CN103323420B - A kind of for gastric cancer detection Terahertz system sample sampling apparatus and using method thereof - Google Patents
A kind of for gastric cancer detection Terahertz system sample sampling apparatus and using method thereof Download PDFInfo
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- CN103323420B CN103323420B CN201310201962.9A CN201310201962A CN103323420B CN 103323420 B CN103323420 B CN 103323420B CN 201310201962 A CN201310201962 A CN 201310201962A CN 103323420 B CN103323420 B CN 103323420B
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Abstract
The invention discloses a kind of for gastric cancer detection Terahertz system sample sampling apparatus and using method thereof.The present invention includes apparatus structure and gathers light path；In apparatus structure, top board is provided with motor, the bottom mounting seat of left and right side plate；Four right angle ends of base install straight optical axis；Vertical and horizontal translation mechanism it has been respectively mounted on lifting platform, specimen holder it is mounted with on laterial translation mechanism, the right-hand member of base plate is provided with electric machine controller, the two ends, left and right of lifting platform have been respectively mounted two left straight optical axis bearings and two right straight optical axis bearings, left screw mandrel, one end of right screw mandrel are separately fixed at left end and the right-hand member of top board lower surface, and the other end is fixed on base through the through hole on lifting platform；Gathering femto-second laser pulse in light path and be divided into pumping pulse and direct impulse by beam splitter after half-wave plate, the substrate surface of antenna emitter stage is incided in pumping pulse after optical delay line.Inventive samples is installed the most succinctly, measuring accuracy is high, data acquisition is accurate.
Description
Technical field
The present invention relates to a kind of Terahertz system sample sampling apparatus, particularly relate to one and detect too for gastric cancer
Hertz system sample device and using method thereof.
Background technology
China is the district occurred frequently of gastric cancer, increases patient about people more than 400,000 year newly, accounts for the 42% of whole world number of the infected,
And sickness rate is in increasing trend year by year.THz wave (Terahertz Wave is called for short THz ripple) is often referred to frequency
Rate electromagnetic radiation in the range of 0.1～10THz, the THz spectrum of material depends on the space of molecule
Interaction between structure and molecule, corresponding vibration mode contains intramolecular and intermolecular vibration (collection
Body vibrates), for the research structure of biomacromolecule, intermolecular reaction, molecule and environment interphase interaction etc.
There is unique advantage.THz ripple is used for infantile tumour diagnosis by the most external research worker that has, and achieves
Gratifying achievement.During Terahertz systematic sampling, sample making is the heaviest in Terahertz experimentation
The link wanted, its quality made directly affects the Exact Travelling of data.But the polytropy due to sample
And the complexity of test process so that complex operation during changing sample and experiment, conventional efficient is low
Under, system is unstable.Develop clamped one time complete multi-point sampler, faster convenient specimen holder be improve
The effective way of gastric cancer detection Terahertz system effectiveness.
Summary of the invention
It is an object of the invention to for problems of the prior art, it is provided that a kind of for gastric cancer detection terahertz
Hereby system sample sampling apparatus and using method thereof.
A kind of for gastric cancer detection Terahertz system sample sampling apparatus, including apparatus structure and collection light path.Dress
Put in structure, top board be mounted with the left side of left motor and right motor, top board is mounted with left plate,
The right side of top board is mounted with right plate；The bottom of left plate and right plate is mounted with base；Under in left plate
Portion is mounted with proximity switch, and four right angle ends of base are mounted with straight optical axis, i.e. two left straight optical axis and
Two right straight optical axis；It is respectively mounted longitudinal translation mechanism and laterial translation mechanism on lifting platform, has laterally put down
Being mounted with specimen holder on moving mechanism, the right-hand member of base plate is provided with electric machine controller, and the two ends, left and right of lifting platform are respectively
It is mounted with two left straight optical axis bearings and two right straight optical axis bearings, left straight optical axis, right straight optical axis
One end be separately fixed at left end and the right-hand member of top board lower surface, the other end is through the left line light on lifting platform
After axle bearing and right straight optical axis bearing, it is fixed on base；Left screw mandrel, the end of right screw mandrel are separately fixed at
The left end of top board lower surface and right-hand member, the other end is fixed on base through the through hole on lifting platform；And left silk
Bar, left straight optical axis, right screw mandrel, right straight optical axis and left plate, right plate are parallel；
Longitudinal translation mechanism includes lifting platform, left rail cushion block, left line slideway, left linear slider, longitudinal direction
Platform, longitudinal motor, right guide rail cushion block, right line slideway, right straight-line guide rail slide block；On lifting platform
Surface is provided with on left rail cushion block and right guide rail cushion block；Equipped with left line slideway, Zuo Zhi on left rail cushion block
Line guide rail is provided with left linear slider, and left linear slider is arranged on longitudinal platform lower surface；On right guide rail cushion block
Being provided with right line slideway, right line slideway is provided with right linear slider, and right linear slider is arranged on longitudinal platform
Lower surface.Lifting platform upper surface is provided with longitudinal motor contiguous block, equipped with longitudinal stepping on longitudinal motor contiguous block
Motor, the front end of longitudinal motor is equipped with longitudinal shaft coupling, and longitudinal shaft coupling is by longitudinal screw mandrel front end axle
Hold the one end with longitudinal screw mandrel to be connected, the other end of longitudinal screw mandrel is provided with longitudinal screw mandrel bolt, longitudinal silk
Bar bolt is connected with longitudinal platform with longitudinal platform contiguous block II by longitudinal platform contiguous block I.
