CN103340893A - Montmorillonite product and application thereof - Google Patents
Montmorillonite product and application thereof Download PDFInfo
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- CN103340893A CN103340893A CN2013102094687A CN201310209468A CN103340893A CN 103340893 A CN103340893 A CN 103340893A CN 2013102094687 A CN2013102094687 A CN 2013102094687A CN 201310209468 A CN201310209468 A CN 201310209468A CN 103340893 A CN103340893 A CN 103340893A
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Abstract
The invention provides a low-concentration montmorillonite product and an application thereof in preparing medicines, foodstuff or health products. The product facilitates thorough defecation, and is used for improving a smooth degree of the defecation, treating or preventing mild and moderate constipation, and/or improving visual senses of the defecation, and thus is good for the defecation.
Description
Invention field
The invention belongs to medicine/food/field of health care products, particularly, the present invention relates to be conducive to medicine/food/health product and the application thereof of non-severe constipation and the thorough defecation of non-diarrhoea crowd.
Background of invention
Montmorillonitum, be acknowledged as the effect with relieving diarrhea with astringents, the diseases such as gastroenteritis that are used for the treatment of diarrhoea and caused by long-term diarrhea (referring to Chinese patent 98126152,00109389,200410042539,200610005685,200610037180,200610050245,200610050246,200710025564 etc.).Commercial medicine comprises dioctahedral smectite etc., but main side effect is to cause that the defecation frequency reduces, defecation is smooth and constipation situation such as defecation is not thorough.
And, in the prior art, Montmorillonitum is to be configured to oral solid formulation (as tablet, capsule on substantially, even enteric dosage form) and administration, even with the liquid preparation administration, also being that liquid preparation with the high concentration Montmorillonitum carries out administration, is 0.1g/ml as concentration in the Chinese patent 200710025564 disclosed smectite turbid liquors.
Take a hint the dietetic therapy among the people from some and the inventor is accidental when among the people visiting, through long-term and arduous research, making us under the insufferable experimental condition, through over thousands of person-time test and check, update prescription during this time, just develop the medicine/food/health product that are conducive to thorough defecation finally, be fit to the crowd of non-serious constipation and non-diarrhoea.This medicine/food/health product taking convenience, take and do not disturb the daily life custom substantially, can make this crowd's defecation smooth and easy, defecation is thorough, moistening, the long and molding of feces, make that stool quality promotes and make that visual perception's degree of feces is better, can also alleviate mild or moderate constipation situation, and not cause diarrhoea.
Summary of the invention
The technical problem to be solved in the present invention is the Montmorillonitum product that provides new, and it is conducive to the thorough defecation of people, is used for promoting the smooth and easy degree of defecation, be used for the treatment of or prevent the mild or moderate constipation, be used for to improve the defecation quality, and/or, be used for promoting visual perception's degree of defecation.In addition, the present invention also provides the application of this Montmorillonitum product etc.
Particularly, in first aspect, the invention provides medicine, it is liquid preparation or liquid preparation preparation that Montmorillonitum concentration is lower than 80mg/ml; The invention provides food, it is liquid preparation or liquid preparation preparation that Montmorillonitum concentration is lower than 80mg/ml; And/or, the invention provides health product, it is liquid preparation or liquid preparation preparation that Montmorillonitum concentration is lower than 80mg/ml.In this article, Montmorillonitum is montmorillonite powder preferably, if can be by the montmorillonite powder of 40 mesh sieves.Montmorillonitum can be provided by bentonite etc., has had the Montmorillonitum of pharmaceutical grade and food stage or bentonite to sell in market at present, so can easily obtain by market channel.
In this article, " medicine " refers to the pharmaceutical preparation that " state-promulgated pharmacopoeia " put down in writing or the crude drug with pharmaceutically active, comprises Western medicine and Chinese medicine, and its use needs national drug authorization mechanism to examine the approval of flow process by medicine.Montmorillonitum product of the present invention can be used as medicine and authorizes, but since its consumption well below the existing lower limit that contains the medicine of Montmorillonitum, its safety has abundant guarantee, so also can not authorize as medicine.
In this article, " food " and " health product " can exchange use, refers to food or raw-food material that general public is understood, comprises integration of edible and medicinal herbs but low dosage is unessential when using pass through the material that medicine is evaluated.The use of food or health product only need be satisfied general health and prescription, need not national drug authorization mechanism examines flow process by medicine approval.
