CN103272121B - 一种治疗破伤风的中药制剂 - Google Patents
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Abstract
一种治疗破伤风的中药制剂，由如下重量份的原料药制成：百蕊草13-17份、玉竹13-17份、土贝母13-17份、白芍13-17份、黄芪10-14份、生地黄10-14份、车前草10-14份、当归9-11份、蜈蚣9-11份、僵蚕9-11份、钩藤6-8份、白附子6-8份、防风6-8份、全蝎4-6份、天南星4-6份。本发明具有疗效显著、见效快、毒副作用小的优点；经临床验证，本发明对于治疗破伤风的有效率为96%。
Description
技术领域
本发明涉及中药制药技术领域，特别是涉及一种治疗破伤风的中药制剂。
背景技术
破伤风是由破伤风杆菌的感染所致；破伤风杆菌属革兰阳性产芽胞性厌氧菌，广泛地散布于泥土中，粪便中亦含有该菌；单纯破伤风杆菌芽胞侵入伤口并不足以引起本病，必须要有其他细菌，或有异物如木头、玻璃等的碎片同时存在；破伤风杆菌仅孳长在厌氧伤口内，并不散播到别处，但该菌产生外毒素可致使神经系统中毒；当毒素作用于脑干和脊髓后，由于主动肌和拮抗肌二者均收缩，因而产生特异性的肌肉痉挛；主要症状为出现的牙关紧闭，以及全身各部位骨骼肌发生痉挛所出现的颈项强直、角弓反张与呼吸困难等。
目前，治疗破伤风主要是使用大剂量的破伤风抗毒素，氯化筒箭毒碱抗痉挛治疗，青霉素抗感染治疗等方法；存在治疗时间长、效果差、毒副作用大等不足。
发明内容
本发明要解决的技术问题是：为解决现有技术的不足，本发明提供了一种治疗破伤风的中药制剂，具有疗效显著、见效快、毒副作用小的优点。
一种治疗破伤风的中药制剂，其特征是：由如下重量份的原料药制成：百蕊草13-17份、玉竹13-17份、土贝母13-17份、白芍13-17份、黄芪10-14份、生地黄10-14份、车前草10-14份、当归9-11份、蜈蚣9-11份、僵蚕9-11份、钩藤6-8份、白附子6-8份、防风6-8份、全蝎4-6份、天南星4-6份。
所述的治疗破伤风的中药制剂，其特征是：由如下重量份的原料药制成：百蕊草15份、玉竹15份、土贝母15份、白芍15份、黄芪12份、生地黄12份、车前草12份、当归10份、蜈蚣10份、僵蚕10份、钩藤7份、白附子7份、防风7份、全蝎5份、天南星5份。
所述的治疗破伤风的中药制剂的制备方法，包括以下步骤：
（1）按照所述重量份数称取原料药；
（2）将称取好的原料药杀菌、混合，以每袋250-350克装袋即得。
用法及用量：将制成的中药制剂按常规方法加水煎熬，每付药可煎熬二次，患者每天早、晚各服用一次，3天为一个疗程。
本发明的各原料药的药用性能如下：
百蕊草：性味归经：辛、微苦，性寒，归脾、肾经；功效：清热;利湿;解毒。
玉竹：性味归经：微寒、甘，归肺、胃经；功效：养阴润燥，生津止渴。
土贝母：性味归经：苦，微寒，归肺、脾经；功效：散结，消肿，解毒。
白芍：性味归经：微寒、苦、酸，归肝、脾经；功效：平肝止痛，养血调经，敛阴止汗。
黄芪：性味归经：甘，微温，归肺、脾、肝、肾经；功效：补齐固表，托疮生肌。
生地黄：性味归经：甘苦，凉，归心、肝、肾经；功效：清热、生津滋阴，养血。
车前草：性味归经：甘，寒，归肝、肾、肺、小肠经；功效：清热利尿，祛痰，凉血，解毒。
当归：性味归经：甘、辛、温；归肝、心、脾经；功效：补血活血、调经止痛、润燥滑肠。
蜈蚣：性味归经：辛，温；有毒；归肝经；功效：息风镇痉，功毒散结，通络止痛。
僵蚕：性味归经：咸、辛，平；归肝、肺、胃经；功效：祛风定惊，化痰散结。
钩藤：性味归经：甘，凉；归肝、心包经；功效：清热平肝，息风定惊。
白附子：性味归经：辛，温，有毒；归胃、肝经；功效：祛风痰，定惊搐，解毒散结止痛。
防风：性味归经：辛、甘、微温，归膀胱、肺、脾、肝；功效：祛风解表、胜湿止痛、解痉、止痒。
全蝎：性味归经：辛、平，有毒；归肝经；功效：息风镇痉，攻毒散结，通络止痛。
天南星：性味归经：苦、辛，温；归肺、肝、脾经；功效：燥湿化痰，祛风止痉，散结消肿。
本发明是在传统中医理论和临床经验指导下，精选出上述各原料药及其配比制成中药制剂，具有清热解毒、温阳通络、驱风镇经的作用，从而达到治疗破伤风的目的。