In described longitudinal sliding motion mechanism, lifting platform is connected with left rail cushion block by longitudinally connected bolt, left
Guide rail cushion block is connected with left line slideway by guide rail connecting bolt.Equipped with left linear slider on left line slideway,
Left linear slider is connected with longitudinal platform by slide block connecting bolt.
Laterial translation mechanism include cross lead screw terminal shaft bearing, horizontal bearing terminal shaft hold, cross lead screw,
End bearing block, cross lead screw before horizontal platform, horizontal platform contiguous block, cross lead screw bolt, cross lead screw
Front end bearing, horizontal shaft coupling, cross motor contiguous block, cross motor, cross motor contiguous block bolt,
Rear rail cushion block, transverse slider, fromer rail cushion block；
End bearing block and laterally it is fixedly installed before cross lead screw terminal shaft bearing, cross lead screw on longitudinal platform
Motor contiguous block, cross lead screw terminal shaft bearing is provided with horizontal bearing terminal shaft and holds, horizontal bearing terminal shaft
Holding the one end with cross lead screw to fix, the other end of cross lead screw is installed on end bearing block before cross lead screw
Cross lead screw front end bearing after, be connected with one end of horizontal shaft coupling, the other end of horizontal shaft coupling with
The output shaft of cross motor is connected；Cross motor is fixedly installed on cross motor contiguous block, cross motor
Contiguous block is connected with longitudinal platform by cross motor contiguous block bolt.The rear portion of longitudinal platform and anterior difference
It is provided with rear rail cushion block and fromer rail cushion block, rear rail cushion block and fromer rail cushion block by transverse slider with horizontal
Platform is connected.
Specimen holder includes specimen holder lid, sample bin, sample bin air inlet, sample bin support, sample bin support
Bolt, specimen holder base plate；It is connected with sample bin pedestal lower end by sample bin support bracket bolt on specimen holder base plate,
Sample bin pedestal upper end is provided with sample bin, and the lower surface of sample bin has sample bin air inlet, and upper surface is provided with
Specimen holder lid, is provided with sample panel, cladding plate in sample bin, cladding plate is arranged on the front portion of sample panel, sample bin
Side be provided with humidity sensor.
It is provided with sample panel, cladding plate, and cladding plate in sample bin to be connected with sample panel by cladding plate bolt, sample
Product plate is positioned at specimen holder lid bottom, and its front portion is provided with sample, and the front portion of sample is provided with cladding plate, covers
Plate is pressed on sample by cladding plate spring, and the right side of cladding plate spring is provided with cladding plate adjusting nut, and cladding plate is adjusted
Joint nut and cladding plate spring are all contained on cladding plate bolt.
Described collection light path includes electric machine controller, femto-second laser, collimating lens I, half slide, divides
Shu Jing, collimating lens II, reflecting mirror I, differential detector I, differential detector II, wollaston prism,
Quarter-wave plate, ZnTe crystal, Si mirror, paraboloidal mirror I, paraboloidal mirror II, sample fill
Put, paraboloidal mirror III, paraboloidal mirror IV, GaAs crystal, reflecting mirror II, reflecting mirror III, reflection
Mirror IV, chopper, lock-in amplifier, computer, electric machine controller, electric platforms；
The laser that femto-second laser produces by being divided into two-way by beam splitter after collimating lens I and half slide, the
One road laser arrives reflecting mirror IV, laser by chopper after inciding reflecting mirror I after collimating lens II
Paraboloidal mirror III is arrived by GaAs crystal after reflecting mirror IV, reflecting mirror II, reflecting mirror III,
After sample and sample device, paraboloidal mirror II is arrived afterwards after paraboloidal mirror IV reflects,
Laser is through paraboloidal mirror II, paraboloidal mirror I, Si mirror, ZnTe crystal；Second road laser is through silicon
Arrive ZnTe crystal after reflecting mirror reflection to converge with first via laser.Laser after converging is through 1/4th
Wave plate, wollaston prism, differential detector I, differential detector II, lock-in amplifier arrive computer,
Nitrogen cylinder is connected in sample device by trachea, and whole process is by motor controller controls electric platforms
Complete.
