CN103330652B - Oral composition and application thereof - Google Patents
Oral composition and application thereof Download PDFInfo
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- CN103330652B CN103330652B CN201310303521.XA CN201310303521A CN103330652B CN 103330652 B CN103330652 B CN 103330652B CN 201310303521 A CN201310303521 A CN 201310303521A CN 103330652 B CN103330652 B CN 103330652B
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- oral cavity
- calcium glycerophosphate
- functional oligose
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Abstract
The invention provides an oral composition which is prepared by mixing calcium glycerophosphate and/or tetrasodium pyrophosphate and functional oligosaccharide. The oral composition provided by the invention can better maintain and adjust oral micro-ecological balance, enable oral microorganisms to be in a stable state, keep oral health through mutual suppression and mutual influence of strains, and effectively prevent oral diseases, particularly caries, ozostomia and periodontal diseases.
Description
Technical field
The present invention relates to oral care techniques field, be specifically related to a kind of composition for oral cavity and application thereof.
Background technology
Oral cavity is a complexity and complete microecosystem, and field planting and the breeding of the various microorganism of boil on the nape opposite the mouth intracavity provide environment and condition.Under normal circumstances, between oral microorganism, between microorganism and host, be in poised state, participate in the metabolism of body, immunity, nutrition and maintain the effects such as oral health.When keeping the state of balance mutually between body and normal flora, normal flora display plays a part useful to host; But when in environment, some factor disturbs this poised state, dysbacteriosis is caused as temperature, oxygen tension, pH, life-time service antibiotic, excess hormones etc., this is just for normal flora provides the chance of its illeffects of display, these original no pathogenicities or antibacterial that virulence is very weak, then become opportunist and cause autogenous infection disease.Because a variety of causes causes internal mouth environment to there occurs change, cause micropopulation in oral cavity unbalance, occur some flora amount reproduction, and suppress the growth of another flora, occur that Flora Disturbance is lacked of proper care, finally make the generation of disease.Oral cavity commonly encountered diseases---dental caries and periodontal disease are exactly one of performance of oral cavity ecological disturbance.
Xu Hongyun etc. study discovery, and the distribution of ozostomia patient oral cavity flora and sum exist significant difference with normal population, and the pathogenic bacterium quantity relevant with periodontal disease is apparently higher than normal population.Wang Jianzhang etc. are by the Auele Specific Primer of design streptococcus, Wei Rong bacterium and Neisseria three kinds of coccuses, fluorescent quantitative PCR technique is adopted to carry out detection by quantitative to above-mentioned three kinds of Pseudomonas, result shows the content all comparatively normal healthy controls group reduction of ulcer group three kinds of Pseudomonas streptococcus intermediuses genus and Wei Rong Pseudomonas, show that in recurrent oral ulceration, these Pseudomonas content there occurs change, generation, the development of prompting recurrent oral ulceration change relevant to Oral health behaviours.The malignant bacteria causing dental caries, by degraded low molecular weight sugar or other food, produces acidic materials, oral pH is reduced.Oral cavity acidity reduction causes the balance of the demineralization of enamel and demineralization to be again broken, and hydroxy-apatite dirt rock glacier loses.Normal oral pH value is between 6.7-7.4, is in and dissolves with the dynamic equilibrium of deposition, maintain adamantine normal condition between enamel main component hydroxyapatite and enamel external environment inorganic ion.Because of other factors, as the acid of: Production by Bacteria, long-term taking acidic beverages, repeatedly diet etc. cause mouth cavity liquid, the pH value of saliva and dental plaque fluid reduce time, the solubility product of hydroxyapatite increases, and solid-state hydroxyapatite changes to liquid hydroxyapatite, and dental caries damage and formed.If the acid-base value of enamel external environment condition can be made to keep certain limit, the balance of adamantine demineralization and demineralization is again continued, dental caries can not occur.
