CN105820574B - A kind of organosilicon serum separation gel and preparation method thereof with bin stability - Google Patents
A kind of organosilicon serum separation gel and preparation method thereof with bin stability Download PDFInfo
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Abstract
The present invention provides a kind of serum separation gel and preparation methods.This kind of serum separation gel is made of 100 parts of (weight ratio, similarly hereinafter) organopolysiloxanes, 4-16 parts of hydroxy-terminated polysiloxanes, 4.0-12 parts of methyl silicone rubbers, 14-25 parts of white carbons, 3-9 parts of surface conditioning agents, 0.4-2.5 parts of polytetrafluoroethylene powders, 0.6-5 parts of MQ silicones and 0.03-0.8 parts of organic silicon modified by polyether oligomer.Serum separation gel proportion made from this kind of method is easy regulation and control, the heparin tube that coagulant is added in cooperation uses, it can be with quick separating serum and blood cell after sterilized, with stable stalling characteristic and good separating effect, product safety is nontoxic, production process low energy consumption is pollution-free, and product cost is low, has high performance-price ratio and high added value.
Description
Technical field
The present invention relates to a kind of organic silicon separation gels and preparation method thereof detached with clot for serum.
Background technology
Serum separation gel be one kind can be formed between serum and clot separation layer to serum and clot it is separated into
It practises medicine and learns the colloid of detection.Serum separation gel property generally comprises, hydrophobicity is strong, thixotropy is good, with reaction of blood inertia, nontoxic
Pollution-free, the key with separation serum and clot is colloid itself with thixotropy, and proportion is between serum and blood
Between block.
When thixotropy refers to that object is sheared, consistency becomes smaller, when stopping shearing, consistency and increased property.Serum point
With thixotropy it is because with hydrogen bond inside serum glue from glue.Effect of this hydrogen bond in centrifugal force
Under be destroyed, form the low fluid of viscosity, serum, serum glue, clot are pressed upper next arrangement by proportion size in test tube, from
Mental and physical efforts form reticular structure again after disappearing, serum glue reverts to highly viscous fluid, and stabilization is isolated in serum and clot
Between.The organic silicon serum glue main component that we research and develop has white carbon and silicone oil, there is a large amount of silicone hydroxyl on white carbon, this
A little silicone hydroxyls can form hydrogen bond between each other, and to which hard charcoal black track producing particle is combined into chain, reticular structure is formed in silicone oil.
General serum ratio weighs about 1.02g/cm3, clot ratio weigh about 1.08g/cm3, separation gel proportion maintain 1.05g/cm3Left and right.
Traditional blood testing sample is by centrifuging the blood solidified completely acquisition, but this side after venous blood collection
The time longer stability that method obtains blood sample needs is relatively low, and as time goes by, the component of serum and blood plasma still can phase
Counterdiffusion can not ensure the accuracy and timeliness of detection.Along with clinical examination field serum sample detection limit increase and
The raising of the degree of automation, can it is simple, quickly, the serum separation gel that efficiently separates serum come into being, in the market demand
It is rapidly developed under stimulation.Research starting of the foreign technology personnel in this field is more early, and the U.S. in 1973 has utilized organic
Silicon raw material is made serum separation gel and launches but not yet realize merchandized handling.Japanese ponding chemistry is in this technology later
Realize commercialization.China starts late in serum separation gel technical field, domestic many researchs under the stimulation of the market demand
Mechanism and enterprise, which are taken up in order of priority, develops a large amount of serum separation gel, but home products is detaching and storing stabilization more so far
Property and separating effect in terms of there are problems, domestic organosilicon series serum separation gel product be also in low side level,
And the organosilicon serum separation gel product market of middle and high end is then controlled by external a small number of major companies, higher price.