The medicine of first aspect present invention, food or health product are conducive to the thorough defecation of people, and namely defecation length is grown and can be agreed with the intestinal inner wall shape; The medicine of first aspect present invention, food or health product are for the smooth and easy degree that promotes defecation; The medicine of first aspect present invention, food or health product are used for the treatment of or prevent the mild or moderate constipation, and wherein for the sake of clarity, term herein " mild or moderate constipation " refers to that to have defecation frequency in 14 days be 7-11 time situation; The medicine of first aspect present invention, food or health product are for improving the defecation quality, i.e. moistening, the long and molding of feces, the sign of not suffering from diarrhoea; And/or the medicine of first aspect present invention, food or health product are for the visual perception's degree that promotes defecation.Because after taking Montmorillonitum product of the present invention, feces intuitively just can allow the people feel defecation thoroughly (although the diarrhoea defecation is thorough, visual perception's degree is also bad), defecation quality are high, also be very useful for people's psychology.
Medicine, food or the health product of preferred first aspect present invention are liquid preparations, suspension preferably, and Montmorillonitum concentration is 3～30mg/ml in described liquid preparation or the suspension, 5～15mg/ml more preferably, be more preferably 6～12mg/ml, as 7～10mg/ml, most preferably be 8mg/ml.Such concentration is lower than the concentration of the Montmorillonitum product of existing relieving diarrhea with astringents, and its safety in utilization is indubitable, can take for a long time; Although there is not the described significant diarrhea effect of prior art, for non-severe constipation and non-diarrhoea crowd, be very useful.
Those skilled in the art have the ability according to prescription, and Montmorillonitum is distributed in the solvent according to a certain percentage, prepare liquid preparation or suspension.In this article, solvent is water or beverage preferably, as the fruit juice beverage.The inventor finds that Montmorillonitum is stable in water, and suitable high temperature sterilize, so the solvent of preferred suspension of the present invention is water.
Also medicine, food or the health product of preferred first aspect present invention are the liquid preparation preparations, suspension preparation preferably, Montmorillonitum concentration is 3～30mg/ml in described liquid preparation preparation or the suspension preparation, 5～15mg/ml more preferably, be more preferably 6～12mg/ml, as 7～10mg/ml, most preferably be 8mg/ml.In this article, " preparation " of certain preparation refers to Montmorillonitum and solvent unmixed (physically isolating) still makes up or prompting is combined, thereby can make this kind preparation.In this article, the concentration of Montmorillonitum refers in the preparation, make this kind preparation after, the concentration of Montmorillonitum in this kind preparation is equivalent to make the bulking value ratio of Montmorillonitum and solvent before this kind preparation substantially.The solvent of suspension preparation of the present invention can be water, also can be beverage, as the fruit juice beverage.The latter can improve mouthfeel, but the inventor discovers, Montmorillonitum lost efficacy in beverage (especially acidic beverages, as a large amount of commercially available fruit drinks) easily, therefore need face the time spent preparation, so preferred drink (especially fruit drink) is for suspension preparation of the present invention.The inventor discovers, the independent high temperature sterilize of Montmorillonitum, and the meeting dehydration also influences effect, so the Montmorillonitum in preparation is fit to the sterilization method of non high temperature, sterilizes as radioactivity; In addition, fruit drink, the especially high fruit drink of pure juice content, mouthfeel meeting deterioration behind the high temperature sterilize is so the beverage in preparation is fit to the sterilization method of non high temperature or is directly provided by the commercial goods.
More preferably the medicine of first aspect present invention, food or health product are liquid preparation preparations of combining, comprise container A and container B as preferred it, wherein container A comprises Montmorillonitum, container B comprises solvent, and the w/v of wherein said Montmorillonitum and solvent is preferably 3～30mg/ml for being lower than 80mg/ml, 5～15mg/ml more preferably, be more preferably 6～12mg/ml, as 7～10mg/ml, most preferably be 8mg/ml.Like this, open container A and B, mix material wherein, just can be mixed with liquid preparation of the present invention.
Also more preferably the medicine of first aspect present invention, food or health product are liquid preparation preparations that prompting is combined, comprise container and description as preferred it, wherein container comprises Montmorillonitum, description record is mixed with Montmorillonitum concentration with solvent with described Montmorillonitum and is lower than 80mg/ml and (is preferably 3～30mg/ml, 5～15mg/ml more preferably, be more preferably 6～12mg/ml, as 7～10mg/ml, most preferably be 8mg/ml) liquid preparation after oral.Because water and fruit drink etc. are easy to obtain, so only need prompting to specifications, the group of solvents of the application quantity mutually of the material in the container and prompting is lumped together, just can be hybridly prepared into liquid preparation of the present invention.
