CN103301322A - Dendrobium ultramicro-pure powder, as well as preparation method and preparation thereof - Google Patents
Dendrobium ultramicro-pure powder, as well as preparation method and preparation thereof Download PDFInfo
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Abstract
The invention discloses dendrobium ultramicro-pure powder, as well as a preparation method and a preparation thereof. The dendrobium ultramicro-pure powder is prepared by taking fresh dendrobium as a raw material and performing the steps of pretreatment, drying, coarse crushing, ultramicro crushing, subpackaging and sterilization. The preparation method of the dendrobium ultramicro-pure powder comprises the steps of pretreatment, drying, coarse crushing, ultramicro crushing, subpackaging and sterilization, and specifically comprises the following steps of: removing miscellaneous objects in the dendrobium, selecting, washing, cutting into segments, sun-drying, drying, crushing by a coarse crushing machine, and screening by a 10-mesh screen; performing ultramicro crushing on the material after coarse crushing to obtain a target object; and subpackaging and sterilizing the target object, sampling, inspecting and issuing an inspection report. The preparation comprises powder, granules and tablets. The dendrobium ultramicro-pure powder disclosed by the invention takes the nuisance-free dendrobium as the raw material, pharmaceutical active ingredients of the dendrobium can be retained to the greatest extent during the processing process, the waste of dendrobium resources is reduced, the bioavailability of the dendrobium is improved, and the dendrobium can be utilized efficiently.
Description
Technical field
The invention belongs to the processing technique of Chinese herbs field, be specifically related to pure powder of a kind of Herba Dendrobii ultra micro and preparation method thereof and preparation.
Background technology
Herba Dendrobii, one of orchid mainly is distributed in the torrid zone, Asia and subtropical zone, Australia and Pacific Islands, China's major part is distributed in ground such as southwest, south China, Taiwan.The principal item of Herba Dendrobii has Dendrobium nobile, dendrobium, Dendrobium chrysotoxum etc.Can be used as medicine, Herba Dendrobii by name drives solution deficiency-heat, curative effects such as beneficial smart reinforcing YIN-essence to human body.Along with the rise of the industry of flowers and plants, Herba Dendrobii also becomes a kind of ornamental plant.The planting type of Herba Dendrobii is generally potted plant.Because Herba Dendrobii has firm, the happy and auspicious affable makings of nature, is described as father's flower.The plant of Herba Dendrobii is made of pedicle, and thick leaf such as Folium Bambusae scape are extracted out from axil as middle finger, and every Roripa is spent seven or eight, every 6 lobes of spending, and scatter in the four sides, and the petal limit is purple, and the lobe heart is white.
At present, the Chinese medicine decoction pieces decocts trouble, it is inconvenient to use, quality unstable easily go mouldy infested, be difficult to the bottleneck that keeping, the low several shortcomings of bioavailability become prepared slices of Chinese crude drugs development, therefore, develop a kind of bioavailability height, save Chinese material medicine resource, quality controllable, hygienic and convenient, compatibility is flexible, and the Chinese medicine ultramicro decoction piece of exempting to decoct is very important.
Summary of the invention
First purpose of the present invention is to provide a kind of Herba Dendrobii ultra micro pure powder; Second purpose is to provide the preparation method of the pure powder of described Herba Dendrobii ultra micro; The 3rd purpose is to provide the preparation of the pure powder of described Herba Dendrobii ultra micro.
First purpose of the present invention is achieved in that with fresh Herba Dendrobii be raw material, makes through pre-treatment, drying, coarse pulverization, micronizing, packing sterilization steps.
Second purpose of the present invention is achieved in that and comprises pre-treatment, drying, coarse pulverization, micronizing, packing sterilization steps, specifically comprises:
A, pre-treatment: foreign material in the Herba Dendrobii are rejected, through cleaning, clean, dry cutting, drying for standby;
B, coarse pulverization: the raw material after pre-treatment was pulverized 10 mesh sieves with Roughpulverizer;
C, micronizing: the material of coarse pulverization is carried out micronizing namely get object;
D, packing sterilization: with object packing sterilization, pick test is provided inspection report.
