanacis, 8-25 parts of Astragalus membranaceus, 1-10 parts of asarum, 5-25 parts of Eucommia ulmoides, 5-20 parts of radix angelicae pubescentis and 8-25 parts of Chaenomeles sinensis Koehne. The traditional Chinese medicine composition disclosed by the invention is free from irritation and toxic and side effects, high in safety, good in sameness prevention, quick effect, short in treatment cycle and low in recurrence rate, and can treat lumbar and cervical vertebra diseases by treating both manifestation and root cause of diseases. The traditional Chinese medicine composition is higher in cure rate and effective rate to lumbar and cervical vertebra diseases, and the cure rate is 97% and the effective rate is 100%.
Description
Technical field
The invention belongs to the field of Chinese medicines for the treatment of waist cervical spondylosis, particularly Chinese medicine composition of a kind of disease such as treatment prolapse of lumbar intervertebral disc, cervical spondylosis of preparing taking Chinese herbal medicine as raw material and preparation method thereof and purposes.
Technical background
Because occupation needs, a lot of people are long-term sitting, and therefore waist cervical spondylosis becomes a kind of disease occurred frequently, and refractory is healed, easily recurrence.The Chinese medicine for the treatment of waist cervical spondylosis has much at present, but the cost of material of medicine is higher, and treatment cycle is long, and relapse rate is high, can not effect a permanent cure.Chinese patent CN101455770A discloses a kind of with Radix Achyranthis Bidentatae, Eupolyphaga Seu Steleophaga, Herba Ephedrae, Rhizoma Atractylodis, Radix Angelicae Sinensis, the Radix Paeoniae Alba, the Radix Polygoni Multiflori, Fructus Lycii, Fang Fen, Cortex Acanthopancis, Folium Artemisiae Argyi, DUISHANYAO, Radix Codonopsis, the Radix Astragali, Rhizoma Smilacis Glabrae, Fructus Psoraleae, Semen Cuscutae, Flos Carthami, Pericarpium Citri Reticulatae, Herba Asari, Rhizoma Acori Graminei, Radix Aconiti Lateralis Preparata, Cortex Cinnamomi, Radix Glycyrrhizae, Gecko, Semen Strychni, Olibanum, Myrrha, three Ten Herbs such as Scorpio and Mel are the Chinese medicine pill of the treatment prolapse of lumbar intervertebral disc that makes of raw material, this Chinese medicine pill therapeutic effect is remarkable, but raw materials used kind is many, price, and do not relate to the research for the treatment of cycle and relapse rate.Chinese patent CN101185699A discloses a kind of with 10 grams of Radix Saposhnikoviaes, 15 grams of Carapax et Plastrum Testudiniss, 10 grams of Rhizoma Drynariae, 10 grams of Radix Angelicae Sinensis, 15 grams of the Cortexs Eucommiae, 15 grams of Cornu Cervi Degelatinatums, 10 grams, Radix Rehmanniae Preparata, 15 grams of Rhizoma Chuanxiongs, 15 grams of Radix Clematidis, the Chinese medicine decoction of the treatment cervical spondylosis that 3 grams of 15 grams of Eupolyphaga Seu Steleophagas, 15 grams of Caulis Spatholobis, Herba Asari make for raw material, instant effect, short treating period, expense are low, but are only applicable to the treatment of cervical spondylosis.
Summary of the invention
The Chinese medicine composition of the treatment waist cervical spondylosis that the object of this invention is to provide that a kind of degree of safety is high, concertedness good, treatment cycle is short, relapse rate is low, can treating both the principal and secondary aspects of a disease.
Another object of the present invention is to provide the preparation method of this Chinese medicine composition.
The Chinese medicine composition for the treatment of waist cervical spondylosis of the present invention, the primary raw material weight portion of preparing described Chinese medicine composition consists of: Zaocys 10-30, Semen Strychni (processed) 1-10, Agkistrodon 8-25, Semen Coicis 5-20, Carapax Trionycis 8-25, big gun first 8-25, Radix Gentianae Macrophyllae 5-18, king do not stay 8-25.
The Chinese medicine composition for the treatment of waist cervical spondylosis of the present invention, the parts by weight of raw materials composition of preparing described Chinese medicine composition also comprises: Rhizoma Atractylodis 5-20, Radix Saposhnikoviae 5-20, Cortex Acanthopancis 8-25, Radix Astragali 8-25, Herba Asari 1-10, Cortex Eucommiae 5-25, Radix Angelicae Pubescentis 5-20, Fructus Chaenomelis 8-25.
The Chinese medicine composition for the treatment of waist cervical spondylosis of the present invention, the primary raw material weight portion of preparing described Chinese medicine composition consists of: Zaocys 15-25, Semen Strychni (processed) 4-6, Agkistrodon 12-20, Semen Coicis 8-15, Carapax Trionycis 12-20, big gun first 12-20, Radix Gentianae Macrophyllae 8-12, king do not stay 8-25, Rhizoma Atractylodis 8-15, Radix Saposhnikoviae 8-15, Cortex Acanthopancis 12-20, Radix Astragali 12-20, Herba Asari 4-6, Cortex Eucommiae 10-20, Radix Angelicae Pubescentis 8-15, Fructus Chaenomelis 12-20.
The Chinese medicine composition for the treatment of waist cervical spondylosis of the present invention, the primary raw material weight portion of preparing described Chinese medicine composition consists of: Zaocys 20, Semen Strychni (processed) 5, Agkistrodon 15, Semen Coicis 12, Carapax Trionycis 15, big gun first 15, Radix Gentianae Macrophyllae 10, king do not stay 15, Rhizoma Atractylodis 12, Radix Saposhnikoviae 12, Cortex Acanthopancis 15, the Radix Astragali 15, Herba Asari 5, the Cortex Eucommiae 14, Radix Angelicae Pubescentis 12, Fructus Chaenomelis 15.