The using method of a kind of gastric cancer detection Terahertz system sample sampling apparatus, comprises the steps:
Step (1). select sample panel and the pore size of cladding plate according to the diameter of sample sheet.
Step (2). by sample as between sample panel and cladding plate, then sample panel is positioned over sample
Storehouse.
Step (3). nitrogen tube is linked at the air inlet of sample bin, is filled with nitrogen to reduce storehouse humidity
To 3%.
Step (4). regulate sample bin location by electric machine controller so that it is center is at Terahertz
Ripple focal point.
Step (5). fix all optics in pumping light path and detection light path according to the propagation path of light path
Device, it is ensured that laser beam passes sequentially through the center of each optics and light path at same level height.
Step (6). regulation electric platforms, when making motor move, light path keeps constant.Make terahertz simultaneously
The pumping light path of hereby pulse and detection light path equivalent optical path, if unequal, then by regulation reflecting mirror II
Optical path difference therebetween is made up with the position of reflecting mirror IV.
Step (7). confirm that laser beam passes through collimating lens I, the center of collimating lens II, if there is partially
Difference can pass through reflecting mirror II, reflecting mirror III is adjusted.THz wave transmitting crystal GaAs strictly to be put
Putting in the focus of paraboloidal mirror III, in like manner electro-optic detection crystal ZnTe also must necessarily be placed in paraboloidal mirror I
In focus.
Step (8). just can carry out the measurement of experimental data after having debugged the light path of system.Energy in experimentation
Enough pass through motor controller controls, in order to sample each at be scanned with sampled data.
The present invention has the beneficial effect that:
1, the present invention uses vertical structure, elegant in appearance, convenient operating maintenance.Industrial computer is used to realize test
The Automatic Control of process, control sample bin location by operation software.
2, sample is easy for installation, according to the diameter of different sample strip, can select different size sample panel and
Cladding plate.By spring, sample strip is reliably pressed in sample panel, it is ensured that the stability of sample position.Greatly
Improve greatly the efficiency of experimentation, ensure that the stability of data simultaneously.
3, sample bin is provided with nitrogen inlet, can introduce nitrogen gas in sample bin easily, in order to by storehouse endogenous dampness
Degree quickly drops to regulation requirement, also saves the usage amount of nitrogen simultaneously.
The present invention has sample installation the most in a word, and measuring accuracy advantages of higher can preferably ensure terahertz
The accuracy of hereby experimental system data acquisition, improves conventional efficient.
Accompanying drawing explanation
Fig. 1 is the front schematic view of Terahertz system sample sampling apparatus of the present invention；
Fig. 2 is the schematic top plan view of Terahertz system sample sampling apparatus of the present invention；
Fig. 3 is the front schematic view of Terahertz of the present invention system sample sampling apparatus longitudinal sliding motion mechanism；
Fig. 4 is the schematic top plan view of Terahertz of the present invention system sample sampling apparatus longitudinal sliding motion mechanism；
Fig. 5 is Terahertz system sample sampling apparatus longitudinal rail scheme of installation of the present invention；
Fig. 6 is Terahertz system sample sampling apparatus transverse sliding mechanism front schematic view of the present invention；
Fig. 7 is Terahertz system sample sampling apparatus transverse sliding mechanism schematic top plan view of the present invention；
Fig. 8 is Terahertz system sample sampling apparatus sample bin front schematic view of the present invention；
Fig. 9 is Terahertz system sample sampling apparatus sample bin schematic top plan view of the present invention；
Figure 10 is Terahertz system sample sampling apparatus specimen holder front elevation of the present invention；
Figure 11 is Terahertz system sample sampling apparatus specimen holder side schematic view of the present invention；
Figure 12 is Terahertz system experimental device system structure schematic diagram of the present invention；
Figure 13 is workflow diagram of the present invention.
