CN103333446A - Serum separation gel and preparation method thereof - Google Patents
Serum separation gel and preparation method thereof Download PDFInfo
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- CN103333446A CN103333446A CN2013102500873A CN201310250087A CN103333446A CN 103333446 A CN103333446 A CN 103333446A CN 2013102500873 A CN2013102500873 A CN 2013102500873A CN 201310250087 A CN201310250087 A CN 201310250087A CN 103333446 A CN103333446 A CN 103333446A
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- separation gel
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- polyacrylate
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- 238000000926 separation method Methods 0.000 title claims abstract description 48
- 210000002966 serum Anatomy 0.000 title claims abstract description 48
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 238000001879 gelation Methods 0.000 title description 2
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 24
- 229920000058 polyacrylate Polymers 0.000 claims description 15
- 239000000178 monomer Substances 0.000 claims description 14
- 230000002209 hydrophobic effect Effects 0.000 claims description 10
- 238000006243 chemical reaction Methods 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 claims description 8
- 239000013008 thixotropic agent Substances 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 239000004925 Acrylic resin Substances 0.000 claims description 4
- 229920001577 copolymer Polymers 0.000 claims description 4
- 230000006837 decompression Effects 0.000 claims description 4
- 238000004821 distillation Methods 0.000 claims description 4
- 239000011347 resin Substances 0.000 claims description 4
- 229920005989 resin Polymers 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 210000004369 blood Anatomy 0.000 abstract description 8
- 239000008280 blood Substances 0.000 abstract description 8
- 238000012360 testing method Methods 0.000 abstract description 6
- 229920000642 polymer Polymers 0.000 abstract description 4
- 239000000084 colloidal system Substances 0.000 abstract description 3
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 238000004132 cross linking Methods 0.000 abstract 1
- 230000007850 degeneration Effects 0.000 abstract 1
- 230000005251 gamma ray Effects 0.000 abstract 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 12
- 150000002148 esters Chemical class 0.000 description 8
- 238000005516 engineering process Methods 0.000 description 6
- 229910002012 Aerosil® Inorganic materials 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 239000000377 silicon dioxide Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- 229920001083 polybutene Polymers 0.000 description 3
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 2
- 230000003471 anti-radiation Effects 0.000 description 2
- 238000010241 blood sampling Methods 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 238000003912 environmental pollution Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 229960002897 heparin Drugs 0.000 description 2
- 229920000669 heparin Polymers 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 229920002545 silicone oil Polymers 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 1
- 235000017491 Bambusa tulda Nutrition 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 244000082204 Phyllostachys viridis Species 0.000 description 1
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 1
- 239000006087 Silane Coupling Agent Substances 0.000 description 1
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000011425 bamboo Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000005660 chlorination reaction Methods 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 238000007334 copolymerization reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000004134 energy conservation Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000010528 free radical solution polymerization reaction Methods 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 210000003677 hemocyte Anatomy 0.000 description 1
- 229940000351 hemocyte Drugs 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 150000001282 organosilanes Chemical group 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229960001866 silicon dioxide Drugs 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 238000007614 solvation Methods 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 230000009974 thixotropic effect Effects 0.000 description 1
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention relates to the technical field of preparation of high molecular polymers, and in particular relates to serum separation gel. The prepared serum separation gel appears as a colorless transparent colloid, and has high drawing property, and is at a viscosity of about 1*104cps and a density of 1.050-1.060. The serum separation gel is added to the bottom of a test tube and has no leveling phenomenon when being randomly placed, so that high thixotropy is ensured. When being radiated with a gamma-ray (irradiation dose of 20KGy), the serum separation gel does not generate crosslinking or structuring serious degeneration and has steady anti-irradiation property. While being placed in a blood collection tube for collecting blood and separating blood centrifugally, the serum separation gel can be overturned well to form uniform and transparent separation gel layer between the serum and the blood clot.
Description
Technical field
The present invention relates to a kind of high molecular polymer preparing technical field, particularly relate to a kind of serum separation gel.
Background technology
The serum separation gel be chemically inert, have thixotropic viscoloid, its density is about 1.04, just in time between the density of serum and clot, after the blood sampling, centrifugation, separation gel moves on to heparin tube central authorities, and serum and blood plasma are isolated fully, has avoided fusing mutually between hemocyte and the serum, guaranteed blood sample composition stability within a certain period of time, prolong the storage period of institute's blood-sample withdrawal greatly, alleviated laboratory technician's labour intensity, improved working efficiency.