The Chinese medicine composition for the treatment of waist cervical spondylosis of the present invention, makes powder by described Chinese medicine composition, and described powder comprises Chinese medicine composition and the adjuvant of following weight portion composition:
The Chinese medicine composition for the treatment of waist cervical spondylosis of the present invention, makes electuary by described Chinese medicine composition, and described electuary comprises Chinese medicine composition and the adjuvant of following weight portion composition:
The Chinese medicine composition for the treatment of waist cervical spondylosis of the present invention, makes tablet by described Chinese medicine composition, and described tablet comprises Chinese medicine composition and the adjuvant of following weight portion composition:
The Chinese medicine composition for the treatment of waist cervical spondylosis of the present invention, makes pill by described Chinese medicine composition, and described pill comprises Chinese medicine composition and the adjuvant of following weight portion composition:
The Chinese medicine composition for the treatment of waist cervical spondylosis of the present invention, makes capsule by described Chinese medicine composition, and described capsule comprises Chinese medicine composition and the adjuvant of following weight portion composition:
The preparation method of the Chinese medicine composition for the treatment of waist cervical spondylosis of the present invention, comprises the steps:
A) first by clean ten Six-element Chinese medicines, cutting dry, ratio of component is weighed by weight, for subsequent use;
B) decocting that the Zaocys of described components by weight percent ratio, Semen Strychni (processed), Agkistrodon, Carapax Trionycis, big gun first, Wang Buliu, the Radix Astragali, Herba Asari, Radix Angelicae Pubescentis, Fructus Chaenomelis is added to 3～6 times of volumes boils 3 times, to water surplus be original 1/4, it is 40～70 minutes at every turn, filter and merging filtrate, be condensed into proportion and be 1.3 extractum, add 91%～96% ethanol and carry out precipitate with ethanol, reclaim ethanol concentrated, dry at 50～55 DEG C, make extractum 1;
C) Semen Coicis, Radix Gentianae Macrophyllae, Radix Saposhnikoviae, Rhizoma Atractylodis, Cortex Acanthopancis, the Cortex Eucommiae of described components by weight percent ratio are added to alcohol reflux 0.5～1.5h of 91%～96%, described ethanol consumption is 4～7 times of Six-element Chinese medicine volume, obtain extracting solution and reclaim ethanol, dry at 47～52 DEG C, obtain dry extract 2;
D) merge extractum 1 and extractum 2, be ground into fine powder mix homogeneously, make Chinese medicine composition of the present invention.
The Chinese medicine composition for the treatment of waist cervical spondylosis of the present invention, its pharmacological action is complicated and comprehensive, can adjust the allomeric function of human body.Semen Strychni is in prescription, to get the critical medicine of effect, its meridian dredging, and reducing swelling and alleviating pain, reaches the power in joint thoroughly, outclass in fact its medicine." surgery entirely raw collection " carries: " can search muscles and bones and enter the rheumatism of joint, the expectorant poison that the flesh side film of dispelling condenses outward." Compendium of Material Medica Li Shizhen (1518-1593 A.D.) introduction: " shape is like the therefore named Semen Strychni of company's money of horse, and 120 kinds of diseases controlled in that person's speech, and every disease has soup to draw ", point out Semen Strychni to there are very strong research and development and be worth.The Chinese medicine composition for the treatment of waist cervical spondylosis of the present invention, the principle of the mutual compatibility of utilization medicine, can effectively dispel the toxic and side effects of Semen Strychni, makes medication safe and reliable.Main pharmacological has dredge the meridian passage, promoting blood circulation and stopping pain, and vigorate qi and replenish the blood, expelling wind and cold, dehumidifying detumescence, relaxing muscles and tendons bone strengthening, the merit of strong nerve, its outstanding feature is at " a leading to " word.The Chinese medicine composition for the treatment of waist cervical spondylosis of the present invention is pure Chinese medicinal preparation, and it is main being conceived to effect a permanent cure, and long-term taking is without any side effects, and has the feature that late result is good.After sick good, be difficult for recurrence, truly have the merit of bone and muscle strengthening, the effect of replenishing kidney, strengthening waist, both dredge the meridian passage, again can promoting blood circulation and stopping pain; Both expelling wind and cold, the detumescence that can dehumidify again, has tonifying YANG to control the merit of flaccidity.Harmless to health fertility cerebral nerve, after taking medicine, obviously appetite strengthening, inspires enthusiasm.The Chinese medicine composition for the treatment of waist cervical spondylosis of the present invention also has good curative effect to diseases such as rheumatism, rheumatoid arthritis, sciatica, waist hyperosteogeny of cervical vertebra, ankylosing spondylitis, scapulohumeral periarthritis, Wei Ruan paralysed disease, gouts.
In the present invention, the source of primary raw material used is as follows:
Zaocys (Dioscorea opposita): Colubridae, Zaocys belong to animal.Sweet in the mouth, property is flat, nontoxic.Cure mainly that the raw leprosy of all wind of insensitive impediment, munbness, wind addiction pruritus, scabies, skin, eyebrow beard come off, deafness, scrofula caused by pathogenic wind disease, swollen and rigid tongue plug, pathogenic wind toxic gas, gallbladder give birth to nebula, lockjaw lip boil.
Semen Strychni (Semen Strychni): Loganiaceae, Poisonnut plant.Bitter in the mouth, cold in nature, poisonous.Excited stomach invigorating, detumescence poison, removing heat from blood.Cure mainly numb limbs and tense tendons, paralysis, inappetence, mass in the abdomen, carbuncle pyogenic infections from tumour or sore, laryngopharynx swelling and pain.Semen Strychni (processed): sand is processed, oil is processed, the general designation of water Semen Strychni (processed) is the dry mature seed of Semen Strychni.Promoting blood circulation to remove obstruction in the collateral, antiphlogistic antibacterial, pain relieving, expelling the stasis for the new.
