CN103284765B - A kind of aneurysm vascular model and preparation method thereof - Google Patents
A kind of aneurysm vascular model and preparation method thereof Download PDFInfo
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Abstract
The invention provides a kind of aneurysm vascular model, this aneurysm vascular model is designed to the block transparent material with pipe-like internal path, and can comprise further and being connected and detachable bifurcated artery vascular pattern with this aneurysm vascular model.Present invention also offers a kind of manufacture method of aneurysm vascular model, the method comprises: (1) creates aneurysm blood vessel electronic 3-D model; (2) aneurysm blood vessel solid model is made; (3) mold of aneurysm blood vessel is made; (4) second aneurysm blood vessel solid model is made; (5) aneurysm vascular model is made.The present invention is applied to aneurysm Wicresoft intervene operation operation practice, the performance test of aneurysm Wicresoft intervention apparatus and checking and to the dynamic (dynamical) research of aneurysm vessel inner blood.
Description
Technical field
The present invention relates to and be a kind ofly mainly used in aneurysm vascular model of the purposes such as the performance test of aneurysm interventional operation equipment, surgical simulation experiment, hematodinamics simulation experiment and preparation method thereof.
Background technology
Aneurysm is a kind of common vascular lesion, shows as arterial wall outside bulging because of local weak or structural deterioration, forms the expansion of permanent limitation.Aneurysm can be formed at any position, but the most common and the most troublesome position comprises cerebral arteries, ventral aorta, thoracic aorta etc.Background note is carried out below for cerebral aneurysm.
Cerebral aneurysm is that the local of internal artery blood vessel wall exists weak region, under long-term blood flow impacts, outwards expands gradually, is formed as ballooning hemangioma.The blood stream pressure of local is larger, and the danger that aneurysm is broken is higher.When cracking occurs, blood enters surrounding tissue, forms subarachnoid hemorrhage.Cerebral aneurysm first time hemorrhage mortality rate is 20%-40%; If the patient survived is not treated timely, second time will soon occur hemorrhage, mortality rate at this moment will up to 60%-80%.
Along with developing rapidly of video diagnostic technology, the discovery rate of cerebral aneurysm raises day by day.The method of traditional treatment cerebral aneurysm is surgery Clipping, and this operation is operation of opening cranium, process is complicated, wound is large, mortality rate is high.Wicresoft's intervene operation (comprising Coil embolization art, support secondary spring circle Embolization etc.) treatment cerebral aneurysm is adopted to have little, the safe and effective advantage of wound, thus accepted by most of doctor and patient, become the primary treatments of cerebral aneurysm.Especially for advanced age and the many patient of complication, or even unique Therapeutic Method.
Minimally Interventional Therapy method to the clinical experience of operative doctor and technical operation level requirement very high, need operative doctor to be familiar with very much internal blood vessel structure, human vas can be got involved rapidly, quickly and accurately implantation instrument to be delivered to vascular lesion position.Obviously, can not operator be effectively made to possess aforementioned capabilities already by static blood vessel picture.Operation training and the experiment of current comparatively effective blood vessel Wicresoft intervene operation have mainly been come by zoopery, but animal blood vessels and human vas have gap after all, and zoopery cost is higher, the repeatability of operation technique exercise is low.
Therefore a kind of convenience, cheapness and the intervene operation training of effective aneurysm Wicresoft and operating theater instruments performance testing tool is provided to have very large real value.
Summary of the invention
One object of the present invention is to provide a kind of transparent, clear and intuitive and with low cost, reusable aneurysm vascular model.Another object of the present invention is to provide a kind of method making described aneurysm vascular model.
Technical scheme of the present invention is:
Aneurysm vascular model provided by the invention is designed to the block transparent material with pipe-like internal path, the inwall of described pipe-like internal path has the profile identical with lesion vessels inwall, the normal blood vessels that described lesion vessels comprises at least one aneurysm tumor body and is connected with this aneurysm tumor body, the length of described normal blood vessels can suitably be chosen as required.