U.S. PECTON company in 1973 with silicone oil and silica be raw material make gel and the glass test tube of packing in put on market; Nineteen eighty-two Japan ponding chemical industry and colleague thereof replace glass test tube to realize commercialization with plastic test tube; United States Patent (USP) silicone oil, silicon-dioxide, the vinylchlorid powdered preparation serum separation gel, but after placing for some time, serum separation gel viscosity changes, and influences the disintegrate-quality of serum; Japanese Patent has been introduced with chlorine treatment polybutene technology, though can prepare qualified serum separation gel, the polybutene chlorination process is complicated, and causes environmental pollution easily; European patent publication a kind of synthetic method of serum separation gel, raw material is epoxidised soybean oil through polybutene and the water drain silica of chloridized, also has problem of environmental pollution.
In recent years, the development of vacuum blood collector industry was like rain the back spring bamboo, and each enterprise has reached the degree of " becoming a bestseller " to the demand of separation gel, and the blood separating colloid external product has monopolized the domestic market rapidly.What the serum separation gel of the used vacuum test tube of each large hospital of China overwhelming majority was used at present is the product of U.S. company BD, though homemade serum separation gel comes into the market, but the stability of homemade separation gel, clinging power and thixotropy are relatively poor, anti-gamma-radiation ability, bigger with the quality level gap of U.S. company BD serum separation gel, generally be reluctant on the market to accept.Because the product preparation of serum separation gel relates to medical science, polymer science, organic chemistry, inorganic chemistry, analytical chemistry, biology, multidisciplinary field such as materialogy, have higher technology content and strict production and use processing condition, and in clinical chemistry, serology, during immunologys etc. detect, required sample mostly needs separation of serum, and therefore, the market demand of serum separation gel is quite big.
Summary of the invention
At the characteristics of above-mentioned technology, a kind of serum separation gel is formed by the feedstock production of following mass parts:
100 parts of polyacrylate resins
5～10 parts of the hydrophobic gas-phase silicas of thixotropic agent
0～10 part of thinner DOP
Wherein said polyacrylate resin is prepared from according to following proportioning:
A kind of preparation method of serum separation gel comprises the steps:
(1) butyl acrylate of toluene, 2 mercapto ethanol, 50% mass ratio and mixture and 0.6 part of BPO of Jia Jibingxisuanyizhi are joined in the flask;
(2) stir intensification, when temperature reached 85 ℃～90 ℃, the monomer mixture that residue is contained 0.6 part of BPO, butyl acrylate and Jia Jibingxisuanyizhi was added drop-wise to from dropping funnel in the reaction flask, kept 85 ℃～90 ℃ of temperature, dripped off monomer in the 3h;
(3) behind the continuation reaction 1h, cool to below 70 ℃, obtain acrylate copolymer solution;
(4) solution decompression distillation 2h removes solvent toluene and unreacted monomer, obtains polyacrylate solution;
(5) 5～10 parts of hydrophobic aerosils and thinner DOP0～10 part are added in the polyacrylate solution, stir;
(6) vacuumizing and defoaming obtains product serum separation gel.
Beneficial effect of the present invention is, the present invention has that preparation technology is simple, production process is easy to control, raw materials cost is low, energy-conservation and characteristics that product performance are more stable.Serum separation gel force of cohesion with present method preparation is strong, has stringiness and thixotropy preferably.
Embodiment
The invention provides a kind of serum separation gel, be equipped by the raw material of following mass parts:
100 parts of polyacrylate resins
5～10 parts of the hydrophobic gas-phase silicas of thixotropic agent
0～10 part of thinner DOP
Wherein said polyacrylate resin is prepared from according to following proportioning:
A kind of preparation method of serum separation gel comprises the steps:
(1) butyl acrylate of toluene, 2 mercapto ethanol, 50% mass ratio and mixture and 0.6 part of BPO of Jia Jibingxisuanyizhi are joined in the flask;
(2) stir intensification, when temperature reached 85 ℃～90 ℃, the monomer mixture that residue is contained 0.6 part of BPO, butyl acrylate and Jia Jibingxisuanyizhi was added drop-wise to from dropping funnel in the reaction flask, kept 85 ℃～90 ℃ of temperature, dripped off monomer in the 3h;
(3) behind the continuation reaction 1h, cool to below 70 ℃, obtain acrylate copolymer solution;
(4) solution decompression distillation 2h removes solvent toluene and unreacted monomer, obtains polyacrylate solution;
(5) 5～10 parts of hydrophobic aerosils and thinner DOP0～10 part are added in the polyacrylate solution, stir;
(6) vacuumizing and defoaming obtains product serum separation gel.