Agkistrodon (Agkistrodonacutus (Gunther)): being dried of Viperidae animal point kiss Pallas pit viper (Agkistrodon) is all.Sweet in the mouth, salty, slightly warm in nature is poisonous.Dispel the wind, dredging collateral, relieving convulsion.For rheumatoid arthritis stubborn, numbness contracture, middle air port is askew, hemiplegia, tic spasm, tetanus, leprosy scabies, scrofula malignant boil.
Semen Coicis (Coix lacroyma-jobi L.var.ma-yuen (Roman.) Stapf): grass family, the super family of Semen Maydis, Coix plant.Sweet in the mouth, light, cold nature.Control cold syndrome of the stomach pain, deficient qi and blood.
Carapax Trionycis (Carapax Trionycis): salty in the mouth, cold in nature.Nourishing kidney YANG hyperactivity suppressing, hard masses softening and resolving.Cure mainly hard under hectic fever due to YIN-deficiency consumptive fever, malaria with splenomegaly, the side of body, lumbago, the diseases such as amenorrhea lump in the abdomen.
Big gun first (Pangolin Scales): the scute of Manidae animal Manitis.Salty in the mouth, cool in nature.The routed carbuncle of detumescence, searches wind active, the stimulating milk secretion of stimulating the menstrual flow.
Radix Gentianae Macrophyllae (G. macrophylla): Gentianaceae Gentiana dicotyledon.Acrid in the mouth, hardship, cold nature.Wind-damp dispelling, relaxing muscles and tendons network, clearind deficient heat.For rheumatic arthralgia, the contracture of muscle arteries and veins, joint is ached, afternoon fever, infantile malnutrition heating.
King does not stay (Semen Vaccariae): the dry mature seed of Caryophyllaceae Vaccaria plant Vaccaria segetalis.Bitter in the mouth, property is flat.Promoting blood circulation to restore menstrual flow, stimulating milk secretion detumescence.
Rhizoma Atractylodis (Rhizoma Atractylodis): the plant of Compositae, [WTBX.Acrid in the mouth, hardship, warm in nature.Cure mainly the transporting imbalance that the spleen being blocked by dampness causes, inappetence, vomiting is unhappy, and abdominal distention is had loose bowels, arthralgia.
Radix Saposhnikoviae (Radix Saposhnikoviae): the root of Umbelliferae herbaceos perennial Radix Saposhnikoviae.Acrid in the mouth, sweet, slightly warm in nature.Expelling pathogenic wind from the body surface, removing dampness to relieve pain, spasmolytic, antipruritic.Cure mainly that affection of exogenous wind-cold, headache general pain, rheumatic arthralgia, joint are ached, stomachache is had loose bowels, discharging fresh blood stool, tetanus, rubella pruritus, skin infection from the beginning of.
Cortex Acanthopancis (.Cortex Acan thopanacis Gracilistyli): Araliaceae, acanthopanax plant.Acrid in the mouth, hardship, warm in nature.Wind-damp dispelling; Invigorating the liver and kidney; Bone and muscle strengthening; The arteries and veins of invigorating blood circulation.For anemofrigid-damp arthralgia; Lumbocrural pain; Muscles and bones flaccidity is soft; Children's's walking retardation in children; Body void is frail; Traumatic injury; Fracture; Edema; Foot gas; Uncontrolled urination is itched.
The Radix Astragali (Leguminosae): pulse family, Astragalus.Radix Astragali sweet in the mouth, slightly warm in nature, returns liver, spleen, lung, kidney channel.Invigorating QI to consolidate the body surface resistance, diuretic detumescent, toxin expelling evacuation of pus, granulation promoting.
Herba Asari (Herba Asari): Aristolochiaceae, Asarum.Acrid in the mouth; Warm in nature; Mild toxicity.Dispel the wind, cold expelling, row water, has one's ideas straightened out.Cure mainly air-cooled headache, nasal sinusitis, toothache, phlegm retention cough with dyspnea, rheumatic arthralgia.
The Cortex Eucommiae (Eucommia ulmoides): the dry bark of Eucommiaceae Cortex Eucommiae platymiscium.Sweet in the mouth, micro-pungent, warm in nature.Invigorating the liver and kidney, bone and muscle strengthening, adjusting blood pressure.Cure mainly lumbago due to renal deficiency, fetal movement vaginal bleeding during pregnancy, hypertension.
Radix Angelicae Pubescentis (Radix Angelicae Biseratae): the dry root of Umbelliferae, heracleum hemsleyanum michaux plant Angelica pubescens.Acrid in the mouth, hardship, slightly warm in nature.Expelling wind and dampness; Dispersing cold for relieving pain.For anemofrigid-damp arthralgia; Lumbocrural pain; Few cloudy volt wind headache, headache toothache.
Fructus Chaenomelis (Chaenome lesspeciosa): Rosaceae, Chaenomeles shrub plant.Sour in the mouth, puckery, warm in nature, nontoxic.Help digestion, anthelmintic, heat clearing away, dispels the wind; Cure mainly stomachache, dyspepsia, lung-heat dry cough, galactostasis, eczema, parasitic disease, the diseases such as trick spasm pain.
Beneficial effect of the present invention is:
Adopt raw material mostly to be the pure plant that degree of safety is high, pure animal extracts, preparation Chinese medicine composition non-stimulated, have no side effect, degree of safety is high, concertedness good, instant effect, short treating period, can treating both the principal and secondary aspects of a disease, relapse rate is low, waist cervical spondylosis cure rate and effective percentage are higher, cure rate 97%, effective percentage 100%.
For this situation is described, now further illustrate effect of the present invention by test example as follows:
Test example 1 intervertebral disc prolapse:
Treatment group 30 examples, 20～55 years old age, average 36 years old, the course of disease 3～18 months.