The present invention's the 3rd purpose is achieved in that the pure powder of described Herba Dendrobii ultra micro is distributed into powder through sterilization, makes granule through granulation technique, is pressed into tablet through pressed-disc technique.
Description of drawings
Fig. 1 is process chart of the present invention.
The specific embodiment
The present invention is further illustrated below in conjunction with accompanying drawing, but never in any form the present invention is limited, and any conversion or replacement based on training centre of the present invention is done all belong to protection scope of the present invention.
The pure powder of Herba Dendrobii ultra micro of the present invention is to be raw material with fresh Herba Dendrobii, makes through pre-treatment, drying, coarse pulverization, micronizing, packing sterilization steps.In the pure powder course of processing of Herba Dendrobii, do not add any adjuvant.The pure powder preparation of Herba Dendrobii need not to decoct, can be directly oral.
The pure powder of described Herba Dendrobii ultra micro directly is 1-75mm.
The preparation method of the pure powder of Herba Dendrobii ultra micro of the present invention comprises pre-treatment, drying, coarse pulverization, micronizing, packing sterilization steps, specifically comprises:
A, pre-treatment: foreign material in the Herba Dendrobii are rejected, through cleaning, clean, dry cutting, drying for standby;
B, coarse pulverization: the raw material after pre-treatment was pulverized 10 mesh sieves with Roughpulverizer;
C, micronizing: the material of coarse pulverization is carried out micronizing namely get object;
D, packing sterilization: with object packing sterilization, pick test is provided inspection report.
Described cleaning to using the flowing water rinsing.
Described drying to putting under the nature sunlight allows its natural drying.
Described cutting is for being cut into the long section of 2 ~ 10cm.
Described drying is a kind of in microwave drying, far-infrared ray drying, heat-wind circulate drying, vacuum lyophilization and the solar energy drying.
Described micronizing was 200 mesh sieves.
Described sterilization is a kind of in dry heat sterilization, microwave sterilizating, heat-wind circulate drying sterilization, far infrared sterilization and the ozone sterilization.
The pure powder of Herba Dendrobii ultra micro of the present invention is inspected under 40 power microscopes, must not detect greater than 75 μ m and complete cell.
The preparation of the pure powder of Herba Dendrobii ultra micro of the present invention is characterized in that preparation is that the pure powder of described Herba Dendrobii ultra micro is distributed into powder through sterilization, makes granule through granulation technique, is pressed into tablet through pressed-disc technique.
Characteristics of the present invention: 1, improve the dissolution rate of active component in the medicine, increase the biological utilisation amount of medicine; 2, save medical material, reduce drug dose; 3, be conducive to preserve bioactive ingredients; 4, improve the mouthfeel of the prepared slices of Chinese crude drugs; 5, improve hygienic quality.
Embodiment 1
Get the 50Kg Herba Dendrobii, wherein foreign material are rejected, and through cleaning, clean, and dry, and are cut into the long section of 2cm, through microwave drying, pulverize 10 mesh sieves with Roughpulverizer; Carry out micronizing again and namely get object; The packing dry heat sterilization, pick test is provided inspection report.
Embodiment 2
Get the 50Kg Herba Dendrobii, wherein foreign material are rejected, and through cleaning, clean, and dry, and are cut into the long section of 2 ~ 5cm, through far-infrared ray drying; Pulverized 10 mesh sieves with Roughpulverizer; Carry out micronizing again and namely get object; The packing microwave sterilizating, pick test is provided inspection report.
