CN103341011A - Chinese medicine composite capable of improving immunity - Google Patents
Chinese medicine composite capable of improving immunity Download PDFInfo
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- CN103341011A CN103341011A CN2013102814090A CN201310281409A CN103341011A CN 103341011 A CN103341011 A CN 103341011A CN 2013102814090 A CN2013102814090 A CN 2013102814090A CN 201310281409 A CN201310281409 A CN 201310281409A CN 103341011 A CN103341011 A CN 103341011A
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Abstract
The invention discloses a Chinese medicine composite capable of improving immunity. The composite comprises the following components: 30-60% of barbary wolfberry fruit, 10-50% of white atractylodes rhizome, 10-50% of Chinese yam, 10-40% of liquorice and 10-40% of medicated leaven. The composite can be prepared into medicines in the forms of powder, liquid, paste, particles or capsules or a pharmaceutically acceptable physical form. According to the Chinese medicine composite disclosed by the invention, the survive rate can reach 70%, the immunity is effectively improved, and specific to the immune organ indexes, the spleen index is improved by 23.2 percent, the thymus index is improved by 32.4%, and the index of bursa of Fabricius is improved by 41.2%; and especially, in terms of the contents of serum globulins, the content of IgA (immunoglobulin A) is improved by 20.7%, and the content of IgY (immunoglobulin Y) is improved by 23.4%, so that the composite disclosed by the invention can obviously promote specific immunity.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition that improves immunologic function, belong to the veterinary drug preparation field.
Background technology
No matter be " fast live chickens " event or " waterborne float pig " event, all reflect the difficult problem that current obstruction animal husbandry develops in a healthy way, hypoimmunity is the key issue that causes the veterinary disease infringement, it not only causes culture benefit to glide, and also causes entire society to face the danger that the meat product residue of veterinary drug exceeds standard.Therefore, be badly in need of a kind ofly can either improving the beasts immunologic function, can realize the preparation of the immunopotentiation of noresidue again.
Summary of the invention
The present invention provides a kind of Chinese medicine composition that improves immunologic function in order to overcome the above-mentioned shortcoming that exists in the prior art.
For achieving the above object, the technology used in the present invention solution is: a kind of Chinese medicine composition that improves immunologic function comprises Fructus Lycii 30%～60%, the Rhizoma Atractylodis Macrocephalae 10%～50%, Rhizoma Dioscoreae 10%～50%, Radix Glycyrrhizae 10%～40%, Massa Medicata Fermentata 10%～40%; Said composition can be prepared into medicine or pharmaceutically acceptable physical aspects such as powder, liquid, paste, granule or capsule.
Using method and the use amount of above-mentioned composition are: pulverize, press 0.1～10.0% of complete feed weight behind the mix homogeneously and mix use; Or said composition extracted make extracting solution, add water 20kg～2000kg by 1 liter of extracting solution and freely drink for the chicken group.
Further, the form of described composition component is Chinese crude drug or decoction pieces or through one or more of the powder of pulverizing or pressing process deforms, agglomerate.
Further, the method that extracting solution is made in described extraction is: the form that Fructus Lycii, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Radix Glycyrrhizae adopt high-temperature water to decoct is extracted-is concentrated, and filters, and gets its supernatant and is cooled to below 45 ℃ temporary; Massa Medicata Fermentata adopts cold-maceration to extract, and the water management that namely adds in Massa Medicata Fermentata is put below 45 ℃ and kept in extracting, filter, get its supernatant below 45 ℃; Merge above two kinds of supernatant, sterile filling namely.
Further, described high temperature water boiling and extraction-concentrate twice behind the merging extracted twice liquid, is filtered.
Further, in the leaching process of described Massa Medicata Fermentata, use ultrasound wave or microwave-assisted to extract.