Preferably in medicine, food or the health product of first aspect present invention, described liquid preparation is by Montmorillonitum and solvent composition.As, the medicine of first aspect present invention, food or health product are liquid preparations, wherein liquid preparation is by Montmorillonitum and solvent composition; Perhaps, the medicine of first aspect present invention, food or health product are liquid preparation preparations, and the liquid preparation that makes is by Montmorillonitum and solvent composition.
The unit dose of medicine, food or the health product of preferred first aspect present invention with the stereometer of its liquid preparation, is 300～2000ml, and preferably 350～1800ml is more preferably 400～1600ml, as 500～1500ml.In this article, " unit dose " amount of referring to one day or once taking.Those skilled in the art can converse the amount of Montmorillonitum by the volume of liquid preparation according to concentration.The inventor has discovered that such unit dose is very useful to non-severe constipation and non-diarrhoea crowd, and such unit dose just in time can partly or entirely be replaced daily water or beverage of every day, and mouthfeel and part drinking water and beverage approach, get final product so only need in drinking-water or beverage, replace to drink, do not disturb people's daily habits substantially.The product comparting packaging of unit dose is prepared into medicine, food or the health product of first aspect present invention, can be convenient to take, prevent from taking deficiency or overdose.
In second aspect, the invention provides the application of Montmorillonitum in the preparation medicine, wherein said medicine is liquid preparation or the liquid preparation preparation that Montmorillonitum concentration is lower than 80mg/ml; The invention provides Montmorillonitum in the preparation Application in Food, wherein said food is liquid preparation or the liquid preparation preparation that Montmorillonitum concentration is lower than 80mg/ml; And/or, the invention provides the application of Montmorillonitum in the preparation health product, wherein said health product are liquid preparation or liquid preparation preparations that Montmorillonitum concentration is lower than 80mg/ml.
In the application of preferred second aspect present invention, described medicine, food or health product are liquid preparations, suspension preferably, Montmorillonitum concentration is 3～30mg/ml in described liquid preparation or the suspension, 5～15mg/ml more preferably, be more preferably 6～12mg/ml, as 7～10mg/ml, most preferably be 8mg/ml.
Also in the application of preferred second aspect present invention, described medicine, food or health product are liquid preparation preparations, suspension preparation preferably, Montmorillonitum concentration is 3～30mg/ml in described liquid preparation preparation or the suspension preparation, 5～15mg/ml more preferably, be more preferably 6～12mg/ml, as 7～10mg/ml, most preferably be 8mg/ml.
The inventor discovers, so the Montmorillonitum of low dosage is not good for the effect of reading constipation and diarrhoea again, but is particularly suitable for non-severe constipation and non-diarrhoea crowd, so in the application of preferred second aspect present invention, described people is the people of non-severe constipation and non-diarrhoea.Although there is not the evidence child not take, for the purpose of careful, in the application of preferred second aspect present invention, described people is the adult, preferably is the adult of non-severe constipation and non-diarrhoea.
In the application of preferred second aspect present invention, described medicine, food or health product are conducive to the thorough defecation of people, and namely defecation length is grown and can be agreed with the intestinal inner wall shape; The medicine of first aspect present invention, food or health product are for the smooth and easy degree that promotes defecation; The medicine of first aspect present invention, food or health product are used for the treatment of or prevent the mild or moderate constipation, and wherein for the sake of clarity, term herein " mild or moderate constipation " refers to that to have defecation frequency in 14 days be 7-11 time situation; The medicine of first aspect present invention, food or health product are for improving the defecation quality, i.e. moistening, the long and molding of feces, the sign of not suffering from diarrhoea; And/or the medicine of first aspect present invention, food or health product are for the visual perception's degree that promotes defecation.Because after taking Montmorillonitum product of the present invention, feces intuitively just can allow the people feel defecation thoroughly (although the diarrhoea defecation is thorough, visual perception's degree is also bad), defecation quality are high, also be very useful for people's psychology.
In the application of preferred second aspect present invention, the unit dose of described medicine, food or health product with the stereometer of its liquid preparation, is 300～2000ml, and preferably 350～1800ml is more preferably 400～1600ml, as 500～1500ml.
In the application of preferred second aspect present invention, the solvent in described liquid preparation or the liquid preparation preparation is water or beverage, as the fruit juice beverage.
In the third aspect, the invention provides the method that the people substitutes drinking water or beverage, it comprises the food of drinking first aspect present invention.The suspension that preferred described food is first aspect present invention or suspension preparation.Because the mouthfeel of the food of first aspect present invention and water or beverage are very nearly the same, so can substitute daily drinking-water and beverage fully.When being preparation, drink the process that also comprises preparation described in this method.In addition, wherein said drinking can be drunk one or more times.
The method of third aspect present invention is the method for drinking food product, its non-Therapeutic Method.People described in this method can be healthy people.Owing to can make feces longer but moistening, the visual perception's degree that promotes feces is better, even can't be used for the treatment of constipation (because original no constipation symptom), also is well-adapted for healthy population.
Beneficial effect of the present invention has been to break through the restriction of the Montmorillonitum use of prior art, to non-severe constipation and non-diarrhoea crowd's onset, be conducive to the thorough defecation of people, can be used for promoting the smooth and easy degree of defecation, can be used for the treatment of or prevent the mild or moderate constipation, the defecation quality can be used for improving, and/or visual perception's degree of defecation can be used for promoting; In addition, Montmorillonitum product consumption of the present invention is few, easy to prepare, cost even also lower than Montmorillonitum diarrhea medicine of the prior art; Montmorillonitum product of the present invention does not influence people's living habit substantially yet, taking convenience, and mouthfeel can be accepted or be good, can take for a long time, is convenient to promote.
Below will describe in detail the present invention by specific embodiment and accompanying drawing.It needs to be noted that these descriptions only are exemplary descriptions, do not constitute limitation of the scope of the invention.According to the argumentation of this description, many variations of the present invention, change have been obviously all concerning one of ordinary skill in the art.In addition, the present invention has quoted open source literature, and these documents are in order more clearly to describe the present invention, its in full content all include this paper in and carry out reference, just look like their in full in this article entire teachings gone over.
Description of drawings
Fig. 1,2,3 and 4 is photo examples that various crowds take feces behind the Montmorillonitum product of the present invention, and the part that wherein relates to individual privacy is all concealed.
The specific embodiment
Following examples are not construed as limiting the invention for illustrating, and wherein raw materials usedly all can obtain by buying on the market.
The preparation of embodiment 1 smectite turbid liquor
Get the pharmaceutical grade montmorillonite powder and (can moisten Longhua worker Co., Ltd available from the Inner Mongol, meet GB WS1-(X-165)-2004Z), collected the powder of 40 mesh sieves, add the suspension that pure water is configured to 8mg/ml, airtight back namely gets smectite turbid liquor in boiling sterilization 30 minutes.
Face the time spent, with this suspension concussion mixing, oral, its mouthfeel is acceptable close to the tap water taste of northern China water quality than hard place district (as Inner Mongol, Hebei and other places) for the adult.
The preparation of embodiment 2 smectite turbid liquor preparations
Get the pharmaceutical grade montmorillonite powder, collected the powder of 40 mesh sieves, cobalt 60 sterilization back packing, every bag 4g; Other gets apple juice (commercially available product, (pure) juice content 10%) 500ml.Both have constituted the smectite turbid liquor preparation for this.
Face the time spent, wherein pharmaceutical grade montmorillonite powder be mixed in the apple juice, oral with suspensions, good mouthfeel, covered fully Montmorillonitum with uncomfortable taste.
The curative effect of embodiment 3 smectite turbid liquors
Under the situation of informed consent, successively there are 408 person-times of volunteers (22～65 years old) to participate in test, following a few class is arranged altogether:
The 1st class: 17 person-times, severe constipation symptom is arranged, test namely that defecation frequency is below 6 times or 6 times in preceding 14 days, feces is dry and hard shape, and substitute smectite turbid liquor 500ml or the 1500ml that takes embodiment 1 preparation every day during drinking water, took continuously 5 days, except 1 person-time, all the other do not represent that all the constipation situation takes a turn for the better, and wherein have 5 person-times of expression constipation situations to increase the weight of, so the class test stops.
The 2nd class: 6 person-times, the person that has the symptom of diarrhea, substitute the smectite turbid liquor 500ml that take embodiment 1 preparation during drinking water every day, took continuously 3 days, has 1 people's diarrhoea situation still, and 2 people's diarrhoea situations increase the weight of, so the class test stops.
