CN103285365B - Drug for preventing chilblain and preparation method thereof - Google Patents
Drug for preventing chilblain and preparation method thereof Download PDFInfo
- Publication number
- CN103285365B CN103285365B CN201310267523.8A CN201310267523A CN103285365B CN 103285365 B CN103285365 B CN 103285365B CN 201310267523 A CN201310267523 A CN 201310267523A CN 103285365 B CN103285365 B CN 103285365B
- Authority
- CN
- China
- Prior art keywords
- parts
- powder
- grinding
- horn
- medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003814 drug Substances 0.000 title claims abstract description 59
- 208000010445 Chilblains Diseases 0.000 title abstract description 33
- 229940079593 drug Drugs 0.000 title abstract description 9
- 238000002360 preparation method Methods 0.000 title abstract description 5
- 239000000843 powder Substances 0.000 claims abstract description 81
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 57
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims abstract description 37
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 19
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 19
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 19
- 239000004202 carbamide Substances 0.000 claims abstract description 19
- 239000008367 deionised water Substances 0.000 claims abstract description 19
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 19
- 235000008434 ginseng Nutrition 0.000 claims abstract description 19
- 229940099259 vaseline Drugs 0.000 claims abstract description 19
- 241001494479 Pecora Species 0.000 claims abstract description 7
- 239000000463 material Substances 0.000 claims abstract description 7
- 208000001034 Frostbite Diseases 0.000 claims description 34
- 241000283898 Ovis Species 0.000 claims description 25
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 24
- 241000628997 Flos Species 0.000 claims description 24
- 229910052799 carbon Inorganic materials 0.000 claims description 24
- 238000000227 grinding Methods 0.000 claims description 24
- 241000208340 Araliaceae Species 0.000 claims description 18
- 235000013877 carbamide Nutrition 0.000 claims description 18
- 239000002994 raw material Substances 0.000 claims description 18
- ZJTLZYDQJHKRMQ-UHFFFAOYSA-N menadiol Chemical compound C1=CC=CC2=C(O)C(C)=CC(O)=C21 ZJTLZYDQJHKRMQ-UHFFFAOYSA-N 0.000 claims description 16
- 241000180649 Panax notoginseng Species 0.000 claims description 12
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 238000010438 heat treatment Methods 0.000 claims description 7
- 241000283690 Bos taurus Species 0.000 claims description 6
- 241000283707 Capra Species 0.000 claims description 6
- 241000283007 Cervus nippon Species 0.000 claims description 6
- -1 Herba Menthae Chemical compound 0.000 claims description 6
- 235000002791 Panax Nutrition 0.000 claims description 6
- 241000208343 Panax Species 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 238000005303 weighing Methods 0.000 claims description 6
- 241000219322 Dianthus Species 0.000 claims description 3
- 239000008868 Flower Essence Substances 0.000 claims description 3
- 235000018958 Gardenia augusta Nutrition 0.000 claims description 3
- 241001632576 Hyacinthus Species 0.000 claims description 3
- 235000014443 Pyrus communis Nutrition 0.000 claims description 3
- 241000775848 Syringa oblata Species 0.000 claims description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 3
- 239000003205 fragrance Substances 0.000 abstract description 3
- 230000002265 prevention Effects 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 2
- 244000131316 Panax pseudoginseng Species 0.000 abstract 2
- CNHDIAIOKMXOLK-UHFFFAOYSA-N toluquinol Chemical compound CC1=CC(O)=CC=C1O CNHDIAIOKMXOLK-UHFFFAOYSA-N 0.000 abstract 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- 235000006679 Mentha X verticillata Nutrition 0.000 abstract 1
- 235000002899 Mentha suaveolens Nutrition 0.000 abstract 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 abstract 1
- 235000003181 Panax pseudoginseng Nutrition 0.000 abstract 1
- 210000003056 antler Anatomy 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
- NWVVVBRKAWDGAB-UHFFFAOYSA-N hydroquinone methyl ether Natural products COC1=CC=C(O)C=C1 NWVVVBRKAWDGAB-UHFFFAOYSA-N 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 8
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000003449 preventive effect Effects 0.000 description 2