Embodiment 3
Get the 50Kg Herba Dendrobii, wherein foreign material are rejected, and through cleaning, clean, and dry, and are cut into the long section of 4 ~ 6cm, through heat-wind circulate drying; Pulverized 10 mesh sieves with Roughpulverizer; Carry out micronizing again and namely get object; The hot air circulation sterilization, pick test is provided inspection report.
Embodiment 4
Get the 50Kg Herba Dendrobii, wherein foreign material are rejected, and through cleaning, clean, and dry, and are cut into the long section of 5 ~ 8cm, through vacuum lyophilization; Pulverized 10 mesh sieves with Roughpulverizer; Carry out micronizing again and namely get object; The sterilization of packing far infrared, pick test is provided inspection report.
Embodiment 5
Get the 50Kg Herba Dendrobii, wherein foreign material are rejected, and through cleaning, clean, and dry, and are cut into the long section of 8 ~ 10cm, through solar energy drying; Pulverized 10 mesh sieves with Roughpulverizer; Carry out micronizing again and namely get object; Ozone sterilization, pick test is provided inspection report.
Embodiment 6
Get the pure powder of Herba Dendrobii ultra micro of embodiment 1 preparation, powder is made in pack.
Embodiment 7
Get the pure powder of Herba Dendrobii ultra micro of embodiment 4 preparations, make the agent of Herba Dendrobii ultra micro pure powder particles through granulation technique.
Embodiment 8
Get the Herba Dendrobii ultra micro pure powder particles of embodiment 7 preparations, make the pure powder tablet of Herba Dendrobii ultra micro through pressed-disc technique.
Experimental example 1
The effect of Herba Dendrobii superfine powder and common flour antagonism stomach of rats ulcer recurrence relatively
1 materials and methods
1.1 60 of animal Wistar rats, body weight 160～180g, male and female are usefulness all, purchases the Experimental Animal Center in Anhui Province Medicine Research Inst., and random assortment is 6 groups, 10 every group.
1.2 medicine and reagent Herba Dendrobii common flour are purchased the big pharmacy in Hefei, identify through Anhui Chinese Medicine College crude drug teaching and research room really to be medicinal dendrobium; Herba Dendrobii superfine powder (the luxuriant Pharmacy stock Co., Ltd in the river in Jiangsu Province which flows into the Huangpu River of Shanghai, Pu'er provides); Positive control drug: omeprazole enteric-coated, the auspicious pharmaceutcal corporation, Ltd in last Haifeng county produces (lot number: 050301), be made into desired concn with distilled water before the experiment, put 4 ℃ of refrigerators and preserve standby; Synthetic people IL-1 β is that Britain Peprotech company produces; SOD, MDA testing cassete all build up bio-engineering research institute available from Nanjing.
1.3 method
1.3.1 the extraction of dendrobium polysaccharide and preparation
It is an amount of to get Herba Dendrobii common flour and superfine powder respectively, and petroleum ether refluxes, and gets the residue after the filtration, volatilizes solvent.80% alcohol reflux is got the residue after the filtration, volatilizes solvent.Distilled water reflux, extract, 2 times, residue hot wash, merge extractive liquid, and cleaning mixture.The buchner funnel sucking filtration is got filtrate, and Rotary Evaporators is concentrated into certain volume.Concentrated solution adds equivalent sevag reagent (by n-butyl alcohol: chloroform=4:1 is formulated) and repeatedly extracts deproteinize.Get the dehydrated alcohol precipitation of 4 times of volumes of supernatant liquid dropping.Get precipitation sucking filtration drying, namely get crude polysaccharides.Adopt the sugared content (showing with the scale that is equivalent to glucose) of this Herba Dendrobii crude polysaccharides of sulphuric acid anthrone reagent colorimetric method for determining to be respectively 90.4%, 81.6%.The crude polysaccharides that takes by weighing above-mentioned drying respectively is an amount of, and physiological saline solution is made into debita spissitudo, filtration sterilization (0.45m filter membrane) before using.
