CN103298828B - 犹他游动放线菌的基因组学 - Google Patents
犹他游动放线菌的基因组学 Download PDFInfo
- Publication number
- CN103298828B CN103298828B CN201180048284.6A CN201180048284A CN103298828B CN 103298828 B CN103298828 B CN 103298828B CN 201180048284 A CN201180048284 A CN 201180048284A CN 103298828 B CN103298828 B CN 103298828B
- Authority
- CN
- China
- Prior art keywords
- gene
- bacterial strain
- sequence
- wild
- strain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 241000187840 Actinoplanes utahensis Species 0.000 title description 35
- XUFXOAAUWZOOIT-SXARVLRPSA-N (2R,3R,4R,5S,6R)-5-[[(2R,3R,4R,5S,6R)-5-[[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-1-cyclohex-2-enyl]amino]-2-oxanyl]oxy]-3,4-dihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-6-(hydroxymethyl)oxane-2,3,4-triol Chemical compound O([C@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O[C@H]1O[C@@H]([C@H]([C@H](O)[C@H]1O)N[C@@H]1[C@@H]([C@@H](O)[C@H](O)C(CO)=C1)O)C)[C@@H]1[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]1O XUFXOAAUWZOOIT-SXARVLRPSA-N 0.000 claims description 26
- 229960002632 acarbose Drugs 0.000 claims description 26
- XUFXOAAUWZOOIT-UHFFFAOYSA-N acarviostatin I01 Natural products OC1C(O)C(NC2C(C(O)C(O)C(CO)=C2)O)C(C)OC1OC(C(C1O)O)C(CO)OC1OC1C(CO)OC(O)C(O)C1O XUFXOAAUWZOOIT-UHFFFAOYSA-N 0.000 claims description 26
- 238000000034 method Methods 0.000 claims description 14
- 230000008859 change Effects 0.000 claims description 11
- 244000005700 microbiome Species 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 abstract description 93
- 230000001580 bacterial effect Effects 0.000 abstract description 47
- 238000004519 manufacturing process Methods 0.000 abstract description 18
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract description 9
- 102000004169 proteins and genes Human genes 0.000 abstract description 9
- 230000035772 mutation Effects 0.000 abstract description 7
- 238000012239 gene modification Methods 0.000 abstract description 4
- 230000005017 genetic modification Effects 0.000 abstract description 4
- 235000013617 genetically modified food Nutrition 0.000 abstract description 4
- 238000012986 modification Methods 0.000 abstract description 3
- 230000004048 modification Effects 0.000 abstract description 3
- 108020004414 DNA Proteins 0.000 description 18
- 238000012163 sequencing technique Methods 0.000 description 14
- 238000002474 experimental method Methods 0.000 description 10
- 239000002773 nucleotide Substances 0.000 description 10
- 125000003729 nucleotide group Chemical group 0.000 description 10
- 231100000350 mutagenesis Toxicity 0.000 description 9
- 235000018102 proteins Nutrition 0.000 description 9
- 238000002703 mutagenesis Methods 0.000 description 8
- 108090000790 Enzymes Proteins 0.000 description 5
- 102000004190 Enzymes Human genes 0.000 description 5
- 229940088598 enzyme Drugs 0.000 description 5
- 239000012634 fragment Substances 0.000 description 5
- 238000003780 insertion Methods 0.000 description 5
- 230000037431 insertion Effects 0.000 description 5
- 230000028327 secretion Effects 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 125000003275 alpha amino acid group Chemical group 0.000 description 4
- 230000008034 disappearance Effects 0.000 description 4
- 230000004907 flux Effects 0.000 description 4
- 238000013507 mapping Methods 0.000 description 4
- 230000003505 mutagenic effect Effects 0.000 description 4
- 239000002244 precipitate Substances 0.000 description 4
- 238000012797 qualification Methods 0.000 description 4
- 241000187844 Actinoplanes Species 0.000 description 3
- 108700026244 Open Reading Frames Proteins 0.000 description 3
- 108010076504 Protein Sorting Signals Proteins 0.000 description 3
- 102000040739 Secretory proteins Human genes 0.000 description 3
- 108091058545 Secretory proteins Proteins 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 238000012937 correction Methods 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- 239000002207 metabolite Substances 0.000 description 3
- 231100000219 mutagenic Toxicity 0.000 description 3
- 238000013518 transcription Methods 0.000 description 3
- 230000035897 transcription Effects 0.000 description 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 102000007474 Multiprotein Complexes Human genes 0.000 description 2
- 108010085220 Multiprotein Complexes Proteins 0.000 description 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 2