- 206010007882 Cellulitis Diseases 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 240000004859 Gamochaeta purpurea Species 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 241000270295 Serpentes Species 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 206010047115 Vasculitis Diseases 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 238000004378 air conditioning Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 235000020965 cold beverage Nutrition 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 229940040145 liniment Drugs 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000009182 swimming Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- SWGJCIMEBVHMTA-UHFFFAOYSA-K trisodium;6-oxido-4-sulfo-5-[(4-sulfonatonaphthalen-1-yl)diazenyl]naphthalene-2-sulfonate Chemical compound [Na+].[Na+].[Na+].C1=CC=C2C(N=NC3=C4C(=CC(=CC4=CC=C3O)S([O-])(=O)=O)S([O-])(=O)=O)=CC=C(S([O-])(=O)=O)C2=C1 SWGJCIMEBVHMTA-UHFFFAOYSA-K 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention belongs to the technical field of pharmaceutical chemicals, and particularly relates to a drug for preventing chilblain. The drug is characterized by comprising the following materials in parts by weight: 4-8 parts of deionized water, 1-3 parts of sheep horn powder or ox horn powder or antler powder of which the fineness is smaller than 150 meshes, 7-9 parts of flowers carthami, 2-4 parts of mint, 4-8 parts of rhizoma zingiberis, 1-3 parts of ginseng, 3-5 parts of pseudo-ginseng, 4-6 parts of borneol, 60-80 parts of vaseline, 12-18 parts of glycerol, 2-4 parts of urea, 0.4-0.6 parts of methylhydroquinone, and 2-5 parts of hydroxyethyl carbon amide. The invention also discloses a preparation method of the drug for preventing chilblain. The drug has the following beneficial effects that preparation is simple, quality guarantee period is long and prevention effect is good, so that the skin is elastic, bright, and the like. The drug has fragrance, and is more comfortable when a user uses the drug.
Description
Technical field
The invention belongs to pharmaceutical chemistry technical field, especially relate to medicine of a kind of anti-frostbite and preparation method thereof.
Background technology
Chilblain is more common in the low and humid region comparatively of winter temperature: be apt to occur in hands, foot, auricle and nose etc. and locate.Mainly repeatedly be exposed to low temperature environment and protect poor relevant with disease damage position.Finding expression in part has skin purple red color spot, pimple or the nodular lesion of gargalesthesia or distending pain, can accompany edema and water cellulitis.Course of disease mesocuticle is tear-away, hemorrhage, rotten to the corn or occur ulcer finally forming paralysed trace or fibrosis.Chilblain easily recurs, and reduces relevant with chronic vasculitis inflammatory and the skin resistance of ill rear local skin.The medicine of existing treatment chilblain is few and therapeutic effect is good not, and treatment time is long, and medical expense is high, uses inconvenient.
The domestic research for chilblain medicine has for many years and has a large amount of achievements in research, as the patent No. is: 200710168576.9, denomination of invention is: a kind of medicine for external use of anti-treating chilblain; As profit number is: 201110265936.3, denomination of invention is: snake oil liniment for preventing chilblain; And for example the patent No. is: 200810123744.7, denomination of invention is: a kind of medicine for the treatment of chilblain; For another example profit number is: 201210013689.2, denomination of invention is: a kind of Chinese medicine for the treatment of chilblain; Etc. patent of invention, all studied the medicine for the treatment of chilblain, still, they are all the medicines after forming for chilblain, curative effect is all undesirable.
As a rule, anti-frostbite mainly contains following measures:
(1) doing more physical exercises at ordinary times, increase the resistivity of oneself with resisting cold ability, is best bet like this.
Such as wintertime swimming, have a cold bath; But a lot of people do not have so much time and energy is realized this measure.
(2) eat of warm nature food more, such as Carnis caprae seu ovis, Carnis Equi Asini, Carnis Canitis, has certain help for resisting cold like this.Vary with each individual, somebody person is weary of this group food.
(3), when it cyclostrophic is cool at ordinary times, remembering increases warming medicated clothing to health, allows health not be subject to outside invading.Such as allow the old and the children go out less as far as possible, open air-conditioning, heating installation at home.Conventionally, northerly outdoor, be easy to suffer from cold; The dark and damp weather in south, also bad control medicated clothing.
For this reason, society urgently has the medicine of anti-frostbite to occur, in just prevention of premorbid, just can not bring misery maybe can reduce misery to patient.