1.3.2 acetic acid type gastric ulcer model preparation
Improvement preparation GU model.Except normal group, each organizes the rat injecting anesthetic behind the fasting 24h of freely drinking water, face upward fixedly cropping of position, sterilization, vertical about 2cm of open abdomen takes out stomach under xiphoid-process, between the coat of the stomach flesh layer and placenta percreta of the nearly lesser curvature side of gastric antrum antetheca, inject 20% acetic acid 0.05ml, continue 60S, dry with filter paper, normal saline is smeared 2 times, also receives stitching.
1.3.3 animal grouping and administration
Laboratory animal is divided into the dendrobium polysaccharide group of normal group, not recurrence group of model, model recurrence group, the extraction of Herba Dendrobii common flour, dendrobium polysaccharide group, the omeprazole group that superfine powder extracts.The acetic acid type gastric ulcer model prepares postoperative 24 h, and normal group, not recurrence group of model, model recurrence group are irritated stomach with normal saline, and the dendrobium polysaccharide group gives the dendrobium polysaccharide of common flour extraction and the dendrobium polysaccharide 200mgkg that superfine powder extracts respectively
-1D
-1Irritate stomach, the omeprazole group gives omeprazole 3.6mgkg
-1D
-1Irritate stomach.Adopt IL-1 β to prepare GU recurrence model behind the 90d, wherein, normal group, not recurrence group of model rats by intraperitoneal injection equivalent normal saline, all the other respectively organize the equal lumbar injection IL-1 of rat β 1ug/kg, fasting behind 24h, and chloral hydrate anesthesia is put to death behind the 48h, abdominal aortic blood, get stomach tailing edge greater gastric curvature and cut off, perusal under the magnifier, mucosa is pale to have, edema, erosion, hyperemia, ulcer etc. are judged to be ulcer recurrence.
1.3.4 the calculating of rat ulcer relapse rate
Vertical footpath and transverse diameter with vernier caliper measurement ulcer are designated as D1 and D2 respectively, calculate the ulcer area, calculate relapse rate with the ulcer area of the ulcer area behind every group of rats by intraperitoneal injection IL-1 β before divided by lumbar injection IL-1 β.
1.4 GU recurrence rat stomach mucous membrane tissue pathological observation
Contain the about 1cm of ulcer spot * 1cm gastric tissue in modeling place clip, no ulcer person draws materials at corresponding site, 4% paraformaldehyde is fixed, with fixing rat stomach tissue specimen ethanol dehydration, dimethylbenzene is transparent, and paraffin embedding is made paraffin section, gastric mucosa histological characteristic is observed in HE dyeing under light microscopic.
1.5 gastric mucosa superoxide dismutase (SOD), malonaldehyde (MDA) content detection
The passivity blade is scraped and is got gastric mucosa and put liquid nitrogen flash freezer immediately,-70 ℃ of preservations, nature rewarming when doing homogenate, the absorbent paper suck dry moisture, weigh, add the abundant homogenate of PBS buffer and make 10% homogenate, the centrifugal 15min of 3000r/min leaves and takes supernatant and uses xanthine oxidase and thiobarbituricacid method (TBA method) to measure SOD and MDA in the gastric mucosa respectively according to the test kit description.
1.6 statistical method adopts variance analysis and q check.
2 results
2.1 dendrobium polysaccharide is to the influence of GU recurrence rat stain infections relapse rate
After experimental rat was put to death, normal rats was not seen ulcer, and the gastric mucosa pleat is orderly, and the mucosa color is light red; Model art recurrence group rat ulcer heals mostly; Model recurrence group rat is in the recurrence of former ulcer modeling position, and ulcer is dark, big, relapse rate height (83.3%); Compare with model recurrence group relapse rate, omeprazole group (45.2%), common flour dendrobium polysaccharide group (46.3%), superfine powder Herba Dendrobii group (45.9%) ulcer recurrence rate all reduce.