本发明与现有技术相比所具有的有益效果是：本发明具有疗效显著、见效快、毒副作用小的优点；经临床验证，本发明对于治疗破伤风的有效率为96%。
具体实施方式
实施例1：
一种治疗破伤风的中药制剂，其特征是：由如下重量份的原料药制成：百蕊草15份、玉竹15份、土贝母15份、白芍15份、黄芪12份、生地黄12份、车前草12份、当归10份、蜈蚣10份、僵蚕10份、钩藤7份、白附子7份、防风7份、全蝎5份、天南星5份。
所述的治疗破伤风的中药制剂的制备方法，包括以下步骤：
（1）按照所述重量份数称取原料药；
（2）将称取好的原料药杀菌、混合，以每袋250-350克装袋即得。
实施例2：
一种治疗破伤风的中药制剂，其特征是：由如下重量份的原料药制成：
百蕊草13份、玉竹13份、土贝母13份、白芍13份、黄芪10份、生地黄10份、车前草10份、当归9份、蜈蚣9份、僵蚕9份、钩藤6份、白附子6份、防风6份、全蝎4份、天南星4份。
所述的治疗破伤风的中药制剂的制备方法，包括以下步骤：
（1）按照所述重量份数称取原料药；
（2）将称取好的原料药杀菌、混合，以每袋250-350克装袋即得。
实施例3：
一种治疗破伤风的中药制剂，其特征是：由如下重量份的原料药制成：
百蕊草17份、玉竹17份、土贝母17份、白芍17份、黄芪14份、生地黄14份、车前草14份、当归11份、蜈蚣11份、僵蚕11份、钩藤8份、白附子8份、防风8份、全蝎6份、天南星6份。
所述的治疗破伤风的中药制剂的制备方法，包括以下步骤：
（1）按照所述重量份数称取原料药；
（2）将称取好的原料药杀菌、混合，以每袋250-350克装袋即得。
实验例：
一、临床资料：采用本发明治疗破伤风患者31例，其中男19例，女12例，年龄最大的54岁，最小的6岁。
二、临床症状：多有外伤接触泥土或污物史，一般破伤感邪后2-15天发病，但亦可短至1天或长达数月者；始有形寒，头痛，乏力，多汗，烦躁不安；创口疼痛并有紧张牵引感，伤口干陷无脓，周围肤色暗红；发病时张口困难，咀嚼肌酸胀，牙关紧闭，面呈苦笑表情，硕背强直，甚至角弓反张，或腹部强硬如板，大便秘结，小便不通，剧烈抽搐可造成肌肉撕裂或骨折。
三、治疗方法：将制成的中药制剂按常规方法加水煎熬，每付药可煎熬二次，患者每天早、晚各服用一次，3天为一个疗程。
四、疗效评价标准：
治愈：全身症状消失，伤口愈合；
好转：全身症状好转，伤口未完全愈合；
未愈：全身症状未见改善。
五、典型病例：
1、黄某，男，9岁，患病半个月前左手被撞伤，症状表现为牙关紧闭，面部呈苦笑表情，肌肉痉挛抽搐，言语不清等，诊断为破伤风；使用本发明的中药制剂1个疗程后症状明显改善，3个疗程痊愈，随访2年未复发。
2、程某某，女，37岁，因左腿腿部受伤患破伤风，症状表现为牙关紧闭，全身肌肉阵发性痉挛，大便秘结，小便不通，呼吸急促等；使用本发明的中药制剂1个疗程后症状明显改善，4个疗程痊愈，随访1年未复发。
3、柯某某，男，23岁，患破伤风，就诊3天前脚被铁钉扎伤，症状表现为呼吸、说话、吞咽俱感困难，剧烈抽搐，面色青紫；使用本发明的中药制剂2个疗程后症状明显改善，5个疗程痊愈，随访1年未复发。
六、治疗结果：
采用本发明治疗破伤风患者31例，经过2-5个疗程的治疗，其中治愈29例，未愈2例，有效率为96%，治疗过程中未见有毒副作用；结果表明，本发明具有疗效显著、见效快、毒副作用小的优点。
Claims (2)
1.一种治疗破伤风的中药制剂，其特征是：由如下重量份的原料药制成：百蕊草13-17份、玉竹13-17份、土贝母13-17份、白芍13-17份、黄芪10-14份、生地黄10-14份、车前草10-14份、当归9-11份、蜈蚣9-11份、僵蚕9-11份、钩藤6-8份、白附子6-8份、防风6-8份、全蝎4-6份、天南星4-6份。
2.根据权利要求1所述的治疗破伤风的中药制剂，其特征是：由如下重量份的原料药制成：百蕊草15份、玉竹15份、土贝母15份、白芍15份、黄芪12份、生地黄12份、车前草12份、当归10份、蜈蚣10份、僵蚕10份、钩藤7份、白附子7份、防风7份、全蝎5份、天南星5份。
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