CN103301296B - Aloe-peach leaf gel preparation and preparation method thereof - Google Patents
Aloe-peach leaf gel preparation and preparation method thereof Download PDFInfo
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- CN103301296B CN103301296B CN201310263669.5A CN201310263669A CN103301296B CN 103301296 B CN103301296 B CN 103301296B CN 201310263669 A CN201310263669 A CN 201310263669A CN 103301296 B CN103301296 B CN 103301296B
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Abstract
The invention relates to an aloe-peach leaf gel preparation and a preparation method thereof. The gel preparation is prepared from aloe stoste, peach leaf ethanol extract, and matrix. The product forms a transparent or translucent gel state. The preparation disclosed by the invention is mainly used for repairing after sunburn, relieving itching, preventing and treating mosquito bite and treating solar dermatitis and the like. The preparation disclosed by the invention is single in prescription, simple in preparation technology, easy to coat and use, and fast to absorb. A protection film is formed on the skin surface; and the aloe-peach leaf gel preparation has moisturizing and treating effects, and good stability.
Description
Technical field
The present invention relates to a kind of Aloe-Folium Persicae gel preparation and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Folium Persicae is the leaf of rosaceous plant Fructus Persicae or Prunus davidiana, and blade multireel shortens strip into, is oval shape lanceolar after moistening flattening, long 6-15cm, and wide 2-3.5cm, tip is point gradually, the wide wedge shape of base portion, edge tool serration or rough sawn tooth.Bottle green above, brighter, lower complexion is lighter.Matter is crisp.Feeble QI, mildly bitter flavor." Bencao Tujing " recorded that Folium Persicae is multiplex leads medicine as soup, marked tender person's name Fructus Persicae heart, You Sheng.Zhang Wenzhong controls day row, has the smoked bodily movement of practising Wushu of imperial physician's Folium Persicae soup, and water one stone, boils Folium Persicae, gets seven buckets, thinks paving seat, certainly encloses clothing and covers, and An Taotang, under mattress, takes advantage of heat from smoked, stops when few when rain antiperspirant, and antiperspirant time, goes soup to wait to have a rest, fast powder it, and moxibustion big vertebra.In prior art, also report: it is basically identical that the effect of wriggler is killed in the leaf of Fructus Persicae immersion (1%) of different cultivars, can make wriggler dead more than 95% in 24 hours; Low concentration (0.25-0.5%) immersion effect is not showing; Fresh leaf is similar to cured leaf curative effect, and the mosquitoes such as culex, Anopheles sinensis, armigeres obturbans are all had to effect.Someone evidence, leaf of Fructus Persicae can replace chloroform or other anesthetics poisoning anopheles; Tender leaf is better than Lao Ye, and fresh leaf is than Chen Yehao, and blade is rubbed with the hands broken better than dipping.Because Folium Persicae is containing glycocide, rubs with the hands when broken and can emit hydrocyanic acid through enzyme effect.With 1: 100 above dilution leaf of Fructus Persicae decocting liquid direct microscopy or in vitro cultivate after 1,6,12,24 or 48 hour and observe in vitro, kill leptospiral effect.After seed, flower, leaf and the bark hydrolysis of peach tree, all can produce hydrocyanic acid.Leaf of Fructus Persicae is once as cathartic, anthelmintic and treatment pertussis.Leaf of Fructus Persicae, flower and kernel are all poisonous.