Take mode: treatment group: the oral oral formulations being made by Chinese medicine composition of the present invention, respectively take once after the meal every day sooner or later half an hour, takes after mixing it with water with hydromel, takes continuously two courses for the treatment of, and be surrounding a course for the treatment of.Matched group: oral YAOTONGNING JIAONANG (composition: Semen Strychni Pulveratum, Eupolyphaga Seu Steleophaga, Herba Ephedrae, Olibanum, Myrrha, Radix Cyathulae, Scorpio, Bombyx Batryticatus, Rhizoma Atractylodis, Radix Glycyrrhizae), sooner or later respectively once, take continuously two courses for the treatment of every day, and be eight weeks a course for the treatment of.
Observation index: before and after observing treatment, which disease has change, symptom after treatment, sign disappears or alleviates; X-ray plain film shows that intervertebral space recovers normal, and it is normal that spinal column recovers; CT examination shows that former diseased region recovers normal; MRI checks that the recovery of lesions showed position is normal.
Curative effect determinate standard: the variation which aspect and which degree have occurred before and after treatment just belongs to recovery from illness, effective, improvement; Clinical recovery: intervertebral space recovers normal, it is normal that spinal column recovers, and it is normal that former diseased region recovers; Effective: the symptom of narrowing of intervertebral space has larger recovery, skoliosis symptom also has larger recovery; Effective: the symptom of narrowing of intervertebral space is recovered to some extent, skoliosis symptom is also recovered to some extent; Invalid: intervertebral space is narrow, skoliosis.
Result of the test is as follows:
Efficacy evaluation: in the clinical trial of intervertebral disk hernia, it is 29 examples, effective person 30 examples, improvement person's 30 examples, nonresponder's 0 example, obvious effective rate 100%, cure rate 97% that treatment group is taken the oral formulations healing person who is made by Chinese medicine composition of the present invention; And matched group to take YAOTONGNING JIAONANG healing person be 15 examples, effective person 26 examples, improvement person's 28 examples, nonresponder's 2 examples, obvious effective rate 87%, cure rate 50%.The effect for the treatment of group and matched group relatively shows, treated effect and the cure rate of the oral formulations being made by Chinese medicine composition of the present invention to intervertebral disk hernia is higher, and cure rate reaches 97%, and treatment cycle is short.The patient who fully recovers in treatment group is paid a return visit, find in 3 years without recidivist.
Test example 2 cervical spondylosiss:
Treatment group 30 examples, 25～60 years old age, average 39 years old, the course of disease 3～18 months.
Take mode: treatment group: the oral oral formulations being made by Chinese medicine composition of the present invention, respectively take once after the meal every day sooner or later half an hour, takes after mixing it with water with hydromel, takes continuously two courses for the treatment of, and be surrounding a course for the treatment of.Matched group: oral 'Gu Jin Wan ' capsule (composition: Olibanum, Myrrha, the Radix Paeoniae Alba, Rhizoma Corydalis (vinegar system), Radix Notoginseng, the Radix Aucklandiae, Flos Carthami, Radix Curcumae, Radix Angelicae Pubescentis, Radix Achyranthis Bidentatae, Radix Gentianae Macrophyllae, Ramulus Cinnamomi, Sanguis Draxonis, Semen Strychni (system)), every day sooner or later respectively once, take continuously three courses for the treatment of, be surrounding a course for the treatment of.
Observation index: before and after examining treatment, which disease has change, symptom after treatment, sign disappears or alleviates;
Cervical X-ray sheet: cervical vertebra normal physiological curvature disappears or anti-sheet, stenosis of disc space, spinal canal stenosis, poerior aspect of vertebral body forms, and extends through and bends that can also to observe cervical vertebra segmental on bit slice unstable in the mistake of cervical vertebra.
Cervical vertebra CT: the hypertrophy calcification of cervical vertebra.
Cervical vertebra MRI: intervertebral disc protrusion of cervical vertebra compressing spinal cord.
Curative effect determinate standard: the variation which aspect and which degree have occurred before and after treatment just belongs to recovery from illness, effective, improvement; Clinical recovery: cervical curvature is normal, intervertebral space, canalis spinalis are normal, and poerior aspect of vertebral body disappears, and cervical vertebra is stable, cervical vertebra calcification, outstanding disappearance; Effective: cervical curvature recovers to some extent, intervertebral space, spinal canal stenosis alleviate to some extent, and poerior aspect of vertebral body disappears substantially, and cervical vertebra is basicly stable, and cervical vertebra calcification takes a turn for the better to some extent, outstanding basic disappearance; Effective: cervical curvature slightly recovers, intervertebral space, spinal canal stenosis have the tendency of alleviating, and poerior aspect of vertebral body has disappearance trend, and cervical vertebra is unstable, and cervical vertebra calcification takes a turn for the better to some extent; Invalid: cervical vertebra normal physiological curvature disappears or anti-sheet, stenosis of disc space, spinal canal stenosis, poerior aspect of vertebral body, cervical vertebra is unstable, hyperosteogeny calcification, intervertebral disc protrusion of cervical vertebra compressing spinal cord.
Result of the test is as follows:
Efficacy evaluation: in the clinical trial of cervical spondylosis, it is 29 examples, effective person 30 examples, improvement person's 30 examples, nonresponder's 0 example, obvious effective rate 97%, cure rate 90% that treatment group is taken the oral formulations healing person who is made by Chinese medicine composition of the present invention, and matched group to take 'Gu Jin Wan ' capsule healing person be 20 examples, effective person 26 examples, improvement person's 29 examples, nonresponder's 1 example, obvious effective rate 87%, cure rate 67%.The effect for the treatment of group and matched group relatively shows, treated effect and the cure rate of the oral formulations being made by Chinese medicine composition of the present invention to cervical spondylosis is higher, and cure rate reaches 97%, and treatment cycle is short.The patient who fully recovers in treatment group is paid a return visit, find in 3 years without recidivist.