2.2 dendrobium polysaccharide is to the influence of GU recurrence rat stomach mucosa SOD activity, MDA content
Compare active reduce (P＜0.01) of SOD in the model recurrence group rat stomach mucosa with not recurrence group of model; With model recurrence group relatively, the superfine powder dendrobium polysaccharide GU recurrence rat stomach mucosa SOD activity (P＜0.01) that can significantly raise.Each organizes the equal not statistically significant of MDA content difference in the rat stomach mucosa (P〉0.05) (seeing Table 1).
Table 1 dendrobium polysaccharide is to the influence of GU recurrence rat stomach mucosa SOD activity, MDA content (x ± s)
Q check: compare #P＜0.01 with not recurrence group of model; Compare * * P＜0.01 with model recurrence group
2.3 dendrobium polysaccharide is to the pathological influence of GU recurrence rat stomach mucous membrane tissue
Normal group is not seen ulcer, and stomach knits that structure is normally clear, and the mucosal epithelium cell is the monolayer column, marshalling, and basic N/D or come off, the mucosa lamina propria has a small amount of lymphocytic infiltration.Model group is not seen recurrence, but the gastric mucosa attenuation, body of gland is arranged and is owed regular, is scar tissue under the mucosa, and the cicatrix mucosa has chronic inflammatory cell to soak into.Model recurrence group gastric mucosa is significantly congested, edema, and ulcer is invaded the mucosa holostrome, and the visible residual regeneration mucosa in ulcer edge has massive inflammatory cells infiltrated, and is obvious with neutrophil infiltration.Omeprazole group, dendrobium polysaccharide group especially superfine powder group regeneration mucosa are thicker, and the mucosa reparation is more complete, and gastric epithelial cells is arranged more neat.
Claims (10)
1. pure powder of Herba Dendrobii ultra micro is characterized in that being is raw material with fresh Herba Dendrobii, makes through pre-treatment, drying, coarse pulverization, micronizing, packing sterilization steps.
2. the pure powder of Herba Dendrobii ultra micro according to claim 1 is characterized in that the pure powder of described Herba Dendrobii ultra micro directly is 1-75mm.
3. the preparation method of the pure powder of the described Herba Dendrobii ultra micro of claim 1 is characterized in that comprising pre-treatment, drying, coarse pulverization, micronizing, packing sterilization steps, specifically comprises:
A, pre-treatment: foreign material in the Herba Dendrobii are rejected, through cleaning, clean, dry cutting, drying for standby;
B, coarse pulverization: the raw material after pre-treatment was pulverized 10 mesh sieves with Roughpulverizer;
C, micronizing: the material of coarse pulverization is carried out micronizing namely get object;
D, packing sterilization: with object packing sterilization, pick test is provided inspection report.
4. the preparation method of the pure powder of Herba Dendrobii ultra micro according to claim 3 is characterized in that described cleaning to using the flowing water rinsing.
5. the preparation method of the pure powder of Herba Dendrobii ultra micro according to claim 3 is characterized in that described drying to putting under the nature sunlight, allows its natural drying.
6. the preparation method of the pure powder of Herba Dendrobii ultra micro according to claim 3 is characterized in that described cutting is for being cut into the long section of 2 ~ 10cm.
7. the preparation method of the pure powder of Herba Dendrobii ultra micro according to claim 3 is characterized in that described drying is a kind of in microwave drying, far-infrared ray drying, heat-wind circulate drying, vacuum lyophilization and the solar energy drying.
8. according to the preparation method of claim 3 or the pure powder of 7 described Herba Dendrobii ultra micros, it is characterized in that described micronizing was 200 mesh sieves.
9. the preparation method of the pure powder of Herba Dendrobii ultra micro according to claim 3 is characterized in that described sterilization is a kind of in dry heat sterilization, microwave sterilizating, heat-wind circulate drying sterilization, far infrared sterilization and the ozone sterilization.