Summary of the invention
In order to address the above problem, the object of the invention is to disclose a kind of medicine of anti-frostbite, it can make patient use as early as possible, prevents trouble before it happens, and before there is chilblain, just prevention, does not stop the generation of chilblain effectively, greatly reduces the probability of patient's morbidity; Another object of the present invention is to disclose the manufacture method of this medicine.They are realized by the following technical solutions.
A kind of medicine of anti-frostbite, it is characterized in that by weight, it includes following raw material: deionized water: 4～8 parts, fineness are less than 150 object Cornu Caprae seu Ovis powder or horn powder or harts horn carbon: 1～3 part, Flos Carthami: 7～9 parts, Herba Menthae: 2～4 parts, Rhizoma Zingiberis: 4～8 parts, Radix Ginseng: 1～3 part, Radix Notoginseng: 3～5 parts, Borneolum Syntheticum: 4～6 parts, vaseline: 60～80 parts, glycerol: 12～18 parts, carbamide: 2～4 parts, methylnaphthohydroquinone: 0.4～0.6 part, BSJ15: 2～5 parts.
In embodiment 1 of the present invention, a kind of medicine of anti-frostbite, it is characterized in that by weight, it includes following raw material: deionized water: 6 parts, fineness are less than 150 object Cornu Caprae seu Ovis powder or horn powder or harts horn carbon: 2 parts, Flos Carthami: 8 parts, Herba Menthae: 3 parts, Rhizoma Zingiberis: 6 parts, Radix Ginseng: 2 parts, Radix Notoginseng: 4 parts, Borneolum Syntheticum: 5 parts, vaseline: 70 parts, glycerol: 15 parts, carbamide: 3 parts, methylnaphthohydroquinone: 0.5 part, BSJ15: 3 parts.
In embodiment 2 of the present invention, a kind of medicine of anti-frostbite, it is characterized in that by weight, it includes following raw material: deionized water: 4 parts, fineness are less than 150 object Cornu Caprae seu Ovis powder or horn powder or harts horn carbon: 1 part, Flos Carthami: 7 parts, Herba Menthae: 2 parts, Rhizoma Zingiberis: 4 parts, Radix Ginseng: 1 part, Radix Notoginseng: 3 parts, Borneolum Syntheticum: 4 parts, vaseline: 60 parts, glycerol: 12 parts, carbamide: 2 parts, methylnaphthohydroquinone: 0.4 part, BSJ15: 2 parts.
In embodiment 3 of the present invention, a kind of medicine of anti-frostbite, it is characterized in that by weight, it includes following raw material: deionized water: 8 parts, fineness are less than 150 object Cornu Caprae seu Ovis powder or horn powder or harts horn carbon: 3 parts, Flos Carthami: 9 parts, Herba Menthae: 4 parts, Rhizoma Zingiberis: 8 parts, Radix Ginseng: 3 parts, Radix Notoginseng: 5 parts, Borneolum Syntheticum: 6 parts, vaseline: 80 parts, glycerol: 18 parts, carbamide: 4 parts, methylnaphthohydroquinone: 0.6 part, BSJ15: 5 parts.
The medicine of anti-frostbite described above, wherein said Cornu Caprae seu Ovis powder is the powder that the angle of goat or sheep or Saigae Tataricae is pulverized and formed after grinding; Described horn powder is the powder that the angle of Babalus bubalis L. or cattle is pulverized and formed after grinding; Described harts horn carbon is the powder that the angle of elk or Cervus nippon Temminck is pulverized and formed after grinding.
The medicine of above-mentioned anti-frostbite, is characterized in that it makes by the following method: (1) takes each raw material by weight; (2) by Flos Carthami, Rhizoma Zingiberis, Radix Ginseng, panax mixed and wear into fineness and be less than 150 object powder; (3) fineness is less than to 150 object Cornu Caprae seu Ovis powder or horn powder or harts horn carbon, Herba Menthae, Borneolum Syntheticum, base hydroquinone, BSJ15 mixed grinding becomes powder; (4) carbamide is dissolved in deionized water; (5) by vaseline, glycerol Hybrid Heating to 85 ± 5 ℃, and the liquid state that stirs; Gained material in (2), (3), (4) is added respectively and be constantly stirred to evenly, cool to room temperature, the get product medicine of anti-frostbite of weighing and bagging.
The medicine of above-mentioned anti-frostbite, is characterized in that by weight, and it also includes 1-3 part essence, and described essence is jasmin essence or Syringa oblata Lindl. essence or orange taste essence or Dianthus carryophyllus essence or hyacinth essence or Flos Mume essence or Flos persicae essence or pear flower essence.