Model case 1:
Lee, man, 50 years old.Main suit: buttocks distending pain 2 years, numb distending pain 1 year, walk 200 meters and occurs limpings outside lumbosacral region companion shank, and aggravation before 1 month, can not independently leave the bed, and pain is hard to bear.By medical to my institute.Have a medical check-up: vital sign is steady, sanity, the cooperation of having a medical check-up, lumbar vertebra CT shows L4/5 intervertebral disc outstanding about 0.78cm backward, dural sac and root compression, around little joint hyperplasia; Waist mobility is seriously limited, tenderness between L4/5/S1 sour jujube, and straight-leg raising test L65 ° of (-) R18 ° (+), waist side bend test (+), Achilles tendon reflex L (+) R (-), lower-limb muscular strength obviously declines.Treatment: by taking the oral formulations being made by the Chinese medicine composition for the treatment of waist cervical spondylosis of the present invention the course for the treatment of, instructions of taking for early, after dinner half an hour respectively take 1 dose, take after mixing it with water with hydromel, within 4 weeks, be 1 course for the treatment of.Treat after 1 course for the treatment of, the former pain malaise symptoms of patient disappears substantially, walking normal, and CT examination shows that the symptom of narrowing of intervertebral space has larger recovery, skoliosis reduces; Treat after 2 courses for the treatment of, the former pain malaise symptoms of patient disappears, and walking is normal, and it is normal that intervertebral space recovers, and outstanding position disappears, and it is normal that spinal column recovers, and it is normal that former diseased region recovers.Within 3 years, pay a return visit afterwards, patient's recovery situation is good, without recurrence.
Model case 2:
Zhang, female, 32 years old.Main suit: neck and shoulder part pain companion right upper extremity numb pain 1 year, take during this time other drug treatment, there is alleviation, but easily recur, before 5 days, increased the weight of, neck and shoulder pain and right upper extremity fiber crops pain increase the weight of, numbness of the fingers.By medical to my institute.Have a medical check-up: vital sign is steady, sanity, the cooperation of having a medical check-up, CT shows C5-6 intervertebral disk hernia 0.65cm; The muscle spasm of neck shoulder, sour jujube ligament anxiety, tenderness (+), the other tenderness of C5-6 vertebra (+), intervertebral foramina squeeze test (+), brachial plexus nerve distraction test (+), RHG weakens.Treatment: by taking the oral formulations being made by the Chinese medicine composition for the treatment of waist cervical spondylosis of the present invention the course for the treatment of, instructions of taking for early, after dinner half an hour respectively take 1 dose, take after mixing it with water with hydromel, within 4 weeks, be 1 course for the treatment of.Treat after 1 course for the treatment of, the former malaise symptoms of patient disappears substantially, finger normal, and CT examination shows that the symptom of narrowing of intervertebral space has larger recovery, skoliosis reduces; Treat after 2 courses for the treatment of, the former pain malaise symptoms of patient disappears, and it is normal that intervertebral space recovers, and outstanding position disappears, and it is normal that spinal column recovers, and finger recovers flexibly.Within 3 years, pay a return visit afterwards, patient's recovery situation is good, without recurrence.
Model case 3:
Liu, female, 38 years old.Main suit: the cervical region companion that aches is revolved obstacle 1 year after right limb, increases the weight of hurt like hell, upper limb numbness before 1 month.By medical to my institute.Have a medical check-up: vital sign is steady, sanity, the cooperation of having a medical check-up, cervical X-ray sheet shows that cervical vertebra normal physiological curvature disappears, stenosis of disc space, vertebral body trailing edge has hyperosteogeny to form; Cervical vertebra CT shows cervical vertebra degeneration, cervical vertebra 4/5, cervical vertebra 5/6 annuler bulge; Cervical vertebra MRI shows intervertebral disc protrusion of cervical vertebra compressing spinal cord; Cervical region tenderness (+), the other tenderness of C5-6 vertebra (+), distraction test (±), pressure measurement by compression of neck (±).Treatment: by taking the oral formulations being made by the Chinese medicine composition for the treatment of waist cervical spondylosis of the present invention the course for the treatment of, instructions of taking for early, after dinner half an hour respectively take 1 dose, take after mixing it with water with hydromel, within 4 weeks, be 1 course for the treatment of.Treat after 1 course for the treatment of, the former malaise symptoms of patient disappears substantially, and upper limb numbness disappears substantially, cervical curvature recovers to some extent, and intervertebral space, spinal canal stenosis alleviate to some extent, and poerior aspect of vertebral body disappears substantially, cervical vertebra is basicly stable, and cervical vertebra calcification takes a turn for the better to some extent, outstanding basic disappearance; Treat after 2 courses for the treatment of, the former pain malaise symptoms of patient disappears, upper limb numbness disappears, and cervical curvature is normal, and intervertebral space, canalis spinalis are normal, and poerior aspect of vertebral body disappears, and cervical vertebra is stable, cervical vertebra calcification, outstanding disappearance.Within 3 years, pay a return visit afterwards, patient's recovery situation is good, without recurrence.