- 101150036080 at gene Proteins 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 238000005314 correlation function Methods 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 238000012268 genome sequencing Methods 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- PHTQWCKDNZKARW-UHFFFAOYSA-N isoamylol Chemical compound CC(C)CCO PHTQWCKDNZKARW-UHFFFAOYSA-N 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 238000005457 optimization Methods 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 230000014616 translation Effects 0.000 description 2
- 108091005703 transmembrane proteins Proteins 0.000 description 2
- 102000035160 transmembrane proteins Human genes 0.000 description 2
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- NOIRDLRUNWIUMX-UHFFFAOYSA-N 2-amino-3,7-dihydropurin-6-one;6-amino-1h-pyrimidin-2-one Chemical compound NC=1C=CNC(=O)N=1.O=C1NC(N)=NC2=C1NC=N2 NOIRDLRUNWIUMX-UHFFFAOYSA-N 0.000 description 1
- 241000186361 Actinobacteria <class> Species 0.000 description 1
- 241001156739 Actinobacteria <phylum> Species 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 229940077274 Alpha glucosidase inhibitor Drugs 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 239000002028 Biomass Substances 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 108010059892 Cellulase Proteins 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 108091029795 Intergenic region Proteins 0.000 description 1
- 241000222065 Lycoperdon Species 0.000 description 1
- 229920002774 Maltodextrin Polymers 0.000 description 1
- 239000005913 Maltodextrin Substances 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 108091092724 Noncoding DNA Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 241000768494 Polymorphum Species 0.000 description 1
- 102000002278 Ribosomal Proteins Human genes 0.000 description 1
- 108010000605 Ribosomal Proteins Proteins 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 102000004357 Transferases Human genes 0.000 description 1
- 108090000992 Transferases Proteins 0.000 description 1
- 102000008579 Transposases Human genes 0.000 description 1
- 108010020764 Transposases Proteins 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 101150036253 acbC gene Proteins 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 239000011543 agarose gel Substances 0.000 description 1
- 239000002168 alkylating agent Substances 0.000 description 1
- 229940100198 alkylating agent Drugs 0.000 description 1
- 239000003888 alpha glucosidase inhibitor Substances 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000008275 binding mechanism Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 229940106157 cellulase Drugs 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
- 238000010205 computational analysis Methods 0.000 description 1
- 108091036078 conserved sequence Proteins 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 1
- 235000011180 diphosphates Nutrition 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000002532 enzyme inhibitor Substances 0.000 description 1
- 229940125532 enzyme inhibitor Drugs 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 230000037433 frameshift Effects 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 229950006191 gluconic acid Drugs 0.000 description 1
- 230000034659 glycolysis Effects 0.000 description 1
- 239000000413 hydrolysate Substances 0.000 description 1
- 238000009655 industrial fermentation Methods 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 229940035034 maltodextrin Drugs 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- 239000003471 mutagenic agent Substances 0.000 description 1
- 231100000707 mutagenic chemical Toxicity 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000007030 peptide scission Effects 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 108010022393 phosphogluconate dehydratase Proteins 0.000 description 1
- 102000054765 polymorphisms of proteins Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000013441 quality evaluation Methods 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 230000037432 silent mutation Effects 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 150000003608 titanium Chemical class 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/365—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinoplanes (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/12—Unicellular algae; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