In figure: left motor 1, right motor 2, top board 3, left plate 4, left screw mandrel 5, Zuo Zhi
Linear light axle 6, specimen holder 7, right plate 8, right screw mandrel 9, right straight optical axis 10, transverse sliding mechanism 11,
Proximity switch 12, lifting platform 13, left straight optical axis bearing 14, longitudinal sliding motion mechanism 15, right straight optical axis
Bearing 16, base 17, electric machine controller 18, left rail cushion block 19, longitudinal motor 20, right guide rail
Cushion block 21, left line slideway 22, left linear slider 23, longitudinal platform 24, longitudinal platform contiguous block I 25,
Right straight-line guide rail slide block 26, right line slideway 27, slide block connecting bolt 28, guide rail connecting bolt 29, pad
Block connecting bolt 30, longitudinal platform contiguous block II 31, longitudinal screw mandrel bolt 32, longitudinal screw mandrel 33, longitudinal direction
Screw mandrel front end bearing 34, longitudinal shaft coupling 35, longitudinal motor contiguous block 36, cross lead screw terminal shaft bearing
37, horizontal bearing terminal shaft hold 38, cross lead screw 39, horizontal platform 40, horizontal platform contiguous block 41,
End bearing block 43, cross lead screw front end bearing 44, horizontal shaft coupling before cross lead screw bolt 42, cross lead screw
Device 45, cross motor contiguous block 46, cross motor 47, cross motor contiguous block bolt 48, rear rail pad
Block 49, front linear slider 50, fromer rail cushion block 51, specimen holder lid 52, sample bin 53, sample bin prop up
Frame 54, specimen holder base plate 55, sample bin air inlet 56, sample bin support bracket bolt 57, sample bonnet bolt 58,
Cladding plate 59, cladding plate bolt 60, sample panel 61, sample 62, cladding plate spring 63, cladding plate adjusting nut
64, femto-second laser 65, collimating lens I 66, half slide 67, beam splitter 68, collimating lens II 69,
Reflecting mirror I 70, differential detector I 71, differential detector II 72, wollaston prism 73, four/
One wave plate 74, ZnTe crystal 75, Si mirror 76, paraboloidal mirror I 77, paraboloidal mirror II 78, sample
Sampling apparatus 79, paraboloidal mirror III 80, paraboloidal mirror IV 81, GaAs crystal 82, reflecting mirror II 83,
Reflecting mirror III 84, reflecting mirror IV 85, chopper 86, lock-in amplifier 87, computer 88, nitrogen cylinder
89, humidity sensor 90, electric platforms 91.
Detailed description of the invention
Below in conjunction with accompanying drawing, the invention will be further described.
As shown in Figure 1 and Figure 2, a kind of for gastric cancer detection Terahertz system sample sampling apparatus, at top board 3
On be mounted with that the left side of left motor 1 and right motor 2, top board is mounted with left plate 4, the right side of top board
Side is mounted with right plate 8；The bottom of left plate 4 and right plate 8 is mounted with base 17；Under in left plate
Portion is mounted with proximity switch 12, and four right angle ends of base 17 are mounted with straight optical axis, i.e. two left straight lines
Optical axis 6 and two right straight optical axis 10；Longitudinal translation mechanism 15 it has been respectively mounted with horizontal on lifting platform 13
Translation mechanism 11, laterial translation mechanism 11 is mounted with specimen holder 7, the right-hand member of base plate 17 are provided with motor control
Device 18 processed, the two ends, left and right of lifting platform 13 have been respectively mounted two left straight optical axis bearings 14 and two right sides are straight
Linear light axle bearing 16, left straight optical axis 6, one end of right straight optical axis 10 are separately fixed at top board 3 lower surface
Left end and right-hand member, the other end is through the left straight optical axis bearing 14 on lifting platform 13 and right straight optical axis axle
After holding 16, it is fixed on base 17；Left screw mandrel 5, the end of right screw mandrel 9 are separately fixed at top board 3 following table
The left end in face and right-hand member, the other end is fixed on base 17 through the through hole on lifting platform 13；And left screw mandrel
5, left straight optical axis 6, right screw mandrel 9, right straight optical axis 10 and left plate 4, right plate 8 are parallel；
As shown in Figure 3, Figure 4, longitudinal translation mechanism 15 includes lifting platform 13, left rail cushion block 19, indulges
To motor 20, right guide rail cushion block 21, left line slideway 22, left linear slider 23, longitudinal platform 24,
Right straight-line guide rail slide block 26, right line slideway 27；Lifting platform 13 upper surface is provided with on left rail cushion block 19
With right guide rail cushion block 21；Equipped with left line slideway 22 on left rail cushion block 19, left line slideway 22 is provided with
Left linear slider 23, left linear slider 23 is arranged on longitudinal platform 24 lower surface；On right guide rail cushion block 21
Being provided with right line slideway 27, right line slideway 27 is provided with right linear slider 26, and right linear slider 26 is installed
At longitudinal platform 24 lower surface；Longitudinal platform contiguous block I 25 and longitudinal platform contiguous block II 36 are by longitudinally
Screw mandrel bolt 32 is connected with longitudinal platform 24, and longitudinal motor 20 is arranged on longitudinal platform contiguous block I 25
With on longitudinal platform contiguous block II 36；The front end of longitudinal motor 20 is equipped with longitudinal shaft coupling 35, longitudinally
Shaft coupling 35 is connected by one end of longitudinal screw mandrel front end bearing 34 with longitudinal screw mandrel 33, longitudinal screw mandrel 33
The other end be connected with longitudinal platform contiguous block.