Antibacterial is the arch-criminal causing various oral problem.Antibacterial common in oral care product is Chinese herbal medicine and chemical composition antibacterial or antibacterial, and chemical classes is as compositions such as triclosan, cetylpyridinium chloride, hibitane, antibiotic, and these compositions have bitter in the mouth, irritant, and oral mucosa can be stimulated to cause inflammation.Hibitane can make tooth staining, and triclosan was once in the news and has carcinogenesis.These antibacterial of frequent use, antibacterial will develop immunity to drugs.Chinese herbal medicine is not only antibacterial, and has the effects such as antiinflammatory, hemostasis, analgesia, in oral care product, enjoy favor.But Chinese herbal medicine instability, easily oxidized, perishable in toothpaste is deposited, lose activity.Meanwhile, often use the oral care product containing antibacterial composition, easily cause oral cavity bacterium ecological disturbance, or make bacterial resistance occurred, the effect of prevention oral disease can not be reached, cause other multiple oral diseases on the contrary.
In sum, intraoral microorganism constitutes the microbial ecological group of a complicated multiple genus, mutually suppresses, mutually regulates between them, and participate in the homergy in oral cavity, the immunocompetence that enhancing body is disease-resistant, safeguards the health in oral cavity.Therefore, maintaining the microecological balance in oral cavity, is the key guaranteeing oral health.
Summary of the invention
The object of the invention is to the defect overcoming above-mentioned prior art, a kind of composition for oral cavity is provided, it can maintain preferably, regulate intraoral microecological balance, intraoral microorganism is made to be in a kind of stable state, each strain mutually restricts, influences each other, make body be in a kind of state of health, effectively prevent oral disease, especially dental caries, halitosis and periodontal.
Another object of the present invention is to the application that above-mentioned composition for oral cavity is provided.
Present inventor finds, functional oligose and calcium glycerophosphate or mixing of tetrasodium pyrophosphate can play the good effect maintaining Oral health behaviours and balance.Therefore, technical scheme of the present invention is as follows:
A kind of composition for oral cavity, said composition is mixed by calcium glycerophosphate and/or tetrasodium pyrophosphate and functional oligose.
Realizing object of the present invention can also take following measures to reach:
Realizing a kind of mode of the present invention is: said composition is that the calcium glycerophosphate of 1:1 ~ 10 and functional oligose mix by mass ratio.
Realizing a kind of mode of the present invention is: said composition is that the calcium glycerophosphate of 1:4 and functional oligose mix by mass ratio.
Realizing a kind of mode of the present invention is: said composition is that the tetrasodium pyrophosphate of 1:1 ~ 10 and functional oligose mix by mass ratio.
Realizing a kind of mode of the present invention is: said composition is that the tetrasodium pyrophosphate of 1:4 and functional oligose mix by mass ratio.
Realizing a kind of mode of the present invention is: said composition by mass ratio be the calcium glycerophosphate of 1:1:1 ~ 15, tetrasodium pyrophosphate and functional oligose mix.
Realizing a kind of mode of the present invention is: said composition by calcium glycerophosphate, tetrasodium pyrophosphate and functional oligose in mass ratio for 1:1:8 mixes
Realizing a kind of mode of the present invention is: described functional oligose is one or more mixing in oligomeric xylose, oligofructose, Oligomeric maltose, dextrinosan, oligomeric galactose, soybean oligo saccharide, oligo-chitosan and trehalose.Oligosaccharide, also known as oligosaccharide, can be divided into ordinary oligosaccharide and the large class of functional oligose two.Sucrose, lactose, maltose etc. belong to ordinary oligosaccharide, can be utilized by antibacterials such as Streptococcus mutans, produce the acidic materials such as lactic acid, oral pH is reduced.Functional oligose is that to be polymerized with glycosidic bond by 2-10 identical or different monosaccharide (can be straight chain, also can be side chain), there is the characteristic of saccharide, can directly as sweet food ingredient, but not by human body alimentary canal enzyme and gastric acid degradation, not by (or difficult quilt) intestinal absorption, and there is the physiological functions such as the propagation promoting human body bifidus bacillus.Described functional oligose preferably uses oligofructose.Oligofructose can not be generated cohesiveness polysaccharide by Streptococcus mutans as fermentation substrate---glucosan, microbe deposition can not be provided for oral cavity, produce the condition of acid and corrosion, the lactic acid quantity generated by oligofructose is less than 50% of sucrose, make oral cavity acid-base value maintain normal level, effectively prevent dental caries.