Aloe, as crude drug, has been applied more than 1,000 year in China, treats tens kinds of inside and outside section diseases with it, and using method is also varied, and leaf as fresh in edible Aloe and fresh juice, take Aloe powder, is coated with aloe leaf external application etc. with fresh aloe juice outward.With Aloe and other drug matching, for habitual constipation and infantile malnutrition as danggui longhui pills, danggui longhui wan, fattening baby pill etc.In " China's book on Chinese herbal medicine ", the health care of Aloe is summarized as follows: under rush down (1), i.e. loosening bowel to relieve constipation; (2) adjusting immunity of human body; (3) antitumor; (4) the liver protecting; (5) anti-gastric injury; (6) anti-inflammation; (7) repair tissue damage; (8) protective effect to skin.Aspect aesthetic health care, it is sun-proof, moisturizing, anti-inflammatory anti-itch, and promotes epithelial cell growth effect to highlight especially.From the world to China, Aloe was applied in cosmetics and skincare product in recent years, and it treats disease beauty treatment, skin-protection and health-care advantage is larger, and effect is more desirable.As " Yi Shameier " beauty mask that Shenyang health products Co., Ltd of Dong Yu group produces, adopt just fresh Aloe gel produced in USA and there is beauty care drug matching use.
Although reported all pharmacological effects of Folium Persicae and Aloe in above-mentioned prior art, but up to now, also do not report that Folium Persicae and Aloe combined use, more do not report by these two kinds of medicines be prepared into a kind of have after shining repair, antipruritic, mosquito control bites and treats the gel preparation of the effects such as solar dermatitis.
Summary of the invention
The object of the invention is to: a kind of Aloe-Folium Persicae gel preparation and preparation method thereof is provided; Present invention is directed at prior art, effectively Folium Persicae and Aloe are combined, for shining rear reparation, antipruritic, mosquito control bites and treats solar dermatitis, and this combination is prepared into gel preparation so that patient uses, improves therapeutic effect.
Gel preparation of the present invention is constructed as follows: aloe stoste 8-25 weight portion, Folium Persicae ethanol extraction 12-28 weight portion
,carbomer 1-4 weight portion, Mentholum 0.05-0.7 weight portion, laurocapram 1-4 parts by volume, ethyl hydroxybenzoate 0.7-3 weight portion, glycerol 3-12 parts by volume, pure water 15.5-49.5 parts by volume, dehydrated alcohol exists with the amount of having dissolved ethyl hydroxybenzoate and Mentholum, and sodium hydroxide solution is so that the amount existence that the pH value of preparation is 6.5-7.5.
Gel preparation of the present invention is constructed as follows: aloe stoste 14.565 weight portions, Folium Persicae ethanol extraction 13.335 weight portions
,carbomer 1 weight portion, Mentholum 0.05 weight portion, laurocapram 2 parts by volume, ethyl hydroxybenzoate 0.75 weight portion, glycerol 4 parts by volume, pure water 30 parts by volume, dehydrated alcohol 4 parts by volume, sodium hydroxide solution is so that the amount existence that the pH value of preparation is 6.5-7.5.
Gel preparation of the present invention is constructed as follows: aloe stoste 14.565g, Folium Persicae ethanol extraction 13.335g
,carbomer 1g, Mentholum 0.05g, laurocapram 2ml, ethyl hydroxybenzoate 0.75g, glycerol 4ml, pure water 30ml, dehydrated alcohol 4ml, sodium hydroxide solution is so that the amount existence that the pH value of preparation is 6.5-7.5.
Described aloe stoste is adopted preparation with the following method: remove the peel after Aloe is cleaned (1), obtains the inner spawn of Aloe, puts it in agitator, adds proper amount of boiling water burn 10-15min(to kill enzyme), spawn is blended, obtain gel liquid; (2) in Aloe gel shape liquid, add 0.2%-0.4% active carbon to do filter aid, stir 10min, put into centrifuge centrifugal (rotating speed is 1800-4000r/min) 30-35min, obtain Aloe solution; (3) above-mentioned solution is carried out to concentrating under reduced pressure, temperature is 35-50 DEG C, and the time is 20-40min, obtains concentrated solution; (4) sterilization: 30-45min sterilizes at 40-50 DEG C of temperature; (5) add 0.01-0.1% antioxidant; (6) add 0.01-0.3% antiseptic; (7) add 0.01-0.1%pH regulator, prepare stock solution, wherein " % " in step 2 refers to that active carbon is for the weight of gel liquid, and " % " in step 5-7 refers to that the weight that adds material is for concentrated solution weight.The character of the stock solution obtaining is as follows: pH is about 6.5, contains 1 g crude drug in every ml, and density is 0.971g/ml.