Alternatively, described aneurysm vascular model can be connected by two or more and detachable submodule is formed, and has at least the blood vessel corresponding to pipe-like internal path of a submodule to contain at least one aneurysm tumor body.
Preferably, the inwall of the pipe-like internal path of described block transparent material has the character such as the elasticity similar to human vas, toughness and surface roughness.Alternatively, described transparent material can be selected from the flexible high molecular materials such as silicone rubber.
Preferably, the inwall of the pipe-like internal path of described block transparent material is with one deck overlay film, and its effect makes the frictional force of aneurysm vascular model inwall close to the frictional force of real blood vessels inwall.Alternatively, described covering material is silicone rubber based low friction surface coating material.
Preferably, described aneurysm vascular model is closely fixed in a control box, and described control box is made up of rigid transparent material; On tank wall, the import and export of corresponding described aneurysm vascular model is provided with and imports and exports the consistent perforate of shape with corresponding, and can be provided with removable sealing-plug at the tapping of described control box.
The manufacture method of aneurysm vascular model provided by the invention comprises:
(1) aneurysm blood vessel electronic 3-D model is created;
(2) aneurysm blood vessel solid model is made;
(3) mold of aneurysm blood vessel is made;
(4) second aneurysm blood vessel solid model is made;
(5) aneurysm vascular model is made;
The manufacture method of above-mentioned aneurysm vascular model, wherein, described step (2) comprises further:
(2.1) three-dimensional fast shaping mechanism is utilized to make aneurysm blood vessel solid model;
(2.2) grinding process is carried out to the defect mending of the aneurysm blood vessel solid model of step (2.1) and surface.
The manufacture method of above-mentioned aneurysm vascular model, wherein, described step (3) comprises further:
(3.1) the aneurysm blood vessel solid model of step (2) is fixed in mold case;
(3.2) molding material and coagulant are mixed into solution by a certain percentage;
(3.3) solution of step (3.2) is poured in mold case, and allow described solution fully solidify, form mold;
(3.4) mold is cut along aneurysm blood vessel solid model centrage, and aneurysm blood vessel solid model is taken out from mold.
The manufacture method of above-mentioned aneurysm vascular model, wherein, described step (4) comprises further:
(4.1) mold cut in step (3.4) is reconsolidated fixing; ;
(4.2) the making material of second aneurysm blood vessel solid model is fused into liquid state;
(4.3) liquid material of step (4.2) is poured into step (4.1) to merge in the mold after fixing, and allow described liquid material fully solidify, form second aneurysm blood vessel solid model;
(4.4) second aneurysm blood vessel solid model of step (4.3) is taken out from mold, and defect mending and grinding process are carried out to its surface.
The manufacture method of above-mentioned aneurysm vascular model, wherein, described step (5) comprises further:
(5.1) second aneurysm blood vessel solid model of step (4) is fixed in mold case;
(5.2) aneurysm vascular model material and coagulant are mixed into solution by a certain percentage;
(5.3) solution of step (5.2) is poured in mold case, and allow described solution fully solidify, form aneurysm vascular model;
(5.4) aneurysm vascular model of step (5.3) is placed in baking box, baking box temperature is set as the fusing point higher than second aneurysm blood vessel physical model material, makes second aneurysm blood vessel solid model fusing and flow out from aneurysm vascular model;
(5.5) inwall of the aneurysm vascular model of cleaning step (5.4).
Preferably, the manufacture method of above-mentioned aneurysm vascular model also can comprise further:
(6) overlay film is carried out to the inwall of aneurysm vascular model.