Chinese patent (CN1281145A) discloses a kind of low-cost serum separation gel preparation method, using natural rubber
One or more of glue, polyisobutene, atoleine, 90-120# industrial napthas, one kind in 20#-60# machinery oil or several
Kind is reacted 1-3 hours after being mixed in proportion with silica at 100 DEG C -200 DEG C can be prepared by.Chinese patent
(CN102309870A) use chlorinated paraffin as proportion conditioning agent, dibenzylidene sorbitol is as organic gel agent, nanometer
Row is added as viscosity modifier, by other components in addition to nano silicon dioxide as thixotropic agent, polyisobutene in silica
Star mixing machine is warming up to 120 DEG C and is thoroughly mixed, and stirs evenly and is cooled to 60 DEG C or less addition nanometers two after fully dissolving
After silica, decompression vacuum pumping stirs evenly, and is cooled to room temperature.This kind of preparation method be made blood separating colloid physical characteristic compared with
It is good, and it is resistant to conventional sterilant dosage gamma ray.Chinese patent (CN101570637A) discloses a kind of organosilicon separation
The preparation method of glue, using the organopolysiloxane of certain component, the fumed silica and silicon of hydroxy silicon oil, hydrophobic treatment
Alkane coupling agent is uniformly mixed, and is warming up to 60-116 DEG C of stirring and is kept the temperature 5-12 hours, it is small then to vacuumize 1-6 at 120-180 DEG C
When product is made, preparation process is simple, and product safety is nontoxic, and thixotropic property is superior.Serum separation gel described in above-mentioned patent is equal
It is not directed to the long time stored stability of product and high temperature ageing performance, this large-scale promotion application and market for product
Change very crucial.Serum glue final products need to carry out high-temperature process in favor of preserving for a long time, in addition in Product transport process
Middle packaging the temperature inside the box can be more than 60 DEG C, and the high temperature ageing performance and high-temperature storage stability of product are extremely important.Domestic serum
The problems such as glue product is unstable except there are separating effects, and bin stability is bad, there is also perishable, serum blood under such as high temperature
Block isolation is not strong, the problems such as impurity effect testing result is easily introduced in serum.The present invention provides a kind of of low cost, techniques
Simple and stable, production low energy consumption is pollution-free, and product inversion effect is good, isolation is strong, stable components free from admixture, high temperature ageing performance
It is good, and convenient for the preparation method and application for the serum separation gel product stored for a long time, and the above-mentioned organic silicon serum that is related to detaches
The patent proportion adjusting controllability of glue product is not strong, and it is bad to will produce separating effect during the use of serum separation gel product
The problems such as, product provided by the invention equally has superiority in terms of proportion regulation and control.
Invention content
Proportion Modulatory character, bin stability and the high temperature ageing performance of product are that current homemade goods are produced in the marketization
The major issue faced in, the present invention provides a kind of serum separation gel product preparation sides that can solve problem above
Case.
The present invention provides a kind of serum separation gel, it includes：
A) 100 parts by weight in dimethyl silicone polymer, polydiethylsiloxane or polymethylphenylsiloxane
The organopolysiloxane of one or more of mixtures；
B) 4-16 parts by weight, preferably 6-14 parts by weight, more preferable 8-12 parts by weight structural formula be HO-Si (CH3)2O[Si
(CH3)2O]mSi(CH3)2- OH (wherein m values be 50-350, preferably 100~300, the poly- silicon of terminal hydroxy group of more preferable 150~250)
Oxygen alkane；
C) 4.0-12 parts by weight, preferably 4.8-10 parts by weight, more preferable 5.5-8 parts by weight general structure be CH3[Si
(CH3)2O]nCH3The methyl silicone rubber of (n values be 6000-10000, preferably 7000~9000)；
D) the white carbon of 14-25 parts by weight, preferably 15-22 parts by weight, more preferable 17-20 parts by weight；
E) the surface conditioning agent of 3-9 parts by weight, preferably 4-8 parts by weight, more preferable 5-7 parts by weight；
F) 0.4-2.5 parts by weight, preferably 0.6-2.1 parts by weight, more preferable 0.8-1.8 parts by weight polytetrafluorethylepowder powder；
G) 0.6-5 parts by weight, preferably 0.8-4.5 parts by weight, more preferable 1-4 parts by weight, more preferable 1.5-3.5 parts by weight
Structural formula isMQ silicones；With
H) 0.03-0.8 parts by weight, 0.04-0.6 parts by weight, more preferable 0.05-0.4 parts by weight organic silicon modified by polyether are low
Polymers.
Preferably, the organopolysiloxane is that proportion is 0.96-1.06g/cm at 25 DEG C3, preferably 0.98-1.04g/cm3
(such as 1.01g/cm3), viscosity (25 DEG C) is 500~20000, preferably 800-15000mm2/ s, preferably 1000-12500mm2/s、
More preferable 5000-10000mm2/ s, more preferable 6000-8000mm2The dimethyl silicone polymers of/s ranges, polydiethylsiloxane,
One or more of mixtures of polymethylphenylsiloxane.