When having essence, the medicine of described anti-frostbite, is characterized in that it makes by the following method: (1) takes each raw material by weight; (2) by Flos Carthami, Rhizoma Zingiberis, Radix Ginseng, panax mixed and wear into fineness and be less than 150 object powder; (3) fineness is less than to 150 object Cornu Caprae seu Ovis powder or horn powder or harts horn carbon, Herba Menthae, Borneolum Syntheticum, base hydroquinone, BSJ15 mixed grinding becomes powder; (4) carbamide is dissolved in deionized water; (5) by vaseline, glycerol Hybrid Heating to 85 ± 5 ℃, and the liquid state that stirs; Gained material in (2), (3), (4) is added respectively and be constantly stirred to evenly cool to room temperature; (6) add essence to be stirred to evenly, the get product medicine of anti-frostbite of standing and weighing and bagging.
Using method of the present invention: when temperature is 5～15 ℃, the present invention is coated in to chilblain position, every 12～13 hours once, at least continuous coating is for 5 times a course for the treatment of above.
Use medicine of the present invention, for 150 patients that suffered from chilblain upper one year, carry out clinical use, as stated above, in affected part, apply and use after the course for the treatment of, arrive in the winter time after (minimum 7 days minimum temperatures are lower than 0 ℃ continuously), have 126 people not suffer from again chilblain.
Use medicine of the present invention, for 120 patients that suffered from chilblain upper one year, carry out clinical use, as stated above, in affected part, apply and use after two courses for the treatment of, arrive in the winter time after (minimum 7 days minimum temperatures are lower than 0 ℃ continuously), have 119 people not suffer from again chilblain.
Therefore, medicine of the present invention has good clinical effectiveness.
In the present invention, there is methylnaphthohydroquinone, when can make patient apply, make skin brighter; In the present invention, there is BSJ15, can make water loss in patient skin still less, make skin have more elasticity.
The present invention has following main beneficial effect: make simple, long shelf-life, preventive effect is good, make skin have more elasticity, the advantage such as brighter and the present invention has fragrance, more comfortable when user is used.
The specific embodiment
embodiment 1
A kind of medicine of anti-frostbite, it is characterized in that by weight, it includes following raw material: deionized water: 6 parts, fineness are less than 150 object Cornu Caprae seu Ovis powder or horn powder or harts horn carbon: 2 parts, Flos Carthami: 8 parts, Herba Menthae: 3 parts, Rhizoma Zingiberis: 6 parts, Radix Ginseng: 2 parts, Radix Notoginseng: 4 parts, Borneolum Syntheticum: 5 parts, vaseline: 70 parts, glycerol: 15 parts, carbamide: 3 parts, methylnaphthohydroquinone: 0.5 part, BSJ15: 3 parts.
embodiment 2
A kind of medicine of anti-frostbite, it is characterized in that by weight, it includes following raw material: deionized water: 4 parts, fineness are less than 150 object Cornu Caprae seu Ovis powder or horn powder or harts horn carbon: 1 part, Flos Carthami: 7 parts, Herba Menthae: 2 parts, Rhizoma Zingiberis: 4 parts, Radix Ginseng: 1 part, Radix Notoginseng: 3 parts, Borneolum Syntheticum: 4 parts, vaseline: 60 parts, glycerol: 12 parts, carbamide: 2 parts, methylnaphthohydroquinone: 0.4 part, BSJ15: 2 parts.
embodiment 3
A kind of medicine of anti-frostbite, it is characterized in that by weight, it includes following raw material: deionized water: 8 parts, fineness are less than 150 object Cornu Caprae seu Ovis powder or horn powder or harts horn carbon: 3 parts, Flos Carthami: 9 parts, Herba Menthae: 4 parts, Rhizoma Zingiberis: 8 parts, Radix Ginseng: 3 parts, Radix Notoginseng: 5 parts, Borneolum Syntheticum: 6 parts, vaseline: 80 parts, glycerol: 18 parts, carbamide: 4 parts, methylnaphthohydroquinone: 0.6 part, BSJ15: 5 parts.