Operation principle: in five elements' theory, immunity belongs to stern function of " lung " gold, and hypoimmunity explanation " lung " deficiency of vital energy causes stern unable, " lung " gold can not give birth to " kidney " water, shows as insufficiency of kidney-YANG, edema, poor growth; Therefore, want to improve immunity, on the one hand must spleen invigorating according to the principle of Difficult Classic " reinforcing the mother-organ for treating deficiency of the son-organ ", and the Rhizoma Atractylodis Macrocephalae to be the spleen invigorating key medicine become first-selection; On the other hand then energetically " the kidney invigorating " can not give birth to the pressure of " kidney " water to alleviate " lung " gold, Fructus Lycii becomes first-selection, then according to the drug matching needs, increases Rhizoma Dioscoreae, Radix Glycyrrhizae and Massa Medicata Fermentata, benefit " lung kidney " when mending " taste " plays the effect of reinforced immunological function.
The invention has the beneficial effects as follows: improve survival rate by the present invention and reach more than 7%, and effectively raise immunity, at the immune organ index, index and spleen index has improved 23.2%, thymus index has improved 32.4%, the fabricius bursa index has improved 41.2%; Particularly aspect the content of serum globulin, the content of IgA has improved 20.7%, the content of IgY has improved 23.4%, it serves to show that the present invention has obvious facilitation at specific immunity.
The specific embodiment
The present invention is further illustrated below in conjunction with embodiment.
A kind of Chinese medicine composition that improves immunologic function comprises Fructus Lycii 30%～60%, the Rhizoma Atractylodis Macrocephalae 10%～50%, Rhizoma Dioscoreae 10%～50%, Radix Glycyrrhizae 10%～40%, Massa Medicata Fermentata 10%～40%; Said composition can be prepared into medicine or pharmaceutically acceptable physical aspects such as powder, liquid, paste, granule or capsule.
Further, the form of described composition component is Chinese crude drug or decoction pieces or through one or more of the powder of pulverizing or pressing process deforms, agglomerate.
In five elements' theory, immunity belongs to stern function of " lung " gold, and hypoimmunity explanation " lung " deficiency of vital energy causes stern unable, " lung " gold can not give birth to " kidney " water, shows as insufficiency of kidney-YANG, edema, poor growth; Therefore, want to improve immunity, on the one hand must spleen invigorating according to the principle of Difficult Classic " reinforcing the mother-organ for treating deficiency of the son-organ ", and the Rhizoma Atractylodis Macrocephalae to be the spleen invigorating key medicine become first-selection; On the other hand then energetically " the kidney invigorating " can not give birth to the pressure of " kidney " water to alleviate " lung " gold, Fructus Lycii becomes first-selection, then according to the drug matching needs, increases Rhizoma Dioscoreae, Radix Glycyrrhizae and Massa Medicata Fermentata, benefit " lung kidney " when mending " taste " plays the effect of reinforced immunological function.
The various components of described compositions all meet " two ones of Chinese veterinary drug allusion quotations " specified standard.
Choose the medium Luo Si of management level 308 broiler plants, from advancing chicken, finish the observation to broiler trial in its two hen houses, condition is these two, and the hen house management level are suitable, Historical Results is suitable.Organize in contrast for one, another is as test group.21 days experimental periods.Hen house must pass through strict sterilization before the test, and test group and matched group all adopt online raising, and free choice feeding is freely drunk water, and general feeding and management requirement is followed in temperature, humidity, illumination etc. in the house, and the epidemic prevention operation is undertaken by this original program.Basal diet the unified feedstuff feeding that provides according to breed company is provided.In case the burst state of an illness is arranged, will take indiscriminate therapeutic scheme to two hen houses.