Preferably, hydroxy-terminated polysiloxane viscosity at 25 DEG C is 100-1000mm2/ s, preferably 200-800mm2/s、
It is preferred that 300-700mm2/ s, molal weight 4200-26000g/mol, preferably 6000-20000g/mol, more preferable 9000-
16000g/mol.Hydroxy radical content is 0.1%-0.8% (wt), preferably 0.2%-0.7% (wt), more preferable 0.3%-0.6%
(wt), more preferable 0.35%-0.55% (wt).
Preferably, the molecular weight of the methyl silicone rubber is 45 × 104-70×104(number is equal), preferably 50 × 104-60×
104.Its fugitive constituent (150 DEG C × 3h) content≤3.0%.Its proportion is 0.965-0.985g/cm at 25 DEG C3, preferably
0.970-0.982g/cm3, more preferable 0.972-0.980g/cm3。
The white carbon is the precipitation method or fume colloidal silica, specific surface area 100-400m2/ g, preferably 150-350m2/
G, more preferable 180-320m2/g.Carbon atom mass percent is 2.0%-4.0%.What karr Fischer moisture measuring method measured
Moisture is 0.2%-0.5% mass parts.Methanol value is not less than 58.6, generally in 59.0-80.Proportion 2.0- at 25 DEG C
2.6g/cm3, preferably 2.1-2.5g/cm3, more preferable 2.15-2.55g/cm3.Preferably, more than the white carbon has been used in advance
The surface conditioning agent has carried out surface modification, that is, the white carbon is to have carried out table with above-described surface conditioning agent
The white carbon that face is modified.
The surface conditioning agent is silazane class coupling agent or silane coupling agent, preferably hexamethyldisilazane, six
Tetramethyldisiloxane, octamethylcy-clotetrasiloxane, hexamethyl cyclotrisiloxane, trimethylethoxysilane, trimethyl methoxy
One or more of silane.
The polytetrafluorethylepowder powder is superfine powder of polytetrafluoroethylene, and primary particle size is 0.1-0.5 μm, preferably
0.15-0.45 μm, it is 0.2-0.4 μm more preferable.Proportion is 2.0-2.5g/cm at 25 DEG C3, preferably 2.1-2.45g/cm3, more preferably
2.15-2.40g/cm3.Specific surface area is 8-20m2/ g, preferably 10-18m2/ g, more preferable 12-16m2/g。
MQ silicones proportion preferably at 25 DEG C is 1.045-1.054g/cm3, preferably 1.047-1.052g/cm3。M:
Value=0.6~0.9 Q:1, preferably 0.7~0.8:1.Viscosity (25 DEG C) be usually 100-2500 centipoises, preferably 200-2000 lis
Pool, more preferable 500-1800 centipoises.
The organic silicon modified by polyether oligomer (or making polyether-modified oligosiloxane, abbreviation organosilicon) is polyethylene
The oligosiloxane that oxide (or polyethylene glycol oxide) or polypropylene oxide (polypropylene oxide) or the two are modified jointly.Including
Side-chain structure, linear structure and the polyether-modified silicone oligomer of trisiloxanes class.Molecular weight is preferably 600-4000, preferably
1200-3000.Surface tension is 20-40mN/m, preferably 25-35mN/m.The organic silicon modified by polyether oligomer generally includes
Polysiloxanes segment and polyether segment (that is, polyethylene oxide (or polyethylene glycol oxide) segment or polypropylene oxide (or it is poly-
Propylene oxide) segment or the respective segment of both polyethylene glycol oxide and polypropylene oxide or both copolymer segment).Its
The number-average molecular weight of middle polysiloxanes segment is 300-2000, preferably 500-1500, more preferable 700-1400.Wherein polyethers
The degree of polymerization of segment is that the number-average molecular weight of 10-40 or polyether segment is 400-1600, preferably 600-1200.For example, polyethers
Modified organic silicon oligomer has following structure：
In formula：N=0-108 (such as 20-50), m=2-11 (such as 3-8), p=10-18 and q=0-18.Polyethers is side in formula
Chain structure.