Repetition test through applicant, and clinical practice, find to adopt the medicine of following formula, can reach the application's object: a kind of medicine of anti-frostbite, it is characterized in that by weight, it includes following raw material: deionized water: 4～8 parts, fineness is less than 150 object Cornu Caprae seu Ovis powder or horn powder or harts horn carbon: 1～3 part, Flos Carthami: 7～9 parts, Herba Menthae: 2～4 parts, Rhizoma Zingiberis: 4～8 parts, Radix Ginseng: 1～3 part, Radix Notoginseng: 3～5 parts, Borneolum Syntheticum: 4～6 parts, vaseline: 60～80 parts, glycerol: 12～18 parts, carbamide: 2～4 parts, methylnaphthohydroquinone: 0.4～0.6 part, BSJ15: 2～5 parts.
The medicine of anti-frostbite described in above-mentioned arbitrary embodiment, wherein said Cornu Caprae seu Ovis powder is the powder that the angle of goat or sheep or Saigae Tataricae is pulverized and formed after grinding; Described horn powder is the powder that the angle of Babalus bubalis L. or cattle is pulverized and formed after grinding; Described harts horn carbon is the powder that the angle of elk or Cervus nippon Temminck is pulverized and formed after grinding.
The medicine of anti-frostbite described in above-mentioned arbitrary embodiment, is characterized in that it makes by the following method: (1) takes each raw material by weight; (2) by Flos Carthami, Rhizoma Zingiberis, Radix Ginseng, panax mixed and wear into fineness and be less than 150 object powder; (3) fineness is less than to 150 object Cornu Caprae seu Ovis powder or horn powder or harts horn carbon, Herba Menthae, Borneolum Syntheticum, base hydroquinone, BSJ15 mixed grinding becomes powder; (4) carbamide is dissolved in deionized water; (5) by vaseline, glycerol Hybrid Heating to 85 ± 5 ℃, and the liquid state that stirs; Gained material in (2), (3), (4) is added respectively and be constantly stirred to evenly, cool to room temperature, the get product medicine of anti-frostbite of weighing and bagging.
The medicine of anti-frostbite described in above-mentioned arbitrary embodiment, it is characterized in that by weight, it also includes 1-3 part essence, and described essence is jasmin essence or Syringa oblata Lindl. essence or orange taste essence or Dianthus carryophyllus essence or hyacinth essence or Flos Mume essence or Flos persicae essence or pear flower essence.
When having essence, the medicine of anti-frostbite described above, is characterized in that it makes by the following method: (1) takes each raw material by weight; (2) by Flos Carthami, Rhizoma Zingiberis, Radix Ginseng, panax mixed and wear into fineness and be less than 150 object powder; (3) fineness is less than to 150 object Cornu Caprae seu Ovis powder or horn powder or harts horn carbon, Herba Menthae, Borneolum Syntheticum, base hydroquinone, BSJ15 mixed grinding becomes powder; (4) carbamide is dissolved in deionized water; (5) by vaseline, glycerol Hybrid Heating to 85 ± 5 ℃, and the liquid state that stirs; Gained material in (2), (3), (4) is added respectively and be constantly stirred to evenly cool to room temperature; (6) add essence to be stirred to evenly, the get product medicine of anti-frostbite of standing and weighing and bagging.
Using method of the present invention: when temperature is 5～15 ℃, the present invention is coated in to chilblain position, every 12～13 hours once, at least continuous coating is for 5 times a course for the treatment of above.
Use medicine of the present invention, for 150 patients that suffered from chilblain upper one year, carry out clinical use, as stated above, adopt the formula in embodiment 1, in affected part, apply and use after the course for the treatment of, arrive in the winter time after (minimum 7 days minimum temperatures are lower than 0 ℃ continuously), have 126 people not suffer from again chilblain.
Use medicine of the present invention, for 120 patients that suffered from chilblain upper one year, carry out clinical use, as stated above, adopt the formula in embodiment 1, in affected part, apply and use after two courses for the treatment of, arrive in the winter time after (minimum 7 days minimum temperatures are lower than 0 ℃ continuously), have 119 people not suffer from again chilblain.
Use medicine of the present invention, for second group of 150 patient who suffered from chilblain upper one year, carry out clinical use, as stated above, adopt the formula in embodiment 2, in affected part, apply and use after the course for the treatment of, arrive in the winter time after (minimum 7 days minimum temperatures are lower than 0 ℃ continuously), have 120 people not suffer from again chilblain.