Embodiment 1
Fructus Lycii 30kg, the Rhizoma Atractylodis Macrocephalae 20 kg, Rhizoma Dioscoreae 20 kg, Radix Glycyrrhizae 20 kg, Massa Medicata Fermentata 10 kg.Aforementioned component can be Chinese crude drug, decoction pieces or forms such as the powder that deforms through processes such as pulverizing, compactings, agglomerate.Preceding four flavors merge extracted twice liquid with high temperature water boiling and extraction-concentrate twice, filter, and getting its supernatant, to be cooled to back below 45 ℃ temporary standby; Massa Medicata Fermentata then adopts 40 ℃ of water cold-macerations to extract 2 hours, filters, and it is standby to get its supernatant; Merge two kinds of supernatant (being equivalent to the 1g raw medicinal herbs with the 1ml medicinal liquid is example), sterile filling 500ml/ bottle, namely.Convert water 100kg by 1 Hydrargyri Oxydum Rubrum liquid and freely drink for the chicken group, began to observe chicken mine massively appetite, sickness rate in three days later on.Matched group is blank.
In the leaching process of described Massa Medicata Fermentata, use ultrasound wave or microwave-assisted to extract.
During off-test, add up two chicken groups' survival rate respectively; Two chicken groups' immune organ exponential sum serum globulin is measured in sampling.
Testing index and method: during off-test, randomly draw 15 chickens for every group and weigh and record data early morning, only gather heart blood 5ml/ then.With blood sample separation of serum after 37 ℃ of water-baths are left standstill 2 hours, measure the content of IgA, IgY respectively behind the labelling with the ELISA method on the one hand; On the other hand, the chicken after the blood sampling is butchered after the cervical region blood-letting, won spleen, thymus, fabricius bursa, reject fatty tissue, calculate the immune organ index.Immune organ index (g/kg)=organ weight/live body is heavy.
Last test data adopts average to represent.
Result of the test is as follows:
1. survival rate: test group 98.2%; Matched group 91.7%.
2. immune organ index (g/kg):
| Grouping | Index and spleen index | Thymus index | The fabricius bursa index |
| Test group | 6.16 | 5.97 | 3.05 |
| Matched group | 5.00 | 4.51 | 2.16 |
3. the content of serum globulin (g/L)
| Grouping | IgA | IgY |
| Test group | 5.02 | 5.96 |
| Matched group | 4.16 | 4.83 |
Embodiment 2
Fructus Lycii 50kg, Rhizoma Atractylodis Macrocephalae 20kg, Rhizoma Dioscoreae 10kg, Radix Glycyrrhizae 10kg, Massa Medicata Fermentata 10kg.Preceding four flavors are with high temperature water boiling and extraction-concentrate twice, merge extracted twice liquid, filtering, get its supernatant, to be cooled to back below 45 ℃ temporary standby; Massa Medicata Fermentata then adopt 45 ℃ of water cold-macerations extract 2 hours, to filter, get its supernatant standby; Merge two kinds of supernatant (being equivalent to the 1g raw medicinal herbs with the 1ml medicinal liquid is example), sterile filling 500ml/ bottle, namely.Convert water 1000kg by 1 Hydrargyri Oxydum Rubrum liquid and freely drink for the chicken group, began to observe chicken mine massively appetite, sickness rate in three days later on.
Result of the test is as follows:
1. survival rate: test group 99.1%; Matched group 91.6%.
2. immune organ index (g/kg):
| Grouping | Index and spleen index | Thymus index | The fabricius bursa index |
| Test group | 6.18 | 5.99 | 3.07 |
| Matched group | 5.01 | 4.50 | 2.17 |
3. the content of serum globulin (g/L)
| Grouping | IgA | IgY |
| Test group | 5.03 | 5.95 |
| Matched group | 4.15 | 4.84 |
Conclusion is analyzed:
1. aspect survival rate, test group exceeds 7.1% than matched group.Illustrate that this test drug has the effect of tangible raising survival rate.
2. aspect the immune organ index, compare with matched group, the index and spleen index of test group has improved 23.2%, thymus index has improved 32.4%, the fabricius bursa index has improved 41.2%.The height of immune organ index is determining the height of immunologic function, this as a result this test drug of side light have the effect that improves immunologic function.