The present invention also provides the method for preparing above-described serum separation gel, this method includes：By white carbon and it is selected from
Dimethyl silicone polymer, polydiethylsiloxane, polymethylphenylsiloxane one or more of mixtures organic poly- silica
Alkane stirs (such as -1 hour 15 minutes) and is uniformly mixed, and surface conditioning agent stir process (such as 0.5-3 hours) is then added, and rises
The temperature of temperature to 80-120 DEG C is stirred (such as 1-2 hours), and methyl silicone rubber, MQ silicones and polytetrafluoroethylene powder is added
End is uniformly mixed, and is then further heated up to 130-170 DEG C (such as 140,150 or 160 DEG C) and is vacuumized stirring (such as 3-6
Hour), it is cooled to room temperature and hydroxy-terminated polysiloxane and organic silicon modified by polyether oligomer is added and stirs evenly.
The preparation method of serum separation gel product provided by the present invention, its step are as follows：
1, white carbon and organopolysiloxane are stirred -1 hour 15 minutes to addition surface conditioning agent after being uniformly mixed stir
After mixing processing 0.5-3 hours, insulated and stirred 1-2 hours at 90-120 DEG C.
2, it is added after methyl silicone rubber, MQ silicones and polytetrafluorethylepowder powder are suitably uniformly mixed and is warming up to 150
DEG C vacuumize stirring 3-6 hours.
3, the hydroxy-terminated polysiloxane of corresponding deal is added after being cooled to room temperature and organic silicon modified by polyether and stirs evenly.
Compared with existing serum glue technology, it is an advantage of the present invention that the collaboration use of a variety of organosilicon materials is ensureing
Serum glue improves the cohesive energy of sizing material while having certain lubricity, strengthen the reversion performance of serum glue product, sizing material
Inversion effect is more stablized, and makees thixotropic agent using a small amount of organic silicon modified by polyether and can reach extraordinary thixotropy,
Separating effect can be fully achieved in 5 minutes under the conditions of centrifuge 3000r/min in the inversion effect for further improving sizing material.
Sizing material placed under 150 DEG C of hot environments three days can normal use, for a long time (12 months) storage in the case of still can
It is enough all to stablize reversion, it is placed for a long time under 60 DEG C of environment and remained to normal use up to 3 months, the high temperature ageing performance and height of sizing material
Temperature, storage at normal temperature stability are most important to the large-scale production and marketization application of product, and previous organic silicon serum
Glue patent does not then refer to this performance.The present invention is in the high temperature ageing performance of product, the long time stored stabilization of room temperature, high temperature
It has breakthrough in property and proportion Modulatory character, this several performances are very crucial to the large-scale promotion application of product.The present invention
Specific product index be：
Table 1
In addition, the separation gel product of the present invention is by strictly controlling density or proportion, and change surface nature so that point
It is improved from significant effect.
Specific implementation mode
Illustrate the present invention by the following examples.In this application, part refers to parts by weight, unless otherwise prescribed.
Embodiment 1
Weigh 60 parts of viscosity 1000mm2/ s dimethyl silicone polymers (dimethicone, Japanese Toshiba step figure), 40 parts of viscosity
10000 mm2/ s dimethyl silicone polymers (dimethicone, Toshiba step figure), it is equal that 20 parts of fume colloidal silicas stir mixing in 30 minutes
It is even, 4 parts of hexamethyldisilazane is further added and handles white carbon therein after 2 hours, is then warming up to the mixture
90 DEG C are stirred 90 minutes, and 10 parts of methyl silicone rubbers are added, and (molecular weight is 45 × 104, middle indigo plant morning twilight chemical research designing institute is limited
Company) stirring 30 minutes is mediated, add 4 parts of methyl MQ silicones (M:Q=0.6:1, middle indigo plant morning twilight) and 1.1 parts of polytetrafluoroethyl-nes
(primary particle size is that proportion is 2.33g/cm at 0.5 μm, 25 DEG C to alkene superfine powder3, specific surface area 13m2/ g, middle indigo plant morning twilight)
Being warming up to 150 DEG C of stirrings, stirring vacuumizes 4 hours after ten minutes.Sizing material refining is completed after being cooled to room temperature, and is added 6.7 parts and is glued
Spend 750mm2/ s hydroxy-terminated polysiloxanes (hydroxy silicon oil, middle indigo plant morning twilight) and 0.12 part of organic silicon modified by polyether oligomer (divide
Son amount 850, Toshiba steps figure) it stirs evenly.