Model case 4:
Cui, man, 49 years old.Main suit: neck portion pain 1 year, before February, there are the two upper limb numbness of the pain companion of neck portion without obvious inducement, certainly take the pain relief of blood-activating analgesic collare napex, two upper limb numbness improve not obvious, after drug withdrawal, recur.By just precious to my institute.Have a medical check-up: vital sign is steady, sanity, the cooperation of having a medical check-up, c spine ap & lat sheet shows cervical vertebra degenerative change; Cervical vertebra MRI shows that C6-7 intervertebral disc is slightly outstanding; Cervical curvature straightens, musculi colli is stiff, cervical vertebra moving is slightly limited, tenderness (+) between neck 3-neck 5 sour jujubes, bilateral intervertebral foramina squeeze test (-), kowtow top test (-), brachial plexus distraction test left side (+), right side (+), revolve neck test (±).Treatment: by taking the oral formulations being made by the Chinese medicine composition for the treatment of waist cervical spondylosis of the present invention the course for the treatment of, instructions of taking for early, after dinner half an hour respectively take 1 dose, take after mixing it with water with hydromel, within 4 weeks, be 1 course for the treatment of.Treat after 1 course for the treatment of, the former malaise symptoms of patient disappears substantially, and upper limb numbness disappears substantially, cervical curvature recovers to some extent, and intervertebral space, spinal canal stenosis alleviate to some extent, and poerior aspect of vertebral body disappears substantially, cervical vertebra is basicly stable, and cervical vertebra calcification takes a turn for the better to some extent, outstanding basic disappearance; Treat after 2 courses for the treatment of, the former pain malaise symptoms of patient disappears, upper limb numbness disappears, and cervical curvature is normal, and intervertebral space, canalis spinalis are normal, and poerior aspect of vertebral body disappears, and cervical vertebra is stable, cervical vertebra calcification, outstanding disappearance.Within 3 years, pay a return visit afterwards, patient's recovery situation is good, without recurrence.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described:
Embodiment 1 powder
Prescription:
Zaocys 20g, Semen Strychni (processed) 5g, Agkistrodon 15g, Semen Coicis 12g, Carapax Trionycis 15g, big gun first 15g, Radix Gentianae Macrophyllae 10g, king do not stay 15g, Rhizoma Atractylodis 12g, Radix Saposhnikoviae 12g, Cortex Acanthopancis 15g, Radix Astragali 15g, Herba Asari 5g, Cortex Eucommiae 14g, Radix Angelicae Pubescentis 12g, Fructus Chaenomelis 15g; Lactose 20.7g, microcrystalline Cellulose 8.3g, carboxymethyl starch sodium 12.4g, PEG-4000 4.1g.
Method for making:
A) first by clean ten Six-element Chinese medicines, cutting dry, weigh by described weight, for subsequent use;
B) by claim Zaocys, Semen Strychni (processed), Agkistrodon, Carapax Trionycis, big gun first, Wang Buliu, the Radix Astragali, Herba Asari, Radix Angelicae Pubescentis, the Fructus Chaenomelis decocting that adds 5 times of volumes boil 3 times, to water surplus be original 1/4, it is 55 minutes at every turn, filter and merging filtrate, be condensed into proportion and be 1.3 extractum, add 93% ethanol and carry out precipitate with ethanol, reclaim ethanol concentrated, dry at 53 DEG C, make extractum 1;
C) by claim Semen Coicis, Radix Gentianae Macrophyllae, Radix Saposhnikoviae, Rhizoma Atractylodis, Cortex Acanthopancis, the Cortex Eucommiae add 94% alcohol reflux 1h, described ethanol consumption is 5 times of Six-element Chinese medicine volume, obtains extracting solution and reclaims ethanol, dry at 50 DEG C, obtains dry extract 2;
D) merge extractum 1 and extractum 2, be ground into fine powder mix homogeneously, make 20.7g Chinese medicine composition of the present invention.
E) to the lactose, microcrystalline Cellulose, carboxymethyl starch sodium and the PEG-4000 that add described weight in the 20.7g making Chinese medicine composition of the present invention, the Chinese medicine composition of this invention is made to powder.
Embodiment 2 electuaries
Prescription:
Zaocys 10g, Semen Strychni (processed) 1g, Agkistrodon 8g, Semen Coicis 5g, Carapax Trionycis 8g, big gun first 8g, Radix Gentianae Macrophyllae 5g, king do not stay 8g, Rhizoma Atractylodis 5g, Radix Saposhnikoviae 5g, Cortex Acanthopancis 8g, Radix Astragali 8g, Herba Asari 1g, Cortex Eucommiae 5g, Radix Angelicae Pubescentis 5g, Fructus Chaenomelis 8g; Lactose 9.8g, starch slurry 10g, low-substituted hydroxypropyl cellulose 5g, magnesium laurylsulfate 2g.
Method for making:
A) first by clean ten Six-element Chinese medicines, cutting dry, weigh by described weight, for subsequent use;
B) by claim Zaocys, Semen Strychni (processed), Agkistrodon, Carapax Trionycis, big gun first, Wang Buliu, the Radix Astragali, Herba Asari, Radix Angelicae Pubescentis, the Fructus Chaenomelis decocting that adds 3 times of volumes boil 3 times, to water surplus be original 1/4, it is 40 minutes at every turn, filter and merging filtrate, be condensed into proportion and be 1.3 extractum, add 91% ethanol and carry out precipitate with ethanol, reclaim ethanol concentrated, dry at 50 DEG C, make extractum 1;
C) by claim Semen Coicis, Radix Gentianae Macrophyllae, Radix Saposhnikoviae, Rhizoma Atractylodis, Cortex Acanthopancis, the Cortex Eucommiae add 91% alcohol reflux 0.5h, described ethanol consumption is 4 times of Six-element Chinese medicine volume, obtains extracting solution and reclaims ethanol, dry at 47 DEG C, obtains dry extract 2;
D) merge extractum 1 and extractum 2, be ground into fine powder mix homogeneously, make 9.8g Chinese medicine composition of the present invention
E) to the lactose, starch slurry, low-substituted hydroxypropyl cellulose and the magnesium laurylsulfate that add described weight in the 9.8g making Chinese medicine composition of the present invention, the Chinese medicine composition of this invention is made to electuary.
Embodiment 3 tablets
Prescription:
Zaocys 30g, Semen Strychni (processed) 10g, Agkistrodon 25g, Semen Coicis 20g, Carapax Trionycis 25g, big gun first 25g, Radix Gentianae Macrophyllae 18g, king do not stay 25g, Rhizoma Atractylodis 20g, Radix Saposhnikoviae 20g, Cortex Acanthopancis 25g, Radix Astragali 25g, Herba Asari 10g, Cortex Eucommiae 25g, Radix Angelicae Pubescentis 20g, Fructus Chaenomelis 25g; Mannitol 52.2g, corn starch 69.6g, alginic acid 34.8g, PEG-4000 13.9g.