(6.1) all the other import and export are all blocked with sealing-plug by the import and export that of aneurysm vascular model of selected step (5) is larger;
(6.2) silicone rubber based for step low friction surface coating material is poured in the aneurysm vascular model of step (6.1);
(6.3) remove all sealing-plugs in aneurysm vascular model, by emptying for the silicone rubber based low friction surface coating material in the aneurysm vascular model of step (6.2) and at room temperature leave standstill 4-5 hour;
(6.4) aneurysm vascular model of step (6.3) is placed in baking box, the temperature of baking box is set as 50-70 DEG C, take out after about 30 minutes;
(6.5) step (6.1) to (6.4) is repeated to reach the coating layer thickness of needs.
Alternatively, described step (1) medium-sized artery tumor blood vessel electronic 3-D model is from CT or the MRI scan-data of real patient.
Preferably, the optional self-induced transparency of molding material in described step (3), translucent or nontransparent macromolecular material.Alternatively, described macromolecular material is silicone rubber.
Preferably, in described step (4), the material of second aneurysm blood vessel solid model can be selected from low-melting alloy.Alternatively, described low-melting alloy can be the bismuth-base alloy that fusing point is about 40-70 DEG C.
The present invention contrasts prior art following beneficial effect: the present invention mainly solves the problems such as cost is high, operation process is not directly perceived in existing aneurysm Wicresoft intervene operation operation practice process; Meanwhile, can be performance test and verification platform that equipment manufacturers provides a kind of cheapness, effective aneurysm Wicresoft intervention apparatus; In addition, the present invention also can be used for the dynamic (dynamical) occasion of each scientific research institution research aneurysm vessel inner blood.
Accompanying drawing explanation
Fig. 1 shows the schematic diagram of the preferred cerebral aneurysm vascular pattern of the present invention one.
Fig. 2 shows the schematic diagram of the preferred breast of the present invention one, abdominal aortic aneurysm vascular pattern.
Fig. 3 shows the general flow chart of the manufacture method of aneurysm vascular model of the present invention.
Fig. 4 shows the flow chart making aneurysm blood vessel solid model in the manufacture method of aneurysm vascular model of the present invention.
Fig. 5 shows the flow chart of the mold making aneurysm blood vessel in the manufacture method of aneurysm vascular model of the present invention.
Fig. 6 shows the flow chart making second aneurysm blood vessel solid model in the manufacture method of aneurysm vascular model of the present invention.
Fig. 7 shows the flow chart making aneurysm vascular model in the manufacture method of aneurysm vascular model of the present invention.
Fig. 8 shows the flow chart in the manufacture method of aneurysm vascular model of the present invention, the blood vessel of aneurysm vascular model being carried out to overlay film.
Detailed description of the invention
In order to understand the present invention better, below in conjunction with drawings and Examples, the invention will be further described, but it does not limit the present invention.
the embodiment of aneurysm vascular model
Fig. 1 shows the schematic diagram of the preferred aneurysm vascular model of the present invention one.This aneurysm vascular model 1 is cerebral aneurysm vascular pattern, and its block transparent material external form is cube, and pipe-like internal path is set to unobstructed, and aneurysm tumor body 10 is positioned at the crotch of left posterior cerebral artery 11 and right posterior cerebral artery 12.This aneurysm vascular model 1 is split-type structural, comprises submodule 2 and submodule 3.Submodule 2 comprises aneurysm tumor body 10, left posterior cerebral artery 11, right posterior cerebral artery 12, left back arteria communicans 13, right back arteria communicans 14 and basilar artery 15.Submodule 3 comprises basilar artery 16, left posterior inferior cerebellar artery 17, right posterior inferior cerebellar artery 18, left vertebral artery 19, right vertebral artery 20, left posterior inferior cerebellar artery 21, right posterior inferior cerebellar artery 22 and anterior spinal artery 23.Submodule 2 and submodule 3 are at the detachable joint in interface 30 place.