In composition for oral cavity of the present invention functional oligose can play suppress noxious bacteria breeding in oral cavity, delay dental plaque synthesis speed, improve oral environment, adjustment and maintain the effect of Oral health behaviours balance, thus reach effects such as preventing periodontal generation, caries prevention.
Composition for oral cavity of the present invention is applied in oral care product, can anti-halitosis, periodontal and dental caries.
Described oral care product is toothpaste, dentifrice, mouthwass, collutory, foam, mouth spraying agent, lozenge.
Compared with prior art, the invention has the beneficial effects as follows:
Compositions of the present invention does not have zest to oral mucosa, and safety is high; Particularly functional oligose and calcium glycerophosphate and/or tetrasodium pyrophosphate combine and the acid-base value in oral cavity can be made to maintain normal level, for intraoral microecological balance provides favourable condition, and then maintain, regulate intraoral microecological balance, promote beneficial bacteria growth, suppress noxious bacteria breeding, improve oral cavity oneself's detergent power, improve oral environment, the generation of prevention periodontal and dental caries, prevents halitosis.
Detailed description of the invention
Below by specific embodiment, the present invention is described in further details.
Embodiment 1
A kind of composition for oral cavity, it comprises functional oligose, tetrasodium pyrophosphate, calcium glycerophosphate.Described functional oligose is oligofructose.The mass ratio of described oligofructose and calcium glycerophosphate, tetrasodium pyrophosphate is 8:1:1.
Embodiment 2
A kind of composition for oral cavity, it comprises functional oligose and calcium glycerophosphate.Described functional oligose is oligofructose.The mass ratio of described oligofructose and calcium glycerophosphate is 4:1.
Embodiment 3
A kind of composition for oral cavity, it comprises functional oligose and tetrasodium pyrophosphate.Described functional oligose is oligofructose.The mass ratio of described oligofructose and tetrasodium pyrophosphate is 4:1.
Embodiment 4
A kind of composition for oral cavity, it comprises functional oligose and calcium glycerophosphate.Described functional oligose is oligofructose.The mass ratio of described oligofructose and calcium glycerophosphate is 10:1.
Embodiment 5
A kind of composition for oral cavity, it comprises functional oligose, tetrasodium pyrophosphate, calcium glycerophosphate.Described functional oligose is oligofructose.The mass ratio of described oligofructose and calcium glycerophosphate, tetrasodium pyrophosphate is 15:1:1.
Application Example 1
The compositions of Example 1 is used in tooth paste product, specific as follows:
A kind of toothpaste, its percentage is composed of the following components:
Sorbitol 40%
Glycerol 10%
PEG-8 5%
Sodium carboxymethyl cellulose 0.6%
Sodium lauroyl sarcosine 2.0%
Silica 1 8%
Oligofructose 8%
Tetrasodium pyrophosphate 1%
Calcium glycerophosphate 1%
Essence 0.8%
Deionized water surplus.
The preparation method of above-mentioned toothpaste is as follows:
(1) oligofructose, tetrasodium pyrophosphate, calcium glycerophosphate are added in container, add deionized water and stirring and dissolve, after dissolving completely, in container, add sorbitol and glycerol.
(2) join in another container by PEG-8 and sodium carboxymethyl cellulose, dispersed with stirring is even, guarantees that sodium carboxymethyl cellulose does not have conglomeration, then is added by scattered sodium carboxymethyl cellulose in the container of step (1), dispersed with stirring.