Abstract
Description
Claims (3)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10171831 | 2010-08-04 | ||
EP10171831.0 | 2010-08-04 | ||
PCT/EP2011/063243 WO2012016960A1 (en) | 2010-08-04 | 2011-08-01 | Genomics of actinoplanes utahensis |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103298828A CN103298828A (zh) | 2013-09-11 |
CN103298828B true CN103298828B (zh) | 2016-08-03 |
Family
ID=44629912
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201180048284.6A Active CN103298828B (zh) | 2010-08-04 | 2011-08-01 | 犹他游动放线菌的基因组学 |
Country Status (10)
Country | Link |
---|---|
US (1) | US9719064B2 (zh) |
EP (1) | EP2601209B1 (zh) |
JP (3) | JP6332966B2 (zh) |
KR (1) | KR20160073433A (zh) |
CN (1) | CN103298828B (zh) |
CA (1) | CA2807264A1 (zh) |
ES (1) | ES2625773T3 (zh) |
HK (1) | HK1184796A1 (zh) |
TW (1) | TW201217533A (zh) |
WO (1) | WO2012016960A1 (zh) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW201217533A (en) * | 2010-08-04 | 2012-05-01 | Bayer Pharma AG | Genomics of actinoplanes utahensis |
ES2718331T3 (es) * | 2011-12-08 | 2019-07-01 | Bayer Ip Gmbh | Nuevo elemento integrador y conjugador de actinomiceto de Actinoplanes sp. SE50/110 como plásmido para la transformación genética de actinobacterias relacionadas |
US9421199B2 (en) | 2014-06-24 | 2016-08-23 | Sydnexis, Inc. | Ophthalmic composition |
WO2016172712A2 (en) | 2015-04-23 | 2016-10-27 | Sydnexis, Inc. | Ophthalmic composition |
US11382909B2 (en) | 2014-09-05 | 2022-07-12 | Sydnexis, Inc. | Ophthalmic composition |
EP3302426A4 (en) | 2015-05-29 | 2018-12-05 | Sydnexis, Inc. | D2o stabilized pharmaceutical formulations |
WO2017196795A2 (en) * | 2016-05-09 | 2017-11-16 | The Rockefeller University | Bioactive metabolites encoded by the human microbiome using primary sequence alone |
WO2018169926A1 (en) * | 2017-03-14 | 2018-09-20 | Oregon State University | Peptide inhibitors targeting the neisseria gonorrhoeae pivotal anaerobic respiration factor ania |
CN108624544B (zh) * | 2017-03-20 | 2021-08-27 | 浙江海正药业股份有限公司 | 阿卡波糖工程菌及其制备方法和应用 |
CN110914912A (zh) * | 2017-06-06 | 2020-03-24 | 齐默尔根公司 | 对基因修饰进行优先级排序以增加表型优化的吞吐量 |
US20230371483A1 (en) * | 2019-07-25 | 2023-11-23 | The Regents Of The University Of California | Methods and compositions for sexing and sterilization in drosophila suzukii and aedes aegypti |
KR20220081991A (ko) | 2019-10-16 | 2022-06-16 | 바이엘 악티엔게젤샤프트 | 아카르보스의 개선된 형성을 위한 방법 |
CN112903657B (zh) * | 2021-01-28 | 2022-06-24 | 中山大学 | 一种三聚氰胺和甲醛的表面增强拉曼光谱检测方法 |
CN115873886B (zh) * | 2022-04-27 | 2023-11-10 | 武汉合生科技有限公司 | 生物合成麦角硫因的方法及载体 |
WO2023225459A2 (en) | 2022-05-14 | 2023-11-23 | Novozymes A/S | Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1249001A (zh) * | 1997-02-28 | 2000-03-29 | 拜尔公司 | 来自游动放线菌SE50/110的Acarboseacb基因簇 |
DE10021667A1 (de) * | 2000-05-05 | 2001-11-08 | Bayer Ag | Neue Enzyme in der Acarbose-Synthese und deren Verwendung |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7630836B2 (en) * | 2001-05-30 | 2009-12-08 | The Kitasato Institute | Polynucleotides |
TW201217533A (en) * | 2010-08-04 | 2012-05-01 | Bayer Pharma AG | Genomics of actinoplanes utahensis |
-
2011
- 2011-07-28 TW TW100126698A patent/TW201217533A/zh unknown
- 2011-08-01 ES ES11741187T patent/ES2625773T3/es active Active
- 2011-08-01 CA CA2807264A patent/CA2807264A1/en not_active Abandoned
- 2011-08-01 WO PCT/EP2011/063243 patent/WO2012016960A1/en active Application Filing
- 2011-08-01 CN CN201180048284.6A patent/CN103298828B/zh active Active
- 2011-08-01 US US13/814,235 patent/US9719064B2/en active Active
- 2011-08-01 JP JP2013522225A patent/JP6332966B2/ja active Active
- 2011-08-01 KR KR1020137005236A patent/KR20160073433A/ko not_active Application Discontinuation
- 2011-08-01 EP EP11741187.6A patent/EP2601209B1/en active Active
-
2013
- 2013-11-01 HK HK13112299.8A patent/HK1184796A1/zh unknown
-
2016
- 2016-11-22 JP JP2016226705A patent/JP6449214B2/ja active Active
-
2018
- 2018-10-17 JP JP2018195488A patent/JP6700365B2/ja active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1249001A (zh) * | 1997-02-28 | 2000-03-29 | 拜尔公司 | 来自游动放线菌SE50/110的Acarboseacb基因簇 |
DE10021667A1 (de) * | 2000-05-05 | 2001-11-08 | Bayer Ag | Neue Enzyme in der Acarbose-Synthese und deren Verwendung |
Non-Patent Citations (1)
Title |
---|
molecular detection of alpha-glucosidase inhibitor-producing actinomycetes;Chang-Gu Hyun et al.;《The Journal of Microbiology》;20050630;第43卷(第3期);313-318 * |