Aneurysm vascular model 1 to be closely fixed in a control box in 2.Every one side of control box 2 is set to detachably, is fixed by screw 40.On the tank wall of control box 2, the end of corresponding left posterior cerebral artery 11, right posterior cerebral artery 12, left back arteria communicans 13, right back arteria communicans 14, left posterior inferior cerebellar artery 17, right posterior inferior cerebellar artery 18, left vertebral artery 19, right vertebral artery 20, left posterior inferior cerebellar artery 21, right posterior inferior cerebellar artery 22 and anterior spinal artery 23 is provided with the perforate 50 consistent with each end surface shape, and sealing-plug 60 can be used to control its closed and unlatching.
Above-described embodiment is described aneurysm vascular model provided by the present invention for cerebral aneurysm vascular pattern, such as, but aneurysm vascular model provided by the present invention can be the aneurysm vascular model at any position, abdominal aortic aneurysm vascular pattern, aneurysm of thoracic aorta vascular pattern etc.
Fig. 2 shows the schematic diagram of another preferred aneurysm vascular model of the present invention.This aneurysm vascular model is breast, abdominal aortic aneurysm vascular pattern.Aneurysm of thoracic aorta module 5 is made up of the aneurysm of thoracic aorta 31 in Arteria carotis communis 34, left and right subclavian artery 33 and thoracic aorta bow portion.Abdominal aortic aneurysm blood vessel module 6 is by left and right renal artery 36, the total tremulous pulse 35 of left and right hip, the outer tremulous pulse 42 of left and right hip, tremulous pulse 37, left and right femoral artery 38 in the hip of left and right, outside left and right deep femoral artery 39, left and right stock convolution tremulous pulse 41 and between renal artery and the total tremulous pulse of hip abdominal aortic aneurysm 32 form.
Aneurysm of thoracic aorta module 5 and abdominal aortic aneurysm module 6 are connected to interface 90 by connector 100 and are fixed by girth member 80.The blood vessel of the aneurysm vascular model shown by Fig. 2 is imported and exported and is all configured with the connector 70 that can connect external pipe, so that the fluid shuttling movement in model; If do not need the fluid in model to move, the as closed and open to control it in the sealing-plug 60 in Fig. 1 of configuration can be used.
the embodiment of the manufacture method of aneurysm vascular model
Fig. 3 shows the main-process stream of the manufacture method of aneurysm vascular model provided by the present invention.Shown in Figure 3, here is the detailed description to each step in flow process.
Step S1: the threedimensional model creating aneurysm blood vessel on computers, the initial data of this threedimensional model can from CT or the MRI scan-data of real patient, with software data suitably edited and process, remove the burr of uninterested vasculature part and blood vessel surface, and the data storing handled well is become the discernible data format of three-dimensional fast shaping machine.
Step S2: make aneurysm blood vessel solid model.Fig. 4 shows the sub-process of this step.Shown in Figure 4, here is the detailed description to these sub-processes.
Step S21: aneurysm blood vessel three-dimensional model data separate three-dimensional fast shaping mechanism ready in step S1 is made aneurysm blood vessel solid model.
Step S22: utilize the milling tools such as sand paper to polish to aneurysm blood vessel solid model surface, its objective is that to make this model surface smooth as far as possible.
Step S3: the mold making aneurysm blood vessel.Fig. 5 shows the sub-process of this step.Shown in Figure 5, here is the detailed description to these sub-processes.
Step S31: be fixed in mold case by the aneurysm blood vessel solid model completed in step S2, makes the remainder of this aneurysm blood vessel solid model except end not contact with mold case.
Step S32: molding material and solvent are poured in container by a certain percentage, is fully uniformly mixed uniformly solution.In the present embodiment, described molding material can be the SE2005A of ACCSilicones company of Britain, and described coagulant can be the SE2005B of ACCSilicones company of Britain, and the ratio of molding material and coagulant is 100: 1.
Step S33: poured in the mold case described in step S31 by solution obtained in step S32, and be placed in vacuum pump by this mold case, after placing a period of time, makes the solution in mold case fully solidify, and forms solid state mold.