(3) in above-mentioned scattered system, silicon dioxide is added, under vacuo mixed at high speed 15 to 20 minutes.
(4) essence is added and sodium lauroyl sarcosine fully mixes under vacuum, disperses.
Application Example 2
The compositions of Example 4 is used in dentifrice product, and concrete grammar is as follows:
A kind of dentifrice, it is composed of the following components by weight percentage:
Sorbitol: 5%
Calcium carbonate: 45%
Silicon dioxide: 10%
Calcium glycerophosphate: 3.0%
Sodium lauroyl sarcosine: 1.5%
Oligofructose: 30.00%
Essence: 1.0%
Deionized water: add to 100%
The preparation method of above-mentioned dentifrice is as follows:
(1) oligofructose, calcium glycerophosphate are added in container, add deionized water and stirring and dissolve, after dissolving completely, in container, add sorbitol, obtained liquid-phase mixing liquid.
(2) by mix and blend pot, add calcium carbonate, silicon dioxide successively, dispersed with stirring, add liquid-phase mixing liquid afterwards by certain speed, after adding, rapid stirring is about 15min.
(3) essence and sodium lauroyl sarcosine is added, stir about 20min toward above-mentioned scattered system, so that system mix homogeneously.
Application Example 3
Be used in collutory by the compositions of embodiment 3, described rapids saliva percentage is composed of the following components:
Sorbitol: 12%
Propylene glycol: 4%
Tetrasodium pyrophosphate: 1%
Sodium benzoate: 0.25%
Essence: 0.2%
Tween 20: 1.5%
Oligofructose: 4.00%
Deionized water: add to 100%
Preparation technology is as follows:
(1) oligofructose, sodium benzoate, tetrasodium pyrophosphate are added in container 1, add the deionized water through high temperature sterilize and stirring and dissolving, about 20 minutes;
(2) sorbitol, propylene glycol are joined in container 1, and stirring and dissolving, about 5 minutes, add tween 20 afterwards, stirring and dissolving, about 5 minutes;
(3) finally add essence, stir 10 minutes.
Application Example 4
The compositions of Example 5 is used in mouth spraying agent, and described mouth spraying agent percentage is composed of the following components:
Sorbitol: 15%
Ethanol: 8%
Tetrasodium pyrophosphate: 0.6%
Calcium glycerophosphate: 0.6%
Essence: 0.3%
Tween 20: 2.0%
Oligofructose: 9.00%
Sodium benzoate: 0.25%
Deionized water: add to 100%
Preparation technology is as follows:
(1) oligofructose, calcium glycerophosphate, sodium benzoate, tetrasodium pyrophosphate are added in container 1, add the deionized water through high temperature sterilize and stirring and dissolving, about 20 minutes;
(2) sorbitol, ethanol are joined in container 1, and stirring and dissolving, about 5 minutes, add tween 20 afterwards, stirring and dissolving, about 5 minutes;
(3) finally add essence, stir 10 minutes.
Effect is tested
Adopt experiment in vitro, more above-mentioned composition for oral cavity is to oral cavity pathogen (porphyromonas gingivalis, Fusobacterium nucleatum, Streptococcus mutans) and probiotic bacteria (lactobacillus rhamnosus, Lactobacillus acidophilus) growth.
With the colony inoculation of inoculating loop respectively picking porphyromonas gingivalis, Fusobacterium nucleatum, Streptococcus mutans, Lactobacillus acidophilus, lactobacillus rhamnosus in following 5 kinds of fluid mediums, 37 DEG C of incubators cultivate 72h, then with bacterial number in turbidimetry for Determination every milliliter culture fluid.(1) blank: use anaerobe fluid medium, not adding ingredient; (2) experimental group 1: add 0.5% oligofructose powder in anaerobe fluid medium; (3) experimental group 2: the composition for oral cavity powder adding 0.5% embodiment 2 in anaerobe fluid medium; (4) experimental group 3: the composition for oral cavity powder adding 0.5% embodiment 3 in anaerobe fluid medium; (5) experimental group 4: the composition for oral cavity powder adding the embodiment 1 of 0.5% in anaerobe fluid medium; (6) each bacteria quantified method: with Maxwell opacity tube turbidimetric assay.The parallel repetition of each strain 3 times, experimental result is averaged, as table 1.