Embodiment 1:
The invention provides a kind of serum separation gel, formed by the feedstock production of following mass parts:
100 parts of polyacrylate resins
3 parts of the hydrophobic gas-phase silicas of thixotropic agent
Wherein said polyacrylate resin is prepared from according to following proportioning:
In the polyacrylate(s) serum separation gel, the salient features of serum separation gel shows by polyacrylic ester.The polyacrylic ester of solution polymerization has that molecular weight is low, and molecular weight can be regulated, and viscosity is little, the monomer conversion height, and preparation technology is the characteristics of control easily; As the polyacrylic ester of the material of main part monomer copolymerization by different sorts and amount ratio, the density of its density and serum separation gel is approached, satisfied the requirement of serum separation gel density just; The polarity of polyacrylic ester is bigger, and intermolecular internal cohesive energy is big, can form the separation glue-line of transparent and homogeneous when separating blood, and having overcome with organosilicon is the breakable shortcoming of serum separation glue-line of main material, and does not produce wall cling phenomenon; It has polar group, saturated polymer molecule main chain has well anti-oxidant and anti-radiation performance, has well satisfied the processing requirements of disposal vacuum hemostix disinfection.
Itself does not have thixotropy the polyacrylic ester glue, therefore, must add thixotropic agent and carry out modification in polyacrylate(s) serum separation gel.Aerosil is dispersed in the polyacrylic ester system, since polyacrylate backbone with polar group the silicon hydroxyl on aerosil surface is had stronger avidity, make aerosil accumulate in around the polar group in a large number, produced the solvation phenomenon, be difficult in the polyacrylic ester system, form whole network, make that the thixotropy of polyacrylic ester system is relatively poor, therefore, must carry out surface hydrophobicity to gas-phase silica and handle, general hydrophobic treatment agent is organo silane coupling agent.
Embodiment 2:
A kind of preparation method of serum separation gel comprises the steps:
(1) butyl acrylate of toluene, 2 mercapto ethanol, 50% mass ratio and mixture and 0.6 part of BPO of Jia Jibingxisuanyizhi are joined in the flask;
(2) stir to heat up, when temperature reaches 85 ℃, residue is contained the butyl acrylate of 0.6 part of BPO and the monomer mixture of Jia Jibingxisuanyizhi is added drop-wise in the reaction flask from dropping funnel, keep 85 ℃ of temperature, drip off monomer in the 3h;
(3) behind the continuation reaction 1h, cool to below 70 ℃, obtain acrylate copolymer solution;
(4) solution decompression distillation 2h removes solvent toluene and unreacted monomer, obtains polyacrylate solution;
(5) hydrophobic aerosil is added in the polyacrylate solution for 5 parts, stirs;
(6) vacuumizing and defoaming obtains product serum separation gel.
This preparation method's service temperature is lower than 100 ℃, operation easily, and preparation condition relatively easily reaches, and does not produce any poisonous pollutent, whole process of preparation environmental protection in preparation process.
Embodiment 3:
Present embodiment is identical with embodiment 1, and different is to add 10 parts of the hydrophobic gas-phase silicas of thixotropic agent, has added thinner DOP10 part.
Made serum separation gel performance: outward appearance is the water white transparency colloid, has good stringiness, and viscosity is about 1 * 104cps, and density is between 1.050～1.060.
Embodiment 4:
Present embodiment is identical with embodiment 2, and the preparation temperature that different is in the step (2) is 90 ℃, 10 parts of the aerosils that step (5) adds and thinner DOP10 part.
The serum separation gel that present embodiment is obtained is added to the test tube bottom, places no levelling phenomenon arbitrarily, has good thixotropy.By gamma-rays (irradiation dose 20KGy) irradiation, do not produce sex change phenomenon crosslinked or that structurizing is serious, serum separation gel anti-radiation performance is stable.The serum separation gel is placed heparin tube blood sampling, centrifugation blood, can well overturn, between serum and clot, form homogeneous, transparent separation glue-line.