Step S34: mold obtained in step S33 is taken out from mold case, and along the centrage of aneurysm blood vessel solid model, mold is cut in half, thus aneurysm blood vessel solid model is taken out from mold.
Step S4: make second aneurysm blood vessel solid model.Fig. 6 shows the sub-process of this step.Shown in Figure 6, here is the detailed description to these sub-processes.
Step S41: the mold adhesive tape cut in step S3 is bonded together again from outside.
Step S42: the material being used for making second aneurysm blood vessel solid model is placed in container, the temperature of container is increased to the fusing point higher than material, make described material be melt into liquid state.In the present embodiment, the material of second described aneurysm blood vessel solid model can be the low melting point bismuth-base alloy LensAlloy117 of Lowden company of Britain, and its fusing point is about 47.2 degrees Celsius.
Step S43: the material after fusing to be poured in step S41 in obtained mold, and allow the abundant cooled and solidified of described liquid material, form second aneurysm blood vessel solid model.
Step S44: second aneurysm blood vessel solid model obtained in step S43 is taken out from mold, and with instruments such as sand paper, grinding process is carried out to this model surface, make this model surface smooth as far as possible.
Step S5: make aneurysm vascular model.Fig. 7 shows the sub-process of this step.Shown in Figure 7, here is the detailed description to these sub-processes.
Step S51: be fixed in mold case by complete in step S4 second aneurysm blood vessel solid model, makes the remainder of this aneurysm blood vessel solid model except end not contact with mold case.
Step S52: aneurysm vascular model material and solvent are poured in container by a certain percentage, is fully uniformly mixed uniformly solution.In the present embodiment, described aneurysm vascular model material can be the Sylgard184A type silicone rubber of DowCorning company of the U.S., described coagulant can be the Sylgard184B type coagulant of DowCorning company of the U.S., and the ratio of aneurysm vascular model material and solvent is 10: 1.
Step S53: poured in the mold case described in step S51 by solution obtained in step S52, and be placed in vacuum pump by this mold case, after placing a period of time, makes the solution in mold case fully solidify, and forms solid state aneurysm vascular model.
Step S54: aneurysm vascular model obtained in step S53 is vertically placed in baking box, baking box temperature is set as the fusing point higher than second aneurysm blood vessel solid model material, makes second aneurysm blood vessel solid model fusing and flow out from the opening part of aneurysm vascular model.
Step S55: low melting point metal material residual in the aneurysm vascular model of cleaning step S54.
Step S6: overlay film is carried out to the inwall of aneurysm vascular model.Fig. 8 shows the sub-process of this step.Shown in Figure 8, here is the detailed description to these sub-processes.
Step S61: the blood vessel of the aneurysm vascular model made in step S5 is imported and exported except the larger opening of reservation one that remaining is all blocked with sealing-plug;
Step S62: the silicone rubber based low friction surface coating material of step S61 is poured in step S62 aneurysm vascular model;
Step S63: by emptying for the silicone rubber based low friction surface coating material in the aneurysm vascular model of step S63 and at room temperature leave standstill 4-5 hour;
Step S64: the aneurysm vascular model of step S64 is placed in baking box, is set as that by the temperature of baking box 50-70 DEG C is taken out for about 30 minutes;
Step S65: repeat step S62 to S65 to reach required coating layer thickness.
Above-described embodiment is available to those of ordinary skill in the art to realize or uses of the present invention; those of ordinary skill in the art can be without departing from the present invention in the case of the inventive idea; various modifications or change are made to above-described embodiment; thus protection scope of the present invention not limit by above-described embodiment, and should be the maximum magnitude meeting the inventive features that claims are mentioned.