Embodiment 2
Weigh 43 part of 10,000 mm2/ s dimethyl silicone polymers (dimethicone, Toshiba step figure), 57 parts of 1000mm2/ s poly- two
Ethylsiloxane (diethyl silicone oil, Toshiba step figure), 20 parts of fume colloidal silicas are stirred 1 hour and are uniformly mixed, and are added 4.5 part six
After tetramethyldisiloxane is handled 90 minutes, be warming up to 90 DEG C and stir 1 hour, be added 5.7 parts of methyl silicone rubbers (molecular weight is 60 ×
104, middle indigo plant morning twilight), 1.4 parts of methyl MQ silicones (M:Q=0.6:1, middle indigo plant morning twilight), 1 part of superfine powder of polytetrafluoroethylene is (primary
Particle diameter is that proportion is 2.33g/cm at 0.5 μm, 25 DEG C3, specific surface area 13m2/ g, middle indigo plant morning twilight) it is warming up to 150 DEG C and stirs
After mixing 30 minutes, vacuumizes and continue stirring 4 hours.14 parts of 750mm are added after being cooled to room temperature in sizing material2/ s hydroxy-terminated polysiloxanes
(hydroxy silicon oil, middle indigo plant morning twilight) and 0.07 part of organic silicon modified by polyether (molecular weight 1200, Toshiba step figure) are uniformly mixed.
Embodiment 3
Weigh 94 parts of 1000mm2/ s polydiethylsiloxanes (diethyl silicone oil, Toshiba step figure), 6 parts of 1000mm2The poly- first of/s
Base phenyl siloxane (methyl phenyl silicone oil, Toshiba step figure), 18 parts of fume colloidal silicas, stirring is uniformly mixed after twenty minutes, is added
Enter 8 parts of octamethylcy-clotetrasiloxanes and temperature risen into 70 DEG C of stir process white carbons 2 hours, is warming up to 100 DEG C and stirs 1 hour,
8 parts of methyl silicone rubbers are added, and (molecular weight is 45 × 104, it is middle indigo plant morning twilight) mediate stirring 30 minutes after, be added 3.5 parts of methyl MQ silicon
Resin (M:Q=0.8:1, middle indigo plant morning twilight), (primary particle size is to compare at 0.1 μm, 25 DEG C to 1.8 parts of superfine powder of polytetrafluoroethylene
Weight is 2.50g/cm3, specific surface area 19m2/ g, it is middle indigo plant morning twilight) be warming up to 150 DEG C stir 10 minutes, start taken out at 150 DEG C
It is stirred under vacuum 3.5 hours, is cooled to room temperature after the completion of refining, 6 parts of 1000mm are added2/ s hydroxy-terminated polysiloxanes (hydroxy silicon oil,
Middle indigo plant morning twilight) and 0.1 part of organic silicon modified by polyether (molecular weight 4000, Toshiba, which steps, to scheme) stir evenly.Embodiment 4
Weigh 96 parts of 12500mm2/ s dimethyl silicone polymers (dimethicone, Toshiba step figure), 4 parts of 1000mm2The poly- first of/s
Base phenyl siloxane (methyl phenyl silicone oil, Toshiba step figure), 17 parts of precipitated silicas, stirring is uniformly mixed after 1 hour, is added
7 parts of hexamethyldisilazane handle 3 hours, then heat to 90 DEG C of 2 hours of stirring, and 4.8 parts of methyl silicone rubbers are added and (divide
Son amount is 50 × 104, middle indigo plant morning twilight), 1 part of methyl MQ silicones (M:Q=0.8:1, middle indigo plant morning twilight), 0.6 part of polytetrafluoroethylene (PTFE)
(primary particle size is that proportion is 2.14g/cm at 0.2 μm, 25 DEG C to superfine powder3, specific surface area 8m2/ g, middle indigo plant morning twilight), it rises
Temperature after forty minutes, vacuumizes 4 hours of stirring to 150 DEG C of stirrings.Sizing material is cooled to room temperature, 7 parts of 100mm are added2The ends /s hydroxyl
Based polysiloxane (hydroxy silicon oil, middle indigo plant morning twilight) and 0.05 part of organic silicon modified by polyether (molecular weight 1200 steps figure production) stirring
Uniformly.