10. the preparation of a claim 1 or the pure powder of 2 described Herba Dendrobii ultra micros is characterized in that preparation is that the pure powder of described Herba Dendrobii ultra micro is made granule and made tablet through pressed-disc technique through granulation technique.
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| CN103800690A (en) * | 2014-02-20 | 2014-05-21 | 普洱淞茂制药股份有限公司 | Dragon tree leaf/dendrobe pharmaceutical composition, and preparation method, preparation and application thereof |
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| CN105168960A (en) * | 2015-09-30 | 2015-12-23 | 河南行知专利服务有限公司 | Preparation method and application of non-decocting preparation of fresh Dendrobium officinale |
| CN106138747A (en) * | 2015-03-09 | 2016-11-23 | 陈亚海 | Herba Dendrobii dispersible tablet and preparation technology thereof |
| CN107597371A (en) * | 2017-06-09 | 2018-01-19 | 霍山宝信园石斛开发有限公司 | A kind of multi-functional stem of noble dendrobium pulverizer |
| CN107929553A (en) * | 2017-11-29 | 2018-04-20 | 徐小毛 | The processing technology of anti-oxidant dendrobe powder |
| CN110917298A (en) * | 2019-12-30 | 2020-03-27 | 龙陵县石斛研究所 | Preparation method of dendrobium devoninum paxt ultrafine powder |
| CN111760669A (en) * | 2020-07-02 | 2020-10-13 | 无锡紫杉药业有限公司 | Method for screening raw materials for producing paclitaxel |
| CN113058720A (en) * | 2021-03-15 | 2021-07-02 | 霍山县斛状元科技有限公司 | Method for preparing fresh dendrobe juice powder |
| CN113210110A (en) * | 2021-04-26 | 2021-08-06 | 安徽鸿媵堂中药饮片有限公司 | Preparation process of dendrobium superfine powder |
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| CN103800690A (en) * | 2014-02-20 | 2014-05-21 | 普洱淞茂制药股份有限公司 | Dragon tree leaf/dendrobe pharmaceutical composition, and preparation method, preparation and application thereof |
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| CN103920013A (en) * | 2014-04-02 | 2014-07-16 | 浙江亚林生物科技股份有限公司 | Preparation method of dendrobium officinale ultramicro wall-broken powder |
| CN106138747A (en) * | 2015-03-09 | 2016-11-23 | 陈亚海 | Herba Dendrobii dispersible tablet and preparation technology thereof |
| CN105168960A (en) * | 2015-09-30 | 2015-12-23 | 河南行知专利服务有限公司 | Preparation method and application of non-decocting preparation of fresh Dendrobium officinale |
| CN107597371A (en) * | 2017-06-09 | 2018-01-19 | 霍山宝信园石斛开发有限公司 | A kind of multi-functional stem of noble dendrobium pulverizer |
| CN107929553A (en) * | 2017-11-29 | 2018-04-20 | 徐小毛 | The processing technology of anti-oxidant dendrobe powder |
| CN110917298A (en) * | 2019-12-30 | 2020-03-27 | 龙陵县石斛研究所 | Preparation method of dendrobium devoninum paxt ultrafine powder |
| CN111760669A (en) * | 2020-07-02 | 2020-10-13 | 无锡紫杉药业有限公司 | Method for screening raw materials for producing paclitaxel |
| CN111760669B (en) * | 2020-07-02 | 2021-11-19 | 无锡紫杉药业有限公司 | Method for screening raw materials for producing paclitaxel |
| CN113058720A (en) * | 2021-03-15 | 2021-07-02 | 霍山县斛状元科技有限公司 | Method for preparing fresh dendrobe juice powder |
| CN113210110A (en) * | 2021-04-26 | 2021-08-06 | 安徽鸿媵堂中药饮片有限公司 | Preparation process of dendrobium superfine powder |
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Application publication date: 20130918 |