The 3rd class: 121 person-times, mild or moderate constipation symptom is arranged, namely testing in preceding 14 days defecation frequency is 7-11 time (average stool is 0.64 time/day), feces is dry and hard or firmly just shape of cylindricality, substitute the smectite turbid liquor 1500ml that takes embodiment 1 preparation every day during drinking water, after taking 5 days continuously, 98 person-times of smooth and easy condition improveds of expression defecation are arranged, everyone continued to take 20 days, 115 person-times of smooth and easy condition improveds of expression defecation are arranged, and the average stool in these 20 days increases to (being not counted in diarrhea patient) 1.12 times/day.Most of feces as shown in Figure 1, moistening and molding is the shape of agreeing with the intestinal inwall, length adds to be grown to more than the 20cm, shows that defecation is thorough.In addition, duration of test has 4 person-times symptom of diarrhea to occur, and wherein 3 person-times have the irrelevant diarrhoea origin cause of formation of clear and definite and this test.
The 4th class: 56 person-times, mild or moderate constipation symptom is arranged, namely testing in preceding 14 days defecation frequency is 7-11 time (average stool is 0.68 time/day), feces is dry and hard or firmly just shape of cylindricality, substitute the smectite turbid liquor 500ml that takes embodiment 1 preparation every day during drinking water, after taking 5 days continuously, 37 person-times of smooth and easy condition improveds of expression defecation are arranged, everyone continued to take 20 days, 42 person-times of smooth and easy condition improveds of expression defecation are arranged, and the average stool in these 20 days increases to (being not counted in diarrhea patient) 1.03 times/day.Most of feces as shown in Figure 2, moistening and molding is the shape of agreeing with the intestinal inwall, length adds to be grown to more than the 20cm, shows that defecation is thorough.In addition, duration of test has 3 person-times symptom of diarrhea to occur, and the irrelevant diarrhoea origin cause of formation of clear and definite and this test is all arranged.
The 5th class: 180 person-times, mild or moderate constipation symptom is arranged, namely testing in preceding 14 days defecation frequency is 7-11 time (average stool is 0.65 time/day), feces is dry and hard or firmly just shape of cylindricality, substitute the smectite turbid liquor goods 500ml that takes embodiment 2 preparations when drink Sugared beverages every day, after taking 5 days continuously, 125 person-times of smooth and easy condition improveds of expression defecation are arranged, everyone continued to take 20 days, 159 person-times of smooth and easy condition improveds of expression defecation are arranged, and the average stool in these 20 days increases to (being not counted in diarrhea patient) 1.08 times/day.Most of feces as shown in Figure 3, moistening and molding is the shape of agreeing with the intestinal inwall, length adds to be grown to more than the 20cm, shows that defecation is thorough.In addition, duration of test has 11 person-times symptom of diarrhea to occur, and wherein 8 person-times have the irrelevant diarrhoea origin cause of formation of clear and definite and this test.
The 6th class: 28 person-times, healthy person, test namely that defecation frequency is more than 12 times or 12 times in preceding 14 days, and there is not a symptom of diarrhea (average stool be 1.15 times/day), feces is cylindricality firmly just or shaping soft stool shape, substitute the smectite turbid liquor 500ml that takes embodiment 1 preparation every day during drinking water, after taking 25 days continuously, there are 12 people to represent that the smooth and easy situation of defecation more improves, only have 2 people to represent that the smooth and easy situation of defecation worsens to some extent, the average stool in back 20 days increases to (being not counted in diarrhea patient) slightly 1.10 times/day.But, most feces as shown in Figure 4, moistening and molding is the shape of agreeing with the intestinal inwall, length adds to be grown to more than the 20cm, shows that defecation is more thorough.In addition, duration of test has 2 person-times symptom of diarrhea to occur, and the irrelevant diarrhoea origin cause of formation of clear and definite and this test is all arranged.
Above result shows, Montmorillonitum product of the present invention does not have to treat significantly the curative effect of severe constipation and diarrhoea, but do not cause diarrhoea, and treatment and preventive effect are arranged for the mild or moderate constipation patient; Montmorillonitum product of the present invention, can significantly improve the smooth and easy degree of defecation of mild or moderate constipation patient and healthy population (especially the former), defecation is (feces is than length and be the shape of agreeing with the intestinal inwall) thoroughly, and the defecation quality is good, and makes that visual perception's degree of defecation is better; Montmorillonitum product of the present invention all demonstrates the effect for the treatment of or health care in the scope of every day high dose and low dosage, high dose is than the low dosage better effects if, and faces with fruit drink and use preceding preparation, the effect that does not influence treatment or keep healthy.