Method for making:
A) first by clean ten Six-element Chinese medicines, cutting dry, weigh by described weight, for subsequent use;
B) by claim Zaocys, Semen Strychni (processed), Agkistrodon, Carapax Trionycis, big gun first, Wang Buliu, the Radix Astragali, Herba Asari, Radix Angelicae Pubescentis, the Fructus Chaenomelis decocting that adds 6 times of volumes boil 3 times, to water surplus be original 1/4, it is 70 minutes at every turn, filter and merging filtrate, be condensed into proportion and be 1.3 extractum, add 96% ethanol and carry out precipitate with ethanol, reclaim ethanol concentrated, dry at 55 DEG C, make extractum 1;
C) by claim Semen Coicis, Radix Gentianae Macrophyllae, Radix Saposhnikoviae, Rhizoma Atractylodis, Cortex Acanthopancis, the Cortex Eucommiae add 96% alcohol reflux 1.5h, described ethanol consumption is 7 times of Six-element Chinese medicine volume, obtains extracting solution and reclaims ethanol, dry at 52 DEG C, obtains dry extract 2;
D) merge extractum 1 and extractum 2, be ground into fine powder mix homogeneously, make 34.8g Chinese medicine composition of the present invention
E) to the mannitol, corn starch, alginic acid, the PEG-4000 that add described weight in the 34.8g making Chinese medicine composition of the present invention, the Chinese medicine composition of this invention is made to tablet.
Embodiment 4 pills
Prescription:
Zaocys 15g, Semen Strychni (processed) 4g, Agkistrodon 12g, Semen Coicis 8g, Carapax Trionycis 12g, big gun first 12g, Radix Gentianae Macrophyllae g, king do not stay 8g, Rhizoma Atractylodis 8g, Radix Saposhnikoviae 8g, Cortex Acanthopancis 12g, Radix Astragali 12g, Herba Asari 4g, Cortex Eucommiae 10g, Radix Angelicae Pubescentis 8g, Fructus Chaenomelis 12g; Dextrin 15.3g, corn starch 24.8g, polyvinylpolypyrrolidone 8.3g, Pulvis Talci 8.3g.
Method for making:
A) first by clean ten Six-element Chinese medicines, cutting dry, weigh by described weight, for subsequent use;
B) by claim Zaocys, Semen Strychni (processed), Agkistrodon, Carapax Trionycis, big gun first, Wang Buliu, the Radix Astragali, Herba Asari, Radix Angelicae Pubescentis, the Fructus Chaenomelis decocting that adds 4 times of volumes boil 3 times, to water surplus be original 1/4, it is 50 minutes at every turn, filter and merging filtrate, be condensed into proportion and be 1.3 extractum, add 93% ethanol and carry out precipitate with ethanol, reclaim ethanol concentrated, dry at 53 DEG C, make extractum 1;
C) by claim Semen Coicis, Radix Gentianae Macrophyllae, Radix Saposhnikoviae, Rhizoma Atractylodis, Cortex Acanthopancis, the Cortex Eucommiae add 93% alcohol reflux 0.7h, described ethanol consumption is 5 times of Six-element Chinese medicine volume, obtains extracting solution and reclaims ethanol, dry at 49 DEG C, obtains dry extract 2;
D) merge extractum 1 and extractum 2, be ground into fine powder mix homogeneously, make 15.3g Chinese medicine composition of the present invention
E) to the dextrin, corn starch, polyvinylpolypyrrolidone, the Pulvis Talci that add described weight in the 15.3g making Chinese medicine composition of the present invention, the Chinese medicine composition of this invention is made to pill.
Embodiment 5 capsules
Prescription:
Zaocys 25g, Semen Strychni (processed) 6g, Agkistrodon 20g, Semen Coicis 15g, Carapax Trionycis 20g, big gun first 20g, Radix Gentianae Macrophyllae 12g, king do not stay 25g, Rhizoma Atractylodis 15g, Radix Saposhnikoviae 15g, Cortex Acanthopancis 20g, Radix Astragali 20g, Herba Asari 6g, Cortex Eucommiae 20g, Radix Angelicae Pubescentis 15g, Fructus Chaenomelis 20g; Starch 13.7, dextrin slurry 13.7, sodium alginate 27.4, micropowder silica gel 5.5.
Method for making:
A) first by clean ten Six-element Chinese medicines, cutting dry, ratio of component is weighed by weight, for subsequent use;
B) decocting that the Zaocys of described components by weight percent ratio, Semen Strychni (processed), Agkistrodon, Carapax Trionycis, big gun first, Wang Buliu, the Radix Astragali, Herba Asari, Radix Angelicae Pubescentis, Fructus Chaenomelis is added to 5 times of volumes boils 3 times, to water surplus be original 1/4, it is 60 minutes at every turn, filter and merging filtrate, be condensed into proportion and be 1.3 extractum, add 95% ethanol and carry out precipitate with ethanol, reclaim ethanol concentrated, dry at 54 DEG C, make extractum 1;
C) Semen Coicis, Radix Gentianae Macrophyllae, Radix Saposhnikoviae, Rhizoma Atractylodis, Cortex Acanthopancis, the Cortex Eucommiae of described components by weight percent ratio are added to 95% alcohol reflux 1.2h, described ethanol consumption is 6 times of Six-element Chinese medicine volume, obtains extracting solution and reclaims ethanol, dry at 51 DEG C, obtains dry extract 2;
D) merge extractum 1 and extractum 2, be ground into fine powder mix homogeneously, make 27.4g Chinese medicine composition of the present invention
E) to the starch, dextrin slurry, sodium alginate, the micropowder silica gel that add described weight in the 27.4g making Chinese medicine composition of the present invention, the Chinese medicine composition of this invention is made to pill.