As it is shown in figure 5, in described longitudinal sliding motion mechanism 15, lifting platform 13 is by cushion block connecting bolt 30
Being connected with left rail cushion block 19, left rail cushion block 19 is by guide rail connecting bolt 29 and left line slideway 22
It is connected.Equipped with left linear slider 23 on left line slideway 22, left linear slider 23 is by slide block connecting bolt
28 are connected with longitudinal platform 24.
As shown in Figure 6, Figure 7, laterial translation mechanism 11 includes cross lead screw terminal shaft bearing 37, lateral shaft
Hold end bearing 38, cross lead screw 39, horizontal platform 40, horizontal platform contiguous block 41, cross lead screw spiral shell
End bearing block 43 before bolt 42, cross lead screw, cross lead screw front end bearing 44, horizontal shaft coupling 45, laterally
Motor contiguous block 46, cross motor 47, cross motor contiguous block bolt 48, rear rail cushion block 49, laterally
Slide block 50, fromer rail cushion block 51；
It is fixedly installed end bearing block before cross lead screw terminal shaft bearing 37, cross lead screw on longitudinal platform 24
43 and cross motor contiguous block 46, cross lead screw terminal shaft bearing 37 is provided with horizontal bearing terminal shaft and holds 38,
Laterally bearing terminal shaft holds 38 and fixes with one end of cross lead screw 39, and the other end of cross lead screw 39 is through horizontal
After the cross lead screw front end bearing 44 installed on end bearing block 43 before screw mandrel, with the one of horizontal shaft coupling 45
End is connected, and the other end of horizontal shaft coupling 45 is connected with the output shaft of cross motor 47；Cross motor
47 are fixedly installed on cross motor contiguous block 46, and cross motor contiguous block 46 is by cross motor contiguous block
Bolt 48 is connected with longitudinal platform 24.Rear portion and the front portion of longitudinal platform are respectively equipped with rear rail cushion block 49
With fromer rail cushion block 51, rear rail cushion block 49 and fromer rail cushion block 51 by transverse slider 50 with the most flat
Platform 40 is connected.
As shown in Figure 8, Figure 9, specimen holder 7 include specimen holder lid 52, sample bin 53, sample bin support 54,
Specimen holder base plate 55, sample bin air inlet 56, sample bin support bracket bolt 57；Pass through on specimen holder base plate 55
Sample bin support bracket bolt 57 is connected with sample bin support 54 lower end, and sample bin support 54 upper end is provided with sample bin
53, the lower surface of sample bin 53 has sample bin air inlet 56, and upper surface is provided with specimen holder lid 52, sample
Being provided with sample panel 61, cladding plate 59 in storehouse 53, cladding plate 59 is arranged on the front portion of sample panel 61, sample bin
The side of 53 is provided with humidity sensor 87.
As shown in Figure 10, Figure 11, sample panel 61, cladding plate 59, and cladding plate 59 it are provided with in sample bin 53
Being connected with sample panel 61 by cladding plate bolt 60, sample panel 61 is positioned at specimen holder lid 52 bottom, before it
Portion is provided with sample 62, and the front portion of sample 62 is provided with cladding plate 59, and cladding plate 59 is by cladding plate spring
63 are pressed on sample 62, and the right side of cladding plate spring 63 is provided with cladding plate adjusting nut 64, cladding plate regulation spiral shell
Mother 64 and cladding plate spring 63 are all contained on cladding plate bolt 60.
As shown in figure 12, described collection light path includes electric machine controller 18, femto-second laser 65, collimation
Lens I 66, half slide 67, beam splitter 68, collimating lens II 69, reflecting mirror I 70, differential detector I
71, differential detector II 72, wollaston prism 73, quarter-wave plate 74, ZnTe crystal 75, silicon
Reflecting mirror 76, paraboloidal mirror I 77, paraboloidal mirror II 78, sample device 79, paraboloidal mirror III 80,
Paraboloidal mirror IV 81, GaAs crystal 82, reflecting mirror II 83, reflecting mirror III 84, reflecting mirror IV 85,
Chopper 86, lock-in amplifier 87, computer 88, electric machine controller 18, electric platforms 91；
The laser that femto-second laser 65 produces by after collimating lens I 66 and half slide 67 by beam splitter 68
Being divided into pumping light path and detection light path, pumping light path incides reflecting mirror I 70 after collimating lens II 69
Arriving reflecting mirror IV 85 by chopper 86 afterwards, laser is through reflecting mirror IV 85, reflecting mirror II 83, anti-
Paraboloidal mirror III 80 is arrived, afterwards through paraboloidal mirror IV 81 by GaAs crystal 82 after penetrating mirror III 84
After the sample 62 in sample device 79, paraboloidal mirror II 78, pumping light path is arrived after refraction
ZnTe crystal 75 is arrived through paraboloidal mirror II 78, paraboloidal mirror I 77, Si mirror 76；Detection light path
After Si mirror 76 reflects, arrive ZnTe crystal 75 converge with pumping light path.Laser warp after converging
Cross quarter-wave plate 74, wollaston prism 73, differential detector I 71, differential detector II 72, lock
Phase amplifier 87 arrives computer 88, and nitrogen cylinder 89 is connected in sample device 79 by trachea,
Whole process is controlled electric platforms 91 by electric machine controller 18 and completes.