The above only is preferred embodiment of the present invention, and is in order to limit the present invention, within the spirit and principles in the present invention not all, any modification of doing, is equal to replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (2)
1. a serum separation gel is characterized in that, is formed by the feedstock production of following mass parts:
100 parts of polyacrylate resins
5～10 parts of the hydrophobic gas-phase silicas of thixotropic agent
0～10 part of thinner DOP
Wherein said polyacrylate resin is prepared from according to following proportioning:
2. the preparation method of a serum separation gel as claimed in claim 1 is characterized in that, comprises the steps:
(1) butyl acrylate of toluene, 2 mercapto ethanol, 50% mass ratio and mixture and 0.6 part of BPO of Jia Jibingxisuanyizhi are joined in the flask;
(2) stir to heat up, when temperature reaches 85 ℃～90 ℃, residue is contained the butyl acrylate of 0.6 part of BPO and the monomer mixture of Jia Jibingxisuanyizhi is added drop-wise in the reaction flask from dropping funnel, keep 85 ℃～90 ℃ of temperature, drip off monomer in the 3h;
(3) behind the continuation reaction 1h, cool to below 70 ℃, obtain acrylate copolymer solution;
(4) solution decompression distillation 2h removes solvent toluene and unreacted monomer, obtains polyacrylate solution;
(5) 5～10 parts of hydrophobic aerosils and thinner DOP0～10 part are added in the polyacrylate solution, stir;
(6) vacuumizing and defoaming obtains product serum separation gel.
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|---|---|---|---|
| CN2013102500873A CN103333446A (en) | 2013-06-21 | 2013-06-21 | Serum separation gel and preparation method thereof |
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| CN2013102500873A CN103333446A (en) | 2013-06-21 | 2013-06-21 | Serum separation gel and preparation method thereof |
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| CN103333446A true CN103333446A (en) | 2013-10-02 |
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| CN2013102500873A Pending CN103333446A (en) | 2013-06-21 | 2013-06-21 | Serum separation gel and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104262651A (en) * | 2014-09-23 | 2015-01-07 | 武汉辉斯特科技有限公司 | Preparation and application of auto-platelet-rich plasma thixotropic separating gel |
| CN105820574A (en) * | 2015-01-08 | 2016-08-03 | 成都拓利科技股份有限公司 | Organosilicon serum separation gel having storage stability and preparation method thereof |
| CN106366426A (en) * | 2016-08-30 | 2017-02-01 | 成都瑞琦科技实业股份有限公司 | Separation gel system for platelet-rich plasma (PRP) extraction and purification and preparation method thereof |
| CN107353364A (en) * | 2017-06-27 | 2017-11-17 | 湖北博成生物科技有限公司 | A kind of hydrolysis blood separating colloid and preparation method thereof |
| CN113402656A (en) * | 2021-06-22 | 2021-09-17 | 南雄阳普医疗科技有限公司 | Novel resin for serum separation gel, serum separation gel and preparation methods thereof |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104262651A (en) * | 2014-09-23 | 2015-01-07 | 武汉辉斯特科技有限公司 | Preparation and application of auto-platelet-rich plasma thixotropic separating gel |
| CN104262651B (en) * | 2014-09-23 | 2017-05-17 | 武汉辉斯特科技有限公司 | Preparation and application of auto-platelet-rich plasma thixotropic separating gel |
| CN105820574A (en) * | 2015-01-08 | 2016-08-03 | 成都拓利科技股份有限公司 | Organosilicon serum separation gel having storage stability and preparation method thereof |
| CN105820574B (en) * | 2015-01-08 | 2018-10-30 | 成都拓利科技股份有限公司 | A kind of organosilicon serum separation gel and preparation method thereof with bin stability |
| CN106366426A (en) * | 2016-08-30 | 2017-02-01 | 成都瑞琦科技实业股份有限公司 | Separation gel system for platelet-rich plasma (PRP) extraction and purification and preparation method thereof |
| WO2018040847A1 (en) * | 2016-08-30 | 2018-03-08 | 成都瑞琦科技实业股份有限公司 | Separation gel system for extracting and purifying platelet-rich plasma and preparation method therefor |
| CN106366426B (en) * | 2016-08-30 | 2019-08-20 | 成都瑞琦科技实业股份有限公司 | A kind of platelet rich plasma extraction and the separation gel system purified and preparation method thereof |
| CN107353364A (en) * | 2017-06-27 | 2017-11-17 | 湖北博成生物科技有限公司 | A kind of hydrolysis blood separating colloid and preparation method thereof |
| CN113402656A (en) * | 2021-06-22 | 2021-09-17 | 南雄阳普医疗科技有限公司 | Novel resin for serum separation gel, serum separation gel and preparation methods thereof |
| CN113402656B (en) * | 2021-06-22 | 2022-02-08 | 南雄阳普医疗科技有限公司 | Novel resin for serum separation gel, serum separation gel and preparation methods thereof |
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Application publication date: 20131002 |