Claims (9)
1. treat the Chinese medicine composition of waist cervical spondylosis for one kind, it is characterized in that, described Chinese medicine composition is prepared from through processing by the raw material of following weight portion: Zaocys 10-30, Semen Strychni (processed) 1-10, Agkistrodon 8-25, Semen Coicis 5-20, Carapax Trionycis 8-25, big gun first 8-25, Radix Gentianae Macrophyllae 5-18, king do not stay 8-25, Rhizoma Atractylodis 5-20, Radix Saposhnikoviae 5-20, Cortex Acanthopancis 8-25, Radix Astragali 8-25, Herba Asari 1-10, Cortex Eucommiae 5-25, Radix Angelicae Pubescentis 5-20, Fructus Chaenomelis 8-25.
2. the Chinese medicine composition for the treatment of waist cervical spondylosis according to claim 1, it is characterized in that, described Chinese medicine composition is prepared from through processing by the raw material of following weight portion: Zaocys 15-25, Semen Strychni (processed) 4-6, Agkistrodon 12-20, Semen Coicis 8-15, Carapax Trionycis 12-20, big gun first 12-20, Radix Gentianae Macrophyllae 8-12, king do not stay 8-25, Rhizoma Atractylodis 8-15, Radix Saposhnikoviae 8-15, Cortex Acanthopancis 12-20, Radix Astragali 12-20, Herba Asari 4-6, Cortex Eucommiae 10-20, Radix Angelicae Pubescentis 8-15, Fructus Chaenomelis 12-20.
3. the Chinese medicine composition for the treatment of waist cervical spondylosis according to claim 1, it is characterized in that, described Chinese medicine composition is prepared from through processing by the raw material of following weight portion: Zaocys 20, Semen Strychni (processed) 5, Agkistrodon 15, Semen Coicis 12, Carapax Trionycis 15, big gun first 15, Radix Gentianae Macrophyllae 10, king do not stay 15, Rhizoma Atractylodis 12, Radix Saposhnikoviae 12, Cortex Acanthopancis 15, the Radix Astragali 15, Herba Asari 5, the Cortex Eucommiae 14, Radix Angelicae Pubescentis 12, Fructus Chaenomelis 15.
4. the powder being made by the Chinese medicine composition of the treatment waist cervical spondylosis described in claim 1～3 any one, is characterized in that, described powder comprises Chinese medicine composition and the adjuvant of following weight portion composition:
5. the electuary being made by the Chinese medicine composition of the treatment waist cervical spondylosis described in claim 1～3 any one, is characterized in that, described electuary comprises Chinese medicine composition and the adjuvant of following weight portion composition:
6. the tablet being made by the Chinese medicine composition of the treatment waist cervical spondylosis described in claim 1～3 any one, is characterized in that, described tablet comprises Chinese medicine composition and the adjuvant of following weight portion composition:
7. the pill being made by the Chinese medicine composition of the treatment waist cervical spondylosis described in claim 1～3 any one, is characterized in that, described pill comprises Chinese medicine composition and the adjuvant of following weight portion composition:
8. the capsule being made by the Chinese medicine composition of the treatment waist cervical spondylosis described in claim 1～3 any one, is characterized in that, described capsule comprises Chinese medicine composition and the adjuvant of following weight portion composition:
9. according to the preparation method of the Chinese medicine composition of any one treatment waist cervical spondylosis described in claim 1～3, it is characterized in that, described method comprises the steps:
A) first by clean ten Six-element Chinese medicines, cutting dry, ratio of component is weighed by weight, for subsequent use;
B) decocting that the Zaocys of described components by weight percent ratio, Semen Strychni (processed), Agkistrodon, Carapax Trionycis, big gun first, Wang Buliu, the Radix Astragali, Herba Asari, Radix Angelicae Pubescentis, Fructus Chaenomelis is added to 3～6 times of volumes boils 3 times, to water surplus be original 1/4, it is 40～70 minutes at every turn, filter and merging filtrate, be condensed into proportion and be 1.3 extractum, add 91%～96% ethanol and carry out precipitate with ethanol, reclaim ethanol concentrated, dry at 50～55 DEG C, make extractum 1;
C) Semen Coicis, Radix Gentianae Macrophyllae, Radix Saposhnikoviae, Rhizoma Atractylodis, Cortex Acanthopancis, the Cortex Eucommiae of described components by weight percent ratio are added to alcohol reflux 0.5～1.5h of 91%～96%, described ethanol consumption is 4～7 times of Six-element Chinese medicine volume, obtain extracting solution and reclaim ethanol, dry at 47～52 DEG C, obtain dry extract 2;
D) merge extractum 1 and extractum 2, be ground into fine powder mix homogeneously, make Chinese medicine composition.
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| CN201310292337.XA CN103341083B (en) | 2013-07-12 | 2013-07-12 | Traditional Chinese medicine composition for treating lumbar and cervical vertebra diseases and preparation method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1895642A (en) * | 2005-07-12 | 2007-01-17 | 侯保君 | Traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain and preparation method thereof |
| CN102247585A (en) * | 2010-05-20 | 2011-11-23 | 潘治宇 | Chinese medicinal composition for treating rheumatism, preparation thereof and preparation method thereof |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1895642A (en) * | 2005-07-12 | 2007-01-17 | 侯保君 | Traditional Chinese medicine composition for treating neck, shoulder, waist and leg pain and preparation method thereof |
| CN102247585A (en) * | 2010-05-20 | 2011-11-23 | 潘治宇 | Chinese medicinal composition for treating rheumatism, preparation thereof and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 颈椎病中药内治研究进展;李昭敏等;《中医药研究》;19941231(第5期);60-61 * |
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