The titanium sapphire femtosecond laser that terahertz time-domain spectroscopy system and device is manufactured by Coherent company of the U.S.
The THz system that device and Zomega company of the U.S. develop is formed.Laser pulse is as pump light source and detection
Light source.Femto-second laser pulse is divided into pumping pulse and direct impulse by beam splitter after half-wave plate.Pumping pulse
After optical delay line, incide the substrate surface of antenna emitter stage, cover the gap between two electrodes.
Femto-second laser pulse excites GaAs plane of crystal carrier, moves under the driving of AC bias high pressure, radiation
THz pulse (terahertz pulse).Direct impulse is beaten on Si mirror through Si mirror, anti-through silicon
The reflection penetrating mirror is beaten on ZnTe crystal, on ZnTe crystal with through paraboloidal mirror I, paraboloidal mirror II,
Paraboloidal mirror III and paraboloidal mirror IV reflect and pass through sample and be loaded with the THz wave of sample message altogether
Line.It is loaded with after the detection light path of sample message eventually passes through quarter-wave plate and is divided into two by wollaston prism
The component that individual polarization direction is vertical, is finally polarized by measuring two by differential detector I and differential detector II
The strength difference of component and demodulate the information of sample.Measure signal input after lock-in amplifier amplifies to calculate
Machine obtains time-domain spectroscopy.
The using method of a kind of gastric cancer detection Terahertz system sample sampling apparatus, comprises the steps:
Step (1). select sample panel and the pore size of cladding plate according to the diameter of sample sheet.
Step (2). by sample as between sample panel and cladding plate, then sample panel is positioned over sample
Storehouse.
Step (3). nitrogen tube is linked at the air inlet of sample bin, is filled with nitrogen to reduce storehouse humidity
To 3%.
Step (4). regulate sample bin location by electric machine controller so that it is center is at Terahertz
Ripple focal point.
Step (5). fix all optics in pumping light path and detection light path according to the propagation path of light path
Device, it is ensured that laser beam passes sequentially through the center of each optics and light path at same level height.
Step (6). regulation electric platforms, when making motor move, light path keeps constant.Make terahertz simultaneously
The pumping light path of hereby pulse and detection light path equivalent optical path, if unequal, then by changing reflecting mirror II
Optical path difference therebetween is made up with the position of reflecting mirror IV.
Step (7). confirm that laser beam passes through collimating lens I, the center of collimating lens II, if there is partially
Difference can pass through reflecting mirror II, reflecting mirror III is adjusted.THz wave transmitting crystal GaAs strictly to be put
Putting in the focus of paraboloidal mirror III, in like manner electro-optic detection crystal ZnTe also must necessarily be placed in paraboloidal mirror I
In focus.
Step (8). just can carry out the measurement of experimental data after having debugged the light path of system.Energy in experimentation
Enough pass through motor controller controls, in order to sample each at be scanned with sampled data.
As shown in figure 13, the implementation process of the present invention is as follows:
First according to diameter selection sample panel 61 and the cladding plate 59 of sample 62, secondly root before experiment
Thickness adjusted cladding plate adjusting nut 64 according to sample 62 so that cladding plate spring 63 can pass through cladding plate 59
Sample 62 is pressed in sample panel 61.Then by the nitrogen in nitrogen cylinder 89 by sample bin air inlet
Mouth 56 enters in sample bin 53.Then by the humidity value in humidity sensor 90 measuring samples storehouse 53,
When the humidity value in sample bin 53 is less than 3%, regulated residing for sample bin 53 by electric machine controller 18
Position so that it is be at laser spot.All of optics in light path is fixed afterwards according to light path route.
Regulation electric platforms 91 makes Terahertz light path and equivalent optical path.Determine that laser beam route is by each device
Heart position, then opens computer 88, and operation sampling routine carries out the collection of experimental data.
Claims (1)
1. one kind for gastric cancer detect Terahertz system sample sampling apparatus, it is characterised in that include apparatus structure and
Gather light path；Apparatus structure is mounted with on top board left motor and right motor, the left side of top board
Being mounted with left plate, the right side of top board is mounted with right plate；The bottom of left plate and right plate is mounted with the end
Seat；The middle and lower part of left plate is mounted with proximity switch, and four right angle ends of base are mounted with straight optical axis, i.e.