Embodiment 5
Weigh 100 parts of 1000mm2/ s dimethyl silicone polymers (dimethicone, Toshiba step figure) and 19 parts of vapor phase method hard charcoals
Black stirring 45 minutes, 5 parts of trimethylethoxysilanes are added after being uniformly mixed, and that temperature risen to 80 DEG C of stir process 2.5 is small
When, 120 DEG C of 2 hours of stirring are warming up to, 7 parts of methyl silicone rubbers are added, and (molecular weight is 45 × 104, middle indigo plant morning twilight) and 20 are stirred afterwards
After minute, 3 parts of methyl MQ silicones (M are added:Q=0.9:1, middle indigo plant morning twilight), 0.7 part of superfine powder of polytetrafluoroethylene (primary grain
Seed diameter is that proportion is 2.33g/cm at 0.5 μm, 25 DEG C3, specific surface area 13m2/ g) be warming up to 150 DEG C stir 20 minutes, open
Beginning, which vacuumizes, continues to stir 5 hours.Obtained sizing material is cooled to room temperature, 6.5 parts of 1000mm are added2/ s hydroxy-terminated polysiloxanes
(hydroxy silicon oil, middle indigo plant morning twilight) and 0.1 part of organic silicon modified by polyether (molecular weight 1200, Toshiba step figure) stir evenly.
Invention effect
Prepared serum sizing material in above example is taken to be packed into the heparin tube for being coated with coagulant, every loading 1g glue respectively
Material, makes sizing material be stored in blood sampling bottom of the tube using centrifugal device.Venous blood is centrifuged under conditions of 3000r/min × 5min
Sample is observed serum sizing material inversion effect, is observed to the instant inversion effect of serum sizing material.It is loaded into adopting for serum sizing material
Blood vessel is placed 3 days in 150 DEG C of baking oven, and vein blood specimen is centrifuged under conditions of 3000r/min × 5min after cooling,
Separating effect is observed, the high temperature ageing performance of serum sizing material is detected with this.Serum mucilage binding is entered and promotees to coagulate heparin tube, is grown at normal temperatures
Phase places, and reversion test, the bin stability when room temperature of detection serum sizing material is long were carried out to sizing material every 15 days.It is solidifying to be loaded into rush
The serum glue sample of heparin tube is placed 3 months in 60 DEG C of baking ovens, is tested every 15 days.All of above reversion test is each
Test sample quantity is 10.In addition the performances such as the proportion of sizing material, mobility can also influence the large-scale promotion use of sizing material.
√：10 all reversions
×：1 or 1 or more cannot all invert.
Claims (30)
1. a kind of organosilicon serum separation gel of stabilization, it includes：
A) one kind in dimethyl silicone polymer, polydiethylsiloxane or polymethylphenylsiloxane of 100 parts by weight
Or the organopolysiloxane of several mixtures, organopolysiloxane proportion at 25 DEG C is 0.96-1.06g/cm3, 25 DEG C
Viscosity is 500~20000mm2/s；
B) structural formula of 4-16 parts by weight is HO-Si (CH3)2O[Si(CH3)2O]mSi(CH3)2The hydroxy-terminated polysiloxane of-OH,
Wherein m values are 50-350；
C) general structure of 4.0-12 parts by weight is CH3[Si(CH3)2O]nCH3Methyl silicone rubber, wherein n values be 6000-
10000；
D) the white carbon of 14-25 parts by weight；
E) the surface conditioning agent of 3-9 parts by weight, the surface conditioning agent are silazane class coupling agent or silane coupling agent；
F) the polytetrafluorethylepowder powder of 0.4-2.5 parts by weight；
G) structural formula of 0.6-5 parts by weight isMQ silicones；With
H) 0.03-0.8 parts by weight organic silicon modified by polyether oligomer.
2. organosilicon serum separation gel as described in claim 1, wherein relative to 100 parts by weight of component A), other components
Content is as follows：
B) structural formula of 6-14 parts by weight is HO-Si (CH3)2O[Si(CH3)2O]mSi(CH3)2The hydroxy-terminated polysiloxane of-OH,
Wherein m values are 50-350；
C) general structure of 4.8-10 parts by weight is CH3[Si(CH3)2O]nCH3Methyl silicone rubber, wherein n values be 6000-
10000；
D) the white carbon of 15-22 parts by weight；
E) the surface conditioning agent of 4-8 parts by weight；
F) 0.6-2.1 parts by weight polytetrafluorethylepowder powder；
G) structural formula of 0.8-4.5 parts by weight isMQ silicones；With
H) 0.04-0.6 parts by weight organic silicon modified by polyether oligomer.