Use medicine of the present invention, for second group of 120 patient who suffered from chilblain upper one year, carry out clinical use, as stated above, adopt the formula in embodiment 2, in affected part, apply and use after two courses for the treatment of, arrive in the winter time after (minimum 7 days minimum temperatures are lower than 0 ℃ continuously), have 110 people not suffer from again chilblain.
Use medicine of the present invention, for the 3rd group of 150 patients that suffered from chilblain upper one year, carry out clinical use, as stated above, adopt the formula in embodiment 3, in affected part, apply and use after the course for the treatment of, arrive in the winter time after (minimum 7 days minimum temperatures are lower than 0 ℃ continuously), have 128 people not suffer from again chilblain.
Use medicine of the present invention, for the 3rd group of 120 patients that suffered from chilblain upper one year, carry out clinical use, as stated above, adopt the formula in embodiment 3, in affected part, apply and use after two courses for the treatment of, arrive in the winter time after (minimum 7 days minimum temperatures are lower than 0 ℃ continuously), have 120 people not suffer from again chilblain.
Therefore, medicine of the present invention has good clinical effectiveness.
In the present invention, there is methylnaphthohydroquinone, when can make patient apply, make skin brighter; In the present invention, there is BSJ15, can make water loss in patient skin still less, make skin have more elasticity.
The present invention has following main beneficial effect: make simple, long shelf-life, preventive effect is good, make skin have more elasticity, the advantage such as brighter and the present invention has fragrance, more comfortable when user is used.
The present invention is not only suitable for having the personnel of ill history in the past, is also suitable for the normal phase to be the personnel of low temp operation, as made the personnel of cold drink, the personnel that deposit or take out article in be everlasting ice chest or refrigerator; And be staff of low-temperature test etc.; Can effectively prevent occupation disease like this.
The present invention is not limited to above-mentioned preferred forms, should be appreciated that design of the present invention can be by other various forms enforcement utilizations, and they drop in protection scope of the present invention equally.
Claims (7)
1. the medicine of an anti-frostbite, it is characterized in that by weight, it includes following raw material: deionized water: 4～8 parts, fineness are less than 150 object Cornu Caprae seu Ovis powder or horn powder or harts horn carbon: 1～3 part, Flos Carthami: 7～9 parts, Herba Menthae: 2～4 parts, Rhizoma Zingiberis: 4～8 parts, Radix Ginseng: 1～3 part, Radix Notoginseng: 3～5 parts, Borneolum Syntheticum: 4～6 parts, vaseline: 60～80 parts, glycerol: 12～18 parts, carbamide: 2～4 parts, methylnaphthohydroquinone: 0.4～0.6 part, BSJ15: 2～5 parts; Described Cornu Caprae seu Ovis powder is the powder that the angle of goat or sheep or Saigae Tataricae is pulverized and formed after grinding; Described horn powder is the powder that the angle of Babalus bubalis L. or cattle is pulverized and formed after grinding; Described harts horn carbon is the powder that the angle of elk or Cervus nippon Temminck is pulverized and formed after grinding.
2. the medicine of an anti-frostbite, it is characterized in that by weight, it includes following raw material: deionized water: 6 parts, fineness are less than 150 object Cornu Caprae seu Ovis powder or horn powder or harts horn carbon: 2 parts, Flos Carthami: 8 parts, Herba Menthae: 3 parts, Rhizoma Zingiberis: 6 parts, Radix Ginseng: 2 parts, Radix Notoginseng: 4 parts, Borneolum Syntheticum: 5 parts, vaseline: 70 parts, glycerol: 15 parts, carbamide: 3 parts, methylnaphthohydroquinone: 0.5 part, BSJ15: 3 parts; Described Cornu Caprae seu Ovis powder is the powder that the angle of goat or sheep or Saigae Tataricae is pulverized and formed after grinding; Described horn powder is the powder that the angle of Babalus bubalis L. or cattle is pulverized and formed after grinding; Described harts horn carbon is the powder that the angle of elk or Cervus nippon Temminck is pulverized and formed after grinding.