Table 1 oral cavity composition is to oral cavity bacteria effect
Note: in table 1, experimental group 1,2,3,4 is respectively compared with blank group, P < 0.01, and experimental group 2,3,4 contrast experiment organizes 1 respectively is also P < 0.01, there is significant difference.
Result shows, composition for oral cavity of the present invention has the breeding suppressing pathogenic bacterium in oral cavity, promote the breeding of beneficial bacteria, can maintain preferably, regulate intraoral microecological balance, make intraoral microorganism be in a kind of stable state, each strain mutually restricts, influences each other, and makes body be in a kind of state of health, effective prevention oral disease, especially dental caries, halitosis and periodontal.And when composition for oral cavity of the present invention gets functional oligose and calcium glycerophosphate, tetrasodium pyrophosphate three mixture, have synergistic effect, the combination that its effect compares any two kinds has significant difference.
The announcement of book and instruction according to the above description, those skilled in the art in the invention can also change above-mentioned embodiment and revise.Therefore, the present invention is not limited to detailed description of the invention disclosed and described above, also should fall in the protection domain of claim of the present invention modifications and changes more of the present invention.In addition, although employ some specific terms in this description, these terms just for convenience of description, do not form any restriction to the present invention.
Claims (4)
1. a composition for oral cavity, is characterized in that: said composition is mixed by calcium glycerophosphate and tetrasodium pyrophosphate and functional oligose; Said composition by calcium glycerophosphate, tetrasodium pyrophosphate and functional oligose in mass ratio for 1:1:8 mixes.
2. composition for oral cavity as claimed in claim 1, is characterized in that: described functional oligose is one or more mixing in oligomeric xylose, oligofructose, Oligomeric maltose, dextrinosan, oligomeric galactose, soybean oligo saccharide, coupling sugar, oligo-chitosan and trehalose.
3. the composition for oral cavity described in claim 1 to 2 any one is preparing the application in oral care product.
4. application according to claim 3, is characterized in that: described oral care product is toothpaste, dentifrice, mouthwass, collutory, foam, mouth spraying agent, lozenge.
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| CN201310303521.XA CN103330652B (en) | 2013-07-18 | 2013-07-18 | Oral composition and application thereof |
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| CN201310303521.XA CN103330652B (en) | 2013-07-18 | 2013-07-18 | Oral composition and application thereof |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110448480A (en) * | 2019-08-13 | 2019-11-15 | 江苏雪豹日化有限公司 | A kind of oral-care toothpaste containing prebiotics |
| CN111568940A (en) * | 2020-06-19 | 2020-08-25 | 河南华药药业有限公司 | Formula for preventing dental caries and preparation method thereof |
| CN111701014A (en) * | 2020-08-12 | 2020-09-25 | 好易康生物科技(广州)有限公司 | Toothpaste for children and preparation method thereof |
| CN115006341B (en) * | 2022-07-21 | 2023-12-19 | 重庆登康口腔护理用品股份有限公司 | Oral cavity cleaning and nursing composition capable of regulating oral cavity microecological balance and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101564113A (en) * | 2008-04-22 | 2009-10-28 | 天津生机集团股份有限公司 | Anti-caries pet health-care food |
| CN103079526A (en) * | 2010-09-10 | 2013-05-01 | 荷兰联合利华有限公司 | Oral care compositions for benefiting teeth |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101564113A (en) * | 2008-04-22 | 2009-10-28 | 天津生机集团股份有限公司 | Anti-caries pet health-care food |
| CN103079526A (en) * | 2010-09-10 | 2013-05-01 | 荷兰联合利华有限公司 | Oral care compositions for benefiting teeth |
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