Folium Persicae ethanol extraction is adopted preparation with the following method
:get 100 grams of fresh Folium Persicaes, clean and dry rear chopping, bottling, then spend the night by 2000 ml 70% soak with ethanol, supersound extraction 1h, filters and is evaporated to 100 ml, obtains ethanol extraction.The character of the ethanol extraction obtaining is as follows: in every ml solution, contain 1 g crude drug, density is 0.889 g/ml, and pH is 6.5 left and right (have a small amount of blackish green precipitation, should be chlorophyll, use front filtration).
Described carbomer is Acritamer 940, carbomer 934, preferably carbomer 934; Described antioxidant is vitC; Described antiseptic is sodium benzoate; Described pH adjusting agent is citric acid; Described sodium hydroxide solution is 20% sodium hydrate aqueous solution.
The preparation method of gel preparation of the present invention comprises the following steps: take carbomer in prescription ratio, it is scattered in pure water, placing spends the night makes it fully swelling, obtains the swelling body of carbomer; Separately get recipe quantity Mentholum, ethyl hydroxybenzoate and be dissolved in respectively in appropriate dehydrated alcohol, for subsequent use; The swelling body of carbomer that placement is spent the night is ground to the granule carbomer solution that disappears to obtain, separately take aloe stoste, Folium Persicae extracting solution, and with Mentholum solution, ethyl hydroxybenzoate solution, laurocapram, glycerol joins in carbomer solution together, drip sodium hydroxide solution, add pure water, continue grinding and make into gel.
Gel preparation of the present invention is formed by aloe stoste and Folium Persicae ethanol extraction and matrix composition, this product gel that is translucent.Preparation of the present invention is mainly used in shining rear reparation, antipruritic, mosquito control bites and treats solar dermatitis etc.; Preparation prescription of the present invention is single, preparation technology is simple, and is easy to smear use, absorption soon, forms layer protecting film on skin surface, has moisturizing and therapeutical effect, good stability.
detailed description of the invention:
embodiment 1: take carbomer 934 1 g in prescription ratio, make to be scattered in 10 mL pure water, placing spends the night makes it the fully swelling swelling body of carbomer that obtains.(0.05 g), (0.75 g) is dissolved in respectively in 2 mL dehydrated alcohol ethyl hydroxybenzoate, for subsequent use separately to get recipe quantity Mentholum.The carbomer 934 that placement is spent the night is ground to granule and disappears, separately take aloe stoste (15 ml, 14.565g), Folium Persicae extracting solution (15 ml, 13.335g), and with Mentholum solution, ethyl hydroxybenzoate solution, laurocapram (2ml), glycerol (4 ml) joins in carbomer 934 together, drip 5 of 20 % sodium hydroxide solutions, the 20ml that adds water, continues to grind and makes into translucent gels, and the pH in gel preparation is 6.5-7.5.
Described aloe stoste is adopted preparation with the following method: remove the peel after Aloe is cleaned (1), obtains inner Aloe gel shape material, puts it in agitator, adds 50ml water blancing 10-15min(to kill enzyme), spawn is blended, obtain gel liquid; (2) in Aloe gel shape liquid, add 0.2%-0.4% active carbon to do filter aid, stir 10min, put into centrifuge centrifugal (1800-4000r/min) 30-35min, obtain Aloe solution; (3) above-mentioned solution is carried out to concentrating under reduced pressure, 35-50 DEG C, 20-40min, obtains concentrated solution; (4) sterilization: 30-45min sterilizes at 40-50 DEG C of temperature; (5) add 0.01-0.1% antioxidant; (6) add 0.01-0.3% antiseptic; (7) add 0.01-0.1%pH regulator, prepare stock solution, wherein " % " in step 2 refers to that active carbon is for the weight of gel liquid, and " % " in step 5-7 refers to that the weight that adds material is for concentrated solution weight.The character of the stock solution obtaining is as follows: pH is about 6.5, contains 1g crude drug in every ml, and density is 0.971 g/ml.Described antioxidant is vitC; Described antiseptic is sodium benzoate; Described pH adjusting agent is citric acid.
Folium Persicae ethanol extraction is adopted preparation with the following method
:get 100 grams of fresh Folium Persicaes, clean and dry rear chopping, bottling, then spend the night by 2000 ml 70% soak with ethanol, supersound extraction 1h, filters, is evaporated to 100 ml, obtains ethanol extraction.The character of the ethanol extraction obtaining is as follows: in every ml solution, contain 1 g crude drug, density is 0.889 g/ml, and pH is 6.5 left and right (have a small amount of blackish green precipitation, should be chlorophyll, use front filtration).
Preparation-obtained gel preparation is constructed as follows:
Gross weight: 68.12g
Carbomer %:1.47%
Mentholum %:0.07%
Ethyl hydroxybenzoate %:1.1%
Laurocapram %:2.9%(ml/g)
Glycerol %:5.87%(ml/g)
Folium Persicae ethanol extract %:22% (ml/g)
Aloe stoste %:22% (ml/g)
Pure water %:44.03%(ml/g)
PH value is 6.5-7.5
embodiment 2: take carbomer 934 2 g in prescription ratio, make to be scattered in 15 mL pure water, placing spends the night makes it the fully swelling swelling body of carbomer that obtains.(0.2 g), (1.5 g) are dissolved in respectively in 2 mL dehydrated alcohol ethyl hydroxybenzoate, for subsequent use separately to get recipe quantity Mentholum.The carbomer 934 that placement is spent the night is ground to granule and disappears, separately take aloe stoste (15 ml, 14.565g), Folium Persicae ethanol extract (20 ml, 17.78g), and with Mentholum solution, ethyl hydroxybenzoate solution, laurocapram (3ml), glycerol (6 ml) joins in carbomer 934 together, drip 10 of 20 % sodium hydroxide solutions, the 30ml that adds water, continues to grind and makes into translucent gels, and the pH in gel preparation is 6.5-7.5.
Described aloe stoste and Folium Persicae ethanol extract are all to adopt identical method described in embodiment 1 to prepare, and preparation-obtained gel preparation is constructed as follows:
Gross weight: 105.89g
Carbomer %:1.89%
Mentholum %:0.19%
Ethyl hydroxybenzoate %:1.41%
Laurocapram %:2.8%(ml/g)
Glycerol %:5.67%(ml/g)
Folium Persicae ethanol extract %:18.89% (ml/g)
Aloe stoste %:14.16% (ml/g)
Pure water %:42.50%(ml/g)
PH value is 6.5-7.5
embodiment 3: take carbomer 934 1.5 g in prescription ratio, make to be scattered in 15 mL pure water, placing spends the night makes it the fully swelling swelling body of carbomer that obtains.(0.5 g), (2 g) are dissolved in 3 mL dehydrated alcohol ethyl hydroxybenzoate, for subsequent use separately to get recipe quantity Mentholum.The carbomer 934 that placement is spent the night is ground to granule and disappears, separately take aloe stoste (10 ml, 9.71g), Folium Persicae ethanol extract (15 ml, 13.335g), and with Mentholum solution, ethyl hydroxybenzoate solution, laurocapram (2ml), glycerol (8 ml) joins in carbomer 934 together, drip 7 of 20 % sodium hydroxide solutions, the 25ml that adds water, continues to grind and makes into translucent gels, and the pH in gel preparation is 6.5-7.5.
Described aloe stoste and Folium Persicae ethanol extract are all to adopt identical method described in embodiment 1 to prepare, and preparation-obtained gel preparation is constructed as follows:
Gross weight: 81.30g
Carbomer %:1.85%
Mentholum %:0.62%
Ethyl hydroxybenzoate %:2.46%
Laurocapram %:2.46%(ml/g)
Glycerol %:9.84%(ml/g)
Folium Persicae ethanol extract %:18.45% (ml/g)
Aloe stoste %:12.30% (ml/g)
Pure water %:49.2%(ml/g)
PH value is 6.5-7.5
the preparation of embodiment 4(matched group):
Aloe gel: by the process preparation of embodiment 1, only replace Folium Persicae extracting solution (15ml) with same volume distilled water (15 ml).
Folium Persicae gel: by the process preparation of embodiment 1, only replace aloe stoste (15ml) with same volume distilled water (15 ml).
Gel-type vehicle: by the process preparation of embodiment 1, only replace aloe stoste (15ml) and Folium Persicae extracting solution (15ml) with same volume distilled water (30 ml).
embodiment 5
The protective effect of the skin photoage that the 3.1 pairs of ultraviolet cause
Mice is divided into 6 groups at random: model group gives gel-type vehicle, Aloe-Folium Persicae gel prepared by embodiment 1 is divided into high and low dose group, and positive controls 1 gives vitamin E; Positive controls 2 gives Aloe gel; Positive controls 3 gives Folium Persicae gel.Mouse back depilation before experiment, exposed area 4 cm × 3 cm, respectively organize preventative 3 d that smear.Mice is placed in (40 5 of W UVA tubes, 2 of UVB fluorescent tubes) under uviol lamp, and apart from skin, 35 cm places are irradiated, and between the light period, paper using is pulled and covered animal head.Initial irradiation time is 4 h/d, is increased to gradually 12 h/d, Continuous irradiation 4 weeks, perusal record the situation of change of skin in the process of irradiating.
The impact of 3.2 hydrodermas that ultraviolet is caused
Mice is divided into 5 groups at random: model group gives gel-type vehicle, Aloe-Folium Persicae gel prepared by embodiment 1 is divided into high and low dose group, and positive controls 1 gives prednisolone acetate ointment (Tianjin Pharmaceutical Group Corp., Ltd); Positive controls 2 gives Aloe gel.Mouse back depilation before experiment, exposed area 4 cm × 3 cm; Preventative 7 d that smear of each group.Mice is horizontally fixed on brandreth, and (Continuous irradiation 6h, covers animal head with cardboard between the light period for 40 4 of WUVA fluorescent tubes, 16 vertical dimension 10 cm of UVB fluorescent tube with uviol lamp.40 h after irradiating, disconnected ridge is put to death mice, get respectively two ears (d=0. 7 cm) and back (d=2 cm) the circular skin graft through irradiating, accurately take ear weight, tare weight and body weight, calculate ear exponential sum skin index: { heavy (the mg)/body weight of ear (skin) index=ear (skin) (g) × 100}.
3.3 result
3.3.1 perusal
Irradiating after 4 d, there is serious large redness, desquamation in the illuminated skin of model group mice; Vitamin E and Aloe-Folium Persicae gel group, Aloe gel, Folium Persicae gel group skin injury situation are light compared with model group, and desquamation phenomenon is less.Wherein Aloe-Folium Persicae gel group redness, desquamation phenomenon are lighter than Aloe gel group and Folium Persicae gel group.
Irradiate after 15 d, there is large area lamellar erythema, fester in the illuminated skin of model group mice, incrustation, local skin thicken; Vitamin E, Aloe-Folium Persicae gel group and Aloe gel group, Folium Persicae gel group skin injury situation are light compared with model group, and erythema is few, ulceration is lighter.Wherein Aloe-Folium Persicae gel group erythema, festering is lighter than Aloe gel group and Folium Persicae gel group.
Irradiate after 24 d, the illuminated skin of model group mice presents lamellar erythema, festers, vesicle, thicken, tarnish and elasticity, aging obviously; Vitamin E, Aloe-Folium Persicae gel group and Aloe gel group, Folium Persicae gel group skin injury situation are light compared with model group, and erythema is few, ulceration is light, vesicle quantity is few, pachyderma is not obvious.Wherein Aloe-Folium Persicae gel group breakage, vesicle situation are slight compared with Aloe gel group, Folium Persicae gel group.
3.3.2 the impact of hydroderma
As can be seen from Table 1: Aloe-Folium Persicae gel group can reduce mouse ear index, skin index, and difference is very significant (P<0. 01), and its effect is better than Aloe gel group.
The impact of table 1 on mouse ear index, skin index (
, n=10)
| Group | Dosage/(g/Kg) | Ear index/(mg/g × 100) | Skin index/(mg/g × 100) |
| Model control group | Gel-type vehicle 32 | 45.58±2.31 | 812.37±41.56 |
| Prednisolone acetate group | 0.005 | 29.34±1.10 * * | 474.26±31.69 * |
| Aloe gel group | 32 | 41.26±1.58 * *▲▲ | 662.58±41.23 * ▲▲ |
| Folium Persicae gel group | 32 | 41.35±1.78 * *▲▲ | 654.23±38.72 * *▲ |
| Aloe-Folium Persicae gel low dose group | 16 | 38.58±1.26 * *△△☆▲▲ | 591.37±46.51 * *△△☆▲▲ |
| Aloe-Folium Persicae gel high dose group | 48 | 36.01±1.41 * *△△☆☆▲▲ | 585.171±41.28 * *△△☆☆▲ |
With model group comparison
* p﹤ 0.01,
* p﹤ 0.05, with the comparison of Aloe gel group
△ △ p﹤ 0.01,
△ p﹤ 0.05, with the comparison of Folium Persicae gel group
☆ ☆ p﹤ 0.01,
☆ p﹤ 0.05, compares with prednisolone acetate group
▲ ▲ p﹤ 0.01,
▲ p﹤ 0.05
Result shows, the therapeutic effect of gel preparation of the present invention is better than Aloe gel and Folium Persicae gel, adds Folium Persicae can make the pharmacologically active of Aloe greatly strengthen.
Claims (7)
1. Aloe-Folium Persicae gel preparation, is characterized in that each composition and the consumption thereof of said preparation is as follows: aloe stoste 8-25 weight portion, Folium Persicae ethanol extraction 12-28 weight portion
,carbomer 1-4 weight portion, Mentholum 0.05-0.7 weight portion, laurocapram 1-4 parts by volume, ethyl hydroxybenzoate 0.7-3 weight portion, glycerol 3-12 parts by volume, pure water 15.5-49.5 parts by volume, dehydrated alcohol exists with the amount of having dissolved ethyl hydroxybenzoate and Mentholum, and sodium hydroxide solution is so that the amount existence that the pH value of preparation is 6.5-7.5;
Described aloe stoste is adopted preparation with the following method: remove the peel after Aloe is cleaned (1), obtains the inner spawn of Aloe, puts it in agitator, adds proper amount of boiling water burn 10-15min to kill enzyme, and gel is blended, and obtains gel liquid; (2) add 0.2%-0.4% active carbon to do filter aid toward Aloe gel shape liquid, stir 10min, put into centrifuge centrifugal, rotating speed is 1800-4000r/min, and the time is 30-35min, obtains Aloe solution; (3) above-mentioned solution is carried out to concentrating under reduced pressure, temperature is 35-50 DEG C, and the time is 20-40min, obtains concentrated solution; (4) sterilization: 30-45min sterilizes at 40-50 DEG C; (5) add 0.01-0.1% antioxidant; (6) add 0.01-0.3% antiseptic; (7) add 0.01-0.1%pH regulator, prepare aloe stoste, the wherein pH6.5 of stock solution, density is 0.971g/ml;
Folium Persicae ethanol extraction preparation method is as follows: get fresh Folium Persicae, clean and dry rear chopping, bottling, then spend the night by 70% soak with ethanol, supersound extraction 1h, filters concentrating under reduced pressure and obtains ethanol extraction, and wherein extract character is: 1 g crude drug/ml, density is 0.889 g/ml, and pH is 6.5.
2. gel preparation according to claim 1, is characterized in that each composition and the consumption thereof of said preparation is as follows: aloe stoste 14.565 weight portions, Folium Persicae ethanol extract 13.335 weight portions
,carbomer 1 weight portion, Mentholum 0.05 weight portion, laurocapram 2 parts by volume, ethyl hydroxybenzoate 0.75 weight portion, glycerol 4 parts by volume, pure water 30 parts by volume, dehydrated alcohol 4 parts by volume, sodium hydroxide solution is so that the amount existence that the pH value of preparation is 6.5-7.5.
3. according to the arbitrary described gel preparation of claim 1 or 2, it is characterized in that each composition and the consumption thereof of said preparation is as follows: aloe stoste 14.565g, Folium Persicae ethanol extract 13.335g
,carbomer 1g, Mentholum 0.05g, laurocapram 2ml, ethyl hydroxybenzoate 0.75g, glycerol 4ml, pure water 30ml, dehydrated alcohol 4ml, sodium hydroxide solution is so that the amount existence that the pH value of preparation is 6.5-7.5.
4. gel preparation according to claim 1, is characterized in that: described carbomer is Acritamer 940 or carbomer 934.
5. gel preparation according to claim 4, is characterized in that: described antioxidant is VitC; Described antiseptic is sodium benzoate; Described pH adjusting agent is citric acid.
6. a preparation method for gel preparation according to claim 1, it comprises the following steps: take carbomer in prescription ratio, it is scattered in pure water, placing spends the night makes it fully swelling; Separately get recipe quantity Mentholum, ethyl hydroxybenzoate and be dissolved in respectively in appropriate dehydrated alcohol, for subsequent use; The swelling body of carbomer that placement is spent the night is ground to granule and disappears, separately take aloe stoste, Folium Persicae ethanol extraction, and with Mentholum solution, ethyl hydroxybenzoate solution, laurocapram, glycerol joins in the carbomer after grinding together, drip sodium hydroxide solution, add pure water, continue grinding and make into gel.
7. gel preparation claimed in claim 1 is repaired after preparation is shone, antipruritic, mosquito control bites or treat the purposes in solar dermatitis medicine.
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| CN103463333B (en) * | 2013-09-27 | 2015-07-15 | 四川农业大学 | Aloe-cactus-peach leaf gel preparation and preparation method thereof |
| CN107184961A (en) * | 2017-05-27 | 2017-09-22 | 广州润虹医药科技有限公司 | A kind of competent cell renovation agent and preparation method thereof |
| CN108853312B (en) * | 2018-09-25 | 2021-04-16 | 陕西天宇制药有限公司 | Polycinnamic alcohol external gel and preparation method thereof |
| CN115054567A (en) * | 2021-08-30 | 2022-09-16 | 湖南科洛克医药有限公司 | Skin wound repairing gel and using method and application thereof |
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| CN101048133A (en) * | 2004-10-26 | 2007-10-03 | 株式会社资生堂 | Skin preparation for external use |
| CN101288643A (en) * | 2008-06-17 | 2008-10-22 | 杨喜鸿 | Gel composition containing tacrolimu and its preparation method and medicinal application |
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|---|---|---|---|---|
| CN101048133A (en) * | 2004-10-26 | 2007-10-03 | 株式会社资生堂 | Skin preparation for external use |
| CN101288643A (en) * | 2008-06-17 | 2008-10-22 | 杨喜鸿 | Gel composition containing tacrolimu and its preparation method and medicinal application |
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| 张丽.芦荟外擦治疗日光性皮炎.《实用中医内科杂志》.1998,第12卷(第4期), * |
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