Claims (10)
1. a manufacture method for aneurysm vascular model, is characterized in that, described method comprises:
(1) aneurysm blood vessel electronic 3-D model is created;
(2) aneurysm blood vessel solid model is made;
(3) mold of aneurysm blood vessel is made;
(3.1) the aneurysm blood vessel solid model of step (2) is fixed in mold case;
(3.2) molding material and coagulant are mixed into solution by a certain percentage;
(3.3) solution of step (3.2) is poured in mold case, and allow described solution fully solidify, form mold;
(3.4) mold is cut along aneurysm blood vessel solid model centrage, and aneurysm blood vessel solid model is taken out from mold;
(4) second aneurysm blood vessel solid model is made;
(5) aneurysm vascular model is made;
(6) overlay film is carried out to the inwall of aneurysm vascular model.
2. the manufacture method of aneurysm vascular model according to claim 1, is characterized in that, step (2) comprises further:
(2.1) three-dimensional fast shaping machine is utilized to manufacture aneurysm blood vessel solid model;
(2.2) as required, the surface of the aneurysm blood vessel solid model of step (2.1) is cut, defect mending and polishing.
3. the manufacture method of aneurysm vascular model according to claim 1, is characterized in that, step (4) comprises further:
(4.1) mold cut in step (3.4) is reconsolidated fixing;
(4.2) the making material of second aneurysm blood vessel solid model is fused into liquid state;
(4.3) liquid material of step (4.2) is poured into step (4.1) to merge in the mold after fixing, and allow described liquid material fully solidify, form second aneurysm blood vessel solid model;
(4.4) second aneurysm blood vessel solid model of step (4.3) is taken out from mold, and defect mending and grinding process are carried out to its surface.
4. the manufacture method of aneurysm vascular model according to claim 1, is characterized in that, step (5) comprises further:
(5.1) second aneurysm blood vessel solid model of step (4) is fixed in mold case;
(5.2) aneurysm vascular model material and coagulant are mixed into solution by a certain percentage;
(5.3) solution of step (5.2) is poured in mold case, and allow described solution fully solidify, form aneurysm vascular model;
(5.4) aneurysm vascular model of step (5.3) is placed in baking box, baking box temperature is set as the fusing point higher than second aneurysm blood vessel solid model material, makes second aneurysm blood vessel solid model fusing and flow out from aneurysm vascular model;
(5.5) inwall of the aneurysm vascular model of cleaning step (5.4).
5. the manufacture method of aneurysm vascular model according to claim 1, is characterized in that, step (6) comprises further:
(6.1) all the other import and export are all blocked with sealing-plug by the import and export that of aneurysm vascular model of selected step (5) is larger;
(6.2) silicone rubber based for step low friction surface coating material is poured in the aneurysm vascular model of step (6.1);
(6.3) remove all sealing-plugs in aneurysm vascular model, by emptying for the silicone rubber based low friction surface coating material in the aneurysm vascular model of step (6.2) and at room temperature leave standstill 4-5 hour;
(6.4) aneurysm vascular model of step (6.3) is placed in baking box, the temperature of baking box is set as 50-70 DEG C, take out after about 30 minutes;
(6.5) step (6.1) to (6.4) is repeated to reach the coating layer thickness of needs.
6. the manufacture method of aneurysm vascular model according to claim 1, is characterized in that, described step (1) medium-sized artery tumor blood vessel electronic 3-D model is from CT or the MRI scan-data of real patient.
7. the manufacture method of aneurysm vascular model according to claim 1, is characterized in that, in described step (3), molding material is selected from macromolecular material.
8. the manufacture method of aneurysm vascular model according to claim 7, is characterized in that, described macromolecular material is silicone rubber.
9. the manufacture method of aneurysm vascular model according to claim 3, is characterized in that, in described step (4), the material of second aneurysm blood vessel solid model is selected from low-melting alloy.
10. the manufacture method of aneurysm vascular model according to claim 9, is characterized in that, described low-melting alloy to be fusing point the be bismuth-base alloy of 40-70 DEG C.
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| CN103284765A (en) | 2013-09-11 |
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