Two left straight optical axis and two right straight optical axis；Longitudinal translation mechanism it has been respectively mounted with horizontal on lifting platform
Translation mechanism, laterial translation mechanism is mounted with specimen holder, and the right-hand member of base plate is provided with electric machine controller, lifting
The two ends, left and right of platform have been respectively mounted two left straight optical axis bearings and two right straight optical axis bearings, left straight line
Optical axis, one end of right straight optical axis are separately fixed at left end and the right-hand member of top board lower surface, and the other end is through rising
After dropping the left straight optical axis bearing on platform and right straight optical axis bearing, it is fixed on base；Left screw mandrel, right silk
The end of bar is separately fixed at left end and the right-hand member of top board lower surface, and the other end is fixed through the through hole on lifting platform
On base；And left screw mandrel, left straight optical axis, right screw mandrel, right straight optical axis put down with left plate, right plate
OK；
Longitudinal translation mechanism includes lifting platform, left rail cushion block, left line slideway, left linear slider, longitudinal direction
Platform, longitudinal motor, right guide rail cushion block, right line slideway, right straight-line guide rail slide block；On lifting platform
Surface is provided with on left rail cushion block and right guide rail cushion block；Equipped with left line slideway, Zuo Zhi on left rail cushion block
Line guide rail is provided with left linear slider, and left linear slider is arranged on longitudinal platform lower surface；On right guide rail cushion block
Being provided with right line slideway, right line slideway is provided with right linear slider, and right linear slider is arranged on longitudinal platform
Lower surface；Lifting platform upper surface is provided with longitudinal motor contiguous block, equipped with longitudinal stepping on longitudinal motor contiguous block
Motor, the front end of longitudinal motor is equipped with longitudinal shaft coupling, and longitudinal shaft coupling is by longitudinal screw mandrel front end axle
Hold the one end with longitudinal screw mandrel to be connected, the other end of longitudinal screw mandrel is provided with longitudinal screw mandrel bolt, longitudinal silk
Bar bolt is connected with longitudinal platform with longitudinal platform contiguous block II by longitudinal platform contiguous block I；
In described longitudinal sliding motion mechanism, lifting platform is connected with left rail cushion block by longitudinally connected bolt, left
Guide rail cushion block is connected with left line slideway by guide rail connecting bolt；Slide equipped with left straight line on left line slideway
Block, left linear slider is connected with longitudinal platform by slide block connecting bolt；
Laterial translation mechanism include cross lead screw terminal shaft bearing, horizontal bearing terminal shaft hold, cross lead screw,
End bearing block, cross lead screw before horizontal platform, horizontal platform contiguous block, cross lead screw bolt, cross lead screw
Front end bearing, horizontal shaft coupling, cross motor contiguous block, cross motor, cross motor contiguous block bolt,
Rear rail cushion block, transverse slider, fromer rail cushion block；It is fixedly installed cross lead screw terminal shaft on longitudinal platform
End bearing block and cross motor contiguous block before bearing, cross lead screw, cross lead screw terminal shaft bearing is provided with horizontal stroke
To bearing end bearing, one end that horizontal bearing terminal shaft holds with cross lead screw is fixed, another of cross lead screw
After holding the cross lead screw front end bearing installed on end bearing block before cross lead screw, with the one of horizontal shaft coupling
End is connected, and the other end of horizontal shaft coupling is connected with the output shaft of cross motor；Cross motor is fixing to be set
Putting on cross motor contiguous block, cross motor contiguous block is by cross motor contiguous block bolt and longitudinal platform
It is connected；Rear portion and the front portion of longitudinal platform are respectively equipped with rear rail cushion block and fromer rail cushion block, rear rail cushion block
It is connected with horizontal platform by transverse slider with fromer rail cushion block；
Specimen holder includes specimen holder lid, sample bin, sample bin air inlet, sample bin support, sample bin support
Bolt, specimen holder base plate；By sample bin support bracket bolt and sample bin pedestal lower end phase on specimen holder base plate
Even, sample bin pedestal upper end is provided with sample bin, and the lower surface of sample bin has sample bin air inlet, upper surface
Being provided with specimen holder lid, be provided with sample panel, cladding plate in sample bin, cladding plate is arranged on the front portion of sample panel, sample
The side in product storehouse is provided with humidity sensor；It is provided with sample panel, cladding plate, and cladding plate in sample bin and passes through cladding plate