Also Published As
Publication number | Publication date |
---|---|
JP2013535206A (ja) | 2013-09-12 |
HK1184796A1 (zh) | 2014-01-30 |
ES2625773T3 (es) | 2017-07-20 |
US9719064B2 (en) | 2017-08-01 |
KR20160073433A (ko) | 2016-06-27 |
WO2012016960A1 (en) | 2012-02-09 |
JP6332966B2 (ja) | 2018-06-06 |
EP2601209A1 (en) | 2013-06-12 |
US20130302855A1 (en) | 2013-11-14 |
EP2601209B1 (en) | 2017-03-01 |
JP2017060500A (ja) | 2017-03-30 |
JP6449214B2 (ja) | 2019-01-09 |
CN103298828A (zh) | 2013-09-11 |
JP2019030317A (ja) | 2019-02-28 |
JP6700365B2 (ja) | 2020-05-27 |
TW201217533A (en) | 2012-05-01 |
CA2807264A1 (en) | 2012-02-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103298828B (zh) | 犹他游动放线菌的基因组学 | |
Salazar et al. | Nanopore sequencing enables near-complete de novo assembly of Saccharomyces cerevisiae reference strain CEN. PK113-7D | |
Albert et al. | Genetics of trans-regulatory variation in gene expression | |
Yang et al. | Edwardsiella comparative phylogenomics reveal the new intra/inter-species taxonomic relationships, virulence evolution and niche adaptation mechanisms | |
Roberts et al. | Isolation and characterization of the Prochlorococcus carboxysome reveal the presence of the novel shell protein CsoS1D | |
Sommer et al. | β-Carboxysome bioinformatics: identification and evolution of new bacterial microcompartment protein gene classes and core locus constraints | |
Cornet et al. | Metagenomic assembly of new (sub) polar Cyanobacteria and their associated microbiome from non-axenic cultures | |
Pei et al. | Systematic and functional identification of small non-coding RNAs associated with exogenous biofuel stress in cyanobacterium Synechocystis sp. PCC 6803 | |
Petruschke et al. | Discovery of novel community-relevant small proteins in a simplified human intestinal microbiome | |
Pfeiffer et al. | The complete and fully assembled genome sequence of Aeromonas salmonicida subsp. pectinolytica and its comparative analysis with other Aeromonas species: investigation of the mobilome in environmental and pathogenic strains | |
Hayden et al. | Large-insert genome analysis technology detects structural variation in Pseudomonas aeruginosa clinical strains from cystic fibrosis patients | |
Marcet-Houben et al. | Chromosome-level assemblies from diverse clades reveal limited structural and gene content variation in the genome of Candida glabrata | |
Haney et al. | Genomics in anti-infective drug discovery-getting to endgame | |
US20240013862A1 (en) | Methods to identify novel insecticidal proteins from complex metagenomic microbial samples | |
Eastman et al. | Development and validation of an rDNA operon based primer walking strategy applicable to de novo bacterial genome finishing | |
Yuan et al. | A complete genome assembly of Glaciecola mesophila sp. nov. sequenced by using BIGIS-4 sequencer system | |
Wang et al. | Comparative genomic analysis provides insight into the phylogeny and potential mechanisms of adaptive evolution of Sphingobacterium sp. CZ-2 | |
Thompson et al. | Genomics of Helicobacter pylori | |
Goldman et al. | Jaime Simbaqueba1*, Edwin A. Rodríguez1, Diana Burbano-David1, Carolina González1 and Alejandro Caro-Quintero2 | |
Chen | Functional genomics of the unicellular cyanobacterium Synechococcus elongatus PCC 7942 | |
Shen | A comparative genomic analysis of the ecological characters and evolutionary relationship between Escherichia coli and cryptic Escherichia clades | |
Yue et al. | Contrasting genome dynamics between domesticated and wild yeasts | |
Burnsc et al. | Large Insert Genome Analysis (LIGAN) Technology Detects Structural Variation in Pseudomonas aeruginosa Clinical Strains from Cystic Fibrosis Patients1 | |
Vanderhaeghen | Overlapping genes in E. coli EDL933 (EHEC)-Phylostratigraphy of alternative reading frames and functional analysis of the candidate gene asa | |
Uesaka et al. | Deciphering the Genomes of Motility-Deficient Mutants of Vibrio alginolyticus 138-2 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1184796 Country of ref document: HK |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: GR Ref document number: 1184796 Country of ref document: HK |
|
CP02 | Change in the address of a patent holder | ||
CP02 | Change in the address of a patent holder |
Address after: Germany's Rhine River Monheim Patentee after: BAYER INTELLECTUAL PROPERTY GmbH Address before: Germany Patentee before: BAYER INTELLECTUAL PROPERTY GmbH |