3. organosilicon serum separation gel as described in claim 1, wherein relative to 100 parts by weight of component A), other components
Content is as follows：
B) structural formula of 8-12 parts by weight is HO-Si (CH3)2O[Si(CH3)2O]mSi(CH3)2The hydroxy-terminated polysiloxane of-OH,
Wherein m values are 50-350；
C) general structure of 5.5-8 parts by weight is CH3[Si(CH3)2O]nCH3Methyl silicone rubber, wherein n values be 6000-
10000；
D) the white carbon of 17-20 parts by weight；
E) the surface conditioning agent of 5-7 parts by weight；
F) 0.8-1.8 parts by weight polytetrafluorethylepowder powder；
G) structural formula of 1-4 parts by weight isMQ silicones；With
H) 0.05-0.4 parts by weight organic silicon modified by polyether oligomer.
4. serum separation gel as described in claim 1, wherein structural formula is HO-Si (CH3)2O[Si(CH3)2O]mSi
(CH3)2In the hydroxy-terminated polysiloxane of-OH, m values are 150-250, general structure CH3[Si(CH3)2O]nCH3Methyl silicon
In rubber, n values are 7000-9000.
5. serum separation gel as described in claim 1, wherein used organopolysiloxane is that proportion is at 25 DEG C
0.98-1.04g/cm3, 25 DEG C of viscosity are in 800-15000mm2The dimethyl silicone polymer of/s ranges, gathers polydiethylsiloxane
One or more of mixtures of methyl phenyl siloxane.
6. serum separation gel as claimed in claim 5, wherein 25 DEG C of viscosity of organopolysiloxane are 6000-8000mm2/s。
7. the serum separation gel as described in any one of claim 1-5, wherein hydroxy-terminated polysiloxane viscosity at 25 DEG C is
100-1000mm2/ s, molal weight 4200-26000g/mol；And/or hydroxy radical content 0.1-0.8wt%.
8. the serum separation gel as described in any one of claim 1-5, wherein hydroxy-terminated polysiloxane viscosity at 25 DEG C is
200-800mm2/ s, molal weight 6000-20000g/mol；And/or hydroxy radical content 0.2-0.7wt%.
9. the serum separation gel as described in any one of claim 1-5, wherein hydroxy-terminated polysiloxane viscosity at 25 DEG C is
300-700mm2/ s, molal weight 9000-16000g/mol；And/or hydroxy radical content 0.3-0.6wt%.
10. the serum separation gel as described in any one of claim 1-5, wherein methyl silicone rubber number-average molecular weight be 45 ×
104-70×104；And/or volatile content≤3.0% under conditions of 150 DEG C × 3h；And/or proportion is at 25 DEG C
0.965-0.985g/cm3。
11. serum separation gel as claimed in claim 7, wherein methyl silicone rubber number-average molecular weight is 45 × 104-70×104；
And/or volatile content≤3.0% under conditions of 150 DEG C × 3h；And/or proportion is 0.965-0.985g/ at 25 DEG C
cm3。
12. the serum separation gel as described in any one of claim 1-5, wherein methyl silicone rubber number-average molecular weight be 50 ×
104-60×104；And/or proportion is 0.970-0.982g/cm at 25 DEG C3。
13. the serum separation gel as described in any one of claim 1-5, wherein the white carbon is the precipitation method or gas phase
Method white carbon, specific surface area 100-400m2/g。
14. the serum separation gel as described in any one of claim 1-5, wherein the carbon atom quality hundred of the white carbon
It is 2.0%-4.0% to divide ratio, and/or, it is 0.2%-0.5% by the moisture that karr Fischer moisture measuring method measures,
By mass.
15. the serum separation gel as described in any one of claim 1-5, wherein the methanol value of the white carbon is not less than
58.6, and/or, the proportion 2.0-2.6g/cm at 25 DEG C3。
16. the serum separation gel as described in any one of claim 1-5, wherein the methanol value of the white carbon is in 59.0-
80 ranges, and/or, the proportion 2.1-2.5g/cm at 25 DEG C3。
17. the serum separation gel as described in any one of claim 1-5, wherein the white carbon is coupled with silazane class
Agent or silane coupling agent surface conditioning agent have carried out the white carbon of surface modification.