3. aspect the content of serum globulin, compare with matched group, the content of test group IgA has improved 20.7%, the content of IgY has improved 23.4%.This illustrates that this test drug also has obvious facilitation to specific immunity.
The above is the specific embodiment of the present invention only, is not limited thereto, and anyly is familiar with those skilled in the art in the technical scope that this patent discloses, and can expect easily changing or replacing, and all should be encompassed within protection scope of the present invention.
Claims (6)
1. a Chinese medicine composition that improves immunologic function is characterized in that: comprise Fructus Lycii 30%～60%, the Rhizoma Atractylodis Macrocephalae 10%～50%, Rhizoma Dioscoreae 10%～50%, Radix Glycyrrhizae 10%～40%, Massa Medicata Fermentata 10%～40%; Said composition can be prepared into medicine or pharmaceutically acceptable physical aspects such as powder, liquid, paste, granule or capsule.
2. the Chinese medicine composition of raising immunologic function according to claim 1, it is characterized in that: using method and use amount are: pulverize, press 0.1～10.0% of complete feed weight behind the mix homogeneously and mix use; Or said composition extracted make extracting solution, add water 20kg～2000kg by 1 liter of extracting solution and freely drink for the chicken group.
3. the Chinese medicine composition of raising immunologic function according to claim 1 and 2 is characterized in that: the form of described composition component is Chinese crude drug or decoction pieces or through one or more of the powder of pulverizing or pressing process deforms, agglomerate.
4. the Chinese medicine composition of raising immunologic function according to claim 2, it is characterized in that: the method that extracting solution is made in described extraction is: the form that Fructus Lycii, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Radix Glycyrrhizae adopt high-temperature water to decoct is extracted-is concentrated, filter, get its supernatant and be cooled to below 45 ℃ temporary; Massa Medicata Fermentata adopts cold-maceration to extract, and the water management that namely adds in Massa Medicata Fermentata is put below 45 ℃ and kept in extracting, filter, get its supernatant below 45 ℃; Merge above two kinds of supernatant, sterile filling namely.
5. the Chinese medicine composition of raising immunologic function according to claim 4 is characterized in that: described high temperature water boiling and extraction-concentrate twice, merge extracted twice liquid after, filter.
6. the Chinese medicine composition of raising immunologic function according to claim 4 is characterized in that: in the leaching process of described Massa Medicata Fermentata, use ultrasound wave or microwave-assisted to extract.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104323011A (en) * | 2014-10-31 | 2015-02-04 | 广西博白扬翔宝中宝饲料有限责任公司 | Chicken feed for increasing immune organ indexes and preparation method of chicken feed for increasing immune organ indexes |
| CN104323010A (en) * | 2014-10-31 | 2015-02-04 | 广西博白扬翔宝中宝饲料有限责任公司 | Chicken feed capable of reducing death rate of chicken and preparation method of chicken feed |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103055205A (en) * | 2012-11-11 | 2013-04-24 | 新疆维吾尔自治区中医药研究院 | Heterophylla and astragalus mongholicus reinvigorating particle as well as preparation method and application thereof to preparation of medicament for treating acquired immune deficiency syndrome |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103055205A (en) * | 2012-11-11 | 2013-04-24 | 新疆维吾尔自治区中医药研究院 | Heterophylla and astragalus mongholicus reinvigorating particle as well as preparation method and application thereof to preparation of medicament for treating acquired immune deficiency syndrome |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104323011A (en) * | 2014-10-31 | 2015-02-04 | 广西博白扬翔宝中宝饲料有限责任公司 | Chicken feed for increasing immune organ indexes and preparation method of chicken feed for increasing immune organ indexes |
| CN104323010A (en) * | 2014-10-31 | 2015-02-04 | 广西博白扬翔宝中宝饲料有限责任公司 | Chicken feed capable of reducing death rate of chicken and preparation method of chicken feed |
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