Bolt is connected with sample panel, and sample panel is positioned at specimen holder lid bottom, and its front portion is provided with sample, tested
The front portion of sample is provided with cladding plate, and cladding plate is pressed on sample by cladding plate spring, and the right side of cladding plate spring sets
Cladding plate adjusting nut, cladding plate adjusting nut and cladding plate spring is had all to be contained on cladding plate bolt；
Gathered light path includes electric machine controller, femto-second laser, collimating lens I, half slide, beam splitting
Mirror, collimating lens II, reflecting mirror I, differential detector I, differential detector II, wollaston prism,
Quarter-wave plate, ZnTe crystal, Si mirror, paraboloidal mirror I, paraboloidal mirror II, sample fill
Put, paraboloidal mirror III, paraboloidal mirror IV, GaAs crystal, reflecting mirror II, reflecting mirror III, reflection
Mirror IV, chopper, lock-in amplifier, computer, electric machine controller, electric platforms；Femto-second laser
The laser produced is by being divided into two-way by beam splitter after collimating lens I and half slide, and first via laser is through standard
Arriving reflecting mirror IV by chopper after inciding reflecting mirror I after straight lens II, laser is through reflecting mirror
Paraboloidal mirror III is arrived by GaAs crystal, afterwards through throwing after IV, reflecting mirror II, reflecting mirror III
Arriving paraboloidal mirror II after sample and sample device after object plane mirror IV refraction, laser is through throwing
Object plane mirror II, paraboloidal mirror I, Si mirror, ZnTe crystal；Second road laser reflects through Si mirror
Arrive ZnTe crystal afterwards to converge with first via laser；Laser after converging is through quarter-wave plate, Wo La
This prism, differential detector I, differential detector II, lock-in amplifier arrive computer, and nitrogen cylinder leads to
Crossing trachea to be connected in sample device, whole process is completed by motor controller controls electric platforms；
A kind of using method for gastric cancer detection Terahertz system sample sampling apparatus, comprises the steps:
Step (1). select sample panel and the pore size of cladding plate according to the diameter of sample sheet；
Step (2). sample is placed between sample panel and cladding plate, then sample panel is positioned over sample
Storehouse；
Step (3). nitrogen tube is linked at the air inlet of sample bin, is filled with nitrogen to reduce storehouse humidity
To 3%；
Step (4). regulate sample bin location by electric machine controller so that it is center is at Terahertz
Ripple focal point；
Step (5). fix all optics in pumping light path and detection light path according to the propagation path of light path
Device, it is ensured that laser beam passes sequentially through the center of each optics and light path at same level height；
Step (6). regulation electric platforms, when making motor move, light path keeps constant；Make terahertz simultaneously
The pumping light path of hereby pulse and detection light path equivalent optical path, if unequal, then by regulation reflecting mirror II
Optical path difference therebetween is made up with the position of reflecting mirror IV；
Step (7). confirm that laser beam passes through collimating lens I, the center of collimating lens II, if there is partially
Difference can be adjusted by reflecting mirror II, reflecting mirror III；THz wave transmitting crystal GaAs strictly to be put
Putting in the focus of paraboloidal mirror III, in like manner electro-optic detection crystal ZnTe also must necessarily be placed in paraboloidal mirror I's
In focus；
Step (8). carry out the measurement of experimental data after having debugged the light path of system, experimentation can lead to
Cross motor controller controls, in order to sample each at be scanned with sampled data.
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| CN201310201962.9A CN103323420B (en) | 2013-05-27 | 2013-05-27 | A kind of for gastric cancer detection Terahertz system sample sampling apparatus and using method thereof |
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| CN106248616B (en) * | 2016-09-27 | 2017-10-24 | 深圳市太赫兹科技创新研究院有限公司 | The full polarization state detection spectrometer of Terahertz |
| CN106769993B (en) * | 2016-12-21 | 2023-05-26 | 北京农业信息技术研究中心 | Sample tabletting bearing device, terahertz spectrum measuring system and measuring method |
| CN108786999B (en) * | 2018-06-12 | 2020-11-20 | 安徽智时代科技有限公司 | Straw crushing mechanism |
| CN109883984B (en) * | 2019-02-18 | 2021-03-26 | 西安科技大学 | Wide-scale-range-based nano acoustic effect research method |
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| JP5127159B2 (en) * | 2006-05-19 | 2013-01-23 | キヤノン株式会社 | Measuring apparatus and measuring method |
| JP4839481B2 (en) * | 2006-11-29 | 2011-12-21 | 独立行政法人科学技術振興機構 | Pump probe measuring apparatus and scanning probe microscope apparatus using the same |
| CN102590125A (en) * | 2011-11-30 | 2012-07-18 | 天津大学 | Biological tissue moisture measurement device and method based on terahertz wave attenuated total reflectance (ATR) |
| CN203350171U (en) * | 2013-05-27 | 2013-12-18 | 杭州电子科技大学 | Terahertz system sample sampling device for stomach cancer test |
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