18. the serum separation gel as described in any one of claim 1-5, wherein silazane class coupling agent or silanes coupling
Agent is hexamethyldisilazane, hexamethyldisiloxane, octamethylcy-clotetrasiloxane, hexamethyl cyclotrisiloxane, trimethyl second
One or more of oxysilane, trimethylmethoxysilane.
19. serum separation gel as described in claim 1, wherein used polytetrafluorethylepowder powder is super for polytetrafluoroethylene (PTFE)
Fine powder, primary particle size are 0.1-0.5 μm；And/or proportion is 2.0-2.5g/cm at 25 DEG C3, and/or, specific surface area is
8-20m2/g。
20. serum separation gel as described in claim 1, wherein used polytetrafluorethylepowder powder is super for polytetrafluoroethylene (PTFE)
Fine powder, primary particle size are 0.15-0.45 μm；And/or proportion is 2.1-2.45g/cm at 25 DEG C3, and/or, specific surface area
For 10-18m2/g。
21. serum separation gel as described in claim 1, wherein used polytetrafluorethylepowder powder is super for polytetrafluoroethylene (PTFE)
Fine powder, primary particle size are 0.2-0.4 μm；And/or proportion is 2.15-2.40g/cm at 25 DEG C3, and/or, specific surface area
For 12-16m2/g。
22. serum separation gel as described in claim 1, wherein MQ silicones proportion at 25 DEG C is 1.045-1.054g/
cm3, and/or, M:Value=0.6~0.9 Q:1, and/or, 25 DEG C of viscosity are 100-2500 centipoises.
23. serum separation gel as described in claim 1, wherein MQ silicones proportion at 25 DEG C is 1.047-1.052g/
cm3, and/or, M:Value=0.7~0.8 Q:1, and/or, 25 DEG C of viscosity are 200-2000 centipoises.
24. serum separation gel as described in claim 1, wherein used organic silicon modified by polyether oligomer is polyoxygenated
The oligosiloxane that ethylene or polypropylene oxide or the two are modified jointly.
25. serum separation gel as described in claim 1, wherein organic silicon modified by polyether oligomer includes side-chain structure, line style
Structure and the polyether-modified silicone oligomer of trisiloxanes class.
26. serum separation gel as described in claim 1, wherein the molecular weight of organic silicon modified by polyether oligomer is 600-
4000；And/or surface tension 20-40mN/m.
27. serum separation gel as described in claim 1, wherein the molecular weight of organic silicon modified by polyether oligomer is 1200-
3000；And/or surface tension 25-35mN/m.
28. serum separation gel as described in claim 1, wherein the organic silicon modified by polyether oligomer includes polysiloxanes
The number-average molecular weight of segment and polyether segment, wherein polysiloxanes segment is 300-2000, and the number of wherein polyether segment is divided equally
Son amount is 400-1600.
29. serum separation gel as described in claim 1, wherein the organic silicon modified by polyether oligomer includes polysiloxanes
The number-average molecular weight of segment and polyether segment, wherein polysiloxanes segment is 700-1400, and the number of wherein polyether segment is divided equally
Son amount is 600-1200.
30. the method for preparing the serum separation gel described in any one of claim 1-29, it is characterised in that this method packet
It includes：White carbon and the one or more selected from dimethyl silicone polymer, polydiethylsiloxane, polymethylphenylsiloxane are mixed
The organopolysiloxane for closing object is uniformly mixed, and surface conditioning agent stir process is then added, is warming up to 80-120 DEG C of temperature
Degree is stirred, and methyl silicone rubber, MQ silicones and polytetrafluorethylepowder powder is added and is uniformly mixed, then further heats up
Stirring is vacuumized to 130-170 DEG C, is cooled to room temperature and hydroxy-terminated polysiloxane and organic silicon modified by polyether oligomer is added and stirs
It mixes uniformly.
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| CN102872616A (en) * | 2012-09-26 | 2013-01-16 | 成都众睿达科技有限公司 | Blood separating gel and preparation method thereof |
| CN103333446A (en) * | 2013-06-21 | 2013-10-02 | 武汉曙天科技发展有限公司 | Serum separation gel and preparation method thereof |
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| CN102872616A (en) * | 2012-09-26 | 2013-01-16 | 成都众睿达科技有限公司 | Blood separating gel and preparation method thereof |
| CN103333446A (en) * | 2013-06-21 | 2013-10-02 | 武汉曙天科技发展有限公司 | Serum separation gel and preparation method thereof |
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