3. the medicine of an anti-frostbite, it is characterized in that by weight, it includes following raw material: deionized water: 4 parts, fineness are less than 150 object Cornu Caprae seu Ovis powder or horn powder or harts horn carbon: 1 part, Flos Carthami: 7 parts, Herba Menthae: 2 parts, Rhizoma Zingiberis: 4 parts, Radix Ginseng: 1 part, Radix Notoginseng: 3 parts, Borneolum Syntheticum: 4 parts, vaseline: 60 parts, glycerol: 12 parts, carbamide: 2 parts, methylnaphthohydroquinone: 0.4 part, BSJ15: 2 parts; Described Cornu Caprae seu Ovis powder is the powder that the angle of goat or sheep or Saigae Tataricae is pulverized and formed after grinding; Described horn powder is the powder that the angle of Babalus bubalis L. or cattle is pulverized and formed after grinding; Described harts horn carbon is the powder that the angle of elk or Cervus nippon Temminck is pulverized and formed after grinding.
4. the medicine of an anti-frostbite, it is characterized in that by weight, it includes following raw material: deionized water: 8 parts, fineness are less than 150 object Cornu Caprae seu Ovis powder or horn powder or harts horn carbon: 3 parts, Flos Carthami: 9 parts, Herba Menthae: 4 parts, Rhizoma Zingiberis: 8 parts, Radix Ginseng: 3 parts, Radix Notoginseng: 5 parts, Borneolum Syntheticum: 6 parts, vaseline: 80 parts, glycerol: 18 parts, carbamide: 4 parts, methylnaphthohydroquinone: 0.6 part, BSJ15: 5 parts; Described Cornu Caprae seu Ovis powder is the powder that the angle of goat or sheep or Saigae Tataricae is pulverized and formed after grinding; Described horn powder is the powder that the angle of Babalus bubalis L. or cattle is pulverized and formed after grinding; Described harts horn carbon is the powder that the angle of elk or Cervus nippon Temminck is pulverized and formed after grinding.
5. the medicine to any one anti-frostbite described in claim 4 according to claim 1, it is characterized in that by weight, it also includes 1-3 part essence, and described essence is jasmin essence or Syringa oblata Lindl. essence or orange taste essence or Dianthus carryophyllus essence or hyacinth essence or Flos Mume essence or Flos persicae essence or pear flower essence.
6. make claim 1 to the method for the medicine of any one anti-frostbite described in claim 4, it is characterized in that it by the following method step make: (1) takes each raw material by weight; (2) by Flos Carthami, Rhizoma Zingiberis, Radix Ginseng, panax mixed and wear into fineness and be less than 150 object powder; (3) fineness is less than to 150 object Cornu Caprae seu Ovis powder or horn powder or harts horn carbon, Herba Menthae, Borneolum Syntheticum, methylnaphthohydroquinone, BSJ15 mixed grinding becomes powder; (4) carbamide is dissolved in deionized water; (5) by vaseline, glycerol Hybrid Heating to 85 ± 5 ℃, and the liquid state that stirs; Gained material in (2), (3), (4) is added respectively and be constantly stirred to evenly, cool to room temperature, the get product medicine of anti-frostbite of weighing and bagging.
7. make a method for the medicine of anti-frostbite described in claim 5, it is characterized in that it by the following method step make: (1) takes each raw material by weight; (2) by Flos Carthami, Rhizoma Zingiberis, Radix Ginseng, panax mixed and wear into fineness and be less than 150 object powder; (3) fineness is less than to 150 object Cornu Caprae seu Ovis powder or horn powder or harts horn carbon, Herba Menthae, Borneolum Syntheticum, methylnaphthohydroquinone, BSJ15 mixed grinding becomes powder; (4) carbamide is dissolved in deionized water; (5) by vaseline, glycerol Hybrid Heating to 85 ± 5 ℃, and the liquid state that stirs; Gained material in (2), (3), (4) is added respectively and be constantly stirred to evenly cool to room temperature; (6) add essence to be stirred to evenly, the get product medicine of anti-frostbite of standing and weighing and bagging.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310267523.8A CN103285365B (en) | 2013-07-01 | 2013-07-01 | Drug for preventing chilblain and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310267523.8A CN103285365B (en) | 2013-07-01 | 2013-07-01 | Drug for preventing chilblain and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103285365A CN103285365A (en) | 2013-09-11 |
| CN103285365B true CN103285365B (en) | 2014-11-05 |
Family
ID=49087254
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310267523.8A Expired - Fee Related CN103285365B (en) | 2013-07-01 | 2013-07-01 | Drug for preventing chilblain and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103285365B (en) |
