CN103301288B - 一种治疗痛风性关节炎的中药组合物 - Google Patents
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Abstract
本发明公开了一种治疗痛风性关节炎的中药组合物。中医认为痛风属于“痹证”范畴。此病多因平素过食膏粱厚味，以至湿热内蕴，稽留骨骼，气血不能畅通，不通则痛；而气血郁于骨节局部，则灼热红肿。为此，本发明选择中药小飞扬草、茯苓、萆薢、十八症、珍珠梅、过山龙、黄花堇菜、天王七、忍冬藤、白毛夏枯草、仙茅，由我院制剂室制成汤剂，经临床试验，总有效率达到96.9％，血尿酸值也有了明显的下降，值得临床推广应用。
Description
技术领域
本发明涉及一种中药组合物，尤其涉及一种治疗痛风性关节炎的中药组合物。
背景技术
痛风性关节炎是尿酸盐结晶沉积在关节滑膜、滑囊、软骨及其它组织中引起的反复发作性炎症性疾病，急性发作期主要症状为关节红、肿、热、痛，最易受累的部位是跖趾关节。随着社会的发展，人们物质生活水平的提高，痛风病的发病率也越来越高。目前西医治疗主要应用秋水仙碱、别嘌呤醇、非甾体类抗炎药、激素等药物治疗，虽可较快控制急性症状，但因其副作用大，患者往往难以坚持治疗，故复发率很高。
发明内容
本发明的目的是提供一种治疗痛风性关节炎的中药组合物。中医认为痛风属于“痹证”范畴，多因平素过食膏粱厚味，以至湿热内蕴，稽留骨骼，气血不能畅通，不通则痛；而气血郁于骨节局部，则灼热红肿，功能障碍。
本发明的目的是通过以下技术方案实现的，该治疗痛风性关节炎的中药组合物由以下重量份的中药制成：小飞扬草10-20份、茯苓13-18份、萆薢7-12份、十八症15-20份、珍珠梅5-10份、过山龙25-30份、黄花堇菜5-9份、天王七6-11份、忍冬藤8-16份、白毛夏枯草9-18份、仙茅13-17份。
优选的，小飞扬草15份、茯苓16份、萆薢9份、十八症18份、珍珠梅8份、过山龙28份、黄花堇菜7份、天王七8份、忍冬藤12份、白毛夏枯草14份、仙茅15份。
制备方法按传统的制备方法，水煎制成汤剂。
方中：小飞扬草、茯苓、萆薢清热利湿，消肿解毒，健脾安神，利湿去浊，祛风除痹；十八症祛风散寒，消瘀止痛；珍珠梅、过山龙活血祛瘀，消肿止痛，消炎解毒，祛风除湿；黄花堇菜温经通络，除湿止痛；天王七祛风湿，理气活血，健脾胃，消炎镇痛；忍冬藤、白毛夏枯草清热解毒，疏风通络，祛风化痰，清热凉血，活血止痛；仙茅温肾壮阳，强筋骨，祛寒湿。
临床资料
1、一般资料所有病例均为本院门诊患者，共128例，符合国家中医药管理局发布的《中医病证诊断疗效标准》。随机分为治疗组和对照组。其中治疗组64例，男58例，女6例；年龄最大75岁，最小25岁，平均43岁；病程最短的8个月，最长15年，平均4.9年。均为急性发作病例，首次发作14例，第2次发作34例，发作3次以上者16例；饮酒后发作22例，进食高蛋白饮食后发作16例，劳累后发作8例，外伤后发作4例，无明显诱因14例；发病部位：跖趾关节30例，踝关节12例，膝关节6例，其他关节16例。距就诊时间最短3小时，最长72小时，平均19小时；血尿酸＜420mmol/L者8例，＞420mmol/L者26例，＞500mmol/L者20例，＞600mmol/L10例。对照组64例，男55例，女9例。年龄最大70岁，最小23岁，平均39岁；病程最短的7个月，最16年，平均5.0年；均为急性发作病例，首次发作16例，第2次发作36例，发作3次以上者12例；饮酒后发作24例，进食高蛋白饮食后发作16例，劳累后发作10例，外伤后发作2例，无明显诱因12例；发病部位：跖趾关节32例，踝关节14例，膝关节6例，其他关节12例；距就诊时间最短4小时，最长70小时，平均16小时；血尿酸＜420mmol/L者12例，＞420mmol/L者24例，＞500mmol/L者20例，＞600mmol/L8例。两组病人以上资料经统计学处理无显著性差异(P＜0.05)，具有可比性。
2、诊断标准①非对称性关节疼痛，常在夜间发作，红肿、压痛、功能障碍。②以往可有发作史，无症状间歇期，发作可自行停止。③血尿酸浓度增高。④排除其它疾病引起的手足关节肿痛。
3、治疗方法治疗组服用本发明所述的中药组合物，即取小飞扬草15g、茯苓16g、萆薢9g、十八症18g、珍珠梅8g、过山龙28g、黄花堇菜7g、天王七8g、忍冬藤12g、白毛夏枯草14g、仙茅15g，水煎制成汤剂，每日一剂，每日三次；对照组患者给予：别嘌呤醇，0.1/次，3次/d；贝诺酯，0.5/次，3次/d；两组患者均一周为一个疗程。
4、疗效标准参照《中医病证诊断疗效标准》评定，治愈：关节红肿热痛消退，局部无明显异常，活动自如，血尿酸值降至正常范围；好转：关节红肿热痛减轻，血尿酸值下降，但未达到正常范围；未愈：关节红肿热痛症改善不明显，活动受限，血尿酸值不下降。
5、治疗结果(1)两组治疗后疗效比较见表1。
表1两组治疗后疗效比较
与对照组比较P＜0.05。
两组比较，治疗组治愈率、总有效率明显优于对组，具有统计学意义具有可比性。
(2)两组治疗前后血尿酸值检测结果变化情况比较见表2。
表2两组治疗前后血尿酸值检测结果变化情况比较
具体实施方式
实施例一：称取小飞扬草15g、茯苓16g、萆薢9g、十八症18g、珍珠梅8g、过山龙28g、黄花堇菜7g、天王七8g、忍冬藤12g、白毛夏枯草14g、仙茅15g，按传统的制备方法，水煎制成汤剂。
实施例二：称取小飞扬草20g、茯苓13g、萆薢7g、十八症15g、珍珠梅5g、过山龙30g、黄花堇菜5g、天王七11g、忍冬藤8g、白毛夏枯草18g、仙茅13g，按传统的制备方法，水煎制成汤剂。
实施例三：称取小飞扬草10g、茯苓18g、萆薢12g、十八症20g、珍珠梅10g、过山龙25g、黄花堇菜9g、天王七6g、忍冬藤16g、白毛夏枯草9g、仙茅17g，按传统的制备方法，水煎制成汤剂。
Claims (2)
1.一种治疗痛风性关节炎的中药组合物，其特征在于该中药组合物由以下重量份的中药制成：小飞扬草10-20份、茯苓13-18份、萆薢7-12份、十八症15-20份、珍珠梅5-10份、过山龙25-30份、黄花堇菜5-9份、天王七6-11份、忍冬藤8-16份、白毛夏枯草9-18份、仙茅13-17份，按传统的制备方法，水煎制成汤剂。
2.根据权利要求1所述的一种治疗痛风性关节炎的中药组合物，其特征在于该中药组合物由以下重量份的中药制成：小飞扬草15份、茯苓16份、萆薢9份、十八症18份、珍珠梅8份、过山龙28份、黄花堇菜7份、天王七8份、忍冬藤12份、白毛夏枯草14份、仙茅15份。
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