Claims (10)
1. the application of Montmorillonitum (preferably montmorillonite powder) in preparation medicine, food or health product, wherein said medicine, food or health product are that Montmorillonitum concentration is lower than 80mg/ml and (is preferably 3～30mg/ml, 5～15mg/ml more preferably, be more preferably 6～12mg/ml, as 7～10mg/ml, most preferably be 8mg/ml) liquid preparation or liquid preparation preparation (as suspension or suspension preparation).
2. the described application of aforementioned arbitrary claim, wherein said people is the adult, preferably is the adult of non-severe constipation and non-diarrhoea.
3. the described application of aforementioned arbitrary claim, wherein said medicine, food or health product are conducive to the thorough defecation of people, be for the smooth and easy degree that promotes defecation, be used for the treatment of or prevent the mild or moderate constipation, for improving the defecation quality, and/or, be for the visual perception's degree that promotes defecation.
4. the described application of aforementioned arbitrary claim, the unit dose of wherein said medicine, food or health product with the stereometer of its liquid preparation, is 300～2000ml, preferably 350～1800ml is more preferably 400～1600ml, as 500～1500ml.
5. the described application of aforementioned arbitrary claim, the solvent in wherein said liquid preparation or the liquid preparation preparation is water or beverage, as the fruit juice beverage.
6. medicine, food or health product, it is that Montmorillonitum concentration is lower than 80mg/ml and (is preferably 3～30mg/ml, 5～15mg/ml more preferably, be more preferably 6～12mg/ml, as 7～10mg/ml, most preferably be 8mg/ml) liquid preparation or liquid preparation preparation (as suspension or suspension preparation).
7. the described medicine of aforementioned arbitrary claim, food or health product, it comprises container A and container B, and wherein container A comprises Montmorillonitum (preferably montmorillonite powder), and container B comprises solvent, preferably water or beverage, as the fruit juice beverage, and the w/v of wherein said Montmorillonitum and solvent is preferably 3～30mg/ml for being lower than 80mg/ml, 5～15mg/ml more preferably, be more preferably 6～12mg/ml, as 7～10mg/ml, most preferably be 8mg/ml.
8. the described medicine of aforementioned arbitrary claim, food or health product, it comprises container and description, wherein container comprises Montmorillonitum (preferably montmorillonite powder), description record is with solvent (preferably water or beverage, as the fruit juice beverage) with as described in Montmorillonitum be mixed with Montmorillonitum concentration and be lower than 80mg/ml (be preferably 3～30mg/ml, more preferably 5～15mg/ml is more preferably 6～12mg/ml, as 7～10mg/ml, most preferably be 8mg/ml) liquid preparation after oral.
9. the described medicine of aforementioned arbitrary claim, food or health product, wherein said liquid preparation is made up of Montmorillonitum (preferably montmorillonite powder) and solvent (preferably water or beverage, as the fruit juice beverage).
10. the people substitutes the method for drinking water or beverage, and it comprises drinks the described food of aforementioned arbitrary claim (as suspension or suspension preparation).
Priority Applications (1)
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| CN2013102094687A CN103340893A (en) | 2013-05-21 | 2013-05-21 | Montmorillonite product and application thereof |
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| CN2013102094687A CN103340893A (en) | 2013-05-21 | 2013-05-21 | Montmorillonite product and application thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105249453A (en) * | 2015-10-16 | 2016-01-20 | 任瑞刚 | Health-care food for crowds with hypertension, hyperlipidemia and hyperglycemia and eating method of health-care food |
| CN106924283A (en) * | 2017-03-29 | 2017-07-07 | 成都维恒医药科技有限公司 | It is a kind of containing montmorillonite, the antidiarrheal pharmaceutical composition of medicinal carbon and preparation method and purposes |
| CN107265689A (en) * | 2017-06-15 | 2017-10-20 | 康德雨 | Drinking water containing montmorillonite mineral matter |
-
2013
- 2013-05-21 CN CN2013102094687A patent/CN103340893A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105249453A (en) * | 2015-10-16 | 2016-01-20 | 任瑞刚 | Health-care food for crowds with hypertension, hyperlipidemia and hyperglycemia and eating method of health-care food |
| CN106924283A (en) * | 2017-03-29 | 2017-07-07 | 成都维恒医药科技有限公司 | It is a kind of containing montmorillonite, the antidiarrheal pharmaceutical composition of medicinal carbon and preparation method and purposes |
| CN107265689A (en) * | 2017-06-15 | 2017-10-20 | 康德雨 | Drinking water containing montmorillonite mineral matter |
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Application publication date: 20131009 |