-
2013
- 2013-07-01 CN CN201310267523.8A patent/CN103285365B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN103285365A (en) | 2013-09-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101780173B (en) | Detoxifying and dampness-eliminating soup for treating infantile eczema and preparation method thereof | |
| CN101850029B (en) | Tortoise shell ginseng healthcare spirit and preparation method thereof | |
| CN103285365B (en) | Drug for preventing chilblain and preparation method thereof | |
| CN102100862B (en) | Psoriasis-removing soup for treating psoriasis and method for preparing same | |
| CN103977285A (en) | Traditional Chinese medicine for treating spontaneous perspiration and night sweat | |
| CN102090950A (en) | Female sanitary article capable of relieving dysmenorrhea | |
| CN103690747A (en) | Traditional Chinese medicine composition for foot bath | |
| CN103599535B (en) | Utilize externally used paste prepared by i26 immunity powdered egg and Chinese medicine decoction | |
| CN103142807A (en) | Spleen arousing and children strong-keeping soup and preparation method thereof | |
| CN102224973A (en) | Socks capable of preventing and curing gout by wearing to sleep | |
| CN102631581B (en) | Medicament for treating agrypnia and production method thereof | |
| CN104587032B (en) | The anti-cold and hot cataclysm of milk cow spring and sandstorm stress mongolian veterinary drug | |
| CN103191356A (en) | Antibacterial spray and preparation method thereof | |
| CN105148244B (en) | Treat the Chinese medicine preparation of nettle rash | |
| CN101647943B (en) | Medicinal composition | |
| CN104042811B (en) | Externally applied compound medicament for treating catabasis of bronchial asthma, preparation method and application thereof | |
| CN104474045A (en) | Traditional Chinese medicine patch for treating febrile convulsion of infants and preparation method of traditional Chinese medicine patch | |
| CN103285035B (en) | Medicine for treating dry skin chilblain and manufacturing method thereof | |
| CN103127261B (en) | A kind of Chinese medicine composition for the treatment of prurigo | |
| CN103565988A (en) | Medicine for treating rheumatic arthritis | |
| CN103690757B (en) | Traditional Chinese medicine composition for treating lung-spleen deficiency child bronchitis | |
| CN109316540A (en) | A kind of strengthening the spleen and stomach acupoint plaster and preparation method thereof | |
| CN103690704B (en) | A kind of Traditional Chinese medicinal liquid for foot bath | |
| CN106377593A (en) | Traditional Chinese pharmaceutical composition for treating subacute eczema | |
| CN102397465B (en) | Traditional Chinese medicine for treating nanism, activating self growth potential, invigorating brain and increasing intelligence |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C53 | Correction of patent for invention or patent application | ||
| CB02 | Change of applicant information |
Address after: 315700 No. 168 Wanxiang Road, Xiangshan County, Zhejiang, Ningbo Applicant after: Dai Lifen Address before: Wang Changshou City Xin Zhuang Zhen Ni Qiao Cun Suzhou city of Jiangsu Province in 215552 (12) New Village No. 3 Applicant before: Dai Lifen |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee | ||
| CP02 | Change in the address of a patent holder |
Address after: Suzhou City, Jiangsu Province, 215554 Changshou City Shang Hu Zhen Da he Cun Shen Tang Wan Tao (28) No. 79 Patentee after: Dai Lifen Address before: 315700 No. 168 Wanxiang Road, Xiangshan County, Zhejiang, Ningbo Patentee before: Dai Lifen |
|
| CB03 | Change of inventor or designer information |
Inventor after: Huang Quansheng Inventor before: Dai Lifen |
|
| CB03 | Change of inventor or designer information | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20170914 Address after: 450000 No. 2, building 3, No. 67, Longhai West Road, Zhongyuan District, Henan, Zhengzhou 3, China Patentee after: Huang Quansheng Address before: Suzhou City, Jiangsu Province, 215554 Changshou City Shang Hu Zhen Da he Cun Shen Tang Wan Tao (28) No. 79 Patentee before: Dai Lifen |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20180417 Address after: 056999 No. 5, Liu Zhuang village, Daming town, Daming County, Handan, Hebei, China 3 Co-patentee after: Yin Zengmei Patentee after: Bao Huiying Address before: 450000 No. 2, building 3, No. 67, Longhai West Road, Zhongyuan District, Henan, Zhengzhou 3, China Patentee before: Huang Quansheng |
|
| TR01 | Transfer of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20141105 Termination date: 20180701 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |